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UniProtKB - Q15417 (CNN3_HUMAN)

Entry version 188 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Calponin-3

Gene

CNN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15417

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15417

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2157, CNN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602374, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15417

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117519.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1266

Open Targets

More...OpenTargetsi		ENSG00000117519

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26667

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15417, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CNN3

Domain mapping of disease mutations (DMDM)

More...DMDMi		6225157

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002047761 – 329Calponin-3Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23N6-acetyllysineBy similarity1
Modified residuei158N6-methyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15417

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15417

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15417

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15417

PeptideAtlas

More...PeptideAtlasi		Q15417

PRoteomics IDEntifications database

More...PRIDEi		Q15417

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30452
4050
60582 [Q15417-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1059, 6 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15417, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15417

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q15417

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15417

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q15417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117519, Expressed in ventricular zone and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15417, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15417, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117519, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107666, 24 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15417

Protein interaction database and analysis system

More...IntActi		Q15417, 17 interactors

Molecular INTeraction database

More...MINTi		Q15417

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359225

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15417, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15417

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 130Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati164 – 189Calponin-like 1Add BLAST26
Repeati204 – 229Calponin-like 2Add BLAST26
Repeati243 – 268Calponin-like 3Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 329Asp/Glu-rich (acidic)Add BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calponin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2046, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055232_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15417

Identification of Orthologs from Complete Genome Data

More...OMAi		QDDYPRE

Database of Orthologous Groups

More...OrthoDBi		861989at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15417

TreeFam database of animal gene trees

More...TreeFami		TF313921

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001997, Calponin/LIMCH1
IPR000557, Calponin_repeat
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003096, SM22_calponin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00402, Calponin, 3 hits
PF00307, CH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00889, CALPONIN
PR00888, SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01052, CALPONIN_1, 3 hits
PS51122, CALPONIN_2, 3 hits
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL 
        60         70         80         90        100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP 
       110        120        130        140        150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR 
       160        170        180        190        200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD 
       210        220        230        240        250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN 
       260        270        280        290        300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY 
       310        320 
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY
Length:329
Mass (Da):36,414
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF024E169E821A8D8
GO
Isoform 2 (identifier: Q15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:288
Mass (Da):31,738
Checksum:iF4592E7F1B1BD6A8
GO
Isoform 3 (identifier: Q15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-128: Missing.

Show »
Length:283
Mass (Da):31,380
Checksum:i2CB95FDFA4599145
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDU6E9PDU6_HUMAN
Calponin
CNN3
185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21A → S in BAG60421 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0551911 – 41Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_05519283 – 128Missing in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S80562 mRNA Translation: AAB35752.1
AK312370 mRNA Translation: BAG35288.1
AK294141 mRNA Translation: BAG57467.1
AK298145 mRNA Translation: BAG60421.1
AK316398 mRNA Translation: BAH14769.1
CR541848 mRNA Translation: CAG46646.1
AC093429 Genomic DNA No translation available.
AC105942 Genomic DNA No translation available.
AL359554 Genomic DNA Translation: CAC36093.1
CH471097 Genomic DNA Translation: EAW73029.1
BC025372 mRNA Translation: AAH25372.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30775.1 [Q15417-1]
CCDS65592.1 [Q15417-2]
CCDS65593.1 [Q15417-3]

Protein sequence database of the Protein Information Resource

More...PIRi		JC4501

NCBI Reference Sequences

More...RefSeqi		NP_001272984.1, NM_001286055.1 [Q15417-3]
NP_001272985.1, NM_001286056.1 [Q15417-2]
NP_001830.1, NM_001839.4 [Q15417-1]
XP_016855734.1, XM_017000245.1 [Q15417-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370206; ENSP00000359225; ENSG00000117519 [Q15417-1]
ENST00000394202; ENSP00000377752; ENSG00000117519 [Q15417-3]
ENST00000545882; ENSP00000440081; ENSG00000117519 [Q15417-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1266

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1266

UCSC genome browser

More...UCSCi		uc001dqz.6, human [Q15417-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80562 mRNA Translation: AAB35752.1
AK312370 mRNA Translation: BAG35288.1
AK294141 mRNA Translation: BAG57467.1
AK298145 mRNA Translation: BAG60421.1
AK316398 mRNA Translation: BAH14769.1
CR541848 mRNA Translation: CAG46646.1
AC093429 Genomic DNA No translation available.
AC105942 Genomic DNA No translation available.
AL359554 Genomic DNA Translation: CAC36093.1
CH471097 Genomic DNA Translation: EAW73029.1
BC025372 mRNA Translation: AAH25372.1
CCDSiCCDS30775.1 [Q15417-1]
CCDS65592.1 [Q15417-2]
CCDS65593.1 [Q15417-3]
PIRiJC4501
RefSeqiNP_001272984.1, NM_001286055.1 [Q15417-3]
NP_001272985.1, NM_001286056.1 [Q15417-2]
NP_001830.1, NM_001839.4 [Q15417-1]
XP_016855734.1, XM_017000245.1 [Q15417-2]

3D structure databases

SMRiQ15417
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107666, 24 interactors
CORUMiQ15417
IntActiQ15417, 17 interactors
MINTiQ15417
STRINGi9606.ENSP00000359225

PTM databases

GlyConnecti1059, 6 N-Linked glycans (1 site)
GlyGeniQ15417, 1 site
iPTMnetiQ15417
MetOSiteiQ15417
PhosphoSitePlusiQ15417
SwissPalmiQ15417

Genetic variation databases

BioMutaiCNN3
DMDMi6225157

Proteomic databases

EPDiQ15417
jPOSTiQ15417
MassIVEiQ15417
PaxDbiQ15417
PeptideAtlasiQ15417
PRIDEiQ15417
ProteomicsDBi30452
4050
60582 [Q15417-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4078, 209 antibodies

The DNASU plasmid repository

More...DNASUi		1266

Genome annotation databases

EnsembliENST00000370206; ENSP00000359225; ENSG00000117519 [Q15417-1]
ENST00000394202; ENSP00000377752; ENSG00000117519 [Q15417-3]
ENST00000545882; ENSP00000440081; ENSG00000117519 [Q15417-2]
GeneIDi1266
KEGGihsa:1266
UCSCiuc001dqz.6, human [Q15417-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1266
DisGeNETi1266

GeneCards: human genes, protein and diseases

More...GeneCardsi		CNN3
HGNCiHGNC:2157, CNN3
HPAiENSG00000117519, Low tissue specificity
MIMi602374, gene
neXtProtiNX_Q15417
OpenTargetsiENSG00000117519
PharmGKBiPA26667
VEuPathDBiHostDB:ENSG00000117519.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2046, Eukaryota
GeneTreeiENSGT00940000154539
HOGENOMiCLU_055232_0_2_1
InParanoidiQ15417
OMAiQDDYPRE
OrthoDBi861989at2759
PhylomeDBiQ15417
TreeFamiTF313921

Enzyme and pathway databases

PathwayCommonsiQ15417
SIGNORiQ15417

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1266, 5 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CNN3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1266
PharosiQ15417, Tbio

Protein Ontology

More...PROi		PR:Q15417
RNActiQ15417, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117519, Expressed in ventricular zone and 243 other tissues
ExpressionAtlasiQ15417, baseline and differential
GenevisibleiQ15417, HS

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997, Calponin/LIMCH1
IPR000557, Calponin_repeat
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003096, SM22_calponin
PfamiView protein in Pfam
PF00402, Calponin, 3 hits
PF00307, CH, 1 hit
PRINTSiPR00889, CALPONIN
PR00888, SM22CALPONIN
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052, CALPONIN_1, 3 hits
PS51122, CALPONIN_2, 3 hits
PS50021, CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15417
Secondary accession number(s): B4DFK6
, B4DP09, F8WA86, Q6FHA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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