UniProtKB - Q15415 (RBY1F_HUMAN)
Protein
RNA-binding motif protein, Y chromosome, family 1 member F/J
Gene
RBMY1F
moreOrganism
Homo sapiens (Human)
Status
Functioni
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.1 Publication
Miscellaneous
The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: GO_Central
GO - Biological processi
- alternative mRNA splicing, via spliceosome Source: GO_Central
- mRNA splicing, via spliceosome Source: GO_Central
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q15415 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding motif protein, Y chromosome, family 1 member F/JAlternative name(s): Y chromosome RNA recognition motif 2 |
Gene namesi | Name:RBMY1F Synonyms:YRRM2 AND Name:RBMY1J |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23974, RBMY1F HGNC:23917, RBMY1J |
MIMi | 400006, gene |
neXtProti | NX_Q15415 |
VEuPathDBi | HostDB:ENSG00000169800.13 HostDB:ENSG00000226941.7 |
Subcellular locationi
Nucleus
Nucleus
- nuclear speck Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
PharmGKBi | PA134946298 |
Miscellaneous databases
Pharosi | Q15415, Tdark |
Genetic variation databases
BioMutai | RBMY1J |
DMDMi | 166199747 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314164 | 1 – 496 | RNA-binding motif protein, Y chromosome, family 1 member F/JAdd BLAST | 496 |
Proteomic databases
jPOSTi | Q15415 |
MassIVEi | Q15415 |
PaxDbi | Q15415 |
PeptideAtlasi | Q15415 |
PRIDEi | Q15415 |
ProteomicsDBi | 60580 [Q15415-1] 60581 [Q15415-2] |
PTM databases
iPTMneti | Q15415 |
PhosphoSitePlusi | Q15415 |
Expressioni
Tissue specificityi
Testis-specific.1 Publication
Developmental stagei
Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.
Gene expression databases
Bgeei | ENSG00000169800, Expressed in testis and 6 other tissues |
Genevisiblei | Q15415, HS |
Organism-specific databases
HPAi | ENSG00000169800, Tissue enriched (testis) ENSG00000226941, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
Binary interactionsi
Hide detailsQ15415
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 127736, 39 interactors 132082, 29 interactors |
IntActi | Q15415, 35 interactors |
MINTi | Q15415 |
Miscellaneous databases
RNActi | Q15415, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 85 | RRMPROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 254 – 340 | Arg-richAdd BLAST | 87 |
Phylogenomic databases
GeneTreei | ENSGT00940000163524 |
HOGENOMi | CLU_042286_0_0_1 |
InParanoidi | Q15415 |
OMAi | FQSDCRR |
OrthoDBi | 1248417at2759 |
PhylomeDBi | Q15415 |
TreeFami | TF331833 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012604, RBM1CTR IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08081, RBM1CTR, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15415-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF
60 70 80 90 100
AFITFENPAD AKNAAKDMNG TSLHGKAIKV EQAKKPSFQS GGRRRPPASS
110 120 130 140 150
RNRSPSGSLR SARGSSGGTR GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV
160 170 180 190 200
KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI
210 220 230 240 250
SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE
260 270 280 290 300
HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNHRSSR
310 320 330 340 350
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA
360 370 380 390 400
YRDYGHSSWD EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS
410 420 430 440 450
HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD FHYCDREHVC
460 470 480 490
RKDQRNPPSL GRVLPDPREA YGSSSYVASI VDGGESRSEK GDSSRY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KQ82 | J3KQ82_HUMAN | RNA-binding motif protein, Y chromo... | RBMY1F | 459 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | P → A in CAA53660 (PubMed:8269511).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030217 | 397 – 419 | YGTSH…GSTCH → DLSWCTTCKRASDVLWWKHL PRI in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_030218 | 420 – 496 | Missing in isoform 2. 1 PublicationAdd BLAST | 77 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76060 mRNA Translation: CAA53660.1 AK313597 mRNA Translation: BAG36363.1 AC023342 Genomic DNA No translation available. AC007320 Genomic DNA No translation available. BC030018 mRNA Translation: AAH30018.1 BC152392 mRNA Translation: AAI52393.1 |
CCDSi | CCDS35483.1 [Q15415-1] CCDS35484.1 [Q15415-1] |
PIRi | B49418 |
RefSeqi | NP_001006117.2, NM_001006117.3 [Q15415-1] NP_001290339.1, NM_001303410.1 [Q15415-2] NP_689798.1, NM_152585.2 [Q15415-1] |
Genome annotation databases
Ensembli | ENST00000250831; ENSP00000250831; ENSG00000226941 [Q15415-1] ENST00000303766; ENSP00000307155; ENSG00000169800 [Q15415-1] |
GeneIDi | 159163 378951 |
KEGGi | hsa:159163 hsa:378951 |
UCSCi | uc004fva.4, human [Q15415-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76060 mRNA Translation: CAA53660.1 AK313597 mRNA Translation: BAG36363.1 AC023342 Genomic DNA No translation available. AC007320 Genomic DNA No translation available. BC030018 mRNA Translation: AAH30018.1 BC152392 mRNA Translation: AAI52393.1 |
CCDSi | CCDS35483.1 [Q15415-1] CCDS35484.1 [Q15415-1] |
PIRi | B49418 |
RefSeqi | NP_001006117.2, NM_001006117.3 [Q15415-1] NP_001290339.1, NM_001303410.1 [Q15415-2] NP_689798.1, NM_152585.2 [Q15415-1] |
3D structure databases
SMRi | Q15415 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127736, 39 interactors 132082, 29 interactors |
IntActi | Q15415, 35 interactors |
MINTi | Q15415 |
PTM databases
iPTMneti | Q15415 |
PhosphoSitePlusi | Q15415 |
Genetic variation databases
BioMutai | RBMY1J |
DMDMi | 166199747 |
Proteomic databases
jPOSTi | Q15415 |
MassIVEi | Q15415 |
PaxDbi | Q15415 |
PeptideAtlasi | Q15415 |
PRIDEi | Q15415 |
ProteomicsDBi | 60580 [Q15415-1] 60581 [Q15415-2] |
Protocols and materials databases
Antibodypediai | 21887, 81 antibodies 69611, 3 antibodies |
DNASUi | 159163 378951 |
Genome annotation databases
Ensembli | ENST00000250831; ENSP00000250831; ENSG00000226941 [Q15415-1] ENST00000303766; ENSP00000307155; ENSG00000169800 [Q15415-1] |
GeneIDi | 159163 378951 |
KEGGi | hsa:159163 hsa:378951 |
UCSCi | uc004fva.4, human [Q15415-1] |
Organism-specific databases
CTDi | 159163 378951 |
GeneCardsi | RBMY1F RBMY1J |
HGNCi | HGNC:23974, RBMY1F HGNC:23917, RBMY1J |
HPAi | ENSG00000169800, Tissue enriched (testis) ENSG00000226941, Tissue enriched (testis) |
MIMi | 400006, gene |
neXtProti | NX_Q15415 |
PharmGKBi | PA134946298 |
VEuPathDBi | HostDB:ENSG00000169800.13 HostDB:ENSG00000226941.7 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163524 |
HOGENOMi | CLU_042286_0_0_1 |
InParanoidi | Q15415 |
OMAi | FQSDCRR |
OrthoDBi | 1248417at2759 |
PhylomeDBi | Q15415 |
TreeFami | TF331833 |
Enzyme and pathway databases
PathwayCommonsi | Q15415 |
Miscellaneous databases
BioGRID-ORCSi | 159163, 6 hits in 167 CRISPR screens 378951, 7 hits in 159 CRISPR screens |
Pharosi | Q15415, Tdark |
PROi | PR:Q15415 |
RNActi | Q15415, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169800, Expressed in testis and 6 other tissues |
Genevisiblei | Q15415, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012604, RBM1CTR IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08081, RBM1CTR, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBY1F_HUMAN | |
Accessioni | Q15415Primary (citable) accession number: Q15415 Secondary accession number(s): B2R916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot