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Entry version 185 (05 Jun 2019)
Sequence version 3 (08 Mar 2011)
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Protein

Ryanodine receptor 3

Gene

RYR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.By similarity1 Publication

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3883Important for activation by Ca(2+)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYR3
Synonyms:HBRR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10485 RYR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180903 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15413

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4186CytoplasmicBy similarityAdd BLAST4186
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4187 – 4207HelicalSequence analysisAdd BLAST21
Transmembranei4410 – 4430HelicalSequence analysisAdd BLAST21
Transmembranei4485 – 4505HelicalSequence analysisAdd BLAST21
Transmembranei4610 – 4630HelicalSequence analysisAdd BLAST21
Transmembranei4633 – 4653HelicalSequence analysisAdd BLAST21
Transmembranei4672 – 4692HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4723 – 4732Pore-formingBy similarity10
Transmembranei4753 – 4773HelicalSequence analysisAdd BLAST21
Topological domaini4774 – 4870CytoplasmicBy similarityAdd BLAST97

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6263

Open Targets

More...
OpenTargetsi
ENSG00000198838

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34897

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2062

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
749

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RYR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325511382

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193631 – 4870Ryanodine receptor 3Add BLAST4870

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15413

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15413

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15413

PeptideAtlas

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PeptideAtlasi
Q15413

PRoteomics IDEntifications database

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PRIDEi
Q15413

ProteomicsDB human proteome resource

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ProteomicsDBi
60577
60578 [Q15413-2]
60579 [Q15413-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15413

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198838 Expressed in 169 organ(s), highest expression level in diaphragm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15413 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15413 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA062004

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Heterotetramer with RYR2.

Interacts with CALM (By similarity).

Interacts with FKBP1A.

Interacts with SELENON (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112175, 8 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3162 Ryanodine 3 complex

Protein interaction database and analysis system

More...
IntActi
Q15413, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000373884

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14870
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15413

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 155MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini162 – 207MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini215 – 269MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini275 – 333MIR 4PROSITE-ProRule annotationAdd BLAST59
Domaini343 – 400MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini585 – 796B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST212
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati840 – 9531Add BLAST114
Repeati954 – 10682Add BLAST115
Domaini1012 – 1208B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST197
Domaini1254 – 1466B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST213
Repeati2589 – 27073Add BLAST119
Repeati2708 – 28204Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni840 – 28204 X approximate repeatsAdd BLAST1981
Regioni2322 – 2335Interaction with FKBP1A1 PublicationAdd BLAST14
Regioni3469 – 3498Interaction with CALMBy similarityAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231428

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15413

KEGG Orthology (KO)

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KOi
K04963

Database of Orthologous Groups

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OrthoDBi
5161at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15413

TreeFam database of animal gene trees

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TreeFami
TF315244

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH
110 120 130 140 150
RTLLYGHAVL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW
160 170 180 190 200
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSVSNGN IQVDASFMQT
210 220 230 240 250
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRIF
260 270 280 290 300
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
310 320 330 340 350
QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD
360 370 380 390 400
SVCFVQHIAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
410 420 430 440 450
QREESQAARI IRNTTALFSQ FVSGNNRTAA PITLPIEEVL QTLQDLIAYF
460 470 480 490 500
QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNVYNSVAH
510 520 530 540 550
FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN NLDWLISKLD
560 570 580 590 600
RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
610 620 630 640 650
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV
660 670 680 690 700
AEGSAQYKKW YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLRSDD VVSCCLDLGV
760 770 780 790 800
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF
810 820 830 840 850
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT TQFLSQASFI
860 870 880 890 900
PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
910 920 930 940 950
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK
960 970 980 990 1000
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
1010 1020 1030 1040 1050
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN
1060 1070 1080 1090 1100
IEPSDQELAD SAVEKVSIDK IRFFRVERSY AVRSGKWYFE FEVVTGGDMR
1110 1120 1130 1140 1150
VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR TWQPGDVVGC
1160 1170 1180 1190 1200
MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
1210 1220 1230 1240 1250
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD
1260 1270 1280 1290 1300
HPHIEVMRID GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF
1310 1320 1330 1340 1350
SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP
1360 1370 1380 1390 1400
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ
1410 1420 1430 1440 1450
RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ
1460 1470 1480 1490 1500
PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW
1510 1520 1530 1540 1550
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE
1560 1570 1580 1590 1600
QEDLMRFHYH TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG
1610 1620 1630 1640 1650
LLRSGFYDLL ISIHLASAKE RKLMMKNEYI IPITSTTRNI RLFPDESKRH
1660 1670 1680 1690 1700
GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ KQSPEIPLES LRTKALSMLT
1710 1720 1730 1740 1750
EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI
1760 1770 1780 1790 1800
DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
1810 1820 1830 1840 1850
ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ
1860 1870 1880 1890 1900
ALNMSAALTA RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH
1910 1920 1930 1940 1950
EDLLLHCGVP LEEEEEEEED TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE
1960 1970 1980 1990 2000
RCPTTLKELI SQTMICWAQE DQIQDSELVR MMFNLLRRQY DSIGELLQAL
2010 2020 2030 2040 2050
RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM INGLGDIMNN
2060 2070 2080 2090 2100
KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
2110 2120 2130 2140 2150
CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL
2160 2170 2180 2190 2200
ALSLEEPDLE KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR
2210 2220 2230 2240 2250
FAVFVNSESV EENASVVVKL LIRRPECFGP ALRGEGGNGL LAAMQGAIKI
2260 2270 2280 2290 2300
SENPALDLPS QGYKREVSTG DDEEEEEIVH MGNAIMSFYS ALIDLLGRCA
2310 2320 2330 2340 2350
PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP SLNKDGSVSE
2360 2370 2380 2390 2400
PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
2410 2420 2430 2440 2450
TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY
2460 2470 2480 2490 2500
RLSKGRSLTK AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC
2510 2520 2530 2540 2550
KMPLKLLTNH YEQCWKYYCL PSGWGSYGLA VEEELHLTEK LFWGIFDSLS
2560 2570 2580 2590 2600
HKKYDPDLFR MALPCLSAIA GALPPDYLDT RITATLEKQI SVDADGNFDP
2610 2620 2630 2640 2650
KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY GISLDENVKT
2660 2670 2680 2690 2700
HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
2710 2720 2730 2740 2750
NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK
2760 2770 2780 2790 2800
KKLELESKGG GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR
2810 2820 2830 2840 2850
GMKDMELDAS SMEKRFAYKF LKKILKYVDS AQEFIAHLEA IVSSGKTEKS
2860 2870 2880 2890 2900
PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS SPLKPLSSSG YASHKEKEMV
2910 2920 2930 2940 2950
AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT VMKSGSELVK
2960 2970 2980 2990 3000
AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI
3010 3020 3030 3040 3050
LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA
3060 3070 3080 3090 3100
LGECLASLAA AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM
3110 3120 3130 3140 3150
CPDIPQLEGL MKEINDLAES GARYTEMPHV IEVILPMLCN YLSYWWERGP
3160 3170 3180 3190 3200
ENLPPSTGPC CTKVTSEHLS LILGNILKII NNNLGIDEAS WMKRIAVYAQ
3210 3220 3230 3240 3250
PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG KGDTQEAELL
3260 3270 3280 3290 3300
ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI
3310 3320 3330 3340 3350
LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER
3360 3370 3380 3390 3400
KKTKRRGDLY SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSHR
3410 3420 3430 3440 3450
DTDEEVREHL RNNLHLQEKS DDPAVKWQLN LYKDVLKSEE PFNPEKTVER
3460 3470 3480 3490 3500
VQRISAAVFH LEQVEQPLRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP
3510 3520 3530 3540 3550
RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE EEEEETEKQP
3560 3570 3580 3590 3600
DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK
3610 3620 3630 3640 3650
EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK
3660 3670 3680 3690 3700
LGIAILNGGN AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER
3710 3720 3730 3740 3750
QNKAEGLGMV TEEGTLIVRE RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF
3760 3770 3780 3790 3800
QNFLRTQMGN TTTVNVIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH
3810 3820 3830 3840 3850
NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM
3860 3870 3880 3890 3900
QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV
3910 3920 3930 3940 3950
ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG
3960 3970 3980 3990 4000
QKQYTQSEID FLLSCAEADE NDMFNYVDFV DRFHEPAKDI GFNVAVLLTN
4010 4020 4030 4040 4050
LSEHMPNDSR LKCLLDPAES VLNYFEPYLG RIEIMGGAKK IERVYFEISE
4060 4070 4080 4090 4100
SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS
4110 4120 4130 4140 4150
QISESDSADR PEEEEEDEDS SYVLEIAGEE EEDGSLEPAS AFAMACASVK
4160 4170 4180 4190 4200
RNVTDFLKRA TLKNLRKQYR NVKKMTAKEL VKVLFSFFWM LFVGLFQLLF
4210 4220 4230 4240 4250
TILGGIFQIL WSTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDTMEA
4260 4270 4280 4290 4300
ERAEVMEPGI TTELVHFIKG EKGDTDIMSD LFGLHPKKEG SLKHGPEVGL
4310 4320 4330 4340 4350
GDLSEIIGKD EPPTLESTVQ KKRKAQAAEM KAANEAEGKV ESEKADMEDG
4360 4370 4380 4390 4400
EKEDKDKEEE QAEYLWTEVT KKKKRRCGQK VEKPEAFTAN FFKGLEIYQT
4410 4420 4430 4440 4450
KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN
4460 4470 4480 4490 4500
SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV
4510 4520 4530 4540 4550
PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW
4560 4570 4580 4590 4600
DKFVKRKVIN KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW
4610 4620 4630 4640 4650
LSSIDMKYHI WKLGVVFTDN SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA
4660 4670 4680 4690 4700
MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE
4710 4720 4730 4740 4750
DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD
4760 4770 4780 4790 4800
ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY
4810 4820 4830 4840 4850
FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER
4860 4870
CWDFFPAGDC FRKQYEDQLG
Length:4,870
Mass (Da):552,042
Last modified:March 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB953487A89FD480F
GO
Isoform 2 (identifier: Q15413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3337-3341: Missing.

Show »
Length:4,865
Mass (Da):551,484
Checksum:i1967DCA6B019C276
GO
Isoform 3 (identifier: Q15413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3857-3859: DSS → GMW
     3860-4870: Missing.

Show »
Length:3,859
Mass (Da):435,934
Checksum:i637F449F56BDEB60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X080A0A087X080_HUMAN
Ryanodine receptor 3
RYR3
4,873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRH1A0A0U1RRH1_HUMAN
Ryanodine receptor 3
RYR3
4,859Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0X1KG73A0A0X1KG73_HUMAN
Ryanodine receptor 3
RYR3
4,869Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUB0A0A1B0GUB0_HUMAN
Ryanodine receptor 3
RYR3
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR54A0A0U1RR54_HUMAN
Ryanodine receptor 3
RYR3
615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTT7A0A1B0GTT7_HUMAN
Ryanodine receptor 3
RYR3
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVS2A0A1B0GVS2_HUMAN
Ryanodine receptor 3
RYR3
468Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTF2A0A1B0GTF2_HUMAN
Ryanodine receptor 3
RYR3
1,101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVA9A0A1B0GVA9_HUMAN
Ryanodine receptor 3
RYR3
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR21A0A0U1RR21_HUMAN
Ryanodine receptor 3
RYR3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23795 differs from that shown. Reason: Frameshift at positions 742 and 766.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti932A → T in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1081A → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1336A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1480K → E in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1641R → C in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1641R → C in CAA04798 (PubMed:9515741).Curated1
Sequence conflicti2270G → E in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2270G → E in CAA04798 (PubMed:9515741).Curated1
Sequence conflicti2355A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2433A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2546F → I in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2580T → S in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2817A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti3684S → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti3698F → S in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4026E → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4083E → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4537R → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4604I → L in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4709C → R in CAA52326 (PubMed:8276408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024077261R → S1 Publication1
Natural variantiVAR_057166358I → T. Corresponds to variant dbSNP:rs2304380EnsemblClinVar.1
Natural variantiVAR_024078494V → I1 PublicationCorresponds to variant dbSNP:rs2077268Ensembl.1
Natural variantiVAR_011404693Y → C1 Publication1
Natural variantiVAR_011405731I → V1 PublicationCorresponds to variant dbSNP:rs2229116Ensembl.1
Natural variantiVAR_0114061380E → G1 Publication1
Natural variantiVAR_0114072268Missing 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0059543337 – 3341Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_0059553857 – 3859DSS → GMW in isoform 3. Curated3
Alternative sequenceiVSP_0059563860 – 4870Missing in isoform 3. CuratedAdd BLAST1011

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB001025 mRNA Translation: BAA23795.1 Frameshift.
AJ001515 mRNA Translation: CAA04798.1
AC010809 Genomic DNA No translation available.
AC011938 Genomic DNA No translation available.
AC055874 Genomic DNA No translation available.
AC067793 Genomic DNA No translation available.
AC087638 Genomic DNA No translation available.
AJ002512 mRNA Translation: CAA05503.1
X74269 mRNA Translation: CAA52326.1
X74270 Genomic DNA Translation: CAA52327.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45210.1 [Q15413-1]
CCDS58351.1 [Q15413-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S37537
S66631

NCBI Reference Sequences

More...
RefSeqi
NP_001027.3, NM_001036.4 [Q15413-1]
NP_001230925.1, NM_001243996.2 [Q15413-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000415757; ENSP00000399610; ENSG00000198838 [Q15413-2]
ENST00000634891; ENSP00000489262; ENSG00000198838 [Q15413-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6263

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6263

UCSC genome browser

More...
UCSCi
uc001zhi.3 human [Q15413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ryanodine receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001025 mRNA Translation: BAA23795.1 Frameshift.
AJ001515 mRNA Translation: CAA04798.1
AC010809 Genomic DNA No translation available.
AC011938 Genomic DNA No translation available.
AC055874 Genomic DNA No translation available.
AC067793 Genomic DNA No translation available.
AC087638 Genomic DNA No translation available.
AJ002512 mRNA Translation: CAA05503.1
X74269 mRNA Translation: CAA52326.1
X74270 Genomic DNA Translation: CAA52327.1
CCDSiCCDS45210.1 [Q15413-1]
CCDS58351.1 [Q15413-2]
PIRiS37537
S66631
RefSeqiNP_001027.3, NM_001036.4 [Q15413-1]
NP_001230925.1, NM_001243996.2 [Q15413-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ERVX-ray1.75A2597-2800[»]
SMRiQ15413
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112175, 8 interactors
ComplexPortaliCPX-3162 Ryanodine 3 complex
IntActiQ15413, 4 interactors
STRINGi9606.ENSP00000373884

Chemistry databases

ChEMBLiCHEMBL2062
GuidetoPHARMACOLOGYi749

PTM databases

iPTMnetiQ15413
PhosphoSitePlusiQ15413

Polymorphism and mutation databases

BioMutaiRYR3
DMDMi325511382

Proteomic databases

EPDiQ15413
jPOSTiQ15413
PaxDbiQ15413
PeptideAtlasiQ15413
PRIDEiQ15413
ProteomicsDBi60577
60578 [Q15413-2]
60579 [Q15413-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415757; ENSP00000399610; ENSG00000198838 [Q15413-2]
ENST00000634891; ENSP00000489262; ENSG00000198838 [Q15413-1]
GeneIDi6263
KEGGihsa:6263
UCSCiuc001zhi.3 human [Q15413-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6263
DisGeNETi6263

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RYR3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0038065
HGNCiHGNC:10485 RYR3
HPAiHPA062004
MIMi180903 gene
neXtProtiNX_Q15413
OpenTargetsiENSG00000198838
PharmGKBiPA34897

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000155507
HOGENOMiHOG000231428
InParanoidiQ15413
KOiK04963
OrthoDBi5161at2759
PhylomeDBiQ15413
TreeFamiTF315244

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RYR3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RYR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6263

Protein Ontology

More...
PROi
PR:Q15413

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198838 Expressed in 169 organ(s), highest expression level in diaphragm
ExpressionAtlasiQ15413 baseline and differential
GenevisibleiQ15413 HS

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15413
Secondary accession number(s): O15175, Q15412
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 8, 2011
Last modified: June 5, 2019
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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