UniProtKB - Q15404 (RSU1_HUMAN)
Protein
Ras suppressor protein 1
Gene
RSU1
Organism
Homo sapiens (Human)
Status
Functioni
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
GO - Biological processi
- positive regulation of cell-substrate adhesion Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- signal transduction Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q15404 |
Reactomei | R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
SignaLinki | Q15404 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras suppressor protein 1Short name: RSP-1 Short name: Rsu-1 |
Gene namesi | Name:RSU1 Synonyms:RSP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10464, RSU1 |
MIMi | 179555, gene |
neXtProti | NX_Q15404 |
VEuPathDBi | HostDB:ENSG00000148484.17 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6251 |
OpenTargetsi | ENSG00000148484 |
PharmGKBi | PA34876 |
Miscellaneous databases
Pharosi | Q15404, Tbio |
Genetic variation databases
BioMutai | RSU1 |
DMDMi | 2498866 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000097499 | 2 – 277 | Ras suppressor protein 1Add BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q15404 |
jPOSTi | Q15404 |
MassIVEi | Q15404 |
MaxQBi | Q15404 |
PaxDbi | Q15404 |
PeptideAtlasi | Q15404 |
PRIDEi | Q15404 |
ProteomicsDBi | 60570 [Q15404-1] 60571 [Q15404-2] |
2D gel databases
OGPi | Q15404 |
PTM databases
iPTMneti | Q15404 |
MetOSitei | Q15404 |
PhosphoSitePlusi | Q15404 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148484, Expressed in popliteal artery and 245 other tissues |
Genevisiblei | Q15404, HS |
Organism-specific databases
HPAi | ENSG00000148484, Low tissue specificity |
Interactioni
Binary interactionsi
Q15404
With | #Exp. | IntAct |
---|---|---|
LIMS1 [P48059] | 6 | EBI-1057132,EBI-306928 |
Protein-protein interaction databases
BioGRIDi | 112164, 36 interactors |
IntActi | Q15404, 12 interactors |
MINTi | Q15404 |
STRINGi | 9606.ENSP00000367154 |
Miscellaneous databases
RNActi | Q15404, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 41 – 63 | LRR 1Add BLAST | 23 | |
Repeati | 64 – 85 | LRR 2Add BLAST | 22 | |
Repeati | 87 – 109 | LRR 3Add BLAST | 23 | |
Repeati | 110 – 133 | LRR 4Add BLAST | 24 | |
Repeati | 135 – 156 | LRR 5Add BLAST | 22 | |
Repeati | 158 – 179 | LRR 6Add BLAST | 22 | |
Repeati | 181 – 202 | LRR 7Add BLAST | 22 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0617, Eukaryota |
GeneTreei | ENSGT00940000158676 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | Q15404 |
OMAi | IRELHIQ |
OrthoDBi | 1382533at2759 |
PhylomeDBi | Q15404 |
TreeFami | TF314790 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 7 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q15404-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN
60 70 80 90 100
KLTMVPPNIA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT
110 120 130 140 150
LPRGFGSLPA LEVLDLTYNN LSENSLPGNF FYLTTLRALY LSDNDFEILP
160 170 180 190 200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG
210 220 230 240 250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM
260 270
QANPEPPKKN NDKSKKISRK PLAAKNR
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043831 | 1 – 53 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12535 mRNA Translation: AAA60292.1 AK292911 mRNA Translation: BAF85600.1 AK312520 mRNA Translation: BAG35419.1 CR536521 mRNA Translation: CAG38758.1 CR541840 mRNA Translation: CAG46639.1 EF445013 Genomic DNA Translation: ACA06048.1 EF445013 Genomic DNA Translation: ACA06049.1 EF445013 Genomic DNA Translation: ACA06050.1 AC073367 Genomic DNA No translation available. AL365215 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86222.1 CH471072 Genomic DNA Translation: EAW86223.1 CH471072 Genomic DNA Translation: EAW86224.1 BC005993 mRNA Translation: AAH05993.1 BC008691 mRNA Translation: AAH08691.1 BC015644 mRNA Translation: AAH15644.1 |
CCDSi | CCDS31157.1 [Q15404-2] CCDS7112.1 [Q15404-1] |
PIRi | I60122 |
RefSeqi | NP_036557.1, NM_012425.3 [Q15404-1] NP_689937.2, NM_152724.2 [Q15404-2] |
Genome annotation databases
Ensembli | ENST00000345264; ENSP00000339521; ENSG00000148484 [Q15404-1] ENST00000377921; ENSP00000367154; ENSG00000148484 [Q15404-1] ENST00000602389; ENSP00000473588; ENSG00000148484 [Q15404-2] |
GeneIDi | 6251 |
KEGGi | hsa:6251 |
UCSCi | uc001iok.4, human [Q15404-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12535 mRNA Translation: AAA60292.1 AK292911 mRNA Translation: BAF85600.1 AK312520 mRNA Translation: BAG35419.1 CR536521 mRNA Translation: CAG38758.1 CR541840 mRNA Translation: CAG46639.1 EF445013 Genomic DNA Translation: ACA06048.1 EF445013 Genomic DNA Translation: ACA06049.1 EF445013 Genomic DNA Translation: ACA06050.1 AC073367 Genomic DNA No translation available. AL365215 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86222.1 CH471072 Genomic DNA Translation: EAW86223.1 CH471072 Genomic DNA Translation: EAW86224.1 BC005993 mRNA Translation: AAH05993.1 BC008691 mRNA Translation: AAH08691.1 BC015644 mRNA Translation: AAH15644.1 |
CCDSi | CCDS31157.1 [Q15404-2] CCDS7112.1 [Q15404-1] |
PIRi | I60122 |
RefSeqi | NP_036557.1, NM_012425.3 [Q15404-1] NP_689937.2, NM_152724.2 [Q15404-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112164, 36 interactors |
IntActi | Q15404, 12 interactors |
MINTi | Q15404 |
STRINGi | 9606.ENSP00000367154 |
PTM databases
iPTMneti | Q15404 |
MetOSitei | Q15404 |
PhosphoSitePlusi | Q15404 |
Genetic variation databases
BioMutai | RSU1 |
DMDMi | 2498866 |
2D gel databases
OGPi | Q15404 |
Proteomic databases
EPDi | Q15404 |
jPOSTi | Q15404 |
MassIVEi | Q15404 |
MaxQBi | Q15404 |
PaxDbi | Q15404 |
PeptideAtlasi | Q15404 |
PRIDEi | Q15404 |
ProteomicsDBi | 60570 [Q15404-1] 60571 [Q15404-2] |
Protocols and materials databases
Antibodypediai | 25179, 169 antibodies |
DNASUi | 6251 |
Genome annotation databases
Ensembli | ENST00000345264; ENSP00000339521; ENSG00000148484 [Q15404-1] ENST00000377921; ENSP00000367154; ENSG00000148484 [Q15404-1] ENST00000602389; ENSP00000473588; ENSG00000148484 [Q15404-2] |
GeneIDi | 6251 |
KEGGi | hsa:6251 |
UCSCi | uc001iok.4, human [Q15404-1] |
Organism-specific databases
CTDi | 6251 |
DisGeNETi | 6251 |
GeneCardsi | RSU1 |
HGNCi | HGNC:10464, RSU1 |
HPAi | ENSG00000148484, Low tissue specificity |
MIMi | 179555, gene |
neXtProti | NX_Q15404 |
OpenTargetsi | ENSG00000148484 |
PharmGKBi | PA34876 |
VEuPathDBi | HostDB:ENSG00000148484.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0617, Eukaryota |
GeneTreei | ENSGT00940000158676 |
HOGENOMi | CLU_000288_18_15_1 |
InParanoidi | Q15404 |
OMAi | IRELHIQ |
OrthoDBi | 1382533at2759 |
PhylomeDBi | Q15404 |
TreeFami | TF314790 |
Enzyme and pathway databases
PathwayCommonsi | Q15404 |
Reactomei | R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
SignaLinki | Q15404 |
Miscellaneous databases
BioGRID-ORCSi | 6251, 55 hits in 994 CRISPR screens |
ChiTaRSi | RSU1, human |
GeneWikii | RSU1 |
GenomeRNAii | 6251 |
Pharosi | Q15404, Tbio |
PROi | PR:Q15404 |
RNActi | Q15404, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148484, Expressed in popliteal artery and 245 other tissues |
Genevisiblei | Q15404, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSU1_HUMAN | |
Accessioni | Q15404Primary (citable) accession number: Q15404 Secondary accession number(s): A8KA46, D3DRU3, Q6FI17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot