RSU1

Functionⁱ

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

GO - Biological processⁱ

positive regulation of cell-substrate adhesion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 1508180

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkⁱ	Q15404

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras suppressor protein 1 Short name: RSP-1 Short name: Rsu-1
Gene namesⁱ	Name:RSU1 Synonyms:RSP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148484.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10464 RSU1
MIMⁱ	179555 gene
neXtProtⁱ	NX_Q15404

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6251
Open Targets More...OpenTargetsⁱ	ENSG00000148484
PharmGKBⁱ	PA34876

Polymorphism and mutation databases

BioMutaⁱ	RSU1
DMDMⁱ	2498866

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000097499	2 – 277	Ras suppressor protein 1Add BLAST		276

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q15404
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15404
PaxDbⁱ	Q15404
PeptideAtlas More...PeptideAtlasⁱ	Q15404
PRIDEⁱ	Q15404
ProteomicsDBⁱ	60570 60571 [Q15404-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q15404

OGPⁱ

Q15404

PTM databases

iPTMnetⁱ	Q15404
PhosphoSitePlusⁱ	Q15404

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148484 Expressed in 235 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_RSU1
Genevisibleⁱ	Q15404 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA025927

HPAⁱ

HPA025927

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LIMS1	P48059	4	EBI-1057132,EBI-306928

With

Entry

#Exp.

IntAct

Notes

LIMS1

P48059

4

EBI-1057132,EBI-306928

Protein-protein interaction databases

BioGridⁱ	112164, 31 interactors
IntActⁱ	Q15404, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q15404
STRINGⁱ	9606.ENSP00000339521

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15404
SMRⁱ	Q15404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	41 – 63	LRR 1Add BLAST	23
Repeatⁱ	64 – 85	LRR 2Add BLAST	22
Repeatⁱ	87 – 109	LRR 3Add BLAST	23
Repeatⁱ	110 – 133	LRR 4Add BLAST	24
Repeatⁱ	135 – 156	LRR 5Add BLAST	22
Repeatⁱ	158 – 179	LRR 6Add BLAST	22
Repeatⁱ	181 – 202	LRR 7Add BLAST	22

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0617 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148937
HOGENOMⁱ	HOG000116557
HOVERGENⁱ	HBG002478
InParanoidⁱ	Q15404
OMAⁱ	RILNVGM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JL6
PhylomeDBⁱ	Q15404
TreeFamⁱ	TF314790

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855 LRR_8, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 7 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q15404-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN 
        60         70         80         90        100
KLTMVPPNIA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT 
       110        120        130        140        150
LPRGFGSLPA LEVLDLTYNN LSENSLPGNF FYLTTLRALY LSDNDFEILP 
       160        170        180        190        200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG 
       210        220        230        240        250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM 
       260        270 
QANPEPPKKN NDKSKKISRK PLAAKNR

Length:277

Mass (Da):31,540

Last modified:January 23, 2007 - v3

Checksum:ⁱ6EDB2E033F417468

GO

Isoform 2 (identifier: Q15404-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-53: Missing.

« Hide

        10         20         30         40         50
MVPPNIAELK NLEVLNFFNN QIEELPTQIS SLQKLKHLNL GMNRLNTLPR 
        60         70         80         90        100
GFGSLPALEV LDLTYNNLSE NSLPGNFFYL TTLRALYLSD NDFEILPPDI 
       110        120        130        140        150
GKLTKLQILS LRDNDLISLP KEIGELTQLK ELHIQGNRLT VLPPELGNLD 
       160        170        180        190        200
LTGQKQVFKA ENNPWVTPIA DQFQLGVSHV FEYIRSETYK YLYGRHMQAN 
       210        220 
PEPPKKNNDK SKKISRKPLA AKNR

Show »

Length:224

Mass (Da):25,545

Checksum:ⁱ1ACDF598D19296E1

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043831	1 – 53	Missing in isoform 2. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12535 mRNA Translation: AAA60292.1 AK292911 mRNA Translation: BAF85600.1 AK312520 mRNA Translation: BAG35419.1 CR536521 mRNA Translation: CAG38758.1 CR541840 mRNA Translation: CAG46639.1 EF445013 Genomic DNA Translation: ACA06048.1 EF445013 Genomic DNA Translation: ACA06049.1 EF445013 Genomic DNA Translation: ACA06050.1 AC073367 Genomic DNA No translation available. AL365215 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86222.1 CH471072 Genomic DNA Translation: EAW86223.1 CH471072 Genomic DNA Translation: EAW86224.1 BC005993 mRNA Translation: AAH05993.1 BC008691 mRNA Translation: AAH08691.1 BC015644 mRNA Translation: AAH15644.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31157.1 [Q15404-2] CCDS7112.1 [Q15404-1]
PIRⁱ	I60122
NCBI Reference Sequences More...RefSeqⁱ	NP_036557.1, NM_012425.3 [Q15404-1] NP_689937.2, NM_152724.2 [Q15404-2]
UniGeneⁱ	Hs.524161

Genome annotation databases

Ensemblⁱ	ENST00000345264; ENSP00000339521; ENSG00000148484 [Q15404-1] ENST00000377921; ENSP00000367154; ENSG00000148484 [Q15404-1] ENST00000602389; ENSP00000473588; ENSG00000148484 [Q15404-2]
GeneIDⁱ	6251
KEGGⁱ	hsa:6251
UCSC genome browser More...UCSCⁱ	uc001iok.4 human [Q15404-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q15404	Uncharacterized protein		MANLE		277	UniRef100_Q15404
Q15404-2	RSU1 protein (Fragment)		HUMAN		280	UniRef100_Q15404-2

Protein	Similar proteins		Species	Score	Length	Source
Q15404	Ras suppressor protein 1		BOVIN		277	UniRef90_Q15404
Uncharacterized protein		MANLE		277
Uncharacterized protein		GAMAF		289
Ras suppressor protein 1		FUNHE		289
Uncharacterized protein		LEPOC		284
+93
Q15404-2	RSU1 protein (Fragment)		HUMAN		280	UniRef90_Q15404-2
Uncharacterized protein (Fragment)		MACMU		282
Ras suppressor protein 1 (Fragment)		common cuckoo		226

Protein	Similar proteins		Species	Score	Length	Source
Q15404	Ras suppressor protein 1		BOVIN		277	UniRef50_Q15404
Uncharacterized protein		MANLE		277
Uncharacterized protein		GAMAF		289
Ras suppressor protein 1		FUNHE		289
Uncharacterized protein		ASTMX		284
+280
Q15404-2	RSU1 protein (Fragment)		HUMAN		280	UniRef50_Q15404-2
Uncharacterized protein (Fragment)		MACMU		282
Ras suppressor protein 1 (Fragment)		common cuckoo		226
Uncharacterized protein		DENPD		265
Uncharacterized protein		Arion vulgaris		272
+159

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L12535 mRNA Translation: AAA60292.1 AK292911 mRNA Translation: BAF85600.1 AK312520 mRNA Translation: BAG35419.1 CR536521 mRNA Translation: CAG38758.1 CR541840 mRNA Translation: CAG46639.1 EF445013 Genomic DNA Translation: ACA06048.1 EF445013 Genomic DNA Translation: ACA06049.1 EF445013 Genomic DNA Translation: ACA06050.1 AC073367 Genomic DNA No translation available. AL365215 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86222.1 CH471072 Genomic DNA Translation: EAW86223.1 CH471072 Genomic DNA Translation: EAW86224.1 BC005993 mRNA Translation: AAH05993.1 BC008691 mRNA Translation: AAH08691.1 BC015644 mRNA Translation: AAH15644.1
CCDSⁱ	CCDS31157.1 [Q15404-2] CCDS7112.1 [Q15404-1]
PIRⁱ	I60122
RefSeqⁱ	NP_036557.1, NM_012425.3 [Q15404-1] NP_689937.2, NM_152724.2 [Q15404-2]
UniGeneⁱ	Hs.524161

3D structure databases

ProteinModelPortalⁱ	Q15404
SMRⁱ	Q15404
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112164, 31 interactors
IntActⁱ	Q15404, 8 interactors
MINTⁱ	Q15404
STRINGⁱ	9606.ENSP00000339521

PTM databases

iPTMnetⁱ	Q15404
PhosphoSitePlusⁱ	Q15404

Polymorphism and mutation databases

BioMutaⁱ	RSU1
DMDMⁱ	2498866

2D gel databases

OGPⁱ	Q15404

OGPⁱ

Q15404

Proteomic databases

EPDⁱ	Q15404
MaxQBⁱ	Q15404
PaxDbⁱ	Q15404
PeptideAtlasⁱ	Q15404
PRIDEⁱ	Q15404
ProteomicsDBⁱ	60570 60571 [Q15404-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6251
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000345264; ENSP00000339521; ENSG00000148484 [Q15404-1] ENST00000377921; ENSP00000367154; ENSG00000148484 [Q15404-1] ENST00000602389; ENSP00000473588; ENSG00000148484 [Q15404-2]
GeneIDⁱ	6251
KEGGⁱ	hsa:6251
UCSCⁱ	uc001iok.4 human [Q15404-1]

Organism-specific databases

CTDⁱ	6251
DisGeNETⁱ	6251
EuPathDBⁱ	HostDB:ENSG00000148484.17
GeneCardsⁱ	RSU1
HGNCⁱ	HGNC:10464 RSU1
HPAⁱ	HPA025927
MIMⁱ	179555 gene
neXtProtⁱ	NX_Q15404
OpenTargetsⁱ	ENSG00000148484
PharmGKBⁱ	PA34876
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0617 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00920000148937
HOGENOMⁱ	HOG000116557
HOVERGENⁱ	HBG002478
InParanoidⁱ	Q15404
OMAⁱ	RILNVGM
OrthoDBⁱ	EOG091G0JL6
PhylomeDBⁱ	Q15404
TreeFamⁱ	TF314790

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkⁱ	Q15404

Miscellaneous databases

ChiTaRSⁱ	RSU1 human
GeneWikiⁱ	RSU1
GenomeRNAiⁱ	6251
Protein Ontology More...PROⁱ	PR:Q15404
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148484 Expressed in 235 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_RSU1
Genevisibleⁱ	Q15404 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfamⁱ	View protein in Pfam PF13855 LRR_8, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RSU1_HUMAN
Accessionⁱ	Q15404Primary (citable) accession number: Q15404 Secondary accession number(s): A8KA46, D3DRU3, Q6FI17
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q15404 (RSU1_HUMAN)

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Ras suppressor protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ