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Protein

Ras suppressor protein 1

Gene

RSU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkiQ15404

Names & Taxonomyi

Protein namesi
Recommended name:
Ras suppressor protein 1
Short name:
RSP-1
Short name:
Rsu-1
Gene namesi
Name:RSU1
Synonyms:RSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148484.17
HGNCiHGNC:10464 RSU1
MIMi179555 gene
neXtProtiNX_Q15404

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6251
OpenTargetsiENSG00000148484
PharmGKBiPA34876

Polymorphism and mutation databases

BioMutaiRSU1
DMDMi2498866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000974992 – 277Ras suppressor protein 1Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15404
MaxQBiQ15404
PaxDbiQ15404
PeptideAtlasiQ15404
PRIDEiQ15404
ProteomicsDBi60570
60571 [Q15404-2]

2D gel databases

OGPiQ15404

PTM databases

iPTMnetiQ15404
PhosphoSitePlusiQ15404

Expressioni

Gene expression databases

BgeeiENSG00000148484
CleanExiHS_RSU1
GenevisibleiQ15404 HS

Organism-specific databases

HPAiHPA025927

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LIMS1P480594EBI-1057132,EBI-306928

Protein-protein interaction databases

BioGridi112164, 30 interactors
IntActiQ15404, 8 interactors
MINTiQ15404
STRINGi9606.ENSP00000339521

Structurei

3D structure databases

ProteinModelPortaliQ15404
SMRiQ15404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 63LRR 1Add BLAST23
Repeati64 – 85LRR 2Add BLAST22
Repeati87 – 109LRR 3Add BLAST23
Repeati110 – 133LRR 4Add BLAST24
Repeati135 – 156LRR 5Add BLAST22
Repeati158 – 179LRR 6Add BLAST22
Repeati181 – 202LRR 7Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0617 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937
HOGENOMiHOG000116557
HOVERGENiHBG002478
InParanoidiQ15404
OMAiRILNVGM
OrthoDBiEOG091G0JL6
PhylomeDBiQ15404
TreeFamiTF314790

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15404-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN
60 70 80 90 100
KLTMVPPNIA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT
110 120 130 140 150
LPRGFGSLPA LEVLDLTYNN LSENSLPGNF FYLTTLRALY LSDNDFEILP
160 170 180 190 200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG
210 220 230 240 250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM
260 270
QANPEPPKKN NDKSKKISRK PLAAKNR
Length:277
Mass (Da):31,540
Last modified:January 23, 2007 - v3
Checksum:i6EDB2E033F417468
GO
Isoform 2 (identifier: Q15404-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:224
Mass (Da):25,545
Checksum:i1ACDF598D19296E1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438311 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12535 mRNA Translation: AAA60292.1
AK292911 mRNA Translation: BAF85600.1
AK312520 mRNA Translation: BAG35419.1
CR536521 mRNA Translation: CAG38758.1
CR541840 mRNA Translation: CAG46639.1
EF445013 Genomic DNA Translation: ACA06048.1
EF445013 Genomic DNA Translation: ACA06049.1
EF445013 Genomic DNA Translation: ACA06050.1
AC073367 Genomic DNA No translation available.
AL365215 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86222.1
CH471072 Genomic DNA Translation: EAW86223.1
CH471072 Genomic DNA Translation: EAW86224.1
BC005993 mRNA Translation: AAH05993.1
BC008691 mRNA Translation: AAH08691.1
BC015644 mRNA Translation: AAH15644.1
CCDSiCCDS31157.1 [Q15404-2]
CCDS7112.1 [Q15404-1]
PIRiI60122
RefSeqiNP_036557.1, NM_012425.3 [Q15404-1]
NP_689937.2, NM_152724.2 [Q15404-2]
UniGeneiHs.524161

Genome annotation databases

EnsembliENST00000345264; ENSP00000339521; ENSG00000148484 [Q15404-1]
ENST00000377921; ENSP00000367154; ENSG00000148484 [Q15404-1]
ENST00000602389; ENSP00000473588; ENSG00000148484 [Q15404-2]
GeneIDi6251
KEGGihsa:6251
UCSCiuc001iok.4 human [Q15404-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRSU1_HUMAN
AccessioniPrimary (citable) accession number: Q15404
Secondary accession number(s): A8KA46, D3DRU3, Q6FI17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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