UniProtKB - Q15399 (TLR1_HUMAN)
Toll-like receptor 1
TLR1
Functioni
Catalytic activityi
- EC:3.2.2.6PROSITE-ProRule annotationThis reaction proceeds in the forwardPROSITE-ProRule annotation direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 710 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- lipopeptide binding Source: GO_Central
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
- signaling receptor activity Source: GO_Central
- Toll-like receptor 2 binding Source: UniProtKB
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- cell activation Source: AgBase
- cellular response to bacterial lipopeptide Source: GO_Central
- cellular response to triacyl bacterial lipopeptide Source: UniProtKB
- detection of triacyl bacterial lipopeptide Source: MGI
- immune response Source: ProtInc
- inflammatory response Source: GO_Central
- innate immune response Source: UniProtKB-KW
- macrophage activation Source: UniProtKB
- microglial cell activation Source: Ensembl
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of interleukin-8 production Source: ARUK-UCL
- positive regulation of toll-like receptor 2 signaling pathway Source: ARUK-UCL
- positive regulation of tumor necrosis factor production Source: UniProtKB
- signal transduction Source: ProtInc
- toll-like receptor 1 signaling pathway Source: InterPro
- toll-like receptor signaling pathway Source: GO_Central
- toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Receptor |
Biological process | Immunity, Inflammatory response, Innate immunity |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q15399 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1461957, Beta defensins R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand |
Names & Taxonomyi
Protein namesi | Recommended name: Toll-like receptor 1 (EC:3.2.2.6PROSITE-ProRule annotation)Alternative name(s): Toll/interleukin-1 receptor-like protein Short name: TIL CD_antigen: CD281 |
Gene namesi | Name:TLR1 Synonyms:KIAA0012 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11847, TLR1 |
MIMi | 601194, gene |
neXtProti | NX_Q15399 |
VEuPathDBi | HostDB:ENSG00000174125.7 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- phagosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
- Membrane raft 1 Publication
Note: Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.1 Publication
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
Other locations
- membrane Source: UniProtKB
- membrane raft Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 580 | ExtracellularSequence analysisAdd BLAST | 556 | |
Transmembranei | 581 – 601 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 602 – 786 | CytoplasmicSequence analysisAdd BLAST | 185 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 7096 |
MalaCardsi | TLR1 |
MIMi | 613223, phenotype |
OpenTargetsi | ENSG00000174125 |
PharmGKBi | PA36549 |
Miscellaneous databases
Pharosi | Q15399, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3885643 |
Genetic variation databases
BioMutai | TLR1 |
DMDMi | 146291086 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000034705 | 25 – 786 | Toll-like receptor 1Add BLAST | 762 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 110 ↔ 132 | 1 Publication | ||
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 223 ↔ 230 | 1 Publication | ||
Glycosylationi | 330 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 343 ↔ 368 | 1 Publication | ||
Disulfide bondi | 419 ↔ 442 | 1 Publication | ||
Glycosylationi | 429 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 578 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q15399 |
jPOSTi | Q15399 |
MassIVEi | Q15399 |
PaxDbi | Q15399 |
PeptideAtlasi | Q15399 |
PRIDEi | Q15399 |
ProteomicsDBi | 60569 |
PTM databases
GlyGeni | Q15399, 6 sites |
iPTMneti | Q15399 |
PhosphoSitePlusi | Q15399 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000174125, Expressed in blood and 175 other tissues |
ExpressionAtlasi | Q15399, baseline and differential |
Genevisiblei | Q15399, HS |
Organism-specific databases
HPAi | ENSG00000174125, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain).
Interacts with CNPY3 (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ15399
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-9009517,EBI-9009517 |
TLR10 [Q9BXR5] | 3 | EBI-9009517,EBI-16825459 |
TLR2 [O60603] | 3 | EBI-9009517,EBI-973722 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- Toll-like receptor 2 binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112951, 13 interactors |
CORUMi | Q15399 |
IntActi | Q15399, 6 interactors |
STRINGi | 9606.ENSP00000354932 |
Chemistry databases
BindingDBi | Q15399 |
Miscellaneous databases
RNActi | Q15399, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q15399 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15399 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 54 – 77 | LRR 1Add BLAST | 24 | |
Repeati | 78 – 101 | LRR 2Add BLAST | 24 | |
Repeati | 102 – 125 | LRR 3Add BLAST | 24 | |
Repeati | 126 – 150 | LRR 4Add BLAST | 25 | |
Repeati | 151 – 175 | LRR 5Add BLAST | 25 | |
Repeati | 176 – 199 | LRR 6Add BLAST | 24 | |
Repeati | 200 – 223 | LRR 7Add BLAST | 24 | |
Repeati | 224 – 250 | LRR 8Add BLAST | 27 | |
Repeati | 251 – 278 | LRR 9Add BLAST | 28 | |
Repeati | 279 – 308 | LRR 10Add BLAST | 30 | |
Repeati | 309 – 337 | LRR 11Add BLAST | 29 | |
Repeati | 338 – 361 | LRR 12Add BLAST | 24 | |
Repeati | 362 – 388 | LRR 13Add BLAST | 27 | |
Repeati | 389 – 414 | LRR 14Add BLAST | 26 | |
Repeati | 415 – 437 | LRR 15Add BLAST | 23 | |
Repeati | 438 – 457 | LRR 16Add BLAST | 20 | |
Repeati | 458 – 478 | LRR 17Add BLAST | 21 | |
Repeati | 479 – 500 | LRR 18Add BLAST | 22 | |
Repeati | 501 – 524 | LRR 19Add BLAST | 24 | |
Domaini | 525 – 579 | LRRCTAdd BLAST | 55 | |
Domaini | 635 – 776 | TIRPROSITE-ProRule annotationAdd BLAST | 142 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 313 – 316 | Interaction with bacterial lipopeptide | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000162884 |
HOGENOMi | CLU_006000_3_0_1 |
InParanoidi | Q15399 |
OMAi | NNIETTW |
OrthoDBi | 282372at2759 |
PhylomeDBi | Q15399 |
TreeFami | TF351113 |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027190, TLR1 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF261, PTHR24365:SF261, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF01463, LRRCT, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 10 hits PS50104, TIR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL
60 70 80 90 100
NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL
110 120 130 140 150
SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH
160 170 180 190 200
LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK
210 220 230 240 250
EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT
260 270 280 290 300
LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK
310 320 330 340 350
ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF
360 370 380 390 400
LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL
410 420 430 440 450
QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL
460 470 480 490 500
DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN
510 520 530 540 550
SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW
560 570 580 590 600
PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL
610 620 630 640 650
CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW
660 670 680 690 700
VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN
710 720 730 740 750
FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM
760 770 780
ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RAP2 | D6RAP2_HUMAN | Toll-like receptor 1 | TLR1 | 161 | Annotation score: | ||
D6RA99 | D6RA99_HUMAN | Toll-like receptor 1 | TLR1 | 90 | Annotation score: | ||
D6RCE8 | D6RCE8_HUMAN | Toll-like receptor 1 | TLR1 | 48 | Annotation score: | ||
D6RF68 | D6RF68_HUMAN | Toll-like receptor 1 | TLR1 | 23 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | E → G in CAB43364 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 228 | N → S in CAB43364 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 276 | F → S in CAB43364 (PubMed:11230166).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066340 | 44 | S → P1 PublicationCorresponds to variant dbSNP:rs76600635EnsemblClinVar. | 1 | |
Natural variantiVAR_066341 | 75 | I → T1 PublicationCorresponds to variant dbSNP:rs137853170EnsemblClinVar. | 1 | |
Natural variantiVAR_031916 | 80 | R → T3 PublicationsCorresponds to variant dbSNP:rs5743611Ensembl. | 1 | |
Natural variantiVAR_018474 | 118 | H → Y1 PublicationCorresponds to variant dbSNP:rs5743612Ensembl. | 1 | |
Natural variantiVAR_031917 | 248 | N → S May confer susceptibility to leprosy. 4 PublicationsCorresponds to variant dbSNP:rs4833095EnsemblClinVar. | 1 | |
Natural variantiVAR_031918 | 305 | H → L1 PublicationCorresponds to variant dbSNP:rs3923647Ensembl. | 1 | |
Natural variantiVAR_031919 | 315 | P → L Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs5743613Ensembl. | 1 | |
Natural variantiVAR_066342 | 352 | H → N1 PublicationCorresponds to variant dbSNP:rs76796448EnsemblClinVar. | 1 | |
Natural variantiVAR_066343 | 460 | I → V1 PublicationCorresponds to variant dbSNP:rs137853171EnsemblClinVar. | 1 | |
Natural variantiVAR_066344 | 542 | V → A1 PublicationCorresponds to variant dbSNP:rs137853172EnsemblClinVar. | 1 | |
Natural variantiVAR_066345 | 554 | Y → C Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs137853173EnsemblClinVar. | 1 | |
Natural variantiVAR_031920 | 587 | V → G1 PublicationCorresponds to variant dbSNP:rs5743617EnsemblClinVar. | 1 | |
Natural variantiVAR_031921 | 602 | S → I Severe impairment of activity. 5 PublicationsCorresponds to variant dbSNP:rs5743618EnsemblClinVar. | 1 | |
Natural variantiVAR_052358 | 631 | L → R. Corresponds to variant dbSNP:rs5743619Ensembl. | 1 | |
Natural variantiVAR_066346 | 651 | V → A Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs137853174EnsemblClinVar. | 1 | |
Natural variantiVAR_066347 | 674 | V → A1 Publication | 1 | |
Natural variantiVAR_066348 | 720 | H → P Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs113706342Ensembl. | 1 | |
Natural variantiVAR_052359 | 733 | P → L1 PublicationCorresponds to variant dbSNP:rs5743621Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88540 mRNA Translation: AAC34137.1 AB445617 mRNA Translation: BAG55014.1 DQ012259 mRNA Translation: AAY85638.1 DQ012260 mRNA Translation: AAY85639.1 DQ012261 mRNA Translation: AAY85640.1 D13637 mRNA Translation: BAA02801.2 Different initiation. AL050262 mRNA Translation: CAB43364.1 BC109093 mRNA Translation: AAI09094.1 BC109094 mRNA Translation: AAI09095.1 |
CCDSi | CCDS33973.1 |
PIRi | T08664 |
RefSeqi | NP_003254.2, NM_003263.3 XP_005262719.1, XM_005262662.4 XP_011512044.1, XM_011513742.2 XP_011512045.1, XM_011513743.2 XP_011512046.1, XM_011513744.2 XP_011512047.1, XM_011513745.2 XP_016864060.1, XM_017008571.1 XP_016864061.1, XM_017008572.1 |
Genome annotation databases
Ensembli | ENST00000308979; ENSP00000354932; ENSG00000174125 ENST00000502213; ENSP00000421259; ENSG00000174125 |
GeneIDi | 7096 |
KEGGi | hsa:7096 |
UCSCi | uc003gtl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88540 mRNA Translation: AAC34137.1 AB445617 mRNA Translation: BAG55014.1 DQ012259 mRNA Translation: AAY85638.1 DQ012260 mRNA Translation: AAY85639.1 DQ012261 mRNA Translation: AAY85640.1 D13637 mRNA Translation: BAA02801.2 Different initiation. AL050262 mRNA Translation: CAB43364.1 BC109093 mRNA Translation: AAI09094.1 BC109094 mRNA Translation: AAI09095.1 |
CCDSi | CCDS33973.1 |
PIRi | T08664 |
RefSeqi | NP_003254.2, NM_003263.3 XP_005262719.1, XM_005262662.4 XP_011512044.1, XM_011513742.2 XP_011512045.1, XM_011513743.2 XP_011512046.1, XM_011513744.2 XP_011512047.1, XM_011513745.2 XP_016864060.1, XM_017008571.1 XP_016864061.1, XM_017008572.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FYV | X-ray | 2.90 | A | 625-785 | [»] | |
2Z7X | X-ray | 2.10 | B | 25-475 | [»] | |
6NIH | X-ray | 2.30 | A/B | 1-475 | [»] | |
SMRi | Q15399 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112951, 13 interactors |
CORUMi | Q15399 |
IntActi | Q15399, 6 interactors |
STRINGi | 9606.ENSP00000354932 |
Chemistry databases
BindingDBi | Q15399 |
ChEMBLi | CHEMBL3885643 |
PTM databases
GlyGeni | Q15399, 6 sites |
iPTMneti | Q15399 |
PhosphoSitePlusi | Q15399 |
Genetic variation databases
BioMutai | TLR1 |
DMDMi | 146291086 |
Proteomic databases
EPDi | Q15399 |
jPOSTi | Q15399 |
MassIVEi | Q15399 |
PaxDbi | Q15399 |
PeptideAtlasi | Q15399 |
PRIDEi | Q15399 |
ProteomicsDBi | 60569 |
Protocols and materials databases
Antibodypediai | 10459, 647 antibodies |
Genome annotation databases
Ensembli | ENST00000308979; ENSP00000354932; ENSG00000174125 ENST00000502213; ENSP00000421259; ENSG00000174125 |
GeneIDi | 7096 |
KEGGi | hsa:7096 |
UCSCi | uc003gtl.4, human |
Organism-specific databases
CTDi | 7096 |
DisGeNETi | 7096 |
GeneCardsi | TLR1 |
HGNCi | HGNC:11847, TLR1 |
HPAi | ENSG00000174125, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | TLR1 |
MIMi | 601194, gene 613223, phenotype |
neXtProti | NX_Q15399 |
OpenTargetsi | ENSG00000174125 |
PharmGKBi | PA36549 |
VEuPathDBi | HostDB:ENSG00000174125.7 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000162884 |
HOGENOMi | CLU_006000_3_0_1 |
InParanoidi | Q15399 |
OMAi | NNIETTW |
OrthoDBi | 282372at2759 |
PhylomeDBi | Q15399 |
TreeFami | TF351113 |
Enzyme and pathway databases
PathwayCommonsi | Q15399 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1461957, Beta defensins R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand |
Miscellaneous databases
BioGRID-ORCSi | 7096, 4 hits in 876 CRISPR screens |
EvolutionaryTracei | Q15399 |
GeneWikii | TLR_1 |
GenomeRNAii | 7096 |
Pharosi | Q15399, Tbio |
PROi | PR:Q15399 |
RNActi | Q15399, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174125, Expressed in blood and 175 other tissues |
ExpressionAtlasi | Q15399, baseline and differential |
Genevisiblei | Q15399, HS |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027190, TLR1 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF261, PTHR24365:SF261, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF01463, LRRCT, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 10 hits PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TLR1_HUMAN | |
Accessioni | Q15399Primary (citable) accession number: Q15399 Secondary accession number(s): D1CS39 Q9UG90 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | May 1, 2007 | |
Last modified: | February 10, 2021 | |
This is version 205 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families