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UniProtKB - Q15399 (TLR1_HUMAN)

Entry version 205 (10 Feb 2021)
Sequence version 3 (01 May 2007)
Previous versions | rss
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Protein

Toll-like receptor 1

Gene

TLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei710PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Receptor
Biological processImmunity, Inflammatory response, Innate immunity
LigandNAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15399

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1236974, ER-Phagosome pathway
R-HSA-1461957, Beta defensins
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-5602498, MyD88 deficiency (TLR2/4)
R-HSA-5603041, IRAK4 deficiency (TLR2/4)
R-HSA-5686938, Regulation of TLR by endogenous ligand

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 1 (EC:3.2.2.6PROSITE-ProRule annotation)
Alternative name(s):
Toll/interleukin-1 receptor-like protein
Short name:
TIL
CD_antigen: CD281
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLR1
Synonyms:KIAA0012
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11847, TLR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601194, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15399

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000174125.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 580ExtracellularSequence analysisAdd BLAST556
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 786CytoplasmicSequence analysisAdd BLAST185

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7096

MalaCards human disease database

More...MalaCardsi		TLR1
MIMi613223, phenotype

Open Targets

More...OpenTargetsi		ENSG00000174125

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36549

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15399, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3885643

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TLR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		146291086

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003470525 – 786Toll-like receptor 1Add BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 1321 Publication
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi223 ↔ 2301 Publication
Glycosylationi330N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi343 ↔ 3681 Publication
Disulfide bondi419 ↔ 4421 Publication
Glycosylationi429N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15399

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15399

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15399

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15399

PeptideAtlas

More...PeptideAtlasi		Q15399

PRoteomics IDEntifications database

More...PRIDEi		Q15399

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60569

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15399, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15399

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15399

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174125, Expressed in blood and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15399, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15399, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174125, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain).

Interacts with CNPY3 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112951, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q15399

Protein interaction database and analysis system

More...IntActi		Q15399, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354932

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15399

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15399, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1786
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15399

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15399

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 77LRR 1Add BLAST24
Repeati78 – 101LRR 2Add BLAST24
Repeati102 – 125LRR 3Add BLAST24
Repeati126 – 150LRR 4Add BLAST25
Repeati151 – 175LRR 5Add BLAST25
Repeati176 – 199LRR 6Add BLAST24
Repeati200 – 223LRR 7Add BLAST24
Repeati224 – 250LRR 8Add BLAST27
Repeati251 – 278LRR 9Add BLAST28
Repeati279 – 308LRR 10Add BLAST30
Repeati309 – 337LRR 11Add BLAST29
Repeati338 – 361LRR 12Add BLAST24
Repeati362 – 388LRR 13Add BLAST27
Repeati389 – 414LRR 14Add BLAST26
Repeati415 – 437LRR 15Add BLAST23
Repeati438 – 457LRR 16Add BLAST20
Repeati458 – 478LRR 17Add BLAST21
Repeati479 – 500LRR 18Add BLAST22
Repeati501 – 524LRR 19Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 579LRRCTAdd BLAST55
Domaini635 – 776TIRPROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni313 – 316Interaction with bacterial lipopeptide4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4641, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162884

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006000_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15399

Identification of Orthologs from Complete Genome Data

More...OMAi		NNIETTW

Database of Orthologous Groups

More...OrthoDBi		282372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15399

TreeFam database of animal gene trees

More...TreeFami		TF351113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10140, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR027190, TLR1
IPR017241, Toll-like_receptor
IPR035897, Toll_tir_struct_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24365, PTHR24365, 1 hit
PTHR24365:SF261, PTHR24365:SF261, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 2 hits
PF01463, LRRCT, 1 hit
PF01582, TIR, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037595, Toll-like_receptor, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 4 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 10 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15399-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL 
        60         70         80         90        100
NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL 
       110        120        130        140        150
SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH 
       160        170        180        190        200
LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK 
       210        220        230        240        250
EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT 
       260        270        280        290        300
LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK 
       310        320        330        340        350
ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF 
       360        370        380        390        400
LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL 
       410        420        430        440        450
QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL 
       460        470        480        490        500
DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN 
       510        520        530        540        550
SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW 
       560        570        580        590        600
PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL 
       610        620        630        640        650
CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW 
       660        670        680        690        700
VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN 
       710        720        730        740        750
FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM 
       760        770        780 
ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK
Length:786
Mass (Da):90,291
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BFCCC5E42EA5242
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAP2D6RAP2_HUMAN
Toll-like receptor 1
TLR1
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA99D6RA99_HUMAN
Toll-like receptor 1
TLR1
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCE8D6RCE8_HUMAN
Toll-like receptor 1
TLR1
48Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF68D6RF68_HUMAN
Toll-like receptor 1
TLR1
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA02801 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182E → G in CAB43364 (PubMed:11230166).Curated1
Sequence conflicti228N → S in CAB43364 (PubMed:11230166).Curated1
Sequence conflicti276F → S in CAB43364 (PubMed:11230166).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIMi:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06634044S → P1 PublicationCorresponds to variant dbSNP:rs76600635EnsemblClinVar.1
Natural variantiVAR_06634175I → T1 PublicationCorresponds to variant dbSNP:rs137853170EnsemblClinVar.1
Natural variantiVAR_03191680R → T3 PublicationsCorresponds to variant dbSNP:rs5743611Ensembl.1
Natural variantiVAR_018474118H → Y1 PublicationCorresponds to variant dbSNP:rs5743612Ensembl.1
Natural variantiVAR_031917248N → S May confer susceptibility to leprosy. 4 PublicationsCorresponds to variant dbSNP:rs4833095EnsemblClinVar.1
Natural variantiVAR_031918305H → L1 PublicationCorresponds to variant dbSNP:rs3923647Ensembl.1
Natural variantiVAR_031919315P → L Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs5743613Ensembl.1
Natural variantiVAR_066342352H → N1 PublicationCorresponds to variant dbSNP:rs76796448EnsemblClinVar.1
Natural variantiVAR_066343460I → V1 PublicationCorresponds to variant dbSNP:rs137853171EnsemblClinVar.1
Natural variantiVAR_066344542V → A1 PublicationCorresponds to variant dbSNP:rs137853172EnsemblClinVar.1
Natural variantiVAR_066345554Y → C Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs137853173EnsemblClinVar.1
Natural variantiVAR_031920587V → G1 PublicationCorresponds to variant dbSNP:rs5743617EnsemblClinVar.1
Natural variantiVAR_031921602S → I Severe impairment of activity. 5 PublicationsCorresponds to variant dbSNP:rs5743618EnsemblClinVar.1
Natural variantiVAR_052358631L → R. Corresponds to variant dbSNP:rs5743619Ensembl.1
Natural variantiVAR_066346651V → A Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs137853174EnsemblClinVar.1
Natural variantiVAR_066347674V → A1 Publication1
Natural variantiVAR_066348720H → P Severe impairment of activity. 1 PublicationCorresponds to variant dbSNP:rs113706342Ensembl.1
Natural variantiVAR_052359733P → L1 PublicationCorresponds to variant dbSNP:rs5743621Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U88540 mRNA Translation: AAC34137.1
AB445617 mRNA Translation: BAG55014.1
DQ012259 mRNA Translation: AAY85638.1
DQ012260 mRNA Translation: AAY85639.1
DQ012261 mRNA Translation: AAY85640.1
D13637 mRNA Translation: BAA02801.2 Different initiation.
AL050262 mRNA Translation: CAB43364.1
BC109093 mRNA Translation: AAI09094.1
BC109094 mRNA Translation: AAI09095.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33973.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08664

NCBI Reference Sequences

More...RefSeqi		NP_003254.2, NM_003263.3
XP_005262719.1, XM_005262662.4
XP_011512044.1, XM_011513742.2
XP_011512045.1, XM_011513743.2
XP_011512046.1, XM_011513744.2
XP_011512047.1, XM_011513745.2
XP_016864060.1, XM_017008571.1
XP_016864061.1, XM_017008572.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308979; ENSP00000354932; ENSG00000174125
ENST00000502213; ENSP00000421259; ENSG00000174125

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7096

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7096

UCSC genome browser

More...UCSCi		uc003gtl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88540 mRNA Translation: AAC34137.1
AB445617 mRNA Translation: BAG55014.1
DQ012259 mRNA Translation: AAY85638.1
DQ012260 mRNA Translation: AAY85639.1
DQ012261 mRNA Translation: AAY85640.1
D13637 mRNA Translation: BAA02801.2 Different initiation.
AL050262 mRNA Translation: CAB43364.1
BC109093 mRNA Translation: AAI09094.1
BC109094 mRNA Translation: AAI09095.1
CCDSiCCDS33973.1
PIRiT08664
RefSeqiNP_003254.2, NM_003263.3
XP_005262719.1, XM_005262662.4
XP_011512044.1, XM_011513742.2
XP_011512045.1, XM_011513743.2
XP_011512046.1, XM_011513744.2
XP_011512047.1, XM_011513745.2
XP_016864060.1, XM_017008571.1
XP_016864061.1, XM_017008572.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FYVX-ray2.90A625-785[»]
2Z7XX-ray2.10B25-475[»]
6NIHX-ray2.30A/B1-475[»]
SMRiQ15399
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112951, 13 interactors
CORUMiQ15399
IntActiQ15399, 6 interactors
STRINGi9606.ENSP00000354932

Chemistry databases

BindingDBiQ15399
ChEMBLiCHEMBL3885643

PTM databases

GlyGeniQ15399, 6 sites
iPTMnetiQ15399
PhosphoSitePlusiQ15399

Genetic variation databases

BioMutaiTLR1
DMDMi146291086

Proteomic databases

EPDiQ15399
jPOSTiQ15399
MassIVEiQ15399
PaxDbiQ15399
PeptideAtlasiQ15399
PRIDEiQ15399
ProteomicsDBi60569

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10459, 647 antibodies

Genome annotation databases

EnsembliENST00000308979; ENSP00000354932; ENSG00000174125
ENST00000502213; ENSP00000421259; ENSG00000174125
GeneIDi7096
KEGGihsa:7096
UCSCiuc003gtl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7096
DisGeNETi7096

GeneCards: human genes, protein and diseases

More...GeneCardsi		TLR1
HGNCiHGNC:11847, TLR1
HPAiENSG00000174125, Tissue enhanced (blood, lymphoid tissue)
MalaCardsiTLR1
MIMi601194, gene
613223, phenotype
neXtProtiNX_Q15399
OpenTargetsiENSG00000174125
PharmGKBiPA36549
VEuPathDBiHostDB:ENSG00000174125.7

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4641, Eukaryota
GeneTreeiENSGT00940000162884
HOGENOMiCLU_006000_3_0_1
InParanoidiQ15399
OMAiNNIETTW
OrthoDBi282372at2759
PhylomeDBiQ15399
TreeFamiTF351113

Enzyme and pathway databases

PathwayCommonsiQ15399
ReactomeiR-HSA-1236974, ER-Phagosome pathway
R-HSA-1461957, Beta defensins
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168179, Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-5602498, MyD88 deficiency (TLR2/4)
R-HSA-5603041, IRAK4 deficiency (TLR2/4)
R-HSA-5686938, Regulation of TLR by endogenous ligand

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7096, 4 hits in 876 CRISPR screens
EvolutionaryTraceiQ15399

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TLR_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7096
PharosiQ15399, Tbio

Protein Ontology

More...PROi		PR:Q15399
RNActiQ15399, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174125, Expressed in blood and 175 other tissues
ExpressionAtlasiQ15399, baseline and differential
GenevisibleiQ15399, HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR027190, TLR1
IPR017241, Toll-like_receptor
IPR035897, Toll_tir_struct_dom_sf
PANTHERiPTHR24365, PTHR24365, 1 hit
PTHR24365:SF261, PTHR24365:SF261, 1 hit
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF01463, LRRCT, 1 hit
PF01582, TIR, 1 hit
PIRSFiPIRSF037595, Toll-like_receptor, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 4 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit
SUPFAMiSSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 10 hits
PS50104, TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15399
Secondary accession number(s): D1CS39
, D1CS41, O15452, Q32MK3, Q32MK4, Q9UG90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2007
Last modified: February 10, 2021
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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