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Entry version 172 (12 Aug 2020)
Sequence version 2 (13 Sep 2005)
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Protein

Disks large-associated protein 5

Gene

DLGAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.3 Publications

Caution

It was localized to the spindle and the spindle pole (PubMed:12527899) but was later found to be localized to the spindle and to be excluded from the spindle pole (PubMed:15561729).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q15398

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large-associated protein 5
Short name:
DAP-5
Alternative name(s):
Discs large homolog 7
Disks large-associated protein DLG7
Hepatoma up-regulated protein
Short name:
HURP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DLGAP5
Synonyms:DLG7, KIAA0008
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126787.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16864, DLGAP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617859, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15398

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9787

Open Targets

More...
OpenTargetsi
ENSG00000126787

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162383761

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15398, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DLGAP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
82592583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001742991 – 846Disks large-associated protein 5Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei202PhosphoserineCombined sources1
Modified residuei326PhosphothreonineCombined sources1
Modified residuei329Phosphothreonine; by CDK1Combined sources1 Publication1
Modified residuei338PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei401Phosphothreonine; by CDK11 Publication1
Modified residuei402Phosphothreonine; by CDK11 Publication1
Modified residuei618Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei627Phosphoserine; by AURKACombined sources1 Publication1
Modified residuei629PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei639Phosphothreonine; by CDK11 Publication1
Modified residuei642Phosphoserine; by CDK11 Publication1
Modified residuei662PhosphoserineCombined sources1
Modified residuei725Phosphoserine; by AURKACombined sources1 Publication1
Modified residuei757Phosphoserine; by AURKA1 Publication1
Modified residuei759Phosphothreonine; by CDK11 Publication1
Modified residuei774PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei784PhosphothreonineCombined sources1
Modified residuei806PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei830Phosphoserine; by AURKACombined sources1 Publication1
Modified residuei839Phosphoserine; by CDK1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to its degradation.1 Publication
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.3 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1204
CPTAC-1205

Encyclopedia of Proteome Dynamics

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EPDi
Q15398

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15398

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15398

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15398

PeptideAtlas

More...
PeptideAtlasi
Q15398

PRoteomics IDEntifications database

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PRIDEi
Q15398

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
2036
60567 [Q15398-2]
60568 [Q15398-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15398

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q15398

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15398

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000126787, Expressed in secondary oocyte and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15398, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15398, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000126787, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK1.

Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner.

Interacts with CDH1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115131, 27 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q15398

Protein interaction database and analysis system

More...
IntActi
Q15398, 21 interactors

Molecular INTeraction database

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MINTi
Q15398

STRING: functional protein association networks

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STRINGi
9606.ENSP00000247191

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15398, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15398

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili90 – 120Sequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3971, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018126_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15398

KEGG Orthology (KO)

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KOi
K16804

Identification of Orthologs from Complete Genome Data

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OMAi
PSERMNL

Database of Orthologous Groups

More...
OrthoDBi
566337at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15398

TreeFam database of animal gene trees

More...
TreeFami
TF321382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005026, SAPAP

The PANTHER Classification System

More...
PANTHERi
PTHR12353, PTHR12353, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03359, GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15398-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV
60 70 80 90 100
NIPTLEGRIL VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE
110 120 130 140 150
KQLQKLKEQR EKAKRGIFKV GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV
160 170 180 190 200
RITRSKAKDQ MEQTKIDNES DVRAIRPGPR QTSEKKVSDK EKKVVQPVMP
210 220 230 240 250
TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG KVPSKGRPAK
260 270 280 290 300
NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK
310 320 330 340 350
IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV
360 370 380 390 400
DESQATKEIL AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA
410 420 430 440 450
TTKNLNGLPI KEVPSLERNE GRIAQPHHGV PYFRNILQSE TEKLTSHCFE
460 470 480 490 500
WDRKLELDIP DDAKDLIRTA VGQTRLLMKE RFKQFEGLVD DCEYKRGIKE
510 520 530 540 550
TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN MNHNMNKNVF
560 570 580 590 600
RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI
610 620 630 640 650
PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS
660 670 680 690 700
RNEMGIPQQT TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP
710 720 730 740 750
DLIEENHVVN KTDLKVDCLS SERMSLPLLA GGVADDINTN KKEGISDVVE
760 770 780 790 800
GMELNSSITS QDVLMSSPEK NTASQNSILE EGETKISQSE LFDNKSLTTE
810 820 830 840
CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP LQPGEF
Length:846
Mass (Da):95,115
Last modified:September 13, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i588BAF238D6FFB72
GO
Isoform 2 (identifier: Q15398-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:765
Mass (Da):85,668
Checksum:i00AFF91A02387EA1
GO
Isoform 3 (identifier: Q15398-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     807-846: PGLNCSNPFT...TFSPLQPGEF → VGSCYVARAG...AGTTARSKLQ

Show »
Length:842
Mass (Da):94,178
Checksum:iFDEF1E4B900F758C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4E5G3V4E5_HUMAN
Disks large-associated protein 5
DLGAP5
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V543G3V543_HUMAN
Disks large-associated protein 5
DLGAP5
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA02797 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAD62583 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti253E → K in BAA02797 (PubMed:7584026).Curated1
Sequence conflicti328M → T in BAG61340 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02377469G → E1 PublicationCorresponds to variant dbSNP:rs2274271Ensembl.1
Natural variantiVAR_057718324Q → H. Corresponds to variant dbSNP:rs8010791Ensembl.1
Natural variantiVAR_057719469T → I. Corresponds to variant dbSNP:rs17128275Ensembl.1
Natural variantiVAR_062147753E → Q. Corresponds to variant dbSNP:rs35954941Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0155501 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_045341807 – 846PGLNC…QPGEF → VGSCYVARAGLEVLGSSDPT TSASRVAGTTARSKLQ in isoform 3. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB076695 mRNA Translation: BAB97376.1
D13633 mRNA Translation: BAA02797.3 Different initiation.
BX248255 mRNA Translation: CAD62583.1 Different initiation.
BT007344 mRNA Translation: AAP36008.1
AK299338 mRNA Translation: BAG61340.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80664.1
BC010658 mRNA Translation: AAH10658.2
BC016276 mRNA Translation: AAH16276.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS53897.1 [Q15398-3]
CCDS9723.1 [Q15398-2]

NCBI Reference Sequences

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RefSeqi
NP_001139487.1, NM_001146015.1 [Q15398-3]
NP_055565.3, NM_014750.4 [Q15398-2]
XP_016877329.1, XM_017021840.1 [Q15398-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000247191; ENSP00000247191; ENSG00000126787 [Q15398-2]
ENST00000395425; ENSP00000378815; ENSG00000126787 [Q15398-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9787

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9787

UCSC genome browser

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UCSCi
uc001xbs.4, human [Q15398-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076695 mRNA Translation: BAB97376.1
D13633 mRNA Translation: BAA02797.3 Different initiation.
BX248255 mRNA Translation: CAD62583.1 Different initiation.
BT007344 mRNA Translation: AAP36008.1
AK299338 mRNA Translation: BAG61340.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80664.1
BC010658 mRNA Translation: AAH10658.2
BC016276 mRNA Translation: AAH16276.2
CCDSiCCDS53897.1 [Q15398-3]
CCDS9723.1 [Q15398-2]
RefSeqiNP_001139487.1, NM_001146015.1 [Q15398-3]
NP_055565.3, NM_014750.4 [Q15398-2]
XP_016877329.1, XM_017021840.1 [Q15398-2]

3D structure databases

SMRiQ15398
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115131, 27 interactors
ELMiQ15398
IntActiQ15398, 21 interactors
MINTiQ15398
STRINGi9606.ENSP00000247191

PTM databases

iPTMnetiQ15398
MetOSiteiQ15398
PhosphoSitePlusiQ15398

Polymorphism and mutation databases

BioMutaiDLGAP5
DMDMi82592583

Proteomic databases

CPTACiCPTAC-1204
CPTAC-1205
EPDiQ15398
jPOSTiQ15398
MassIVEiQ15398
PaxDbiQ15398
PeptideAtlasiQ15398
PRIDEiQ15398
ProteomicsDBi2036
60567 [Q15398-2]
60568 [Q15398-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q15398, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
5, 235 antibodies

The DNASU plasmid repository

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DNASUi
9787

Genome annotation databases

EnsembliENST00000247191; ENSP00000247191; ENSG00000126787 [Q15398-2]
ENST00000395425; ENSP00000378815; ENSG00000126787 [Q15398-3]
GeneIDi9787
KEGGihsa:9787
UCSCiuc001xbs.4, human [Q15398-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9787
DisGeNETi9787
EuPathDBiHostDB:ENSG00000126787.12

GeneCards: human genes, protein and diseases

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GeneCardsi
DLGAP5
HGNCiHGNC:16864, DLGAP5
HPAiENSG00000126787, Tissue enriched (lymphoid)
MIMi617859, gene
neXtProtiNX_Q15398
OpenTargetsiENSG00000126787
PharmGKBiPA162383761

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3971, Eukaryota
GeneTreeiENSGT00940000158652
HOGENOMiCLU_018126_0_0_1
InParanoidiQ15398
KOiK16804
OMAiPSERMNL
OrthoDBi566337at2759
PhylomeDBiQ15398
TreeFamiTF321382

Enzyme and pathway databases

PathwayCommonsiQ15398
ReactomeiR-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9787, 37 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DLGAP5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DLGAP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9787
PharosiQ15398, Tbio

Protein Ontology

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PROi
PR:Q15398
RNActiQ15398, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126787, Expressed in secondary oocyte and 144 other tissues
ExpressionAtlasiQ15398, baseline and differential
GenevisibleiQ15398, HS

Family and domain databases

InterProiView protein in InterPro
IPR005026, SAPAP
PANTHERiPTHR12353, PTHR12353, 1 hit
PfamiView protein in Pfam
PF03359, GKAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLGP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15398
Secondary accession number(s): A8MTM6
, B4DRM8, Q86T11, Q8NG58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 13, 2005
Last modified: August 12, 2020
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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