UniProtKB - Q15398 (DLGP5_HUMAN)

BLAST

>sp|Q15398|DLGP5_HUMAN Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2
MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRIL
VELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKV
GRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPR
QTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEG
KVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAK
IKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEIL
AQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE
GRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKE
RFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNN
MNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVI
PKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQT
TSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLS
SERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILE
EGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSP
LQPGEF

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History
Entry version 158 (07 Nov 2018)
Sequence version 2 (13 Sep 2005)
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Protein

Disks large-associated protein 5

Gene

DLGAP5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.3 Publications

Caution

It was localized to the spindle and the spindle pole (PubMed:12527899) but was later found to be localized to the spindle and to be excluded from the spindle pole (PubMed:15561729).2 Publications

GO - Molecular functionⁱ

phosphoprotein phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15145941

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 12527899
mitotic chromosome movement towards spindle pole
Source: UniProtKB
Non-traceable author statementⁱ
- 12527899
positive regulation of mitotic metaphase/anaphase transition
Source: UniProtKB
Non-traceable author statementⁱ
- 12527899
positive regulation of transcription of Notch receptor target Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

Reactomeⁱ

R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disks large-associated protein 5 Short name: DAP-5 Alternative name(s): Discs large homolog 7 Disks large-associated protein DLG7 Hepatoma up-regulated protein Short name: HURP
Gene namesⁱ	Name:DLGAP5 Synonyms:DLG7, KIAA0008
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126787.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16864 DLGAP5
MIMⁱ	617859 gene
neXtProtⁱ	NX_Q15398

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9787
Open Targets More...OpenTargetsⁱ	ENSG00000126787
PharmGKBⁱ	PA162383761

Polymorphism and mutation databases

BioMutaⁱ	DLGAP5
DMDMⁱ	82592583

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000174299	1 – 846	Disks large-associated protein 5Add BLAST		846

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	67	Phosphoserine; by CDK1Combined sources1 Publication	1
Modified residueⁱ	202	PhosphoserineCombined sources	1
Modified residueⁱ	326	PhosphothreonineCombined sources	1
Modified residueⁱ	329	Phosphothreonine; by CDK1Combined sources1 Publication	1
Modified residueⁱ	338	PhosphothreonineCombined sources	1
Cross-linkⁱ	347	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	401	Phosphothreonine; by CDK11 Publication	1
Modified residueⁱ	402	Phosphothreonine; by CDK11 Publication	1
Modified residueⁱ	618	Phosphoserine; by CDK1Combined sources1 Publication	1
Modified residueⁱ	627	Phosphoserine; by AURKACombined sources1 Publication	1
Modified residueⁱ	629	PhosphoserineCombined sources	1
Modified residueⁱ	634	PhosphoserineCombined sources	1
Modified residueⁱ	639	Phosphothreonine; by CDK11 Publication	1
Modified residueⁱ	642	Phosphoserine; by CDK11 Publication	1
Modified residueⁱ	662	PhosphoserineCombined sources	1
Modified residueⁱ	725	Phosphoserine; by AURKACombined sources1 Publication	1
Modified residueⁱ	757	Phosphoserine; by AURKA1 Publication	1
Modified residueⁱ	759	Phosphothreonine; by CDK11 Publication	1
Modified residueⁱ	774	PhosphoserineCombined sources	1
Modified residueⁱ	777	PhosphoserineCombined sources	1
Modified residueⁱ	784	PhosphothreonineCombined sources	1
Modified residueⁱ	806	PhosphoserineCombined sources	1
Modified residueⁱ	812	PhosphoserineCombined sources	1
Modified residueⁱ	830	Phosphoserine; by AURKACombined sources1 Publication	1
Modified residueⁱ	839	Phosphoserine; by CDK1Combined sources1 Publication	1

Post-translational modificationⁱ

Ubiquitinated, leading to its degradation.1 Publication

Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.3 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15398
PaxDbⁱ	Q15398
PeptideAtlas More...PeptideAtlasⁱ	Q15398
PRIDEⁱ	Q15398
ProteomicsDBⁱ	60567 60568 [Q15398-1]

PTM databases

iPTMnetⁱ	Q15398
PhosphoSitePlusⁱ	Q15398

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.1 Publication

Developmental stageⁱ

Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000126787 Expressed in 126 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_DLGAP5
ExpressionAtlasⁱ	Q15398 baseline and differential
Genevisibleⁱ	Q15398 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005546

HPAⁱ

HPA005546

Interactionⁱ

Subunit structureⁱ

Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GOLGA2	Q08379	3	EBI-748280,EBI-618309
MTUS2	Q5JR59	3	EBI-748280,EBI-742948

Protein-protein interaction databases

BioGridⁱ	115131, 22 interactors
ELMⁱ	Q15398
IntActⁱ	Q15398, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q15398
STRINGⁱ	9606.ENSP00000247191

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15398
SMRⁱ	Q15398
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	90 – 120	Sequence analysisAdd BLAST		31

Sequence similaritiesⁱ

Belongs to the SAPAP family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3971 Eukaryota ENOG4111JKV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074473
HOGENOMⁱ	HOG000054220
HOVERGENⁱ	HBG062172
InParanoidⁱ	Q15398
KEGG Orthology (KO) More...KOⁱ	K16804
OMAⁱ	KLQCPLG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0224
PhylomeDBⁱ	Q15398
TreeFamⁱ	TF321382

Family and domain databases

InterProⁱ	View protein in InterPro IPR005026 SAPAP
PANTHERⁱ	PTHR12353 PTHR12353, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03359 GKAP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15398-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV 
        60         70         80         90        100
NIPTLEGRIL VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE 
       110        120        130        140        150
KQLQKLKEQR EKAKRGIFKV GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV 
       160        170        180        190        200
RITRSKAKDQ MEQTKIDNES DVRAIRPGPR QTSEKKVSDK EKKVVQPVMP 
       210        220        230        240        250
TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG KVPSKGRPAK 
       260        270        280        290        300
NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 
       310        320        330        340        350
IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV 
       360        370        380        390        400
DESQATKEIL AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA 
       410        420        430        440        450
TTKNLNGLPI KEVPSLERNE GRIAQPHHGV PYFRNILQSE TEKLTSHCFE 
       460        470        480        490        500
WDRKLELDIP DDAKDLIRTA VGQTRLLMKE RFKQFEGLVD DCEYKRGIKE 
       510        520        530        540        550
TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN MNHNMNKNVF 
       560        570        580        590        600
RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 
       610        620        630        640        650
PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS 
       660        670        680        690        700
RNEMGIPQQT TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP 
       710        720        730        740        750
DLIEENHVVN KTDLKVDCLS SERMSLPLLA GGVADDINTN KKEGISDVVE 
       760        770        780        790        800
GMELNSSITS QDVLMSSPEK NTASQNSILE EGETKISQSE LFDNKSLTTE 
       810        820        830        840 
CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP LQPGEF

Length:846

Mass (Da):95,115

Last modified:September 13, 2005 - v2

Checksum:ⁱ588BAF238D6FFB72

Isoform 2 (identifier: Q15398-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-81: Missing.

« Hide

        10         20         30         40         50
MKTILGDQRK QMLQKYKEEK QLQKLKEQRE KAKRGIFKVG RYRPDMPCFL 
        60         70         80         90        100
LSNQNAVKAE PKKAIPSSVR ITRSKAKDQM EQTKIDNESD VRAIRPGPRQ 
       110        120        130        140        150
TSEKKVSDKE KKVVQPVMPT SLRMTRSATQ AAKQVPRTVS STTARKPVTR 
       160        170        180        190        200
AANENEPEGK VPSKGRPAKN VETKPDKGIS CKVDSEENTL NSQTNATSGM 
       210        220        230        240        250
NPDGVLSKME NLPEINTAKI KGKNSFAPKD FMFQPLDGLK TYQVTPMTPR 
       260        270        280        290        300
SANAFLTPSY TWTPLKTEVD ESQATKEILA QKCKTYSTKT IQQDSNKLPC 
       310        320        330        340        350
PLGPLTVWHE EHVLNKNEAT TKNLNGLPIK EVPSLERNEG RIAQPHHGVP 
       360        370        380        390        400
YFRNILQSET EKLTSHCFEW DRKLELDIPD DAKDLIRTAV GQTRLLMKER 
       410        420        430        440        450
FKQFEGLVDD CEYKRGIKET TCTDLDGFWD MVSFQIEDVI HKFNNLIKLE 
       460        470        480        490        500
ESGWQVNNNM NHNMNKNVFR KKVVSGIASK PKQDDAGRIA ARNRLAAIKN 
       510        520        530        540        550
AMRERIRQEE CAETAVSVIP KEVDKIVFDA GFFRVESPVK LFSGLSVSSE 
       560        570        580        590        600
GPSQRLGTPK SVNKAVSQSR NEMGIPQQTT SPENAGPQNT KSEHVKKTLF 
       610        620        630        640        650
LSIPESRSSI EDAQCPGLPD LIEENHVVNK TDLKVDCLSS ERMSLPLLAG 
       660        670        680        690        700
GVADDINTNK KEGISDVVEG MELNSSITSQ DVLMSSPEKN TASQNSILEE 
       710        720        730        740        750
GETKISQSEL FDNKSLTTEC HLLDSPGLNC SNPFTQLERR HQEHARHISF 
       760 
GGNLITFSPL QPGEF

Note: No experimental confirmation available.

Show »

Length:765

Mass (Da):85,668

Checksum:ⁱ00AFF91A02387EA1

Isoform 3 (identifier: Q15398-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
807-846: PGLNCSNPFT...TFSPLQPGEF → VGSCYVARAG...AGTTARSKLQ

« Hide

        10         20         30         40         50
MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV 
        60         70         80         90        100
NIPTLEGRIL VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE 
       110        120        130        140        150
KQLQKLKEQR EKAKRGIFKV GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV 
       160        170        180        190        200
RITRSKAKDQ MEQTKIDNES DVRAIRPGPR QTSEKKVSDK EKKVVQPVMP 
       210        220        230        240        250
TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG KVPSKGRPAK 
       260        270        280        290        300
NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 
       310        320        330        340        350
IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV 
       360        370        380        390        400
DESQATKEIL AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA 
       410        420        430        440        450
TTKNLNGLPI KEVPSLERNE GRIAQPHHGV PYFRNILQSE TEKLTSHCFE 
       460        470        480        490        500
WDRKLELDIP DDAKDLIRTA VGQTRLLMKE RFKQFEGLVD DCEYKRGIKE 
       510        520        530        540        550
TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN MNHNMNKNVF 
       560        570        580        590        600
RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 
       610        620        630        640        650
PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS 
       660        670        680        690        700
RNEMGIPQQT TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP 
       710        720        730        740        750
DLIEENHVVN KTDLKVDCLS SERMSLPLLA GGVADDINTN KKEGISDVVE 
       760        770        780        790        800
GMELNSSITS QDVLMSSPEK NTASQNSILE EGETKISQSE LFDNKSLTTE 
       810        820        830        840 
CHLLDSVGSC YVARAGLEVL GSSDPTTSAS RVAGTTARSK LQ

Note: No experimental confirmation available.

Show »

Length:842

Mass (Da):94,178

Checksum:ⁱFDEF1E4B900F758C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V4E5	G3V4E5_HUMAN	Disks large-associated protein 5 Disks large-associated protein 5	DLGAP5	234	Annotation score:
G3V543	G3V543_HUMAN	Disks large-associated protein 5 Disks large-associated protein 5	DLGAP5	111	Annotation score:

Sequence cautionⁱ

The sequence BAA02797 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAD62583 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	253	E → K in BAA02797 (PubMed:7584026).Curated		1
Sequence conflictⁱ	328	M → T in BAG61340 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023774	69	G → E1 PublicationCorresponds to variant dbSNP:rs2274271Ensembl.	1
Natural variantⁱVAR_057718	324	Q → H. Corresponds to variant dbSNP:rs8010791Ensembl.	1
Natural variantⁱVAR_057719	469	T → I. Corresponds to variant dbSNP:rs17128275Ensembl.	1
Natural variantⁱVAR_062147	753	E → Q. Corresponds to variant dbSNP:rs35954941Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015550	1 – 81	Missing in isoform 2. 1 PublicationAdd BLAST		81
Alternative sequenceⁱVSP_045341	807 – 846	PGLNC…QPGEF → VGSCYVARAGLEVLGSSDPT TSASRVAGTTARSKLQ in isoform 3. 1 PublicationAdd BLAST		40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB076695 mRNA Translation: BAB97376.1 D13633 mRNA Translation: BAA02797.3 Different initiation. BX248255 mRNA Translation: CAD62583.1 Different initiation. BT007344 mRNA Translation: AAP36008.1 AK299338 mRNA Translation: BAG61340.1 AL139316 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80664.1 BC010658 mRNA Translation: AAH10658.2 BC016276 mRNA Translation: AAH16276.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53897.1 [Q15398-3] CCDS9723.1 [Q15398-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001139487.1, NM_001146015.1 [Q15398-3] NP_055565.3, NM_014750.4 [Q15398-2] XP_016877329.1, XM_017021840.1 [Q15398-2]
UniGeneⁱ	Hs.77695

Genome annotation databases

Ensemblⁱ	ENST00000247191; ENSP00000247191; ENSG00000126787 [Q15398-2] ENST00000395425; ENSP00000378815; ENSG00000126787 [Q15398-3]
GeneIDⁱ	9787
KEGGⁱ	hsa:9787
UCSC genome browser More...UCSCⁱ	uc001xbs.4 human [Q15398-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15398	Isoform 2 of Disks large-associated protein 5		HUMAN		765	UniRef100_Q15398
Uncharacterized protein		CHOCR		193
Disks large-associated protein 5		HUMAN		111
Disks large-associated protein 5 (Fragment)		HUMAN		234

Protein	Similar proteins		Species	Score	Length	Source
Q15398	Isoform 2 of Disks large-associated protein 5		HUMAN		765	UniRef90_Q15398
Uncharacterized protein		CHOCR		193
Uncharacterized protein		RHIBE		864
Uncharacterized protein		MACMU		852
Uncharacterized protein		CERAT		851
+57

Protein	Similar proteins		Species	Score	Length	Source
Q15398	Disks large-associated protein 5		MOUSE		808	UniRef50_Q15398
Isoform 2 of Disks large-associated protein 5		HUMAN		765
Uncharacterized protein		CHOCR		193
Uncharacterized protein		RHIBE		864
Uncharacterized protein		MACMU		852
+243

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB076695 mRNA Translation: BAB97376.1 D13633 mRNA Translation: BAA02797.3 Different initiation. BX248255 mRNA Translation: CAD62583.1 Different initiation. BT007344 mRNA Translation: AAP36008.1 AK299338 mRNA Translation: BAG61340.1 AL139316 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80664.1 BC010658 mRNA Translation: AAH10658.2 BC016276 mRNA Translation: AAH16276.2
CCDSⁱ	CCDS53897.1 [Q15398-3] CCDS9723.1 [Q15398-2]
RefSeqⁱ	NP_001139487.1, NM_001146015.1 [Q15398-3] NP_055565.3, NM_014750.4 [Q15398-2] XP_016877329.1, XM_017021840.1 [Q15398-2]
UniGeneⁱ	Hs.77695

3D structure databases

ProteinModelPortalⁱ	Q15398
SMRⁱ	Q15398
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115131, 22 interactors
ELMⁱ	Q15398
IntActⁱ	Q15398, 9 interactors
MINTⁱ	Q15398
STRINGⁱ	9606.ENSP00000247191

PTM databases

iPTMnetⁱ	Q15398
PhosphoSitePlusⁱ	Q15398

Polymorphism and mutation databases

BioMutaⁱ	DLGAP5
DMDMⁱ	82592583

Proteomic databases

EPDⁱ	Q15398
PaxDbⁱ	Q15398
PeptideAtlasⁱ	Q15398
PRIDEⁱ	Q15398
ProteomicsDBⁱ	60567 60568 [Q15398-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9787
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000247191; ENSP00000247191; ENSG00000126787 [Q15398-2] ENST00000395425; ENSP00000378815; ENSG00000126787 [Q15398-3]
GeneIDⁱ	9787
KEGGⁱ	hsa:9787
UCSCⁱ	uc001xbs.4 human [Q15398-2]

Organism-specific databases

CTDⁱ	9787
DisGeNETⁱ	9787
EuPathDBⁱ	HostDB:ENSG00000126787.12
GeneCardsⁱ	DLGAP5
H-InvDBⁱ	HIX0011684
HGNCⁱ	HGNC:16864 DLGAP5
HPAⁱ	HPA005546
MIMⁱ	617859 gene
neXtProtⁱ	NX_Q15398
OpenTargetsⁱ	ENSG00000126787
PharmGKBⁱ	PA162383761
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3971 Eukaryota ENOG4111JKV LUCA
GeneTreeⁱ	ENSGT00550000074473
HOGENOMⁱ	HOG000054220
HOVERGENⁱ	HBG062172
InParanoidⁱ	Q15398
KOⁱ	K16804
OMAⁱ	KLQCPLG
OrthoDBⁱ	EOG091G0224
PhylomeDBⁱ	Q15398
TreeFamⁱ	TF321382

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

Reactomeⁱ

R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

Miscellaneous databases

ChiTaRSⁱ	DLGAP5 human
GeneWikiⁱ	DLGAP5
GenomeRNAiⁱ	9787
Protein Ontology More...PROⁱ	PR:Q15398
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126787 Expressed in 126 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_DLGAP5
ExpressionAtlasⁱ	Q15398 baseline and differential
Genevisibleⁱ	Q15398 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005026 SAPAP
PANTHERⁱ	PTHR12353 PTHR12353, 1 hit
Pfamⁱ	View protein in Pfam PF03359 GKAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DLGP5_HUMAN
Accessionⁱ	Q15398Primary (citable) accession number: Q15398 Secondary accession number(s): A8MTM6 , B4DRM8, Q86T11, Q8NG58
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 13, 2005
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q15398 (DLGP5_HUMAN)

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Disks large-associated protein 5

DLGAP5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Coiled coil

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ