DHCR24

Functionⁱ

Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.3 Publications

Catalytic activityⁱ

5-alpha-cholest-7-en-3-beta-ol + NADP⁺ = 5-alpha-cholesta-7,24-dien-3-beta-ol + NADPH.

Cofactorⁱ

FAD

Pathwayⁱ: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	163 – 175	FADSequence analysisAdd BLAST		13

GO - Molecular functionⁱ

delta24(24-1) sterol reductase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11519011
delta24-sterol reductase activity
Source: Reactome
Inferred from experimentⁱ
- 11519011
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15577914
FAD binding Source: InterPro
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Source: MGI
Inferred from direct assayⁱ
- 11519011
peptide antigen binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15577914

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11007892
cell cycle arrest
Source: UniProtKB
Non-traceable author statementⁱ
- 15577914
cholesterol biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 11519011
cholesterol biosynthetic process via desmosterol Source: Reactome
cholesterol biosynthetic process via lathosterol Source: Reactome
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15688385
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11007892
oxidation-reduction process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11519011
regulation of neuron death
Source: UniProtKB
Non-traceable author statementⁱ
- 16407971
response to oxidative stress
Source: UniProtKB
Inferred from expression patternⁱ
- 11007892
skin development Source: UniProtKB
steroid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tissue development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12457401

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
Ligand	FAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAⁱ	1.3.1.72 2681
Reactomeⁱ	R-HSA-6807047 Cholesterol biosynthesis via desmosterol R-HSA-6807062 Cholesterol biosynthesis via lathosterol
SIGNORⁱ	Q15392
UniPathwayⁱ	UPA00063

Chemistry databases

SwissLipidsⁱ	SLP:000001223

SwissLipidsⁱ

SLP:000001223

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta(24)-sterol reductase (EC:1.3.1.72) Alternative name(s): 24-dehydrocholesterol reductase 3-beta-hydroxysterol Delta-24-reductase Diminuto/dwarf1 homolog Seladin-1
Gene namesⁱ	Name:DHCR24 Synonyms:KIAA0018
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116133.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2859 DHCR24
MIMⁱ	606418 gene
neXtProtⁱ	NX_Q15392

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 31	LumenalSequence analysis	9
Transmembraneⁱ	32 – 52	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	53 – 516	CytoplasmicSequence analysisAdd BLAST	464

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Desmosterolosis (DESMOS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1718
MalaCards human disease database More...MalaCardsⁱ	DHCR24
MIMⁱ	602398 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116133
Orphanetⁱ	35107 Desmosterolosis
PharmGKBⁱ	PA27320

Chemistry databases

ChEMBLⁱ

CHEMBL2331059

Polymorphism and mutation databases

BioMutaⁱ	DHCR24
DMDMⁱ	20141421

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000007230	23 – 516	Delta(24)-sterol reductaseAdd BLAST		494

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	122 – 123	Cleavage; by caspaseSequence analysis		2
Siteⁱ	383 – 384	Cleavage; by caspaseSequence analysis		2

Proteomic databases

EPDⁱ	Q15392
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15392
PaxDbⁱ	Q15392
PeptideAtlas More...PeptideAtlasⁱ	Q15392
PRIDEⁱ	Q15392
ProteomicsDBⁱ	60562

PTM databases

iPTMnetⁱ	Q15392
PhosphoSitePlusⁱ	Q15392
SwissPalmⁱ	Q15392

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000116133 Expressed in 227 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_DHCR24
ExpressionAtlasⁱ	Q15392 baseline and differential
Genevisibleⁱ	Q15392 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037247 HPA017981 HPA063005

HPAⁱ

CAB037247
HPA017981
HPA063005

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15577914

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108064, 28 interactors
IntActⁱ	Q15392, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q15392
STRINGⁱ	9606.ENSP00000360316

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15392
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	58 – 234	FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST		177

Sequence similaritiesⁱ

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1262 Eukaryota COG0277 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008338
HOGENOMⁱ	HOG000243421
HOVERGENⁱ	HBG051349
InParanoidⁱ	Q15392
KEGG Orthology (KO) More...KOⁱ	K09828
OMAⁱ	CPLRLRE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G044Z
PhylomeDBⁱ	Q15392
TreeFamⁱ	TF313170

Family and domain databases

Gene3Dⁱ	3.30.465.10, 1 hit
InterProⁱ	View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016169 FAD-bd_PCMH_sub2 IPR006094 Oxid_FAD_bind_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01565 FAD_binding_4, 1 hit
SUPFAMⁱ	SSF56176 SSF56176, 1 hit
PROSITEⁱ	View protein in PROSITE PS51387 FAD_PCMH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15392-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAVSLAVC ALLFLLWVRL KGLEFVLIHQ RWVFVCLFLL PLSLIFDIYY 
        60         70         80         90        100
YVRAWVVFKL SSAPRLHEQR VRDIQKQVRE WKEQGSKTFM CTGRPGWLTV 
       110        120        130        140        150
SLRVGKYKKT HKNIMINLMD ILEVDTKKQI VRVEPLVTMG QVTALLTSIG 
       160        170        180        190        200
WTLPVLPELD DLTVGGLIMG TGIESSSHKY GLFQHICTAY ELVLADGSFV 
       210        220        230        240        250
RCTPSENSDL FYAVPWSCGT LGFLVAAEIR IIPAKKYVKL RFEPVRGLEA 
       260        270        280        290        300
ICAKFTHESQ RQENHFVEGL LYSLDEAVIM TGVMTDEAEP SKLNSIGNYY 
       310        320        330        340        350
KPWFFKHVEN YLKTNREGLE YIPLRHYYHR HTRSIFWELQ DIIPFGNNPI 
       360        370        380        390        400
FRYLFGWMVP PKISLLKLTQ GETLRKLYEQ HHVVQDMLVP MKCLQQALHT 
       410        420        430        440        450
FQNDIHVYPI WLCPFILPSQ PGLVHPKGNE AELYIDIGAY GEPRVKHFEA 
       460        470        480        490        500
RSCMRQLEKF VRSVHGFQML YADCYMNREE FWEMFDGSLY HKLREKLGCQ 
       510 
DAFPEVYDKI CKAARH

Length:516

Mass (Da):60,101

Last modified:January 31, 2002 - v2

Checksum:ⁱF9A769446FE19E59

GO

Isoform 2 (identifier: Q15392-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-76: MEPAVSLAVC...HEQRVRDIQK → MGAGEQNRQSAHCVQGICGYLEGDEEGEEGEVRST

« Hide

        10         20         30         40         50
MGAGEQNRQS AHCVQGICGY LEGDEEGEEG EVRSTQVREW KEQGSKTFMC 
        60         70         80         90        100
TGRPGWLTVS LRVGKYKKTH KNIMINLMDI LEVDTKKQIV RVEPLVTMGQ 
       110        120        130        140        150
VTALLTSIGW TLPVLPELDD LTVGGLIMGT GIESSSHKYG LFQHICTAYE 
       160        170        180        190        200
LVLADGSFVR CTPSENSDLF YAVPWSCGTL GFLVAAEIRI IPAKKYVKLR 
       210        220        230        240        250
FEPVRGLEAI CAKFTHESQR QENHFVEGLL YSLDEAVIMT GVMTDEAEPS 
       260        270        280        290        300
KLNSIGNYYK PWFFKHVENY LKTNREGLEY IPLRHYYHRH TRSIFWELQD 
       310        320        330        340        350
IIPFGNNPIF RYLFGWMVPP KISLLKLTQG ETLRKLYEQH HVVQDMLVPM 
       360        370        380        390        400
KCLQQALHTF QNDIHVYPIW LCPFILPSQP GLVHPKGNEA ELYIDIGAYG 
       410        420        430        440        450
EPRVKHFEAR SCMRQLEKFV RSVHGFQMLY ADCYMNREEF WEMFDGSLYH 
       460        470 
KLREKLGCQD AFPEVYDKIC KAARH

Note: No experimental confirmation available.

Show »

Length:475

Mass (Da):54,750

Checksum:ⁱC163378CA1E91FC8

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3LIE7	Q3LIE7_HUMAN	Delta(24)-sterol reductase Delta(24)-sterol reductase (cDNA FLJ55321, highly similar to 24-dehydrocholesterol reductase) (cDNA, FLJ79326, highly similar to 24-dehydrocholesterol reductase)	DHCR24 Nbla03646	427	Annotation score:
H7C4B7	H7C4B7_HUMAN	Delta(24)-sterol reductase Delta(24)-sterol reductase	DHCR24	154	Annotation score:

Sequence cautionⁱ

The sequence BAA02806 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012732	191	E → K in DESMOS. 1 PublicationCorresponds to variant dbSNP:rs119475041EnsemblClinVar.	1
Natural variantⁱVAR_012733	294	N → T in DESMOS. 1 PublicationCorresponds to variant dbSNP:rs281797257EnsemblClinVar.	1
Natural variantⁱVAR_012734	306	K → N in DESMOS. 1 PublicationCorresponds to variant dbSNP:rs281797256EnsemblClinVar.	1
Natural variantⁱVAR_012735	471	Y → S in DESMOS. 1 PublicationCorresponds to variant dbSNP:rs28939092EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056479	1 – 76	MEPAV…RDIQK → MGAGEQNRQSAHCVQGICGY LEGDEEGEEGEVRST in isoform 2. 1 PublicationAdd BLAST		76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF261758 mRNA Translation: AAG17288.1 AF398342 AF398341 Genomic DNA Translation: AAL15644.1 D13643 mRNA Translation: BAA02806.3 Different initiation. AK302774 mRNA Translation: BAH13803.1 AC096536 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06663.1 CH471059 Genomic DNA Translation: EAX06664.1 BC004375 mRNA Translation: AAH04375.1 BC011669 mRNA Translation: AAH11669.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS600.1 [Q15392-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_055577.1, NM_014762.3 [Q15392-1]
UniGeneⁱ	Hs.498727

Genome annotation databases

Ensemblⁱ	ENST00000371269; ENSP00000360316; ENSG00000116133 [Q15392-1]
GeneIDⁱ	1718
KEGGⁱ	hsa:1718
UCSC genome browser More...UCSCⁱ	uc001cyc.2 human [Q15392-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15392	Delta(24)-sterol reductase		MACFA		516	UniRef90_Q15392
Delta(24)-sterol reductase		RAT		516
Delta(24)-sterol reductase		MOUSE		516
Uncharacterized protein		RHIRO		590
Uncharacterized protein		RHIBE		517
+113
Q15392-2	cDNA, FLJ79318, highly similar to 24-dehydrocholesterol reductase		HUMAN		475	UniRef90_Q15392-2
delta(24)-sterol reductase		DIPOR		447
UPI00076628C7		PANTA		557
UPI000A1BF42A		Odocoileus virginianus texanus		461
UPI00072D9AE7		ACIJB		460
+1

Protein	Similar proteins		Species	Score	Length	Source
Q15392	Delta(24)-sterol reductase		RAT		516	UniRef50_Q15392
Delta(24)-sterol reductase		MOUSE		516
Delta(24)-sterol reductase		MACFA		516
Uncharacterized protein		RHIRO		590
Uncharacterized protein		RHIBE		517
+150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF261758 mRNA Translation: AAG17288.1 AF398342 AF398341 Genomic DNA Translation: AAL15644.1 D13643 mRNA Translation: BAA02806.3 Different initiation. AK302774 mRNA Translation: BAH13803.1 AC096536 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06663.1 CH471059 Genomic DNA Translation: EAX06664.1 BC004375 mRNA Translation: AAH04375.1 BC011669 mRNA Translation: AAH11669.1
CCDSⁱ	CCDS600.1 [Q15392-1]
RefSeqⁱ	NP_055577.1, NM_014762.3 [Q15392-1]
UniGeneⁱ	Hs.498727

3D structure databases

ProteinModelPortalⁱ	Q15392
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108064, 28 interactors
IntActⁱ	Q15392, 21 interactors
MINTⁱ	Q15392
STRINGⁱ	9606.ENSP00000360316

Chemistry databases

ChEMBLⁱ	CHEMBL2331059
SwissLipidsⁱ	SLP:000001223

PTM databases

iPTMnetⁱ	Q15392
PhosphoSitePlusⁱ	Q15392
SwissPalmⁱ	Q15392

Polymorphism and mutation databases

BioMutaⁱ	DHCR24
DMDMⁱ	20141421

Proteomic databases

EPDⁱ	Q15392
MaxQBⁱ	Q15392
PaxDbⁱ	Q15392
PeptideAtlasⁱ	Q15392
PRIDEⁱ	Q15392
ProteomicsDBⁱ	60562

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1718
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371269; ENSP00000360316; ENSG00000116133 [Q15392-1]
GeneIDⁱ	1718
KEGGⁱ	hsa:1718
UCSCⁱ	uc001cyc.2 human [Q15392-1]

Organism-specific databases

CTDⁱ	1718
DisGeNETⁱ	1718
EuPathDBⁱ	HostDB:ENSG00000116133.11
GeneCardsⁱ	DHCR24
HGNCⁱ	HGNC:2859 DHCR24
HPAⁱ	CAB037247 HPA017981 HPA063005
MalaCardsⁱ	DHCR24
MIMⁱ	602398 phenotype 606418 gene
neXtProtⁱ	NX_Q15392
OpenTargetsⁱ	ENSG00000116133
Orphanetⁱ	35107 Desmosterolosis
PharmGKBⁱ	PA27320
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1262 Eukaryota COG0277 LUCA
GeneTreeⁱ	ENSGT00390000008338
HOGENOMⁱ	HOG000243421
HOVERGENⁱ	HBG051349
InParanoidⁱ	Q15392
KOⁱ	K09828
OMAⁱ	CPLRLRE
OrthoDBⁱ	EOG091G044Z
PhylomeDBⁱ	Q15392
TreeFamⁱ	TF313170

Enzyme and pathway databases

UniPathwayⁱ	UPA00063
BRENDAⁱ	1.3.1.72 2681
Reactomeⁱ	R-HSA-6807047 Cholesterol biosynthesis via desmosterol R-HSA-6807062 Cholesterol biosynthesis via lathosterol
SIGNORⁱ	Q15392

Miscellaneous databases

ChiTaRSⁱ	DHCR24 human
GeneWikiⁱ	24-dehydrocholesterol_reductase
GenomeRNAiⁱ	1718
Protein Ontology More...PROⁱ	PR:Q15392
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116133 Expressed in 227 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_DHCR24
ExpressionAtlasⁱ	Q15392 baseline and differential
Genevisibleⁱ	Q15392 HS

Family and domain databases

Gene3Dⁱ	3.30.465.10, 1 hit
InterProⁱ	View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016169 FAD-bd_PCMH_sub2 IPR006094 Oxid_FAD_bind_N
Pfamⁱ	View protein in Pfam PF01565 FAD_binding_4, 1 hit
SUPFAMⁱ	SSF56176 SSF56176, 1 hit
PROSITEⁱ	View protein in PROSITE PS51387 FAD_PCMH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHC24_HUMAN
Accessionⁱ	Q15392Primary (citable) accession number: Q15392 Secondary accession number(s): B7Z817, D3DQ51, Q9HBA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 31, 2002
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q15392 (DHC24_HUMAN)

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Delta(24)-sterol reductase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol biosynthesis

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Golgi apparatus

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: cholesterol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ