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Protein

Mitochondrial fission regulator 1

Gene

MTFR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission regulator 1
Alternative name(s):
Chondrocyte protein with a poly-proline region
Gene namesi
Name:MTFR1
Synonyms:CHPPR, FAM54A2, KIAA0009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000066855.15
HGNCiHGNC:29510 MTFR1
neXtProtiNX_Q15390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066855
PharmGKBiPA142671305

Polymorphism and mutation databases

BioMutaiMTFR1
DMDMi73920234

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionSequence analysisAdd BLAST48
ChainiPRO_000009662249 – 333Mitochondrial fission regulator 1Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15390
MaxQBiQ15390
PaxDbiQ15390
PeptideAtlasiQ15390
PRIDEiQ15390
ProteomicsDBi60560

PTM databases

iPTMnetiQ15390
PhosphoSitePlusiQ15390

Expressioni

Gene expression databases

BgeeiENSG00000066855 Expressed in 221 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_MTFR1
ExpressionAtlasiQ15390 baseline and differential
GenevisibleiQ15390 HS

Organism-specific databases

HPAiHPA023152
HPA056120

Interactioni

Protein-protein interaction databases

BioGridi115008, 21 interactors
IntActiQ15390, 10 interactors
MINTiQ15390

Structurei

3D structure databases

ProteinModelPortaliQ15390
SMRiQ15390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 304Necessary and sufficient to promote mitochondrial fissionBy similarityAdd BLAST126

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 169Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 197Pro-richAdd BLAST14

Sequence similaritiesi

Belongs to the MTFR1 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiENOG410IEID Eukaryota
ENOG4111K5H LUCA
GeneTreeiENSGT00530000063223
HOGENOMiHOG000013162
HOVERGENiHBG056951
InParanoidiQ15390
OMAiDMPNMLE
OrthoDBiEOG091G0DDL
PhylomeDBiQ15390
TreeFamiTF331404

Family and domain databases

InterProiView protein in InterPro
IPR007972 Mtfr1
PANTHERiPTHR14215 PTHR14215, 1 hit
PfamiView protein in Pfam
PF05308 Mito_fiss_reg, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGWIKRLIR MVFQQVGVSM QSVLWSRKPY GSSRSIVRKI GTNLSLIQCP
60 70 80 90 100
RVQFQINSHA TEWSPSHPGE DAVASFADVG WVAKEEGECS ARLRTEVRSR
110 120 130 140 150
PPLQDDLLFF EKAPSRQISL PDLSQEEPQL KTPALANEEA LQKICALENE
160 170 180 190 200
LAALRAQIAK IVTQQEQQNL TAGDLDSTTF GTIPPHPPPP PPPLPPPALG
210 220 230 240 250
LHQSTSAVDL IKERREKRAN AGKTLVKNNP KKPEMPNMLE ILKEMNSVKL
260 270 280 290 300
RSVKRSEQDV KPKPVDATDP AALIAEALKK KFAYRYRSDS QDEVEKGIPK
310 320 330
SESEATSERV LFGPHMLKPT GKMKALIENV SDS
Length:333
Mass (Da):37,000
Last modified:August 30, 2005 - v2
Checksum:iED8025FCF1B44827
GO
Isoform 2 (identifier: Q15390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-55: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,200
Checksum:iD0FA2FF4881472CF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBZ4H0YBZ4_HUMAN
Mitochondrial fission regulator 1
MTFR1
291Annotation score:
H0YF01H0YF01_HUMAN
Mitochondrial fission regulator 1
MTFR1
185Annotation score:
H7C5V5H7C5V5_HUMAN
Mitochondrial fission regulator 1
MTFR1
144Annotation score:
E5RIB6E5RIB6_HUMAN
Mitochondrial fission regulator 1
MTFR1
56Annotation score:

Sequence cautioni

The sequence BAA02798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135L → R in AAH36116 (PubMed:16421571).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04676523 – 55Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055822 Genomic DNA No translation available.
BC036116 mRNA Translation: AAH36116.1
BC043498 mRNA Translation: AAH43498.1
BX537854 mRNA Translation: CAD97862.1
D13634 mRNA Translation: BAA02798.1 Different initiation.
CR456910 mRNA Translation: CAG33191.1
CCDSiCCDS55240.1 [Q15390-2]
CCDS6182.1 [Q15390-1]
RefSeqiNP_001139310.1, NM_001145838.1 [Q15390-2]
NP_055452.3, NM_014637.3 [Q15390-1]
UniGeneiHs.584788

Genome annotation databases

EnsembliENST00000262146; ENSP00000262146; ENSG00000066855 [Q15390-1]
ENST00000458689; ENSP00000391502; ENSG00000066855 [Q15390-2]
GeneIDi9650
KEGGihsa:9650
UCSCiuc003xvm.3 human [Q15390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055822 Genomic DNA No translation available.
BC036116 mRNA Translation: AAH36116.1
BC043498 mRNA Translation: AAH43498.1
BX537854 mRNA Translation: CAD97862.1
D13634 mRNA Translation: BAA02798.1 Different initiation.
CR456910 mRNA Translation: CAG33191.1
CCDSiCCDS55240.1 [Q15390-2]
CCDS6182.1 [Q15390-1]
RefSeqiNP_001139310.1, NM_001145838.1 [Q15390-2]
NP_055452.3, NM_014637.3 [Q15390-1]
UniGeneiHs.584788

3D structure databases

ProteinModelPortaliQ15390
SMRiQ15390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115008, 21 interactors
IntActiQ15390, 10 interactors
MINTiQ15390

PTM databases

iPTMnetiQ15390
PhosphoSitePlusiQ15390

Polymorphism and mutation databases

BioMutaiMTFR1
DMDMi73920234

Proteomic databases

EPDiQ15390
MaxQBiQ15390
PaxDbiQ15390
PeptideAtlasiQ15390
PRIDEiQ15390
ProteomicsDBi60560

Protocols and materials databases

DNASUi9650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262146; ENSP00000262146; ENSG00000066855 [Q15390-1]
ENST00000458689; ENSP00000391502; ENSG00000066855 [Q15390-2]
GeneIDi9650
KEGGihsa:9650
UCSCiuc003xvm.3 human [Q15390-1]

Organism-specific databases

CTDi9650
EuPathDBiHostDB:ENSG00000066855.15
GeneCardsiMTFR1
HGNCiHGNC:29510 MTFR1
HPAiHPA023152
HPA056120
neXtProtiNX_Q15390
OpenTargetsiENSG00000066855
PharmGKBiPA142671305
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEID Eukaryota
ENOG4111K5H LUCA
GeneTreeiENSGT00530000063223
HOGENOMiHOG000013162
HOVERGENiHBG056951
InParanoidiQ15390
OMAiDMPNMLE
OrthoDBiEOG091G0DDL
PhylomeDBiQ15390
TreeFamiTF331404

Miscellaneous databases

ChiTaRSiMTFR1 human
GenomeRNAii9650
PROiPR:Q15390

Gene expression databases

BgeeiENSG00000066855 Expressed in 221 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_MTFR1
ExpressionAtlasiQ15390 baseline and differential
GenevisibleiQ15390 HS

Family and domain databases

InterProiView protein in InterPro
IPR007972 Mtfr1
PANTHERiPTHR14215 PTHR14215, 1 hit
PfamiView protein in Pfam
PF05308 Mito_fiss_reg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTFR1_HUMAN
AccessioniPrimary (citable) accession number: Q15390
Secondary accession number(s): E7EP84
, Q6IB94, Q7Z669, Q86XH5, Q8IVD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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