TOMM20

Functionⁱ

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).By similarity

GO - Molecular functionⁱ

mitochondrion targeting sequence binding Source: GO_Central
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Source: HGNC
Inferred from direct assayⁱ
- 14557246
unfolded protein binding
Source: HGNC
Inferred from direct assayⁱ
- 14557246

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial outer membrane translocase complex assembly Source: GO_Central
protein deubiquitination Source: Reactome
protein import into mitochondrial matrix Source: GO_Central
protein targeting to mitochondrion
Source: HGNC
Inferred from direct assayⁱ
- 14557246
response to 3,3',5-triiodo-L-thyronine Source: Ensembl
response to muscle activity Source: Ensembl
tRNA import into mitochondrion Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-5689880 Ub-specific processing proteases

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial import receptor subunit TOM20 homolog Alternative name(s): Mitochondrial 20 kDa outer membrane protein Outer mitochondrial membrane receptor Tom20
Gene namesⁱ	Name:TOMM20 Synonyms:KIAA0016
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173726.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20947 TOMM20
MIMⁱ	601848 gene
neXtProtⁱ	NX_Q15388

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 6	Mitochondrial intermembraneSequence analysis	6
Transmembraneⁱ	7 – 24	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	25 – 145	CytoplasmicSequence analysisAdd BLAST	121

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	56	K → R: Defects in mitophagy; when associated with R-61 and R-68. 1 Publication	1
Mutagenesisⁱ	61	K → R: Defects in mitophagy; when associated with R-56 and R-68. 1 Publication	1
Mutagenesisⁱ	68	K → R: Defects in mitophagy; when associated with R-56 and R-61. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173726
PharmGKBⁱ	PA134964372

Polymorphism and mutation databases

BioMutaⁱ	TOMM20
DMDMⁱ	2498697

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051538	1 – 145	Mitochondrial import receptor subunit TOM20 homologAdd BLAST		145

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	35	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	56	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linkⁱ	61	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linkⁱ	68	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residueⁱ	135	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.2 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15388
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15388
PaxDbⁱ	Q15388
PeptideAtlas More...PeptideAtlasⁱ	Q15388
PRIDEⁱ	Q15388
ProteomicsDBⁱ	60558
TopDownProteomicsⁱ	Q15388

PTM databases

iPTMnetⁱ	Q15388
PhosphoSitePlusⁱ	Q15388

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173726 Expressed in 241 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TOMM20
ExpressionAtlasⁱ	Q15388 baseline and differential
Genevisibleⁱ	Q15388 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005585 HPA011562

HPAⁱ

CAB005585
HPA011562

Interactionⁱ

Subunit structureⁱ

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.2 Publications

GO - Molecular functionⁱ

unfolded protein binding
Source: HGNC
Inferred from direct assayⁱ
- 14557246

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115144, 48 interactors
CORUMⁱ	Q15388
Database of interacting proteins More...DIPⁱ	DIP-46735N
IntActⁱ	Q15388, 149 interactors
Molecular INTeraction database More...MINTⁱ	Q15388
STRINGⁱ	9606.ENSP00000355566

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15388
SMRⁱ	Q15388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Tom20 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4056 Eukaryota ENOG4111NAH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011698
HOGENOMⁱ	HOG000006671
HOVERGENⁱ	HBG057315
InParanoidⁱ	Q15388
KEGG Orthology (KO) More...KOⁱ	K17770
OMAⁱ	FVGYCFY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Z80
PhylomeDBⁱ	Q15388
TreeFamⁱ	TF106200

Family and domain databases

Gene3Dⁱ	1.20.960.10, 1 hit
InterProⁱ	View protein in InterPro IPR002056 MAS20 IPR022422 MAS20_rcpt_metazoan IPR023392 Tom20_dom_sf
PANTHERⁱ	PTHR12430 PTHR12430, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02064 MAS20, 1 hit
PIRSFⁱ	PIRSF037707 MAS20_rcpt, 1 hit
PRINTSⁱ	PR01989 EUOM20RECPTR PR00351 OM20RECEPTOR
SUPFAMⁱ	SSF47157 SSF47157, 1 hit
TIGRFAMsⁱ	TIGR00985 3a0801s04tom, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15388-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE 
        60         70         80         90        100
RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC 
       110        120        130        140 
GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE

Length:145

Mass (Da):16,298

Last modified:November 1, 1996 - v1

Checksum:ⁱ5153BD25AC5D9B3A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	145	E → D in CAG32999 (Ref. 6) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052366	117	P → L. Corresponds to variant dbSNP:rs16991984Ensembl.		1
Natural variantⁱVAR_052367	134	V → L. Corresponds to variant dbSNP:rs1049510Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126962 AF126961 Genomic DNA Translation: AAF13354.1 D13641 mRNA Translation: BAA02804.1 AK289810 mRNA Translation: BAF82499.1 CR456718 mRNA Translation: CAG32999.1 AL732292 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW70003.1 BC000882 mRNA Translation: AAH00882.1 BC066335 mRNA Translation: AAH66335.1 BC071994 mRNA Translation: AAH71994.1 BC100286 mRNA Translation: AAI00287.1 BC107851 mRNA Translation: AAI07852.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1603.1
PIRⁱ	S68215
NCBI Reference Sequences More...RefSeqⁱ	NP_055580.1, NM_014765.2
UniGeneⁱ	Hs.533192

Genome annotation databases

Ensemblⁱ	ENST00000366607; ENSP00000355566; ENSG00000173726
GeneIDⁱ	9804
KEGGⁱ	hsa:9804
UCSC genome browser More...UCSCⁱ	uc001hwl.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15388	Mitochondrial import receptor subunit TOM20 homolog		BOVIN		145	UniRef100_Q15388
Mitochondrial import receptor subunit TOM20 homolog		PONAB		145
Uncharacterized protein		PROCO		146
Mitochondrial import receptor subunit TOM20-like protein (Fragment)		wild yak		147
Translocase of outer mitochondrial membrane 20		SAIBB		146
+38

Protein	Similar proteins		Species	Score	Length	Source
Q15388	Mitochondrial import receptor subunit TOM20 homolog		BOVIN		145	UniRef90_Q15388
Mitochondrial import receptor subunit TOM20 homolog		PONAB		145
Mitochondrial import receptor subunit TOM20 homolog		MOUSE		145
Mitochondrial import receptor subunit TOM20 homolog	)	RAT		145
Uncharacterized protein		PROCO		146
+80

Protein	Similar proteins		Species	Score	Length	Source
Q15388	Mitochondrial import receptor subunit TOM20 homolog		BOVIN		145	UniRef50_Q15388
Mitochondrial import receptor subunit TOM20 homolog		PONAB		145
Mitochondrial import receptor subunit TOM20 homolog		MOUSE		145
Mitochondrial import receptor subunit TOM20 homolog	)	RAT		145
Uncharacterized protein		PROCO		146
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF126962 AF126961 Genomic DNA Translation: AAF13354.1 D13641 mRNA Translation: BAA02804.1 AK289810 mRNA Translation: BAF82499.1 CR456718 mRNA Translation: CAG32999.1 AL732292 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW70003.1 BC000882 mRNA Translation: AAH00882.1 BC066335 mRNA Translation: AAH66335.1 BC071994 mRNA Translation: AAH71994.1 BC100286 mRNA Translation: AAI00287.1 BC107851 mRNA Translation: AAI07852.1
CCDSⁱ	CCDS1603.1
PIRⁱ	S68215
RefSeqⁱ	NP_055580.1, NM_014765.2
UniGeneⁱ	Hs.533192

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4APO	X-ray	1.90	D/E	140-145	[»]
ProteinModelPortalⁱ	Q15388
SMRⁱ	Q15388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115144, 48 interactors
CORUMⁱ	Q15388
DIPⁱ	DIP-46735N
IntActⁱ	Q15388, 149 interactors
MINTⁱ	Q15388
STRINGⁱ	9606.ENSP00000355566

PTM databases

iPTMnetⁱ	Q15388
PhosphoSitePlusⁱ	Q15388

Polymorphism and mutation databases

BioMutaⁱ	TOMM20
DMDMⁱ	2498697

Proteomic databases

EPDⁱ	Q15388
MaxQBⁱ	Q15388
PaxDbⁱ	Q15388
PeptideAtlasⁱ	Q15388
PRIDEⁱ	Q15388
ProteomicsDBⁱ	60558
TopDownProteomicsⁱ	Q15388

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9804
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366607; ENSP00000355566; ENSG00000173726
GeneIDⁱ	9804
KEGGⁱ	hsa:9804
UCSCⁱ	uc001hwl.4 human

Organism-specific databases

CTDⁱ	9804
EuPathDBⁱ	HostDB:ENSG00000173726.10
GeneCardsⁱ	TOMM20
HGNCⁱ	HGNC:20947 TOMM20
HPAⁱ	CAB005585 HPA011562
MIMⁱ	601848 gene
neXtProtⁱ	NX_Q15388
OpenTargetsⁱ	ENSG00000173726
PharmGKBⁱ	PA134964372
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4056 Eukaryota ENOG4111NAH LUCA
GeneTreeⁱ	ENSGT00390000011698
HOGENOMⁱ	HOG000006671
HOVERGENⁱ	HBG057315
InParanoidⁱ	Q15388
KOⁱ	K17770
OMAⁱ	FVGYCFY
OrthoDBⁱ	EOG091G0Z80
PhylomeDBⁱ	Q15388
TreeFamⁱ	TF106200

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-5689880 Ub-specific processing proteases

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSⁱ	TOMM20 human
GeneWikiⁱ	TOMM20
GenomeRNAiⁱ	9804
Protein Ontology More...PROⁱ	PR:Q15388
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173726 Expressed in 241 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TOMM20
ExpressionAtlasⁱ	Q15388 baseline and differential
Genevisibleⁱ	Q15388 HS

Family and domain databases

Gene3Dⁱ	1.20.960.10, 1 hit
InterProⁱ	View protein in InterPro IPR002056 MAS20 IPR022422 MAS20_rcpt_metazoan IPR023392 Tom20_dom_sf
PANTHERⁱ	PTHR12430 PTHR12430, 1 hit
Pfamⁱ	View protein in Pfam PF02064 MAS20, 1 hit
PIRSFⁱ	PIRSF037707 MAS20_rcpt, 1 hit
PRINTSⁱ	PR01989 EUOM20RECPTR PR00351 OM20RECEPTOR
SUPFAMⁱ	SSF47157 SSF47157, 1 hit
TIGRFAMsⁱ	TIGR00985 3a0801s04tom, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOM20_HUMAN
Accessionⁱ	Q15388Primary (citable) accession number: Q15388 Secondary accession number(s): A8K195, Q498B3, Q6IBT4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	October 10, 2018
	This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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UniProtKB - Q15388 (TOM20_HUMAN)

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Mitochondrial import receptor subunit TOM20 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ