UniProtKB - Q15388 (TOM20_HUMAN)
Mitochondrial import receptor subunit TOM20 homolog
TOMM20
Functioni
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
By similarityGO - Molecular functioni
- mitochondrion targeting sequence binding Source: GO_Central
- protein-transporting ATPase activity Source: HGNC-UCL
- unfolded protein binding Source: HGNC-UCL
GO - Biological processi
- protein import into mitochondrial matrix Source: GO_Central
- protein insertion into mitochondrial outer membrane Source: ComplexPortal
- protein targeting to mitochondrion Source: HGNC-UCL
- response to 3,3',5-triiodo-L-thyronine Source: Ensembl
- response to muscle activity Source: Ensembl
- tRNA import into mitochondrion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q15388 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-5205685, PINK1-PRKN Mediated Mitophagy R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q15388 |
SIGNORi | Q15388 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial import receptor subunit TOM20 homologAlternative name(s): Mitochondrial 20 kDa outer membrane protein Outer mitochondrial membrane receptor Tom20 |
Gene namesi | Name:TOMM20 Synonyms:KIAA0016 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20947, TOMM20 |
MIMi | 601848, gene |
neXtProti | NX_Q15388 |
VEuPathDBi | HostDB:ENSG00000173726 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 4 Publications; Single-pass membrane protein Sequence analysis
Mitochondrion
- integral component of mitochondrial outer membrane Source: GO_Central
- mitochondrial outer membrane Source: UniProtKB
- mitochondrial outer membrane translocase complex Source: GO_Central
- mitochondrion Source: UniProtKB
Other locations
- mitochondria-associated endoplasmic reticulum membrane Source: MGI
- sperm midpiece Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | Mitochondrial intermembraneSequence analysis | 6 | |
Transmembranei | 7 – 24 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 25 – 145 | CytoplasmicSequence analysisAdd BLAST | 121 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 56 | K → R: Defects in mitophagy; when associated with R-61 and R-68. 1 Publication | 1 | |
Mutagenesisi | 61 | K → R: Defects in mitophagy; when associated with R-56 and R-68. 1 Publication | 1 | |
Mutagenesisi | 68 | K → R: Defects in mitophagy; when associated with R-56 and R-61. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9804 |
OpenTargetsi | ENSG00000173726 |
PharmGKBi | PA134964372 |
Miscellaneous databases
Pharosi | Q15388, Tbio |
Genetic variation databases
BioMutai | TOMM20 |
DMDMi | 2498697 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051538 | 1 – 145 | Mitochondrial import receptor subunit TOM20 homologAdd BLAST | 145 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 56 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Cross-linki | 61 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Cross-linki | 68 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 135 | PhosphoserineCombined sources | 1 | |
Modified residuei | 138 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15388 |
jPOSTi | Q15388 |
MassIVEi | Q15388 |
MaxQBi | Q15388 |
PaxDbi | Q15388 |
PeptideAtlasi | Q15388 |
PRIDEi | Q15388 |
ProteomicsDBi | 60558 |
TopDownProteomicsi | Q15388 |
PTM databases
iPTMneti | Q15388 |
PhosphoSitePlusi | Q15388 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173726, Expressed in forebrain and 253 other tissues |
ExpressionAtlasi | Q15388, baseline and differential |
Genevisiblei | Q15388, HS |
Organism-specific databases
HPAi | ENSG00000173726, Low tissue specificity |
Interactioni
Subunit structurei
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
Interacts with TOM22.
Interacts with APEX1 (PubMed:20231292).
Interacts with TBC1D21 (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- unfolded protein binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 115144, 207 interactors |
ComplexPortali | CPX-6121, TOM40 mitochondrial outer membrane translocase complex |
CORUMi | Q15388 |
DIPi | DIP-46735N |
IntActi | Q15388, 155 interactors |
MINTi | Q15388 |
STRINGi | 9606.ENSP00000355566 |
Miscellaneous databases
RNActi | Q15388, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q15388 |
BMRBi | Q15388 |
SMRi | Q15388 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4056, Eukaryota |
GeneTreei | ENSGT00390000011698 |
HOGENOMi | CLU_100000_0_0_1 |
InParanoidi | Q15388 |
OMAi | VGYCFYF |
OrthoDBi | 1316067at2759 |
PhylomeDBi | Q15388 |
TreeFami | TF106200 |
Family and domain databases
Gene3Di | 1.20.960.10, 1 hit |
InterProi | View protein in InterPro IPR002056, MAS20 IPR022422, MAS20_rcpt_metazoan IPR023392, Tom20_dom_sf |
PANTHERi | PTHR12430, PTHR12430, 1 hit |
Pfami | View protein in Pfam PF02064, MAS20, 1 hit |
PIRSFi | PIRSF037707, MAS20_rcpt, 1 hit |
PRINTSi | PR01989, EUOM20RECPTR PR00351, OM20RECEPTOR |
SUPFAMi | SSF47157, SSF47157, 1 hit |
TIGRFAMsi | TIGR00985, 3a0801s04tom, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE
60 70 80 90 100
RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC
110 120 130 140
GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 145 | E → D in CAG32999 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052366 | 117 | P → L. Corresponds to variant dbSNP:rs16991984Ensembl. | 1 | |
Natural variantiVAR_052367 | 134 | V → L. Corresponds to variant dbSNP:rs1049510Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF126962 , AF126958, AF126959, AF126960, AF126961 Genomic DNA Translation: AAF13354.1 D13641 mRNA Translation: BAA02804.1 AK289810 mRNA Translation: BAF82499.1 CR456718 mRNA Translation: CAG32999.1 AL732292 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW70003.1 BC000882 mRNA Translation: AAH00882.1 BC066335 mRNA Translation: AAH66335.1 BC071994 mRNA Translation: AAH71994.1 BC100286 mRNA Translation: AAI00287.1 BC107851 mRNA Translation: AAI07852.1 |
CCDSi | CCDS1603.1 |
PIRi | S68215 |
RefSeqi | NP_055580.1, NM_014765.2 |
Genome annotation databases
Ensembli | ENST00000366607.5; ENSP00000355566.4; ENSG00000173726.11 |
GeneIDi | 9804 |
KEGGi | hsa:9804 |
MANE-Selecti | ENST00000366607.5; ENSP00000355566.4; NM_014765.3; NP_055580.1 |
UCSCi | uc001hwl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF126962 , AF126958, AF126959, AF126960, AF126961 Genomic DNA Translation: AAF13354.1 D13641 mRNA Translation: BAA02804.1 AK289810 mRNA Translation: BAF82499.1 CR456718 mRNA Translation: CAG32999.1 AL732292 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW70003.1 BC000882 mRNA Translation: AAH00882.1 BC066335 mRNA Translation: AAH66335.1 BC071994 mRNA Translation: AAH71994.1 BC100286 mRNA Translation: AAI00287.1 BC107851 mRNA Translation: AAI07852.1 |
CCDSi | CCDS1603.1 |
PIRi | S68215 |
RefSeqi | NP_055580.1, NM_014765.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4APO | X-ray | 1.90 | D/E | 140-145 | [»] | |
AlphaFoldDBi | Q15388 | |||||
BMRBi | Q15388 | |||||
SMRi | Q15388 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115144, 207 interactors |
ComplexPortali | CPX-6121, TOM40 mitochondrial outer membrane translocase complex |
CORUMi | Q15388 |
DIPi | DIP-46735N |
IntActi | Q15388, 155 interactors |
MINTi | Q15388 |
STRINGi | 9606.ENSP00000355566 |
PTM databases
iPTMneti | Q15388 |
PhosphoSitePlusi | Q15388 |
Genetic variation databases
BioMutai | TOMM20 |
DMDMi | 2498697 |
Proteomic databases
EPDi | Q15388 |
jPOSTi | Q15388 |
MassIVEi | Q15388 |
MaxQBi | Q15388 |
PaxDbi | Q15388 |
PeptideAtlasi | Q15388 |
PRIDEi | Q15388 |
ProteomicsDBi | 60558 |
TopDownProteomicsi | Q15388 |
Protocols and materials databases
Antibodypediai | 2619, 223 antibodies from 34 providers |
DNASUi | 9804 |
Genome annotation databases
Ensembli | ENST00000366607.5; ENSP00000355566.4; ENSG00000173726.11 |
GeneIDi | 9804 |
KEGGi | hsa:9804 |
MANE-Selecti | ENST00000366607.5; ENSP00000355566.4; NM_014765.3; NP_055580.1 |
UCSCi | uc001hwl.4, human |
Organism-specific databases
CTDi | 9804 |
DisGeNETi | 9804 |
GeneCardsi | TOMM20 |
HGNCi | HGNC:20947, TOMM20 |
HPAi | ENSG00000173726, Low tissue specificity |
MIMi | 601848, gene |
neXtProti | NX_Q15388 |
OpenTargetsi | ENSG00000173726 |
PharmGKBi | PA134964372 |
VEuPathDBi | HostDB:ENSG00000173726 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4056, Eukaryota |
GeneTreei | ENSGT00390000011698 |
HOGENOMi | CLU_100000_0_0_1 |
InParanoidi | Q15388 |
OMAi | VGYCFYF |
OrthoDBi | 1316067at2759 |
PhylomeDBi | Q15388 |
TreeFami | TF106200 |
Enzyme and pathway databases
PathwayCommonsi | Q15388 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-5205685, PINK1-PRKN Mediated Mitophagy R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q15388 |
SIGNORi | Q15388 |
Miscellaneous databases
BioGRID-ORCSi | 9804, 599 hits in 1048 CRISPR screens |
ChiTaRSi | TOMM20, human |
GeneWikii | TOMM20 |
GenomeRNAii | 9804 |
Pharosi | Q15388, Tbio |
PROi | PR:Q15388 |
RNActi | Q15388, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173726, Expressed in forebrain and 253 other tissues |
ExpressionAtlasi | Q15388, baseline and differential |
Genevisiblei | Q15388, HS |
Family and domain databases
Gene3Di | 1.20.960.10, 1 hit |
InterProi | View protein in InterPro IPR002056, MAS20 IPR022422, MAS20_rcpt_metazoan IPR023392, Tom20_dom_sf |
PANTHERi | PTHR12430, PTHR12430, 1 hit |
Pfami | View protein in Pfam PF02064, MAS20, 1 hit |
PIRSFi | PIRSF037707, MAS20_rcpt, 1 hit |
PRINTSi | PR01989, EUOM20RECPTR PR00351, OM20RECEPTOR |
SUPFAMi | SSF47157, SSF47157, 1 hit |
TIGRFAMsi | TIGR00985, 3a0801s04tom, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TOM20_HUMAN | |
Accessioni | Q15388Primary (citable) accession number: Q15388 Secondary accession number(s): A8K195, Q498B3, Q6IBT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families