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Protein

Mitochondrial import receptor subunit TOM20 homolog

Gene

TOMM20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor Tom20
Gene namesi
Name:TOMM20
Synonyms:KIAA0016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173726.10
HGNCiHGNC:20947 TOMM20
MIMi601848 gene
neXtProtiNX_Q15388

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneSequence analysis6
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
Topological domaini25 – 145CytoplasmicSequence analysisAdd BLAST121

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56K → R: Defects in mitophagy; when associated with R-61 and R-68. 1 Publication1
Mutagenesisi61K → R: Defects in mitophagy; when associated with R-56 and R-68. 1 Publication1
Mutagenesisi68K → R: Defects in mitophagy; when associated with R-56 and R-61. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000173726
PharmGKBiPA134964372

Polymorphism and mutation databases

BioMutaiTOMM20
DMDMi2498697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515381 – 145Mitochondrial import receptor subunit TOM20 homologAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15388
MaxQBiQ15388
PaxDbiQ15388
PeptideAtlasiQ15388
PRIDEiQ15388
ProteomicsDBi60558
TopDownProteomicsiQ15388

PTM databases

iPTMnetiQ15388
PhosphoSitePlusiQ15388

Expressioni

Gene expression databases

BgeeiENSG00000173726 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_TOMM20
ExpressionAtlasiQ15388 baseline and differential
GenevisibleiQ15388 HS

Organism-specific databases

HPAiCAB005585
HPA011562

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115144, 48 interactors
CORUMiQ15388
DIPiDIP-46735N
IntActiQ15388, 149 interactors
MINTiQ15388
STRINGi9606.ENSP00000355566

Structurei

3D structure databases

ProteinModelPortaliQ15388
SMRiQ15388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4056 Eukaryota
ENOG4111NAH LUCA
GeneTreeiENSGT00390000011698
HOGENOMiHOG000006671
HOVERGENiHBG057315
InParanoidiQ15388
KOiK17770
OMAiFVGYCFY
OrthoDBiEOG091G0Z80
PhylomeDBiQ15388
TreeFamiTF106200

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056 MAS20
IPR022422 MAS20_rcpt_metazoan
IPR023392 Tom20_dom_sf
PANTHERiPTHR12430 PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064 MAS20, 1 hit
PIRSFiPIRSF037707 MAS20_rcpt, 1 hit
PRINTSiPR01989 EUOM20RECPTR
PR00351 OM20RECEPTOR
SUPFAMiSSF47157 SSF47157, 1 hit
TIGRFAMsiTIGR00985 3a0801s04tom, 1 hit

Sequencei

Sequence statusi: Complete.

Q15388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE
60 70 80 90 100
RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC
110 120 130 140
GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE
Length:145
Mass (Da):16,298
Last modified:November 1, 1996 - v1
Checksum:i5153BD25AC5D9B3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145E → D in CAG32999 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052366117P → L. Corresponds to variant dbSNP:rs16991984Ensembl.1
Natural variantiVAR_052367134V → L. Corresponds to variant dbSNP:rs1049510Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126962
, AF126958, AF126959, AF126960, AF126961 Genomic DNA Translation: AAF13354.1
D13641 mRNA Translation: BAA02804.1
AK289810 mRNA Translation: BAF82499.1
CR456718 mRNA Translation: CAG32999.1
AL732292 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70003.1
BC000882 mRNA Translation: AAH00882.1
BC066335 mRNA Translation: AAH66335.1
BC071994 mRNA Translation: AAH71994.1
BC100286 mRNA Translation: AAI00287.1
BC107851 mRNA Translation: AAI07852.1
CCDSiCCDS1603.1
PIRiS68215
RefSeqiNP_055580.1, NM_014765.2
UniGeneiHs.533192

Genome annotation databases

EnsembliENST00000366607; ENSP00000355566; ENSG00000173726
GeneIDi9804
KEGGihsa:9804
UCSCiuc001hwl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126962
, AF126958, AF126959, AF126960, AF126961 Genomic DNA Translation: AAF13354.1
D13641 mRNA Translation: BAA02804.1
AK289810 mRNA Translation: BAF82499.1
CR456718 mRNA Translation: CAG32999.1
AL732292 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70003.1
BC000882 mRNA Translation: AAH00882.1
BC066335 mRNA Translation: AAH66335.1
BC071994 mRNA Translation: AAH71994.1
BC100286 mRNA Translation: AAI00287.1
BC107851 mRNA Translation: AAI07852.1
CCDSiCCDS1603.1
PIRiS68215
RefSeqiNP_055580.1, NM_014765.2
UniGeneiHs.533192

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APOX-ray1.90D/E140-145[»]
ProteinModelPortaliQ15388
SMRiQ15388
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115144, 48 interactors
CORUMiQ15388
DIPiDIP-46735N
IntActiQ15388, 149 interactors
MINTiQ15388
STRINGi9606.ENSP00000355566

PTM databases

iPTMnetiQ15388
PhosphoSitePlusiQ15388

Polymorphism and mutation databases

BioMutaiTOMM20
DMDMi2498697

Proteomic databases

EPDiQ15388
MaxQBiQ15388
PaxDbiQ15388
PeptideAtlasiQ15388
PRIDEiQ15388
ProteomicsDBi60558
TopDownProteomicsiQ15388

Protocols and materials databases

DNASUi9804
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366607; ENSP00000355566; ENSG00000173726
GeneIDi9804
KEGGihsa:9804
UCSCiuc001hwl.4 human

Organism-specific databases

CTDi9804
EuPathDBiHostDB:ENSG00000173726.10
GeneCardsiTOMM20
HGNCiHGNC:20947 TOMM20
HPAiCAB005585
HPA011562
MIMi601848 gene
neXtProtiNX_Q15388
OpenTargetsiENSG00000173726
PharmGKBiPA134964372
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4056 Eukaryota
ENOG4111NAH LUCA
GeneTreeiENSGT00390000011698
HOGENOMiHOG000006671
HOVERGENiHBG057315
InParanoidiQ15388
KOiK17770
OMAiFVGYCFY
OrthoDBiEOG091G0Z80
PhylomeDBiQ15388
TreeFamiTF106200

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSiTOMM20 human
GeneWikiiTOMM20
GenomeRNAii9804
PROiPR:Q15388
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173726 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_TOMM20
ExpressionAtlasiQ15388 baseline and differential
GenevisibleiQ15388 HS

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056 MAS20
IPR022422 MAS20_rcpt_metazoan
IPR023392 Tom20_dom_sf
PANTHERiPTHR12430 PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064 MAS20, 1 hit
PIRSFiPIRSF037707 MAS20_rcpt, 1 hit
PRINTSiPR01989 EUOM20RECPTR
PR00351 OM20RECEPTOR
SUPFAMiSSF47157 SSF47157, 1 hit
TIGRFAMsiTIGR00985 3a0801s04tom, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM20_HUMAN
AccessioniPrimary (citable) accession number: Q15388
Secondary accession number(s): A8K195, Q498B3, Q6IBT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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