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Protein

Poly(rC)-binding protein 1

Gene

PCBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding
Biological processViral RNA replication

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 1
Alternative name(s):
Alpha-CP1
Heterogeneous nuclear ribonucleoprotein E1
Short name:
hnRNP E1
Nucleic acid-binding protein SUB2.3
Gene namesi
Name:PCBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169564.6
HGNCiHGNC:8647 PCBP1
MIMi601209 gene
neXtProtiNX_Q15365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5093
OpenTargetsiENSG00000169564
PharmGKBiPA32986

Polymorphism and mutation databases

BioMutaiPCBP1
DMDMi42560548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000500871 – 356Poly(rC)-binding protein 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei173PhosphoserineCombined sources1
Modified residuei189PhosphoserineBy similarity1
Modified residuei190PhosphoserineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated; lowers poly(rC)-binding activity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15365
PaxDbiQ15365
PeptideAtlasiQ15365
PRIDEiQ15365
ProteomicsDBi60541
TopDownProteomicsiQ15365

2D gel databases

OGPiQ15365
REPRODUCTION-2DPAGEiIPI00016610
UCD-2DPAGEiQ15365

PTM databases

iPTMnetiQ15365
PhosphoSitePlusiQ15365
SwissPalmiQ15365

Expressioni

Tissue specificityi

Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.

Gene expression databases

BgeeiENSG00000169564 Expressed in 239 organ(s), highest expression level in vastus lateralis
CleanExiHS_PCBP1
ExpressionAtlasiQ15365 baseline and differential
GenevisibleiQ15365 HS

Organism-specific databases

HPAiCAB037113
HPA043803
HPA068497

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111126, 185 interactors
DIPiDIP-38136N
IntActiQ15365, 105 interactors
MINTiQ15365
STRINGi9606.ENSP00000305556

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15365
SMRiQ15365
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15365

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 75KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini97 – 162KH 2PROSITE-ProRule annotationAdd BLAST66
Domaini279 – 343KH 3PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiQ15365
KOiK12889
OMAiTLTKLHQ
OrthoDBiEOG091G0DHI
PhylomeDBiQ15365
TreeFamiTF318292

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q15365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS
60 70 80 90 100
EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR
210 220 230 240 250
CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM
260 270 280 290 300
MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA
310 320 330 340 350
NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE

KGMGCS
Length:356
Mass (Da):37,498
Last modified:February 16, 2004 - v2
Checksum:i6D1A261276CA206D
GO

Sequence cautioni

The sequence CAA82631 differs from that shown. Reason: Frameshift at position 301.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205A → V in CAA55016 (PubMed:7607214).Curated1
Sequence conflicti299 – 300Missing in CAA82631 (PubMed:8152927).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78137 mRNA Translation: CAA55016.1
U24223 mRNA Translation: AAA91317.1
Z29505 mRNA Translation: CAA82631.1 Frameshift.
BC039742 mRNA Translation: AAH39742.1
CCDSiCCDS1898.1
RefSeqiNP_006187.2, NM_006196.3
UniGeneiHs.2853

Genome annotation databases

EnsembliENST00000303577; ENSP00000305556; ENSG00000169564
GeneIDi5093
KEGGihsa:5093

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78137 mRNA Translation: CAA55016.1
U24223 mRNA Translation: AAA91317.1
Z29505 mRNA Translation: CAA82631.1 Frameshift.
BC039742 mRNA Translation: AAH39742.1
CCDSiCCDS1898.1
RefSeqiNP_006187.2, NM_006196.3
UniGeneiHs.2853

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVNX-ray2.10A279-356[»]
1ZTGX-ray3.00A/B/C/D14-85[»]
3VKEX-ray1.77A/B/C/D14-86[»]
ProteinModelPortaliQ15365
SMRiQ15365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111126, 185 interactors
DIPiDIP-38136N
IntActiQ15365, 105 interactors
MINTiQ15365
STRINGi9606.ENSP00000305556

PTM databases

iPTMnetiQ15365
PhosphoSitePlusiQ15365
SwissPalmiQ15365

Polymorphism and mutation databases

BioMutaiPCBP1
DMDMi42560548

2D gel databases

OGPiQ15365
REPRODUCTION-2DPAGEiIPI00016610
UCD-2DPAGEiQ15365

Proteomic databases

EPDiQ15365
PaxDbiQ15365
PeptideAtlasiQ15365
PRIDEiQ15365
ProteomicsDBi60541
TopDownProteomicsiQ15365

Protocols and materials databases

DNASUi5093
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303577; ENSP00000305556; ENSG00000169564
GeneIDi5093
KEGGihsa:5093

Organism-specific databases

CTDi5093
DisGeNETi5093
EuPathDBiHostDB:ENSG00000169564.6
GeneCardsiPCBP1
HGNCiHGNC:8647 PCBP1
HPAiCAB037113
HPA043803
HPA068497
MIMi601209 gene
neXtProtiNX_Q15365
OpenTargetsiENSG00000169564
PharmGKBiPA32986
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiQ15365
KOiK12889
OMAiTLTKLHQ
OrthoDBiEOG091G0DHI
PhylomeDBiQ15365
TreeFamiTF318292

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRSiPCBP1 human
EvolutionaryTraceiQ15365
GeneWikiiPCBP1
GenomeRNAii5093
PROiPR:Q15365
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169564 Expressed in 239 organ(s), highest expression level in vastus lateralis
CleanExiHS_PCBP1
ExpressionAtlasiQ15365 baseline and differential
GenevisibleiQ15365 HS

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCBP1_HUMAN
AccessioniPrimary (citable) accession number: Q15365
Secondary accession number(s): Q13157, Q14975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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