UniProtKB - Q15365 (PCBP1_HUMAN)
Protein
Poly(rC)-binding protein 1
Gene
PCBP1
Organism
Homo sapiens (Human)
Status
Functioni
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).1 Publication
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: Ensembl
- mRNA binding Source: BHF-UCL
- RNA binding Source: UniProtKB
- sequence-specific single stranded DNA binding Source: Ensembl
- single-stranded DNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of RNA metabolic process Source: GO_Central
- RNA metabolic process Source: Reactome
- viral RNA genome replication Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Ribonucleoprotein, RNA-binding |
Biological process | Viral RNA replication |
Enzyme and pathway databases
PathwayCommonsi | Q15365 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | Q15365 |
Names & Taxonomyi
Protein namesi | Recommended name: Poly(rC)-binding protein 1Alternative name(s): Alpha-CP1 Heterogeneous nuclear ribonucleoprotein E1 Short name: hnRNP E1 Nucleic acid-binding protein SUB2.3 |
Gene namesi | Name:PCBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8647, PCBP1 |
MIMi | 601209, gene |
neXtProti | NX_Q15365 |
VEuPathDBi | HostDB:ENSG00000169564.6 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: BHF-UCL
- cytoplasmic ribonucleoprotein granule Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5093 |
OpenTargetsi | ENSG00000169564 |
PharmGKBi | PA32986 |
Miscellaneous databases
Pharosi | Q15365, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295825 |
Genetic variation databases
BioMutai | PCBP1 |
DMDMi | 42560548 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050087 | 1 – 356 | Poly(rC)-binding protein 1Add BLAST | 356 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 173 | PhosphoserineCombined sources | 1 | |
Modified residuei | 189 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated; lowers poly(rC)-binding activity.
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-417 CPTAC-418 |
EPDi | Q15365 |
jPOSTi | Q15365 |
MassIVEi | Q15365 |
PaxDbi | Q15365 |
PeptideAtlasi | Q15365 |
PRIDEi | Q15365 |
ProteomicsDBi | 60541 |
TopDownProteomicsi | Q15365 |
2D gel databases
OGPi | Q15365 |
REPRODUCTION-2DPAGEi | IPI00016610 |
UCD-2DPAGEi | Q15365 |
PTM databases
iPTMneti | Q15365 |
MetOSitei | Q15365 |
PhosphoSitePlusi | Q15365 |
SwissPalmi | Q15365 |
Expressioni
Tissue specificityi
Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.
Gene expression databases
Bgeei | ENSG00000169564, Expressed in vastus lateralis and 248 other tissues |
ExpressionAtlasi | Q15365, baseline and differential |
Genevisiblei | Q15365, HS |
Organism-specific databases
HPAi | ENSG00000169564, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ15365
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111126, 488 interactors |
DIPi | DIP-38136N |
IntActi | Q15365, 140 interactors |
MINTi | Q15365 |
STRINGi | 9606.ENSP00000305556 |
Miscellaneous databases
RNActi | Q15365, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15365 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15365 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 75 | KH 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 97 – 162 | KH 2PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 279 – 343 | KH 3PROSITE-ProRule annotationAdd BLAST | 65 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2190, Eukaryota |
GeneTreei | ENSGT00940000161582 |
HOGENOMi | CLU_022670_0_1_1 |
InParanoidi | Q15365 |
OMAi | TLTKLHQ |
OrthoDBi | 954970at2759 |
PhylomeDBi | Q15365 |
TreeFami | TF318292 |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
i Sequence
Sequence statusi: Complete.
Q15365-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS
60 70 80 90 100
EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR
210 220 230 240 250
CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM
260 270 280 290 300
MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA
310 320 330 340 350
NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE
KGMGCS
Sequence cautioni
The sequence CAA82631 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 205 | A → V in CAA55016 (PubMed:7607214).Curated | 1 | |
Sequence conflicti | 299 – 300 | Missing in CAA82631 (PubMed:8152927).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78137 mRNA Translation: CAA55016.1 U24223 mRNA Translation: AAA91317.1 Z29505 mRNA Translation: CAA82631.1 Frameshift. BC039742 mRNA Translation: AAH39742.1 |
CCDSi | CCDS1898.1 |
RefSeqi | NP_006187.2, NM_006196.3 |
Genome annotation databases
Ensembli | ENST00000303577; ENSP00000305556; ENSG00000169564 |
GeneIDi | 5093 |
KEGGi | hsa:5093 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78137 mRNA Translation: CAA55016.1 U24223 mRNA Translation: AAA91317.1 Z29505 mRNA Translation: CAA82631.1 Frameshift. BC039742 mRNA Translation: AAH39742.1 |
CCDSi | CCDS1898.1 |
RefSeqi | NP_006187.2, NM_006196.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WVN | X-ray | 2.10 | A | 279-356 | [»] | |
1ZTG | X-ray | 3.00 | A/B/C/D | 14-85 | [»] | |
3VKE | X-ray | 1.77 | A/B/C/D | 14-86 | [»] | |
SMRi | Q15365 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111126, 488 interactors |
DIPi | DIP-38136N |
IntActi | Q15365, 140 interactors |
MINTi | Q15365 |
STRINGi | 9606.ENSP00000305556 |
Chemistry databases
ChEMBLi | CHEMBL4295825 |
PTM databases
iPTMneti | Q15365 |
MetOSitei | Q15365 |
PhosphoSitePlusi | Q15365 |
SwissPalmi | Q15365 |
Genetic variation databases
BioMutai | PCBP1 |
DMDMi | 42560548 |
2D gel databases
OGPi | Q15365 |
REPRODUCTION-2DPAGEi | IPI00016610 |
UCD-2DPAGEi | Q15365 |
Proteomic databases
CPTACi | CPTAC-417 CPTAC-418 |
EPDi | Q15365 |
jPOSTi | Q15365 |
MassIVEi | Q15365 |
PaxDbi | Q15365 |
PeptideAtlasi | Q15365 |
PRIDEi | Q15365 |
ProteomicsDBi | 60541 |
TopDownProteomicsi | Q15365 |
Protocols and materials databases
Antibodypediai | 16295, 428 antibodies |
DNASUi | 5093 |
Genome annotation databases
Ensembli | ENST00000303577; ENSP00000305556; ENSG00000169564 |
GeneIDi | 5093 |
KEGGi | hsa:5093 |
Organism-specific databases
CTDi | 5093 |
DisGeNETi | 5093 |
GeneCardsi | PCBP1 |
HGNCi | HGNC:8647, PCBP1 |
HPAi | ENSG00000169564, Low tissue specificity |
MIMi | 601209, gene |
neXtProti | NX_Q15365 |
OpenTargetsi | ENSG00000169564 |
PharmGKBi | PA32986 |
VEuPathDBi | HostDB:ENSG00000169564.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2190, Eukaryota |
GeneTreei | ENSGT00940000161582 |
HOGENOMi | CLU_022670_0_1_1 |
InParanoidi | Q15365 |
OMAi | TLTKLHQ |
OrthoDBi | 954970at2759 |
PhylomeDBi | Q15365 |
TreeFami | TF318292 |
Enzyme and pathway databases
PathwayCommonsi | Q15365 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | Q15365 |
Miscellaneous databases
BioGRID-ORCSi | 5093, 766 hits in 1005 CRISPR screens |
ChiTaRSi | PCBP1, human |
EvolutionaryTracei | Q15365 |
GeneWikii | PCBP1 |
GenomeRNAii | 5093 |
Pharosi | Q15365, Tbio |
PROi | PR:Q15365 |
RNActi | Q15365, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169564, Expressed in vastus lateralis and 248 other tissues |
ExpressionAtlasi | Q15365, baseline and differential |
Genevisiblei | Q15365, HS |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCBP1_HUMAN | |
Accessioni | Q15365Primary (citable) accession number: Q15365 Secondary accession number(s): Q13157, Q14975 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 16, 2004 | |
Last modified: | April 7, 2021 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references