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UniProtKB - Q15361 (TTF1_HUMAN)

Entry version 161 (13 Feb 2019)
Sequence version 3 (11 Sep 2007)
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Protein

Transcription termination factor 1

Gene

TTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA replication inhibitor, DNA-binding
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5683826 Surfactant metabolism
R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73863 RNA Polymerase I Transcription Termination

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15361

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription termination factor 1
Short name:
TTF-1
Alternative name(s):
RNA polymerase I termination factor
Transcription termination factor I
Short name:
TTF-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000125482.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:12397 TTF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600777 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15361

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7270

Open Targets

More...OpenTargetsi		ENSG00000125482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37062

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TTF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		158518534

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002504721 – 905Transcription termination factor 1Add BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei248PhosphothreonineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei476PhosphotyrosineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei872PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15361

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15361

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15361

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15361

PeptideAtlas

More...PeptideAtlasi		Q15361

PRoteomics IDEntifications database

More...PRIDEi		Q15361

ProteomicsDB human proteome resource

More...ProteomicsDBi		60539

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15361

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15361

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125482 Expressed in 240 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15361 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15361 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA054837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with BAZ2A/TIP5. Interacts with CAVIN1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113121, 30 interactors

Protein interaction database and analysis system

More...IntActi		Q15361, 11 interactors

Molecular INTeraction database

More...MINTi		Q15361

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q15361

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15361

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini612 – 661Myb-like 1PROSITE-ProRule annotationAdd BLAST50
Domaini661 – 745Myb-like 2PROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 223N-terminal region (NRD)By similarityAdd BLAST223

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 21Poly-Lys5
Compositional biasi216 – 225Poly-Lys10
Compositional biasi272 – 282Poly-LysAdd BLAST11
Compositional biasi329 – 338Poly-Lys10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0051 Eukaryota
COG5147 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159729

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231811

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG104803

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15361

KEGG Orthology (KO)

More...KOi		K15225

Identification of Orthologs from Complete Genome Data

More...OMAi		NHQEFEA

Database of Orthologous Groups

More...OrthoDBi		1474117at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15361

TreeFam database of animal gene trees

More...TreeFami		TF333537

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017877 Myb-like_dom
IPR015495 Myb-like_TF
IPR001005 SANT/Myb

The PANTHER Classification System

More...PANTHERi		PTHR10641 PTHR10641, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00717 SANT, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50090 MYB_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGESSRFEI HTPVSDKKKK KCSIHKERPQ KHSHEIFRDS SLVNEQSQIT 
        60         70         80         90        100
RRKKRKKDFQ HLISSPLKKS RICDETANAT STLKKRKKRR YSALEVDEEA 
       110        120        130        140        150
GVTVVLVDKE NINNTPKHFR KDVDVVCVDM SIEQKLPRKP KTDKFQVLAK 
       160        170        180        190        200
SHAHKSEALH SKVREKKNKK HQRKAASWES QRARDTLPQS ESHQEESWLS 
       210        220        230        240        250
VGPGGEITEL PASAHKNKSK KKKKKSSNRE YETLAMPEGS QAGREAGTDM 
       260        270        280        290        300
QESQPTVGLD DETPQLLGPT HKKKSKKKKK KKSNHQEFEA LAMPEGSQVG 
       310        320        330        340        350
SEVGADMQES RPAVGLHGET AGIPAPAYKN KSKKKKKKSN HQEFEAVAMP 
       360        370        380        390        400
ESLESAYPEG SQVGSEVGTV EGSTALKGFK ESNSTKKKSK KRKLTSVKRA 
       410        420        430        440        450
RVSGDDFSVP SKNSESTLFD SVEGDGAMME EGVKSRPRQK KTQACLASKH 
       460        470        480        490        500
VQEAPRLEPA NEEHNVETAE DSEIRYLSAD SGDADDSDAD LGSAVKQLQE 
       510        520        530        540        550
FIPNIKDRAT STIKRMYRDD LERFKEFKAQ GVAIKFGKFS VKENKQLEKN 
       560        570        580        590        600
VEDFLALTGI ESADKLLYTD RYPEEKSVIT NLKRRYSFRL HIGRNIARPW 
       610        620        630        640        650
KLIYYRAKKM FDVNNYKGRY SEGDTEKLKM YHSLLGNDWK TIGEMVARSS 
       660        670        680        690        700
LSVALKFSQI SSQRNRGAWS KSETRKLIKA VEEVILKKMS PQELKEVDSK 
       710        720        730        740        750
LQENPESCLS IVREKLYKGI SWVEVEAKVQ TRNWMQCKSK WTEILTKRMT 
       760        770        780        790        800
NGRRIYYGMN ALRAKVSLIE RLYEINVEDT NEIDWEDLAS AIGDVPPSYV 
       810        820        830        840        850
QTKFSRLKAV YVPFWQKKTF PEIIDYLYET TLPLLKEKLE KMMEKKGTKI 
       860        870        880        890        900
QTPAAPKQVF PFRDIFYYED DSEGEDIEKE SEGQAPCMAH ACNSSTLGGQ 

GRWII
Length:905
Mass (Da):103,051
Last modified:September 11, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12F829CEFDDF96E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY09A0A087WY09_HUMAN
Transcription termination factor 1
TTF1
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH62692 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI04640 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI27670 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI27671 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI43049 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI43050 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence CAA58807 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence CAA58807 differs from that shown. Reason: Frameshift at position 875.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281K → T in AAH50734 (PubMed:15489334).Curated1
Sequence conflicti649S → R in CAA58807 (PubMed:7597036).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02756335E → K1 PublicationCorresponds to variant dbSNP:rs11550314Ensembl.1
Natural variantiVAR_027564290A → S. Corresponds to variant dbSNP:rs8999Ensembl.1
Natural variantiVAR_027565303V → A. Corresponds to variant dbSNP:rs3739914Ensembl.1
Natural variantiVAR_027566360G → V. Corresponds to variant dbSNP:rs3739915Ensembl.1
Natural variantiVAR_027567401R → Q. Corresponds to variant dbSNP:rs3739916Ensembl.1
Natural variantiVAR_050201473E → K. Corresponds to variant dbSNP:rs12336746Ensembl.1
Natural variantiVAR_061363885A → V. Corresponds to variant dbSNP:rs1752676Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X83973 mRNA Translation: CAA58807.1 Sequence problems.
AL353701 Genomic DNA No translation available.
BC050734 mRNA Translation: AAH50734.1
BC062692 mRNA Translation: AAH62692.1 Sequence problems.
BC104639 mRNA Translation: AAI04640.1 Sequence problems.
BC127669 mRNA Translation: AAI27670.1 Sequence problems.
BC127670 mRNA Translation: AAI27671.1 Sequence problems.
BC143048 mRNA Translation: AAI43049.1 Sequence problems.
BC143049 mRNA Translation: AAI43050.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6948.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38182

NCBI Reference Sequences

More...RefSeqi		NP_001192225.1, NM_001205296.1
NP_031370.2, NM_007344.3
XP_006717336.2, XM_006717273.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.54780
Hs.732733

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334270; ENSP00000333920; ENSG00000125482

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7270

UCSC genome browser

More...UCSCi		uc004cbl.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83973 mRNA Translation: CAA58807.1 Sequence problems.
AL353701 Genomic DNA No translation available.
BC050734 mRNA Translation: AAH50734.1
BC062692 mRNA Translation: AAH62692.1 Sequence problems.
BC104639 mRNA Translation: AAI04640.1 Sequence problems.
BC127669 mRNA Translation: AAI27670.1 Sequence problems.
BC127670 mRNA Translation: AAI27671.1 Sequence problems.
BC143048 mRNA Translation: AAI43049.1 Sequence problems.
BC143049 mRNA Translation: AAI43050.1 Sequence problems.
CCDSiCCDS6948.1
PIRiI38182
RefSeqiNP_001192225.1, NM_001205296.1
NP_031370.2, NM_007344.3
XP_006717336.2, XM_006717273.3
UniGeneiHs.54780
Hs.732733

3D structure databases

ProteinModelPortaliQ15361
SMRiQ15361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113121, 30 interactors
IntActiQ15361, 11 interactors
MINTiQ15361
STRINGi9606.ENSP00000333920

PTM databases

iPTMnetiQ15361
PhosphoSitePlusiQ15361

Polymorphism and mutation databases

BioMutaiTTF1
DMDMi158518534

Proteomic databases

EPDiQ15361
jPOSTiQ15361
MaxQBiQ15361
PaxDbiQ15361
PeptideAtlasiQ15361
PRIDEiQ15361
ProteomicsDBi60539

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7270
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334270; ENSP00000333920; ENSG00000125482
GeneIDi7270
KEGGihsa:7270
UCSCiuc004cbl.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7270
DisGeNETi7270
EuPathDBiHostDB:ENSG00000125482.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		TTF1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0201412
HGNCiHGNC:12397 TTF1
HPAiHPA054837
MIMi600777 gene
neXtProtiNX_Q15361
OpenTargetsiENSG00000125482
PharmGKBiPA37062

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0051 Eukaryota
COG5147 LUCA
GeneTreeiENSGT00940000159729
HOGENOMiHOG000231811
HOVERGENiHBG104803
InParanoidiQ15361
KOiK15225
OMAiNHQEFEA
OrthoDBi1474117at2759
PhylomeDBiQ15361
TreeFamiTF333537

Enzyme and pathway databases

ReactomeiR-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5683826 Surfactant metabolism
R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73863 RNA Polymerase I Transcription Termination
SIGNORiQ15361

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TTF1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Transcription_termination_factor,_RNA_polymerase_I

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7270

Protein Ontology

More...PROi		PR:Q15361

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125482 Expressed in 240 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ15361 baseline and differential
GenevisibleiQ15361 HS

Family and domain databases

InterProiView protein in InterPro
IPR017877 Myb-like_dom
IPR015495 Myb-like_TF
IPR001005 SANT/Myb
PANTHERiPTHR10641 PTHR10641, 2 hits
SMARTiView protein in SMART
SM00717 SANT, 2 hits
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15361
Secondary accession number(s): A1L160
, Q4VXF3, Q58EY2, Q6P5T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 11, 2007
Last modified: February 13, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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