UniProtKB - Q15361 (TTF1_HUMAN)
Protein
Transcription termination factor 1
Gene
TTF1
Organism
Homo sapiens (Human)
Status
Functioni
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.1 Publication
GO - Molecular functioni
- chromatin binding Source: GO_Central
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- DNA-templated transcription, termination Source: UniProtKB
- negative regulation of DNA replication Source: UniProtKB-KW
- termination of RNA polymerase I transcription Source: GO_Central
Keywordsi
Molecular function | DNA replication inhibitor, DNA-binding |
Biological process | Transcription, Transcription regulation, Transcription termination |
Enzyme and pathway databases
PathwayCommonsi | Q15361 |
Reactomei | R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5683826, Surfactant metabolism R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73863, RNA Polymerase I Transcription Termination |
SIGNORi | Q15361 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription termination factor 1Short name: TTF-1 Alternative name(s): RNA polymerase I termination factor Transcription termination factor I Short name: TTF-I |
Gene namesi | Name:TTF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12397, TTF1 |
MIMi | 600777, gene |
neXtProti | NX_Q15361 |
VEuPathDBi | HostDB:ENSG00000125482.12 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7270 |
OpenTargetsi | ENSG00000125482 |
PharmGKBi | PA37062 |
Miscellaneous databases
Pharosi | Q15361, Tbio |
Genetic variation databases
BioMutai | TTF1 |
DMDMi | 158518534 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250472 | 1 – 905 | Transcription termination factor 1Add BLAST | 905 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 65 | PhosphoserineCombined sources | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Modified residuei | 248 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 403 | PhosphoserineCombined sources | 1 | |
Modified residuei | 476 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 478 | PhosphoserineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineCombined sources | 1 | |
Modified residuei | 487 | PhosphoserineCombined sources | 1 | |
Cross-linki | 700 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 872 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15361 |
jPOSTi | Q15361 |
MassIVEi | Q15361 |
MaxQBi | Q15361 |
PaxDbi | Q15361 |
PeptideAtlasi | Q15361 |
PRIDEi | Q15361 |
ProteomicsDBi | 60539 |
PTM databases
iPTMneti | Q15361 |
PhosphoSitePlusi | Q15361 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125482, Expressed in buccal mucosa cell and 252 other tissues |
ExpressionAtlasi | Q15361, baseline and differential |
Genevisiblei | Q15361, HS |
Organism-specific databases
HPAi | ENSG00000125482, Low tissue specificity |
Interactioni
Subunit structurei
Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments.
Interacts with BAZ2A/TIP5.
Interacts with CAVIN1.
By similarityProtein-protein interaction databases
BioGRIDi | 113121, 40 interactors |
IntActi | Q15361, 25 interactors |
MINTi | Q15361 |
STRINGi | 9606.ENSP00000333920 |
Miscellaneous databases
RNActi | Q15361, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 612 – 661 | Myb-like 1PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 661 – 745 | Myb-like 2PROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 223 | N-terminal region (NRD)By similarityAdd BLAST | 223 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 21 | Poly-Lys | 5 | |
Compositional biasi | 216 – 225 | Poly-Lys | 10 | |
Compositional biasi | 272 – 282 | Poly-LysAdd BLAST | 11 | |
Compositional biasi | 329 – 338 | Poly-Lys | 10 |
Domaini
The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.By similarity
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0051, Eukaryota |
GeneTreei | ENSGT00940000159729 |
HOGENOMi | CLU_016962_1_0_1 |
InParanoidi | Q15361 |
OMAi | MQESRPA |
OrthoDBi | 1474117at2759 |
PhylomeDBi | Q15361 |
TreeFami | TF333537 |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR001005, SANT/Myb |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q15361-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGESSRFEI HTPVSDKKKK KCSIHKERPQ KHSHEIFRDS SLVNEQSQIT
60 70 80 90 100
RRKKRKKDFQ HLISSPLKKS RICDETANAT STLKKRKKRR YSALEVDEEA
110 120 130 140 150
GVTVVLVDKE NINNTPKHFR KDVDVVCVDM SIEQKLPRKP KTDKFQVLAK
160 170 180 190 200
SHAHKSEALH SKVREKKNKK HQRKAASWES QRARDTLPQS ESHQEESWLS
210 220 230 240 250
VGPGGEITEL PASAHKNKSK KKKKKSSNRE YETLAMPEGS QAGREAGTDM
260 270 280 290 300
QESQPTVGLD DETPQLLGPT HKKKSKKKKK KKSNHQEFEA LAMPEGSQVG
310 320 330 340 350
SEVGADMQES RPAVGLHGET AGIPAPAYKN KSKKKKKKSN HQEFEAVAMP
360 370 380 390 400
ESLESAYPEG SQVGSEVGTV EGSTALKGFK ESNSTKKKSK KRKLTSVKRA
410 420 430 440 450
RVSGDDFSVP SKNSESTLFD SVEGDGAMME EGVKSRPRQK KTQACLASKH
460 470 480 490 500
VQEAPRLEPA NEEHNVETAE DSEIRYLSAD SGDADDSDAD LGSAVKQLQE
510 520 530 540 550
FIPNIKDRAT STIKRMYRDD LERFKEFKAQ GVAIKFGKFS VKENKQLEKN
560 570 580 590 600
VEDFLALTGI ESADKLLYTD RYPEEKSVIT NLKRRYSFRL HIGRNIARPW
610 620 630 640 650
KLIYYRAKKM FDVNNYKGRY SEGDTEKLKM YHSLLGNDWK TIGEMVARSS
660 670 680 690 700
LSVALKFSQI SSQRNRGAWS KSETRKLIKA VEEVILKKMS PQELKEVDSK
710 720 730 740 750
LQENPESCLS IVREKLYKGI SWVEVEAKVQ TRNWMQCKSK WTEILTKRMT
760 770 780 790 800
NGRRIYYGMN ALRAKVSLIE RLYEINVEDT NEIDWEDLAS AIGDVPPSYV
810 820 830 840 850
QTKFSRLKAV YVPFWQKKTF PEIIDYLYET TLPLLKEKLE KMMEKKGTKI
860 870 880 890 900
QTPAAPKQVF PFRDIFYYED DSEGEDIEKE SEGQAPCMAH ACNSSTLGGQ
GRWII
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY09 | A0A087WY09_HUMAN | Transcription termination factor 1 | TTF1 | 390 | Annotation score: |
Sequence cautioni
The sequence AAH62692 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI04640 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI27670 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI27671 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI43049 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAI43050 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence CAA58807 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence CAA58807 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 281 | K → T in AAH50734 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 649 | S → R in CAA58807 (PubMed:7597036).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027563 | 35 | E → K1 PublicationCorresponds to variant dbSNP:rs11550314Ensembl. | 1 | |
Natural variantiVAR_027564 | 290 | A → S. Corresponds to variant dbSNP:rs8999Ensembl. | 1 | |
Natural variantiVAR_027565 | 303 | V → A. Corresponds to variant dbSNP:rs3739914Ensembl. | 1 | |
Natural variantiVAR_027566 | 360 | G → V. Corresponds to variant dbSNP:rs3739915Ensembl. | 1 | |
Natural variantiVAR_027567 | 401 | R → Q. Corresponds to variant dbSNP:rs3739916Ensembl. | 1 | |
Natural variantiVAR_050201 | 473 | E → K. Corresponds to variant dbSNP:rs12336746Ensembl. | 1 | |
Natural variantiVAR_061363 | 885 | A → V. Corresponds to variant dbSNP:rs1752676Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83973 mRNA Translation: CAA58807.1 Sequence problems. AL353701 Genomic DNA No translation available. BC050734 mRNA Translation: AAH50734.1 BC062692 mRNA Translation: AAH62692.1 Sequence problems. BC104639 mRNA Translation: AAI04640.1 Sequence problems. BC127669 mRNA Translation: AAI27670.1 Sequence problems. BC127670 mRNA Translation: AAI27671.1 Sequence problems. BC143048 mRNA Translation: AAI43049.1 Sequence problems. BC143049 mRNA Translation: AAI43050.1 Sequence problems. |
CCDSi | CCDS6948.1 |
PIRi | I38182 |
RefSeqi | NP_001192225.1, NM_001205296.1 NP_031370.2, NM_007344.3 XP_006717336.2, XM_006717273.3 |
Genome annotation databases
Ensembli | ENST00000334270; ENSP00000333920; ENSG00000125482 |
GeneIDi | 7270 |
KEGGi | hsa:7270 |
UCSCi | uc004cbl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83973 mRNA Translation: CAA58807.1 Sequence problems. AL353701 Genomic DNA No translation available. BC050734 mRNA Translation: AAH50734.1 BC062692 mRNA Translation: AAH62692.1 Sequence problems. BC104639 mRNA Translation: AAI04640.1 Sequence problems. BC127669 mRNA Translation: AAI27670.1 Sequence problems. BC127670 mRNA Translation: AAI27671.1 Sequence problems. BC143048 mRNA Translation: AAI43049.1 Sequence problems. BC143049 mRNA Translation: AAI43050.1 Sequence problems. |
CCDSi | CCDS6948.1 |
PIRi | I38182 |
RefSeqi | NP_001192225.1, NM_001205296.1 NP_031370.2, NM_007344.3 XP_006717336.2, XM_006717273.3 |
3D structure databases
SMRi | Q15361 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113121, 40 interactors |
IntActi | Q15361, 25 interactors |
MINTi | Q15361 |
STRINGi | 9606.ENSP00000333920 |
PTM databases
iPTMneti | Q15361 |
PhosphoSitePlusi | Q15361 |
Genetic variation databases
BioMutai | TTF1 |
DMDMi | 158518534 |
Proteomic databases
EPDi | Q15361 |
jPOSTi | Q15361 |
MassIVEi | Q15361 |
MaxQBi | Q15361 |
PaxDbi | Q15361 |
PeptideAtlasi | Q15361 |
PRIDEi | Q15361 |
ProteomicsDBi | 60539 |
Protocols and materials databases
Antibodypediai | 45229, 228 antibodies |
DNASUi | 7270 |
Genome annotation databases
Ensembli | ENST00000334270; ENSP00000333920; ENSG00000125482 |
GeneIDi | 7270 |
KEGGi | hsa:7270 |
UCSCi | uc004cbl.5, human |
Organism-specific databases
CTDi | 7270 |
DisGeNETi | 7270 |
GeneCardsi | TTF1 |
HGNCi | HGNC:12397, TTF1 |
HPAi | ENSG00000125482, Low tissue specificity |
MIMi | 600777, gene |
neXtProti | NX_Q15361 |
OpenTargetsi | ENSG00000125482 |
PharmGKBi | PA37062 |
VEuPathDBi | HostDB:ENSG00000125482.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0051, Eukaryota |
GeneTreei | ENSGT00940000159729 |
HOGENOMi | CLU_016962_1_0_1 |
InParanoidi | Q15361 |
OMAi | MQESRPA |
OrthoDBi | 1474117at2759 |
PhylomeDBi | Q15361 |
TreeFami | TF333537 |
Enzyme and pathway databases
PathwayCommonsi | Q15361 |
Reactomei | R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5683826, Surfactant metabolism R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73863, RNA Polymerase I Transcription Termination |
SIGNORi | Q15361 |
Miscellaneous databases
BioGRID-ORCSi | 7270, 270 hits in 1019 CRISPR screens |
ChiTaRSi | TTF1, human |
GeneWikii | Transcription_termination_factor,_RNA_polymerase_I |
GenomeRNAii | 7270 |
Pharosi | Q15361, Tbio |
PROi | PR:Q15361 |
RNActi | Q15361, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125482, Expressed in buccal mucosa cell and 252 other tissues |
ExpressionAtlasi | Q15361, baseline and differential |
Genevisiblei | Q15361, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR001005, SANT/Myb |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTF1_HUMAN | |
Accessioni | Q15361Primary (citable) accession number: Q15361 Secondary accession number(s): A1L160 Q6P5T5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | September 11, 2007 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot