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Entry version 179 (07 Oct 2020)
Sequence version 3 (26 Jun 2007)
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Protein

Leucine-rich repeat-containing protein 41

Gene

LRRC41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q15345

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Alternative name(s):
Protein Muf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC41
Synonyms:MUF1
ORF Names:PP7759
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132128.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16917, LRRC41

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618753, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15345

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10489

Open Targets

More...
OpenTargetsi
ENSG00000132128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671529

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15345, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC41

Domain mapping of disease mutations (DMDM)

More...
DMDMi
150421588

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966451 – 812Leucine-rich repeat-containing protein 41Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei155PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15345

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15345

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15345

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15345

PeptideAtlas

More...
PeptideAtlasi
Q15345

PRoteomics IDEntifications database

More...
PRIDEi
Q15345

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60534 [Q15345-2]
60535 [Q15345-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15345

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15345

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132128, Expressed in stomach and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15345, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15345, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132128, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5.

Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41.

Interacts with CUL5, RNF7, ELOB and ELOC.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115752, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q15345, 21 interactors

Molecular INTeraction database

More...
MINTi
Q15345

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000477792

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15345, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati487 – 507LRR 1Add BLAST21
Repeati518 – 530LRR 2Add BLAST13
Repeati531 – 555LRR 3Add BLAST25
Repeati613 – 635LRR 4Add BLAST23
Repeati636 – 659LRR 5Add BLAST24
Repeati701 – 728LRR 6Add BLAST28
Repeati731 – 752LRR 7Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 54Interaction with Elongin BC complexBy similarity10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R5T0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015908

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021836_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15345

KEGG Orthology (KO)

More...
KOi
K10347

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPCMELV

Database of Orthologous Groups

More...
OrthoDBi
322569at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15345

TreeFam database of animal gene trees

More...
TreeFami
TF335481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026137, Leu_rpt_41
IPR032675, LRR_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15354, PTHR15354, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q15345-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDRRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE
360 370 380 390 400
APGTKRSPSA PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA
410 420 430 440 450
RTRQGPGAES EDLYDFVFIV AGEKEDGEEM EIGEVACGAL DGSDPSCLGL
460 470 480 490 500
PALEASQRFR SISTLELFTV PLSTEAALTL CHLLSSWVSL ESLTLSYNGL
510 520 530 540 550
GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT RAIVRALPLL
560 570 580 590 600
RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA
610 620 630 640 650
QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS
660 670 680 690 700
FHDMNLADCQ SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG
710 720 730 740 750
NSTLKGLRLP GNRLGNAGLL ALADVFSEDS SSSLCQLDIS SNCIKPDGLL
760 770 780 790 800
EFAKRLERWG RGAFGHLRLF QNWLDQDAVT AREAIRRLRA TCHVVSDSWD
810
SSQAFADYVS TM
Length:812
Mass (Da):88,650
Last modified:June 26, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9356F26D014B436A
GO
Isoform 3 (identifier: Q15345-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-729: NAGLLALADVFSED → GGQTLGRERGKELG
     730-812: Missing.

Show »
Length:729
Mass (Da):79,298
Checksum:i71719DF9D154D87E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH00A0A0C4DH00_HUMAN
Leucine-rich repeat-containing prot...
LRRC41
617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTU1A0A087WTU1_HUMAN
Leucine-rich repeat-containing prot...
LRRC41
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J2G4A0A0B4J2G4_HUMAN
Leucine-rich repeat-containing prot...
LRRC41
790Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTI9A0A087WTI9_HUMAN
Leucine-rich repeat-containing prot...
LRRC41
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0S7A0A087X0S7_HUMAN
Leucine-rich repeat-containing prot...
LRRC41
521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ15266 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ15266 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86308 differs from that shown. Reason: Frameshift.Curated
The sequence BAC86308 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA60013 differs from that shown. Reason: Frameshift.Curated
The sequence CAD97609 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429E → K in AAQ15266 (PubMed:15498874).Curated1
Sequence conflicti603A → S in BAC86308 (Ref. 7) Curated1
Sequence conflicti654M → I in CAD97609 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051117609V → I2 PublicationsCorresponds to variant dbSNP:rs11542623Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009234716 – 729NAGLL…VFSED → GGQTLGRERGKELG in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_009235730 – 812Missing in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125827 mRNA Translation: BAC86308.1 Sequence problems.
AK291283 mRNA Translation: BAF83972.1
AK297596 mRNA Translation: BAG59981.1
AL121602 Genomic DNA No translation available.
AL122001 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06927.1
BC004953 mRNA Translation: AAH04953.2
BC101522 mRNA Translation: AAI01523.1
BC101524 mRNA Translation: AAI01525.1
BX537366 mRNA Translation: CAD97609.1 Frameshift.
AF370430 mRNA Translation: AAQ15266.1 Sequence problems.
X86018 mRNA Translation: CAA60013.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS533.1 [Q15345-2]

Protein sequence database of the Protein Information Resource

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PIRi
S52797

NCBI Reference Sequences

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RefSeqi
NP_006360.3, NM_006369.4 [Q15345-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343304; ENSP00000343298; ENSG00000132128 [Q15345-2]
ENST00000617190; ENSP00000477792; ENSG00000132128 [Q15345-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10489

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10489

UCSC genome browser

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UCSCi
uc001cpn.4, human [Q15345-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125827 mRNA Translation: BAC86308.1 Sequence problems.
AK291283 mRNA Translation: BAF83972.1
AK297596 mRNA Translation: BAG59981.1
AL121602 Genomic DNA No translation available.
AL122001 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06927.1
BC004953 mRNA Translation: AAH04953.2
BC101522 mRNA Translation: AAI01523.1
BC101524 mRNA Translation: AAI01525.1
BX537366 mRNA Translation: CAD97609.1 Frameshift.
AF370430 mRNA Translation: AAQ15266.1 Sequence problems.
X86018 mRNA Translation: CAA60013.1 Frameshift.
CCDSiCCDS533.1 [Q15345-2]
PIRiS52797
RefSeqiNP_006360.3, NM_006369.4 [Q15345-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115752, 42 interactors
IntActiQ15345, 21 interactors
MINTiQ15345
STRINGi9606.ENSP00000477792

PTM databases

iPTMnetiQ15345
PhosphoSitePlusiQ15345

Polymorphism and mutation databases

BioMutaiLRRC41
DMDMi150421588

Proteomic databases

EPDiQ15345
jPOSTiQ15345
MassIVEiQ15345
PaxDbiQ15345
PeptideAtlasiQ15345
PRIDEiQ15345
ProteomicsDBi60534 [Q15345-2]
60535 [Q15345-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32783, 131 antibodies

Genome annotation databases

EnsembliENST00000343304; ENSP00000343298; ENSG00000132128 [Q15345-2]
ENST00000617190; ENSP00000477792; ENSG00000132128 [Q15345-2]
GeneIDi10489
KEGGihsa:10489
UCSCiuc001cpn.4, human [Q15345-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10489
DisGeNETi10489
EuPathDBiHostDB:ENSG00000132128.16

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC41
HGNCiHGNC:16917, LRRC41
HPAiENSG00000132128, Low tissue specificity
MIMi618753, gene
neXtProtiNX_Q15345
OpenTargetsiENSG00000132128
PharmGKBiPA142671529

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502R5T0, Eukaryota
GeneTreeiENSGT00390000015908
HOGENOMiCLU_021836_0_0_1
InParanoidiQ15345
KOiK10347
OMAiMPCMELV
OrthoDBi322569at2759
PhylomeDBiQ15345
TreeFamiTF335481

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ15345
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10489, 13 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRC41, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LRRC41

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10489
PharosiQ15345, Tdark

Protein Ontology

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PROi
PR:Q15345
RNActiQ15345, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132128, Expressed in stomach and 234 other tissues
ExpressionAtlasiQ15345, baseline and differential
GenevisibleiQ15345, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026137, Leu_rpt_41
IPR032675, LRR_dom_sf
PANTHERiPTHR15354, PTHR15354, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC41_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15345
Secondary accession number(s): A8K5G8
, Q3MJ96, Q5TDF5, Q71RA8, Q9BSM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 26, 2007
Last modified: October 7, 2020
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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