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Protein

Transcription factor E2F5

Gene

E2F5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 118Sequence analysisAdd BLAST72

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCilium biogenesis/degradation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiQ15329

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E2F5
Short name:
E2F-5
Gene namesi
Name:E2F5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000133740.10
HGNCiHGNC:3119 E2F5
MIMi600967 gene
neXtProtiNX_Q15329

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1875
OpenTargetsiENSG00000133740
PharmGKBiPA27577

Polymorphism and mutation databases

BioMutaiE2F5
DMDMi2494230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194691 – 346Transcription factor E2F5Add BLAST346

Proteomic databases

EPDiQ15329
MaxQBiQ15329
PaxDbiQ15329
PeptideAtlasiQ15329
PRIDEiQ15329
ProteomicsDBi60531
60532 [Q15329-2]

PTM databases

iPTMnetiQ15329
PhosphoSitePlusiQ15329

Expressioni

Gene expression databases

BgeeiENSG00000133740 Expressed in 152 organ(s), highest expression level in kidney
CleanExiHS_E2F5
ExpressionAtlasiQ15329 baseline and differential
GenevisibleiQ15329 HS

Organism-specific databases

HPAiHPA055723

Interactioni

Subunit structurei

Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108207, 10 interactors
CORUMiQ15329
DIPiDIP-24229N
IntActiQ15329, 8 interactors
MINTiQ15329
STRINGi9606.ENSP00000398124

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15329
SMRiQ15329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 98Leucine-zipperAdd BLAST23
Regioni119 – 215DimerizationSequence analysisAdd BLAST97
Regioni287 – 346TransactivationSequence analysisAdd BLAST60
Regioni323 – 340RBL2 associationSequence analysisAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 118DEF boxAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 39Poly-Pro7
Compositional biasi233 – 236Poly-Ser4

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2577 Eukaryota
ENOG410XNYI LUCA
GeneTreeiENSGT00550000074403
HOGENOMiHOG000232045
HOVERGENiHBG002227
InParanoidiQ15329
KOiK04682
OMAiAKDQEDY
OrthoDBiEOG091G0CJQ
PhylomeDBiQ15329
TreeFamiTF105566

Family and domain databases

CDDicd14660 E2F_DD, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR015633 E2F
IPR037241 E2F-DP_heterodim
IPR028316 E2F5
IPR032198 E2F_CC-MB
IPR003316 E2F_WHTH_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12081 PTHR12081, 2 hits
PTHR12081:SF35 PTHR12081:SF35, 2 hits
PfamiView protein in Pfam
PF16421 E2F_CC-MB, 1 hit
PF02319 E2F_TDP, 1 hit
SMARTiView protein in SMART
SM01372 E2F_TDP, 1 hit
SUPFAMiSSF144074 SSF144074, 1 hit
SSF46785 SSF46785, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15329-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAEPASSG QQAPAGQGQG QRPPPQPPQA QAPQPPPPPQ LGGAGGGSSR
60 70 80 90 100
HEKSLGLLTT KFVSLLQEAK DGVLDLKAAA DTLAVRQKRR IYDITNVLEG
110 120 130 140 150
IDLIEKKSKN SIQWKGVGAG CNTKEVIDRL RYLKAEIEDL ELKERELDQQ
160 170 180 190 200
KLWLQQSIKN VMDDSINNRF SYVTHEDICN CFNGDTLLAI QAPSGTQLEV
210 220 230 240 250
PIPEMGQNGQ KKYQINLKSH SGPIHVLLIN KESSSSKPVV FPVPPPDDLT
260 270 280 290 300
QPSSQSLTPV TPQKSSMATQ NLPEQHVSER SQALQQTSAT DISSAGSISG
310 320 330 340
DIIDELMSSD VFPLLRLSPT PADDYNFNLD DNEGVCDLFD VQILNY
Length:346
Mass (Da):37,610
Last modified:November 1, 1996 - v1
Checksum:iF1408A755E67D879
GO
Isoform 2 (identifier: Q15329-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-295: Missing.

Show »
Length:345
Mass (Da):37,539
Checksum:i0CBCD335800F4863
GO
Isoform 3 (identifier: Q15329-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):20,192
Checksum:iAECF4C7A7000F8BD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHD4E5RHD4_HUMAN
Transcription factor E2F5
E2F5
173Annotation score:
H0YBK0H0YBK0_HUMAN
Transcription factor E2F5
E2F5
182Annotation score:
C9JYE9C9JYE9_HUMAN
Transcription factor E2F5
E2F5
249Annotation score:
H0YBW8H0YBW8_HUMAN
Transcription factor E2F5
E2F5
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153W → L in CAB01634 (PubMed:9464260).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01434818G → A1 PublicationCorresponds to variant dbSNP:rs4150841Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0446601 – 161Missing in isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_040098295Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31556 mRNA Translation: AAB00179.1
X86097 mRNA Translation: CAA60051.1
U15642 mRNA Translation: AAC50120.1
Z78409 mRNA Translation: CAB01634.1
AY162833 Genomic DNA Translation: AAN46737.1
AL583354 mRNA No translation available.
AC011773 Genomic DNA No translation available.
CCDSiCCDS47885.1 [Q15329-1]
CCDS47886.1 [Q15329-2]
CCDS55254.1 [Q15329-3]
PIRiJC5833
RefSeqiNP_001077057.1, NM_001083588.1 [Q15329-2]
NP_001077058.1, NM_001083589.1 [Q15329-3]
NP_001942.2, NM_001951.3 [Q15329-1]
UniGeneiHs.445758

Genome annotation databases

EnsembliENST00000416274; ENSP00000398124; ENSG00000133740 [Q15329-1]
ENST00000418930; ENSP00000414312; ENSG00000133740 [Q15329-2]
ENST00000517476; ENSP00000429120; ENSG00000133740 [Q15329-3]
GeneIDi1875
KEGGihsa:1875
UCSCiuc003ycz.6 human [Q15329-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31556 mRNA Translation: AAB00179.1
X86097 mRNA Translation: CAA60051.1
U15642 mRNA Translation: AAC50120.1
Z78409 mRNA Translation: CAB01634.1
AY162833 Genomic DNA Translation: AAN46737.1
AL583354 mRNA No translation available.
AC011773 Genomic DNA No translation available.
CCDSiCCDS47885.1 [Q15329-1]
CCDS47886.1 [Q15329-2]
CCDS55254.1 [Q15329-3]
PIRiJC5833
RefSeqiNP_001077057.1, NM_001083588.1 [Q15329-2]
NP_001077058.1, NM_001083589.1 [Q15329-3]
NP_001942.2, NM_001951.3 [Q15329-1]
UniGeneiHs.445758

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TUVX-ray2.90B/E124-232[»]
ProteinModelPortaliQ15329
SMRiQ15329
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108207, 10 interactors
CORUMiQ15329
DIPiDIP-24229N
IntActiQ15329, 8 interactors
MINTiQ15329
STRINGi9606.ENSP00000398124

PTM databases

iPTMnetiQ15329
PhosphoSitePlusiQ15329

Polymorphism and mutation databases

BioMutaiE2F5
DMDMi2494230

Proteomic databases

EPDiQ15329
MaxQBiQ15329
PaxDbiQ15329
PeptideAtlasiQ15329
PRIDEiQ15329
ProteomicsDBi60531
60532 [Q15329-2]

Protocols and materials databases

DNASUi1875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416274; ENSP00000398124; ENSG00000133740 [Q15329-1]
ENST00000418930; ENSP00000414312; ENSG00000133740 [Q15329-2]
ENST00000517476; ENSP00000429120; ENSG00000133740 [Q15329-3]
GeneIDi1875
KEGGihsa:1875
UCSCiuc003ycz.6 human [Q15329-1]

Organism-specific databases

CTDi1875
DisGeNETi1875
EuPathDBiHostDB:ENSG00000133740.10
GeneCardsiE2F5
HGNCiHGNC:3119 E2F5
HPAiHPA055723
MIMi600967 gene
neXtProtiNX_Q15329
OpenTargetsiENSG00000133740
PharmGKBiPA27577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2577 Eukaryota
ENOG410XNYI LUCA
GeneTreeiENSGT00550000074403
HOGENOMiHOG000232045
HOVERGENiHBG002227
InParanoidiQ15329
KOiK04682
OMAiAKDQEDY
OrthoDBiEOG091G0CJQ
PhylomeDBiQ15329
TreeFamiTF105566

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiQ15329

Miscellaneous databases

ChiTaRSiE2F5 human
GeneWikiiE2F5
GenomeRNAii1875
PROiPR:Q15329
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133740 Expressed in 152 organ(s), highest expression level in kidney
CleanExiHS_E2F5
ExpressionAtlasiQ15329 baseline and differential
GenevisibleiQ15329 HS

Family and domain databases

CDDicd14660 E2F_DD, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR015633 E2F
IPR037241 E2F-DP_heterodim
IPR028316 E2F5
IPR032198 E2F_CC-MB
IPR003316 E2F_WHTH_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12081 PTHR12081, 2 hits
PTHR12081:SF35 PTHR12081:SF35, 2 hits
PfamiView protein in Pfam
PF16421 E2F_CC-MB, 1 hit
PF02319 E2F_TDP, 1 hit
SMARTiView protein in SMART
SM01372 E2F_TDP, 1 hit
SUPFAMiSSF144074 SSF144074, 1 hit
SSF46785 SSF46785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE2F5_HUMAN
AccessioniPrimary (citable) accession number: Q15329
Secondary accession number(s): E9PBN9, Q16601, Q92756
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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