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Entry version 164 (07 Oct 2020)
Sequence version 3 (14 Oct 2008)
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Protein

Keratin, type I cuticular Ha1

Gene

KRT31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei305Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q15323

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT31
Synonyms:HHA1, HKA1, KRTHA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000094796.4

Human Gene Nomenclature Database

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HGNCi
HGNC:6448, KRT31

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601077, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15323

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
3881

Open Targets

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OpenTargetsi
ENSG00000094796

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30237

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q15323, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572740

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636841 – 416Keratin, type I cuticular Ha1Add BLAST416

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15323

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15323

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15323

PeptideAtlas

More...
PeptideAtlasi
Q15323

PRoteomics IDEntifications database

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PRIDEi
Q15323

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
12646
60528

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15323

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15323

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15323

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000094796, Expressed in hair follicle and 134 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15323, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000094796, Group enriched (brain, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q15323
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-948001,EBI-2809489
ABI2 [Q9NYB9]5EBI-948001,EBI-743598
ABI3 [Q9P2A4]3EBI-948001,EBI-742038
ABL1 - isoform IB [P00519-2]3EBI-948001,EBI-9254597
ACTR10 [Q9NZ32]3EBI-948001,EBI-2559426
AGR2 [O95994]6EBI-948001,EBI-712648
AGXT [P21549]3EBI-948001,EBI-727098
AIMP2 [Q13155]3EBI-948001,EBI-745226
AKR7A3 [O95154]3EBI-948001,EBI-748869
ALDH3B1 [P43353]3EBI-948001,EBI-2558314
AMOT [A2BDD9]3EBI-948001,EBI-17286414
AMOT - isoform 2 [Q4VCS5-2]3EBI-948001,EBI-3891843
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-948001,EBI-10187270
ANKRD36BP1 [Q96IX9]3EBI-948001,EBI-744859
ANKS1A [Q49AR9]3EBI-948001,EBI-11954519
AQP1 [P29972]3EBI-948001,EBI-745213
AQP5 [P55064]3EBI-948001,EBI-746103
ARID3A [Q99856]3EBI-948001,EBI-5458244
ARMC7 [Q9H6L4]6EBI-948001,EBI-742909
ARSJ [Q8N5N6]3EBI-948001,EBI-10266832
ASMTL [O95671]6EBI-948001,EBI-743231
ASPSCR1 [Q9BZE9]3EBI-948001,EBI-1993677
ATG9A [Q7Z3C6]3EBI-948001,EBI-727146
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-948001,EBI-12006308
ATXN7L1 [Q9ULK2]3EBI-948001,EBI-310660
AVPI1 [Q5T686]3EBI-948001,EBI-8640233
B4GALT7 [Q9UBV7]3EBI-948001,EBI-10319970
BAD [Q92934]3EBI-948001,EBI-700771
BCAS2 [O75934]3EBI-948001,EBI-1050106
BEX1 [Q9HBH7]3EBI-948001,EBI-7162175
BEX2 [Q9BXY8]6EBI-948001,EBI-745073
BFSP2 [Q13515]3EBI-948001,EBI-10229433
BHLHA9 [Q7RTU4]3EBI-948001,EBI-17508719
BTC [P35070]6EBI-948001,EBI-6590057
BYSL [Q13895]3EBI-948001,EBI-358049
C12orf49 [Q9H741]3EBI-948001,EBI-2836158
C19orf57 - isoform 2 [Q0VDD7-2]3EBI-948001,EBI-12040255
C19orf73 [Q9NVV2]3EBI-948001,EBI-2859285
C1orf109 [Q9NX04]6EBI-948001,EBI-8643161
C1orf216 [Q8TAB5]6EBI-948001,EBI-747505
C2CD6 [Q53TS8]6EBI-948001,EBI-739879
C3 [P01024]3EBI-948001,EBI-905851
C5orf49 [A4QMS7]3EBI-948001,EBI-12039847
C5orf60 - isoform 4 [A6NFR6-4]3EBI-948001,EBI-10173955
CA6 [Q8N4G4]3EBI-948001,EBI-10265475
CARD9 [Q9H257]3EBI-948001,EBI-751319
CATIP [Q7Z7H3]6EBI-948001,EBI-10258233
CATSPER1 [Q8NEC5]3EBI-948001,EBI-744545
CBX8 [Q9HC52]3EBI-948001,EBI-712912
CCDC112 [Q8NEF3]3EBI-948001,EBI-745040
CCDC116 [Q8IYX3]3EBI-948001,EBI-744311
CCDC120 [Q96HB5]3EBI-948001,EBI-744556
CCDC120 - isoform 4 [Q96HB5-4]4EBI-948001,EBI-10185348
CCDC146 [Q8IYE0]3EBI-948001,EBI-10749669
CCDC17 [Q96LX7]3EBI-948001,EBI-719840
CCDC196 [A0A1B0GWI1]6EBI-948001,EBI-10181422
CCDC198 [E9PSE9]3EBI-948001,EBI-11748295
CCER1 [Q8TC90]3EBI-948001,EBI-746041
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-948001,EBI-10175300
CCNC [P24863]6EBI-948001,EBI-395261
CD33 [P20138]6EBI-948001,EBI-3906571
CDC20B [Q86Y33]3EBI-948001,EBI-10260504
CDK18 [Q07002]6EBI-948001,EBI-746238
CDKN1A [P38936]6EBI-948001,EBI-375077
CDKN2C [P42773]3EBI-948001,EBI-711290
CDR2L [Q86X02]3EBI-948001,EBI-11063830
CEP57 [Q86XR8]3EBI-948001,EBI-308614
CEP57L1 [Q8IYX8]3EBI-948001,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-948001,EBI-10181988
CEP70 [Q8NHQ1]3EBI-948001,EBI-739624
CFAP206 [Q8IYR0]3EBI-948001,EBI-749051
CFAP53 [Q96M91]3EBI-948001,EBI-742422
CHCHD2 [Q9Y6H1]3EBI-948001,EBI-2321769
CHRNG [P07510]4EBI-948001,EBI-9008836
CHRNG - isoform 2 [P07510-2]6EBI-948001,EBI-11979451
CLCNKA - isoform 3 [P51800-3]3EBI-948001,EBI-11980535
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-948001,EBI-12256978
CLDN2 [P57739]3EBI-948001,EBI-751440
CLEC18A [A5D8T8]3EBI-948001,EBI-10173491
CNNM3 [Q8NE01]3EBI-948001,EBI-741032
CNTF [P26441]3EBI-948001,EBI-1050897
COA5 [Q86WW8]3EBI-948001,EBI-5458774
COMT - isoform Soluble [P21964-2]3EBI-948001,EBI-10200977
COX5A [P20674]3EBI-948001,EBI-715032
COX5B [P10606]3EBI-948001,EBI-1053725
CRACR2A [Q9BSW2]3EBI-948001,EBI-739773
CREB5 - isoform 3 [Q02930-3]3EBI-948001,EBI-10192698
CRH [P06850]3EBI-948001,EBI-3870390
CTSG [P08311]3EBI-948001,EBI-5462635
CYSRT1 [A8MQ03]3EBI-948001,EBI-3867333
DEF6 [Q9H4E7]3EBI-948001,EBI-745369
DGCR6L [Q9BY27]3EBI-948001,EBI-742953
DMRT3 [Q9NQL9]6EBI-948001,EBI-9679045
DOCK2 [Q92608]3EBI-948001,EBI-448771
DTNB [O60941]3EBI-948001,EBI-740402
DTNB - isoform 5 [O60941-5]3EBI-948001,EBI-11984733
EIF4E2 [O60573]3EBI-948001,EBI-398610
EIF4G1 - isoform 9 [Q04637-9]3EBI-948001,EBI-12012124
ENKD1 [Q9H0I2]3EBI-948001,EBI-744099
EPDR1 [Q9UM22]3EBI-948001,EBI-946972
EXOC8 [Q8IYI6]3EBI-948001,EBI-742102
EXOSC5 [Q9NQT4]3EBI-948001,EBI-371876
FADS2 - isoform 3 [O95864-3]3EBI-948001,EBI-12057609
FAM110A [Q9BQ89]6EBI-948001,EBI-1752811
FAM124B [Q9H5Z6]3EBI-948001,EBI-741626
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-948001,EBI-11986315
FAM50B [Q9Y247]3EBI-948001,EBI-742802
FAM71C [Q8NEG0]6EBI-948001,EBI-752049
FAM74A6 [Q5TZK3]3EBI-948001,EBI-10247271
FAM90A1 [Q86YD7]6EBI-948001,EBI-6658203
FARS2 [O95363]3EBI-948001,EBI-2513774
FBF1 - isoform 6 [Q8TES7-6]3EBI-948001,EBI-10244131
FBXW5 [Q969U6]6EBI-948001,EBI-741068
FGF16 [O43320]3EBI-948001,EBI-11479104
FKBP1B [P68106]3EBI-948001,EBI-6693977
FKBP1B - isoform 2 [P68106-2]3EBI-948001,EBI-11998976
FOXB1 [Q99853]3EBI-948001,EBI-3916225
FRS3 [O43559]3EBI-948001,EBI-725515
GAD1 [A0A0S2Z4D9]3EBI-948001,EBI-16430771
GADD45GIP1 [Q8TAE8]3EBI-948001,EBI-372506
GEM [P55040]6EBI-948001,EBI-744104
GFAP [P14136]3EBI-948001,EBI-744302
GFOD1 [Q9NXC2]3EBI-948001,EBI-8799578
GLRX3 [O76003]3EBI-948001,EBI-374781
GNAI2 [P04899]3EBI-948001,EBI-353997
GNE [Q9Y223]3EBI-948001,EBI-4291090
GNE - isoform 2 [Q9Y223-2]3EBI-948001,EBI-11975289
GNG10 [P50151]3EBI-948001,EBI-10211741
GNG5 [P63218]3EBI-948001,EBI-10220734
GOLGA6L2 - isoform 2 [Q8N9W4-2]3EBI-948001,EBI-10268729
GPS2 [Q13227]7EBI-948001,EBI-713355
GSTP1 [P09211]6EBI-948001,EBI-353467
HAPLN2 [Q9GZV7]3EBI-948001,EBI-11956675
HAUS1 [Q96CS2]3EBI-948001,EBI-2514791
HBA2 [P69905]3EBI-948001,EBI-714680
HBZ [P02008]3EBI-948001,EBI-719843
HCK - isoform 2 [P08631-2]3EBI-948001,EBI-9834454
HDAC4 [P56524]3EBI-948001,EBI-308629
HDAC4 - isoform 2 [P56524-2]3EBI-948001,EBI-11953488
HGS [O14964]6EBI-948001,EBI-740220
HOXA1 [P49639]7EBI-948001,EBI-740785
HOXB5 [P09067]3EBI-948001,EBI-3893317
HS6ST1 [O60243]3EBI-948001,EBI-12294537
HSD3B7 [Q9H2F3]3EBI-948001,EBI-3918847
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-948001,EBI-12056251
HSPA12B [Q96MM6]6EBI-948001,EBI-10291310
HSPD1 [P10809]3EBI-948001,EBI-352528
HYAL2 [Q12891]3EBI-948001,EBI-2806068
ICAM4 - isoform 3 [Q14773-3]6EBI-948001,EBI-10233928
IL16 - isoform 2 [Q14005-2]3EBI-948001,EBI-17178971
INPP5D [Q92835]3EBI-948001,EBI-1380477
INPP5K [Q9BT40]6EBI-948001,EBI-749162
INSR [P06213]3EBI-948001,EBI-475899
ITGB2 [P05107]3EBI-948001,EBI-300173
ITGB4 - isoform Beta-4A [P16144-2]3EBI-948001,EBI-11051601
ITGB5 [P18084]3EBI-948001,EBI-1223434
JOSD1 [Q15040]3EBI-948001,EBI-2510602
KCTD9 [Q7L273]3EBI-948001,EBI-4397613
KDM1A [O60341]3EBI-948001,EBI-710124
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-948001,EBI-10188326
KIFC3 [Q9BVG8]3EBI-948001,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-948001,EBI-14069005
KLC1 [Q07866]3EBI-948001,EBI-721019
KLC4 [Q9NSK0]6EBI-948001,EBI-949319
KLHL38 [Q2WGJ6]6EBI-948001,EBI-6426443
KLK8 [O60259]3EBI-948001,EBI-3915857
KRT1 [P04264]3EBI-948001,EBI-298429
KRT2 [P35908]10EBI-948001,EBI-1247312
KRT20 [P35900]3EBI-948001,EBI-742094
KRT3 [P12035]3EBI-948001,EBI-2430095
KRT4 [P19013]3EBI-948001,EBI-2371606
KRT5 [P13647]6EBI-948001,EBI-702187
KRT6A [P02538]12EBI-948001,EBI-702198
KRT6B [P04259]6EBI-948001,EBI-740907
KRT6C [P48668]6EBI-948001,EBI-2564105
KRT71 [Q3SY84]6EBI-948001,EBI-2952676
KRT72 [Q14CN4]3EBI-948001,EBI-1221280
KRT73 - isoform 2 [Q86Y46-2]3EBI-948001,EBI-12039441
KRT74 [Q7RTS7]3EBI-948001,EBI-968660
KRT75 [O95678]3EBI-948001,EBI-2949715
KRT76 [Q01546]5EBI-948001,EBI-2952745
KRT77 [Q0IIN1]3EBI-948001,EBI-2511085
KRT77 [Q7Z794]3EBI-948001,EBI-3045529
KRT78 [Q8N1N4]3EBI-948001,EBI-1056564
KRT79 [Q5XKE5]6EBI-948001,EBI-2514135
KRT8 [P05787]6EBI-948001,EBI-297852
KRT80 - isoform 2 [Q6KB66-2]3EBI-948001,EBI-11999246
KRT81 [Q14533]8EBI-948001,EBI-739648
KRT82 [Q9NSB4]3EBI-948001,EBI-1045341
KRT83 [P78385]6EBI-948001,EBI-10221390
KRT85 [P78386]3EBI-948001,EBI-1049371
KRT86 [O43790]3EBI-948001,EBI-9996498
KRTAP4-12 [Q9BQ66]3EBI-948001,EBI-739863
KRTAP5-6 [Q6L8G9]3EBI-948001,EBI-10250562
KRTAP9-2 [Q9BYQ4]3EBI-948001,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-948001,EBI-1043191
LATS1 [Q6PJG3]3EBI-948001,EBI-10253976
LCE1B [Q5T7P3]3EBI-948001,EBI-10245913
LCE3C [Q5T5A8]3EBI-948001,EBI-10245291
LCE3D [Q9BYE3]3EBI-948001,EBI-6658837
LCE3E [Q5T5B0]3EBI-948001,EBI-10245456
LCE4A [Q5TA78]3EBI-948001,EBI-10246358
LENG1 [Q96BZ8]6EBI-948001,EBI-726510
LIF [P15018]3EBI-948001,EBI-1037189
LIN37 [Q96GY3]3EBI-948001,EBI-748884
LINC00526 [Q96FQ7]3EBI-948001,EBI-10286106
LMF2 [Q9BU23]3EBI-948001,EBI-10298556
LMNTD2 [Q8IXW0]3EBI-948001,EBI-12028858
LMO3 - isoform 4 [Q8TAP4-4]3EBI-948001,EBI-11742507
LMO4 [P61968]6EBI-948001,EBI-2798728
LONRF1 [Q17RB8]6EBI-948001,EBI-2341787
LRRC41 [Q15345]3EBI-948001,EBI-721408
MAB21L2 [Q9Y586]3EBI-948001,EBI-6659161
MAP3K7CL - isoform 1 [P57077-4]3EBI-948001,EBI-10215880
MAPKBP1 [O60336]6EBI-948001,EBI-947402
MARK4 [Q6IPE9]3EBI-948001,EBI-10250211
MARK4 [Q96L34]3EBI-948001,EBI-302319
MGC13033 [Q4ZG74]3EBI-948001,EBI-10241963
MGC50722 [Q8IVT4]3EBI-948001,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-948001,EBI-10172526
MOS [P00540]3EBI-948001,EBI-1757866
MRPL40 [Q9NQ50]3EBI-948001,EBI-1053902
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-948001,EBI-10699187
MTA1 [Q13330]3EBI-948001,EBI-714236
MXD3 [Q9BW11]3EBI-948001,EBI-741574
MXI1 - isoform 3 [P50539-3]3EBI-948001,EBI-10211940
MYOM1 - isoform 2 [P52179-2]3EBI-948001,EBI-12010196
NAV1 - isoform 3 [Q8NEY1-3]3EBI-948001,EBI-11953718
NAV1 - isoform 4 [Q8NEY1-4]3EBI-948001,EBI-10270828
NAXD [Q8IW45]3EBI-948001,EBI-8650724
NEK6 [Q9HC98]3EBI-948001,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-948001,EBI-11750983
NODAL [Q96S42]3EBI-948001,EBI-12386190
NPBWR2 [P48146]6EBI-948001,EBI-10210114
NTAQ1 [Q96HA8]3EBI-948001,EBI-741158
NUDT16L1 [Q9BRJ7]3EBI-948001,EBI-2949792
NUFIP2 [Q7Z417]3EBI-948001,EBI-1210753
OTUB2 [Q9BWI9]3EBI-948001,EBI-10300896
OTX1 [P32242]3EBI-948001,EBI-740446
P2RX7 [Q99572]6EBI-948001,EBI-1753251
P3H3 - isoform 2 [Q8IVL6-2]3EBI-948001,EBI-12149899
PBX3 [Q96AL5]3EBI-948001,EBI-741171
PDGFRB [P09619]3EBI-948001,EBI-641237
PGAP6 [Q9HCN3]3EBI-948001,EBI-10310808
PHC2 [B7ZLY0]3EBI-948001,EBI-14568740
PHLDA1 [A2BDE7]3EBI-948001,EBI-14084211
PIN1 [Q13526]6EBI-948001,EBI-714158
PKN1 [Q16512]6EBI-948001,EBI-602382
PKN3 [Q6P5Z2]3EBI-948001,EBI-1384335
PKP2 - isoform 1 [Q99959-2]3EBI-948001,EBI-10987518
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-948001,EBI-12014286
POLDIP3 [Q8WUT1]3EBI-948001,EBI-10276663
POU4F2 [Q12837]3EBI-948001,EBI-17236143
POU4F3 [Q15319]3EBI-948001,EBI-12033574
PPP1R18 [Q6NYC8]6EBI-948001,EBI-2557469
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-948001,EBI-12000762
PRF1 [P14222]6EBI-948001,EBI-724466
PRKAA2 [P54646]3EBI-948001,EBI-1383852
PRKAB2 [O43741]3EBI-948001,EBI-1053424
PRPF18 [Q99633]3EBI-948001,EBI-2798416
PRPF31 [Q8WWY3]3EBI-948001,EBI-1567797
PRPH [P41219]3EBI-948001,EBI-752074
PRR19 [A6NJB7]3EBI-948001,EBI-10174045
PRR19 - isoform 2 [A6NJB7-2]3EBI-948001,EBI-11998870
PRR35 [P0CG20]3EBI-948001,EBI-11986293
PSMA1 [P25786]3EBI-948001,EBI-359352
PSMB1 [P20618]3EBI-948001,EBI-372273
PSMC5 [P62195]3EBI-948001,EBI-357745
PSMG2 [Q969U7]6EBI-948001,EBI-723276
PSPC1 [Q8WXF1]3EBI-948001,EBI-1392258
PTGER3 - isoform 12 [P43115-12]3EBI-948001,EBI-10234038
PTPMT1 [Q8WUK0]6EBI-948001,EBI-7199479
R3HDM2 [Q9Y2K5]3EBI-948001,EBI-948428
RAB33A [Q14088]3EBI-948001,EBI-744685
RADIL [Q96JH8]6EBI-948001,EBI-744267
RAMAC [Q9BTL3]6EBI-948001,EBI-744023
RCOR3 [Q9P2K3]3EBI-948001,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-948001,EBI-1504830
RHPN1 [Q8TCX5]3EBI-948001,EBI-746325
RIBC1 [Q8N443]6EBI-948001,EBI-10265323
RPS19BP1 [Q86WX3]3EBI-948001,EBI-4479407
RPUSD3 [Q6P087]3EBI-948001,EBI-5458784
RSPH14 [Q9UHP6]6EBI-948001,EBI-748350
RTP5 [Q14D33]3EBI-948001,EBI-10217913
SAMD11 [Q96NU1]3EBI-948001,EBI-14067109
SCNM1 [Q9BWG6]6EBI-948001,EBI-748391
SEC14L4 [Q9UDX3]3EBI-948001,EBI-10320311
SEMA4C [Q9C0C4]6EBI-948001,EBI-10303490
SFRS2 [Q6NXQ0]3EBI-948001,EBI-10251550
SHC3 [Q92529]6EBI-948001,EBI-79084
SHFL - isoform 4 [Q9NUL5-4]3EBI-948001,EBI-11955083
SHISA6 [Q6ZSJ9]3EBI-948001,EBI-12037847
SLC15A3 [Q05CH4]3EBI-948001,EBI-10223741
SLC23A1 [Q9UHI7]3EBI-948001,EBI-1759386
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-948001,EBI-11998660
SLC25A42 [Q86VD7]3EBI-948001,EBI-6598313
SLC25A6 [P12236]3EBI-948001,EBI-356254
SMARCD1 [Q96GM5]3EBI-948001,EBI-358489
SMARCE1 [Q969G3]6EBI-948001,EBI-455078
SMCP [P49901]6EBI-948001,EBI-750494
SMG9 [Q9H0W8]6EBI-948001,EBI-2872322
SNAI1 [O95863]4EBI-948001,EBI-1045459
SNRNP25 [Q9BV90]3EBI-948001,EBI-9675976
SPATA24 [Q86W54]3EBI-948001,EBI-3916986
SPG21 [Q9NZD8]3EBI-948001,EBI-742688
SPON2 [Q9BUD6]6EBI-948001,EBI-10298801
SPRY1 [O43609]3EBI-948001,EBI-3866665
SSX2IP [Q9Y2D8]3EBI-948001,EBI-2212028
STK16 [O75716]3EBI-948001,EBI-749295
TACO1 [Q9BSH4]3EBI-948001,EBI-747797
TAPBPL [Q9BX59]3EBI-948001,EBI-12017416
TCEANC - isoform 2 [Q8N8B7-2]3EBI-948001,EBI-11955057
TEAD4 [Q15561]3EBI-948001,EBI-747736
TEPSIN [Q96N21]3EBI-948001,EBI-11139477
TEX28P2 [O15482]3EBI-948001,EBI-751954
TEX33 - isoform 2 [O43247-2]3EBI-948001,EBI-12093053
TFAP2D [Q7Z6R9]3EBI-948001,EBI-11952651
THAP7 [Q9BT49]6EBI-948001,EBI-741350
TLE5 [Q08117]3EBI-948001,EBI-717810
TMEM106C [Q9BVX2]6EBI-948001,EBI-2821497
TMEM174 [Q8WUU8]3EBI-948001,EBI-10276729
TMEM231 [Q9H6L2]3EBI-948001,EBI-10307654
TMSB4X [P62328]3EBI-948001,EBI-712598
TMSB4X [Q0P5Q0]3EBI-948001,EBI-10226570
TRAF4 [Q9BUZ4]6EBI-948001,EBI-3650647
TRIML2 [Q8N7C3]3EBI-948001,EBI-11059915
TROAP [Q12815]3EBI-948001,EBI-2349743
TSEN54 [Q7Z6J9]3EBI-948001,EBI-2559824
TSG101 [Q99816]6EBI-948001,EBI-346882
TSHZ3 [Q63HK5]3EBI-948001,EBI-9053916
TSNAX [Q99598]3EBI-948001,EBI-742638
TTC23 [Q5W5X9]3EBI-948001,EBI-6447954
TTC23 - isoform 3 [Q5W5X9-3]3EBI-948001,EBI-9090990
TTC9C [Q8N5M4]3EBI-948001,EBI-2851213
TXLNA [P40222]6EBI-948001,EBI-359793
TYK2 [P29597]3EBI-948001,EBI-1383454
UACA [Q9BZF9]3EBI-948001,EBI-350510
UBASH3A - isoform 2 [P57075-2]3EBI-948001,EBI-7353612
USHBP1 [Q8N6Y0]3EBI-948001,EBI-739895
USP2 [O75604]3EBI-948001,EBI-743272
UTP23 [Q9BRU9]3EBI-948001,EBI-5457544
UXT [Q9UBK9]6EBI-948001,EBI-357355
VASN [Q6EMK4]3EBI-948001,EBI-10249550
VPS9D1 [Q9Y2B5]3EBI-948001,EBI-9031083
WDR25 [Q64LD2]3EBI-948001,EBI-744560
WDR25 - isoform 2 [Q64LD2-2]3EBI-948001,EBI-12032042
WFDC6 - isoform 2 [Q9BQY6-2]3EBI-948001,EBI-12176563
ZDHHC1 [Q8WTX9]3EBI-948001,EBI-2818796
ZFHX3 - isoform B [Q15911-2]3EBI-948001,EBI-10237226
ZFYVE21 [Q9BQ24]3EBI-948001,EBI-2849569
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-948001,EBI-10183064
ZIC1 [Q15915]3EBI-948001,EBI-11963196
ZNF124 [Q15973]3EBI-948001,EBI-2555767
ZNF148 [Q9UQR1]3EBI-948001,EBI-2688184
ZNF20 [P17024]3EBI-948001,EBI-717634
ZNF250 - isoform 3 [P15622-3]3EBI-948001,EBI-10177272
ZNF414 [Q96IQ9]3EBI-948001,EBI-744257
ZNF417 [Q8TAU3]3EBI-948001,EBI-740727
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-948001,EBI-740232
ZNF564 [Q8TBZ8]3EBI-948001,EBI-10273713
ZNF569 [Q5MCW4]6EBI-948001,EBI-4395687
ZNF572 [Q7Z3I7]3EBI-948001,EBI-10172590
ZNF587 [Q96SQ5]3EBI-948001,EBI-6427977
ZNF688 [A0A0S2Z5X4]3EBI-948001,EBI-16429014
ZNF688 [A0A0S2Z6P0]3EBI-948001,EBI-16429989
ZNF69 [Q9UC07]3EBI-948001,EBI-10320266
ZNF69 - isoform 2 [Q9UC07-2]3EBI-948001,EBI-12310821
ZNF835 [Q9Y2P0]3EBI-948001,EBI-5667516
Q53FW83EBI-948001,EBI-10242473
Q8N9J23EBI-948001,EBI-10268244

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110079, 379 interactors

Protein interaction database and analysis system

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IntActi
Q15323, 364 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15323, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15323

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 416TailAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502SNBF, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000163841

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15323

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
SNACGKP

Database of Orthologous Groups

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OrthoDBi
772040at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15323

TreeFam database of animal gene trees

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TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

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PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q15323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCT KSENARLVVQ IDNAKLAADD FRTKYQTELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KSNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR REVEQWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT
410
PCAPRPRCGP CNSFVR
Length:416
Mass (Da):47,237
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC284DD33A4896009
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153 – 154QL → HV in CAA60378 (PubMed:7578244).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04698939A → G. Corresponds to variant dbSNP:rs6503628Ensembl.1
Natural variantiVAR_04699082A → V. Corresponds to variant dbSNP:rs6503627Ensembl.1
Natural variantiVAR_046991377A → V. Corresponds to variant dbSNP:rs34293483Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X86570 mRNA Translation: CAA60378.1
Y16787 Genomic DNA Translation: CAA76383.1
CH471152 Genomic DNA Translation: EAW60730.1
BC114468 mRNA Translation: AAI14469.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11391.1

Protein sequence database of the Protein Information Resource

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PIRi
S60034

NCBI Reference Sequences

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RefSeqi
NP_002268.2, NM_002277.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251645; ENSP00000251645; ENSG00000094796
ENST00000573281; ENSP00000460739; ENSG00000262993

Database of genes from NCBI RefSeq genomes

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GeneIDi
3881

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3881

UCSC genome browser

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UCSCi
uc002hwn.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86570 mRNA Translation: CAA60378.1
Y16787 Genomic DNA Translation: CAA76383.1
CH471152 Genomic DNA Translation: EAW60730.1
BC114468 mRNA Translation: AAI14469.1
CCDSiCCDS11391.1
PIRiS60034
RefSeqiNP_002268.2, NM_002277.2

3D structure databases

SMRiQ15323
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110079, 379 interactors
IntActiQ15323, 364 interactors
STRINGi9606.ENSP00000251645

PTM databases

iPTMnetiQ15323
PhosphoSitePlusiQ15323
SwissPalmiQ15323

Polymorphism and mutation databases

BioMutaiKRT31
DMDMi209572740

Proteomic databases

jPOSTiQ15323
MassIVEiQ15323
PaxDbiQ15323
PeptideAtlasiQ15323
PRIDEiQ15323
ProteomicsDBi12646
60528

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55450, 188 antibodies

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796
ENST00000573281; ENSP00000460739; ENSG00000262993
GeneIDi3881
KEGGihsa:3881
UCSCiuc002hwn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3881
DisGeNETi3881
EuPathDBiHostDB:ENSG00000094796.4

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT31
HGNCiHGNC:6448, KRT31
HPAiENSG00000094796, Group enriched (brain, skin)
MIMi601077, gene
neXtProtiNX_Q15323
OpenTargetsiENSG00000094796
PharmGKBiPA30237

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SNBF, Eukaryota
GeneTreeiENSGT00940000163841
HOGENOMiCLU_012560_8_0_1
InParanoidiQ15323
KOiK07604
OMAiSNACGKP
OrthoDBi772040at2759
PhylomeDBiQ15323
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiQ15323
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3881, 18 hits in 871 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KRT31

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3881
PharosiQ15323, Tbio

Protein Ontology

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PROi
PR:Q15323
RNActiQ15323, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000094796, Expressed in hair follicle and 134 other tissues
GenevisibleiQ15323, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1H1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15323
Secondary accession number(s): Q9UE12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: October 7, 2020
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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