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Entry version 183 (07 Oct 2020)
Sequence version 3 (23 Jan 2007)
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Protein

RalA-binding protein 1

Gene

RALBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q15311

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-194840, Rho GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q15311

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15311

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.1.1.1, the non abc multidrug exporter (n-mde) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RalA-binding protein 1
Short name:
RalBP1
Alternative name(s):
76 kDa Ral-interacting protein
Dinitrophenyl S-glutathione ATPase
Short name:
DNP-SG ATPase
Ral-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RALBP1
Synonyms:RLIP1, RLIP76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000017797.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9841, RALBP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605801, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15311

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10928

Open Targets

More...
OpenTargetsi
ENSG00000017797

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34199

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15311, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00564, Carbamazepine
DB00997, Doxorubicin
DB00398, Sorafenib
DB00541, Vincristine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RALBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34098413

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567332 – 655RalA-binding protein 1Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei44PhosphothreonineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1747
CPTAC-1748

Encyclopedia of Proteome Dynamics

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EPDi
Q15311

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15311

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15311

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15311

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15311

PeptideAtlas

More...
PeptideAtlasi
Q15311

PRoteomics IDEntifications database

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PRIDEi
Q15311

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60526

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15311

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15311

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000017797, Expressed in mouth mucosa and 256 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15311, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15311, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000017797, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1.

Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity.

Interacts with DAB2IP.

Interacts with catalytically active CCNB1 and CDK1 during mitosis.

Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q15311
With#Exp.IntAct
AMOTL2 [Q9Y2J4]3EBI-749285,EBI-746752
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-749285,EBI-10187270
C1orf216 [Q8TAB5]6EBI-749285,EBI-747505
CBY1 [Q9Y3M2]4EBI-749285,EBI-947308
CCDC13 [Q8IYE1]3EBI-749285,EBI-10961312
CCDC6 [Q16204]7EBI-749285,EBI-1045350
CCDC88B [A6NC98]3EBI-749285,EBI-347573
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-749285,EBI-10175300
CCL20 [P78556]2EBI-749285,EBI-3913209
CEP57 [Q86XR8]4EBI-749285,EBI-308614
CREBZF [Q9NS37]4EBI-749285,EBI-632965
DLG1 [Q12959]5EBI-749285,EBI-357481
GAS8 [O95995]3EBI-749285,EBI-1052570
GPS2 [Q13227]11EBI-749285,EBI-713355
GSE1 [Q14687]4EBI-749285,EBI-372619
HOOK2 [Q96ED9]3EBI-749285,EBI-743290
HOOK2 - isoform 2 [Q96ED9-2]3EBI-749285,EBI-10961706
KANK2 [Q63ZY3]3EBI-749285,EBI-2556193
LDOC1 [O95751]3EBI-749285,EBI-740738
MSANTD4 [Q8NCY6]4EBI-749285,EBI-7850168
PCM1 - isoform 3 [Q15154-3]3EBI-749285,EBI-11742977
PPL [O60437]5EBI-749285,EBI-368321
PPP1R13B [Q96KQ4]3EBI-749285,EBI-1105153
RALA [P11233]6EBI-749285,EBI-1036803
REPS1 [Q96D71]4EBI-749285,EBI-1171195
SAPCD2 [Q86UD0]6EBI-749285,EBI-2561646
SCRIB [Q14160]2EBI-749285,EBI-357345
SMARCE1 [Q969G3]6EBI-749285,EBI-455078
SYCE1 [Q8N0S2]3EBI-749285,EBI-6872807
TAX1BP1 [Q86VP1]3EBI-749285,EBI-529518
TBRG1 [Q05BL0]3EBI-749285,EBI-10223693
TCP10L [Q8TDR4]3EBI-749285,EBI-3923210
TFPT - isoform 2 [P0C1Z6-2]5EBI-749285,EBI-10178002
TNIP1 [Q15025]4EBI-749285,EBI-357849
TP53BP2 [Q05BL1]3EBI-749285,EBI-11952721
TSFM [P43897]4EBI-749285,EBI-1049298
VHL - isoform 3 [P40337-3]3EBI-749285,EBI-301270
ZNF707 [Q96C28]6EBI-749285,EBI-748111
Q9H6F03EBI-749285,EBI-10307481

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116131, 104 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15311

Protein interaction database and analysis system

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IntActi
Q15311, 129 interactors

Molecular INTeraction database

More...
MINTi
Q15311

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000019317

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15311, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q15311

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15311

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15311

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini192 – 380Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni403 – 499Interaction with RalAAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi164 – 171Poly-Lys8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4370, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154639

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028068_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15311

KEGG Orthology (KO)

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KOi
K08773

Identification of Orthologs from Complete Genome Data

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OMAi
LMHYKRL

Database of Orthologous Groups

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OrthoDBi
514124at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15311

TreeFam database of animal gene trees

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TreeFami
TF315411

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039767, RALBP1
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

The PANTHER Classification System

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PANTHERi
PTHR12783, PTHR12783, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTECFLPPTS SPSEHRRVEH GSGLTRTPSS EEISPTKFPG LYRTGEPSPP
60 70 80 90 100
HDILHEPPDV VSDDEKDHGK KKGKFKKKEK RTEGYAAFQE DSSGDEAESP
110 120 130 140 150
SKMKRSKGIH VFKKPSFSKK KEKDFKIKEK PKEEKHKEEK HKEEKHKEKK
160 170 180 190 200
SKDLTAADVV KQWKEKKKKK KPIQEPEVPQ IDVPNLKPIF GIPLADAVER
210 220 230 240 250
TMMYDGIRLP AVFRECIDYV EKYGMKCEGI YRVSGIKSKV DELKAAYDRE
260 270 280 290 300
ESTNLEDYEP NTVASLLKQY LRDLPENLLT KELMPRFEEA CGRTTETEKV
310 320 330 340 350
QEFQRLLKEL PECNYLLISW LIVHMDHVIA KELETKMNIQ NISIVLSPTV
360 370 380 390 400
QISNRVLYVF FTHVQELFGN VVLKQVMKPL RWSNMATMPT LPETQAGIKE
410 420 430 440 450
EIRRQEFLLN CLHRDLQGGI KDLSKEERLW EVQRILTALK RKLREAKRQE
460 470 480 490 500
CETKIAQEIA SLSKEDVSKE EMNENEEVIN ILLAQENEIL TEQEELLAME
510 520 530 540 550
QFLRRQIASE KEEIERLRAE IAEIQSRQQH GRSETEEYSS ESESESEDEE
560 570 580 590 600
ELQIILEDLQ RQNEELEIKN NHLNQAIHEE REAIIELRVQ LRLLQMQRAK
610 620 630 640 650
AEQQAQEDEE PEWRGGAVQP PRDGVLEPKA AKEQPKAGKE PAKPSPSRDR

KETSI
Length:655
Mass (Da):76,063
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC6F75329FD8D062
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENF8E7ENF8_HUMAN
RalA-binding protein 1
RALBP1
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLT3J3QLT3_HUMAN
RalA-binding protein 1
RALBP1
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRI7A0A1W2PRI7_HUMAN
RalA-binding protein 1
RALBP1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049147617A → V. Corresponds to variant dbSNP:rs35867116Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L42542 mRNA Translation: AAB00103.1
CH471113 Genomic DNA Translation: EAX01601.1
CH471113 Genomic DNA Translation: EAX01602.1
CH471113 Genomic DNA Translation: EAX01604.1
CH471113 Genomic DNA Translation: EAX01605.1
BC013126 mRNA Translation: AAH13126.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11845.1

Protein sequence database of the Protein Information Resource

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PIRi
F59435

NCBI Reference Sequences

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RefSeqi
NP_006779.1, NM_006788.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000019317; ENSP00000019317; ENSG00000017797
ENST00000383432; ENSP00000372924; ENSG00000017797

Database of genes from NCBI RefSeq genomes

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GeneIDi
10928

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10928

UCSC genome browser

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UCSCi
uc002kob.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42542 mRNA Translation: AAB00103.1
CH471113 Genomic DNA Translation: EAX01601.1
CH471113 Genomic DNA Translation: EAX01602.1
CH471113 Genomic DNA Translation: EAX01604.1
CH471113 Genomic DNA Translation: EAX01605.1
BC013126 mRNA Translation: AAH13126.1
CCDSiCCDS11845.1
PIRiF59435
RefSeqiNP_006779.1, NM_006788.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KWHNMR-A393-446[»]
2KWINMR-B393-446[»]
2MBGNMR-A184-446[»]
BMRBiQ15311
SMRiQ15311
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116131, 104 interactors
CORUMiQ15311
IntActiQ15311, 129 interactors
MINTiQ15311
STRINGi9606.ENSP00000019317

Chemistry databases

DrugBankiDB00564, Carbamazepine
DB00997, Doxorubicin
DB00398, Sorafenib
DB00541, Vincristine

Protein family/group databases

TCDBi9.A.1.1.1, the non abc multidrug exporter (n-mde) family

PTM databases

iPTMnetiQ15311
PhosphoSitePlusiQ15311

Polymorphism and mutation databases

BioMutaiRALBP1
DMDMi34098413

Proteomic databases

CPTACiCPTAC-1747
CPTAC-1748
EPDiQ15311
jPOSTiQ15311
MassIVEiQ15311
MaxQBiQ15311
PaxDbiQ15311
PeptideAtlasiQ15311
PRIDEiQ15311
ProteomicsDBi60526

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
21929, 475 antibodies

The DNASU plasmid repository

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DNASUi
10928

Genome annotation databases

EnsembliENST00000019317; ENSP00000019317; ENSG00000017797
ENST00000383432; ENSP00000372924; ENSG00000017797
GeneIDi10928
KEGGihsa:10928
UCSCiuc002kob.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10928
DisGeNETi10928
EuPathDBiHostDB:ENSG00000017797.11

GeneCards: human genes, protein and diseases

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GeneCardsi
RALBP1
HGNCiHGNC:9841, RALBP1
HPAiENSG00000017797, Low tissue specificity
MIMi605801, gene
neXtProtiNX_Q15311
OpenTargetsiENSG00000017797
PharmGKBiPA34199

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4370, Eukaryota
GeneTreeiENSGT00940000154639
HOGENOMiCLU_028068_1_0_1
InParanoidiQ15311
KOiK08773
OMAiLMHYKRL
OrthoDBi514124at2759
PhylomeDBiQ15311
TreeFamiTF315411

Enzyme and pathway databases

PathwayCommonsiQ15311
ReactomeiR-HSA-194840, Rho GTPase cycle
SignaLinkiQ15311
SIGNORiQ15311

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10928, 65 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RALBP1, human
EvolutionaryTraceiQ15311

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RALBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10928
PharosiQ15311, Tbio

Protein Ontology

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PROi
PR:Q15311
RNActiQ15311, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000017797, Expressed in mouth mucosa and 256 other tissues
ExpressionAtlasiQ15311, baseline and differential
GenevisibleiQ15311, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR039767, RALBP1
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PANTHERiPTHR12783, PTHR12783, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15311
Secondary accession number(s): D3DUI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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