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Protein

RalA-binding protein 1

Gene

RALBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SignaLinkiQ15311

Protein family/group databases

TCDBi9.A.1.1.1 the non abc multidrug exporter (n-mde) family

Names & Taxonomyi

Protein namesi
Recommended name:
RalA-binding protein 1
Short name:
RalBP1
Alternative name(s):
76 kDa Ral-interacting protein
Dinitrophenyl S-glutathione ATPase
Short name:
DNP-SG ATPase
Ral-interacting protein 1
Gene namesi
Name:RALBP1
Synonyms:RLIP1, RLIP76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000017797.11
HGNCiHGNC:9841 RALBP1
MIMi605801 gene
neXtProtiNX_Q15311

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10928
OpenTargetsiENSG00000017797
PharmGKBiPA34199

Chemistry databases

DrugBankiDB00564 Carbamazepine
DB00997 Doxorubicin
DB00398 Sorafenib
DB00541 Vincristine

Polymorphism and mutation databases

BioMutaiRALBP1
DMDMi34098413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000567332 – 655RalA-binding protein 1Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei44PhosphothreonineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15311
MaxQBiQ15311
PaxDbiQ15311
PeptideAtlasiQ15311
PRIDEiQ15311
ProteomicsDBi60526

PTM databases

iPTMnetiQ15311
PhosphoSitePlusiQ15311

Expressioni

Tissue specificityi

Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.1 Publication

Gene expression databases

BgeeiENSG00000017797 Expressed in 246 organ(s), highest expression level in mouth mucosa
CleanExiHS_RALBP1
ExpressionAtlasiQ15311 baseline and differential
GenevisibleiQ15311 HS

Organism-specific databases

HPAiCAB046010
HPA046651

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116131, 88 interactors
CORUMiQ15311
IntActiQ15311, 53 interactors
MINTiQ15311
STRINGi9606.ENSP00000019317

Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ15311
SMRiQ15311
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15311

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 380Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni403 – 499Interaction with RalAAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 171Poly-Lys8

Phylogenomic databases

eggNOGiKOG4370 Eukaryota
ENOG410XRJ9 LUCA
GeneTreeiENSGT00920000148941
HOGENOMiHOG000007929
HOVERGENiHBG044496
InParanoidiQ15311
KOiK08773
OMAiLMHYKRL
OrthoDBiEOG091G01CT
PhylomeDBiQ15311
TreeFamiTF315411

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q15311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTECFLPPTS SPSEHRRVEH GSGLTRTPSS EEISPTKFPG LYRTGEPSPP
60 70 80 90 100
HDILHEPPDV VSDDEKDHGK KKGKFKKKEK RTEGYAAFQE DSSGDEAESP
110 120 130 140 150
SKMKRSKGIH VFKKPSFSKK KEKDFKIKEK PKEEKHKEEK HKEEKHKEKK
160 170 180 190 200
SKDLTAADVV KQWKEKKKKK KPIQEPEVPQ IDVPNLKPIF GIPLADAVER
210 220 230 240 250
TMMYDGIRLP AVFRECIDYV EKYGMKCEGI YRVSGIKSKV DELKAAYDRE
260 270 280 290 300
ESTNLEDYEP NTVASLLKQY LRDLPENLLT KELMPRFEEA CGRTTETEKV
310 320 330 340 350
QEFQRLLKEL PECNYLLISW LIVHMDHVIA KELETKMNIQ NISIVLSPTV
360 370 380 390 400
QISNRVLYVF FTHVQELFGN VVLKQVMKPL RWSNMATMPT LPETQAGIKE
410 420 430 440 450
EIRRQEFLLN CLHRDLQGGI KDLSKEERLW EVQRILTALK RKLREAKRQE
460 470 480 490 500
CETKIAQEIA SLSKEDVSKE EMNENEEVIN ILLAQENEIL TEQEELLAME
510 520 530 540 550
QFLRRQIASE KEEIERLRAE IAEIQSRQQH GRSETEEYSS ESESESEDEE
560 570 580 590 600
ELQIILEDLQ RQNEELEIKN NHLNQAIHEE REAIIELRVQ LRLLQMQRAK
610 620 630 640 650
AEQQAQEDEE PEWRGGAVQP PRDGVLEPKA AKEQPKAGKE PAKPSPSRDR

KETSI
Length:655
Mass (Da):76,063
Last modified:January 23, 2007 - v3
Checksum:iEC6F75329FD8D062
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PRI7A0A1W2PRI7_HUMAN
RalA-binding protein 1
RALBP1
242Annotation score:
E7ENF8E7ENF8_HUMAN
RalA-binding protein 1
RALBP1
207Annotation score:
J3QLT3J3QLT3_HUMAN
RalA-binding protein 1
RALBP1
186Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049147617A → V. Corresponds to variant dbSNP:rs35867116Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42542 mRNA Translation: AAB00103.1
CH471113 Genomic DNA Translation: EAX01601.1
CH471113 Genomic DNA Translation: EAX01602.1
CH471113 Genomic DNA Translation: EAX01604.1
CH471113 Genomic DNA Translation: EAX01605.1
BC013126 mRNA Translation: AAH13126.1
CCDSiCCDS11845.1
PIRiF59435
RefSeqiNP_006779.1, NM_006788.3
UniGeneiHs.528993

Genome annotation databases

EnsembliENST00000019317; ENSP00000019317; ENSG00000017797
ENST00000383432; ENSP00000372924; ENSG00000017797
GeneIDi10928
KEGGihsa:10928
UCSCiuc002kob.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42542 mRNA Translation: AAB00103.1
CH471113 Genomic DNA Translation: EAX01601.1
CH471113 Genomic DNA Translation: EAX01602.1
CH471113 Genomic DNA Translation: EAX01604.1
CH471113 Genomic DNA Translation: EAX01605.1
BC013126 mRNA Translation: AAH13126.1
CCDSiCCDS11845.1
PIRiF59435
RefSeqiNP_006779.1, NM_006788.3
UniGeneiHs.528993

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KWHNMR-A393-446[»]
2KWINMR-B393-446[»]
2MBGNMR-A184-446[»]
ProteinModelPortaliQ15311
SMRiQ15311
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116131, 88 interactors
CORUMiQ15311
IntActiQ15311, 53 interactors
MINTiQ15311
STRINGi9606.ENSP00000019317

Chemistry databases

DrugBankiDB00564 Carbamazepine
DB00997 Doxorubicin
DB00398 Sorafenib
DB00541 Vincristine

Protein family/group databases

TCDBi9.A.1.1.1 the non abc multidrug exporter (n-mde) family

PTM databases

iPTMnetiQ15311
PhosphoSitePlusiQ15311

Polymorphism and mutation databases

BioMutaiRALBP1
DMDMi34098413

Proteomic databases

EPDiQ15311
MaxQBiQ15311
PaxDbiQ15311
PeptideAtlasiQ15311
PRIDEiQ15311
ProteomicsDBi60526

Protocols and materials databases

DNASUi10928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000019317; ENSP00000019317; ENSG00000017797
ENST00000383432; ENSP00000372924; ENSG00000017797
GeneIDi10928
KEGGihsa:10928
UCSCiuc002kob.4 human

Organism-specific databases

CTDi10928
DisGeNETi10928
EuPathDBiHostDB:ENSG00000017797.11
GeneCardsiRALBP1
HGNCiHGNC:9841 RALBP1
HPAiCAB046010
HPA046651
MIMi605801 gene
neXtProtiNX_Q15311
OpenTargetsiENSG00000017797
PharmGKBiPA34199
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4370 Eukaryota
ENOG410XRJ9 LUCA
GeneTreeiENSGT00920000148941
HOGENOMiHOG000007929
HOVERGENiHBG044496
InParanoidiQ15311
KOiK08773
OMAiLMHYKRL
OrthoDBiEOG091G01CT
PhylomeDBiQ15311
TreeFamiTF315411

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SignaLinkiQ15311

Miscellaneous databases

ChiTaRSiRALBP1 human
EvolutionaryTraceiQ15311
GeneWikiiRALBP1
GenomeRNAii10928
PROiPR:Q15311
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000017797 Expressed in 246 organ(s), highest expression level in mouth mucosa
CleanExiHS_RALBP1
ExpressionAtlasiQ15311 baseline and differential
GenevisibleiQ15311 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBP1_HUMAN
AccessioniPrimary (citable) accession number: Q15311
Secondary accession number(s): D3DUI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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