UniProtKB - Q15283 (RASA2_HUMAN)
Protein
Ras GTPase-activating protein 2
Gene
RASA2
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 708 – 744 | Btk-typePROSITE-ProRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- GTPase activator activity Source: ProtInc
- metal ion binding Source: UniProtKB-KW
- phospholipid binding Source: InterPro
GO - Biological processi
- MAPK cascade Source: Reactome
- negative regulation of Ras protein signal transduction Source: InterPro
- signal transduction Source: ProtInc
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15283 |
Reactomei | R-HSA-5658442, Regulation of RAS by GAPs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras GTPase-activating protein 2Alternative name(s): GTPase-activating protein 1m Short name: GAP1m |
Gene namesi | Name:RASA2 Synonyms:GAP1M, RASGAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155903.11 |
HGNCi | HGNC:9872, RASA2 |
MIMi | 601589, gene |
neXtProti | NX_Q15283 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: Reactome
Other locations
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 5922 |
MalaCardsi | RASA2 |
OpenTargetsi | ENSG00000155903 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA34233 |
Miscellaneous databases
Pharosi | Q15283, Tdark |
Polymorphism and mutation databases
BioMutai | RASA2 |
DMDMi | 519668674 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000056638 | 2 – 850 | Ras GTPase-activating protein 2Add BLAST | 849 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q15283 |
MassIVEi | Q15283 |
MaxQBi | Q15283 |
PaxDbi | Q15283 |
PeptideAtlasi | Q15283 |
PRIDEi | Q15283 |
ProteomicsDBi | 32185 60511 [Q15283-1] |
PTM databases
iPTMneti | Q15283 |
PhosphoSitePlusi | Q15283 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155903, Expressed in blood and 223 other tissues |
ExpressionAtlasi | Q15283, baseline and differential |
Genevisiblei | Q15283, HS |
Organism-specific databases
HPAi | ENSG00000155903, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111857, 5 interactors |
STRINGi | 9606.ENSP00000286364 |
Miscellaneous databases
RNActi | Q15283, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 138 | C2 1PROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 149 – 289 | C2 2PROSITE-ProRule annotationAdd BLAST | 141 | |
Domaini | 356 – 550 | Ras-GAPPROSITE-ProRule annotationAdd BLAST | 195 | |
Domaini | 604 – 706 | PHPROSITE-ProRule annotationAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 26 | Ala-richAdd BLAST | 25 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 708 – 744 | Btk-typePROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2059, Eukaryota |
GeneTreei | ENSGT00940000158201 |
HOGENOMi | CLU_008096_1_1_1 |
InParanoidi | Q15283 |
OrthoDBi | 145372at2759 |
PhylomeDBi | Q15283 |
TreeFami | TF105302 |
Family and domain databases
CDDi | cd13370, PH_GAP1m_mammal-like, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039360, Ras_GTPase IPR037773, RASA2_PH IPR023152, RasGAP_CS IPR001936, RasGAP_dom IPR008936, Rho_GTPase_activation_prot IPR001562, Znf_Btk_motif |
PANTHERi | PTHR10194, PTHR10194, 1 hit |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00168, C2, 2 hits PF00169, PH, 1 hit PF00616, RasGAP, 2 hits |
PRINTSi | PR00402, TECBTKDOMAIN |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00239, C2, 2 hits SM00233, PH, 1 hit SM00323, RasGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50003, PH_DOMAIN, 1 hit PS00509, RAS_GTPASE_ACTIV_1, 1 hit PS50018, RAS_GTPASE_ACTIV_2, 1 hit PS51113, ZF_BTK, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q15283-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL
60 70 80 90 100
LPYLGPHKMR DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ
110 120 130 140 150
YLSFYVYDKN VLQRDLRIGK VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ
160 170 180 190 200
GKVHLELKLN ELITENGTVC QQLVVHIKAC HGLPLINGQS CDPYATVSLV
210 220 230 240 250
GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ FQVEEEDIEK
260 270 280 290 300
LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS
310 320 330 340 350
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL
360 370 380 390 400
SEICRDKNDA VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS
410 420 430 440 450
LATRCLDEMM KIVGGHYLKV TLKPILDEIC DSSKSCEIDP IKLKEGDNVE
460 470 480 490 500
NNKENLRYYV DKLFNTIVKS SMSCPTVMCD IFYSLRQMAT QRFPNDPHVQ
510 520 530 540 550
YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL ISKTIQTLGS
560 570 580 590 600
WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT
610 620 630 640 650
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI
660 670 680 690 700
YTIPVKNILA VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV
710 720 730 740 750
LCRVSRCNQN RLSFYHPSVY LNGNWLCCQE TGENTLGCKP CTAGVPADIQ
760 770 780 790 800
IDIDEDRETE RIYSLFTLSL LKLQKMEEAC GTIAVYQGPQ KEPDDYSNFV
810 820 830 840 850
IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS KENPIVGKAS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSJ9 | A0A0A0MSJ9_HUMAN | Ras GTPase-activating protein 2 | RASA2 | 853 | Annotation score: | ||
D6RBA9 | D6RBA9_HUMAN | Ras GTPase-activating protein 2 | RASA2 | 47 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | T → A in BAA11230 (PubMed:8917095).Curated | 1 | |
Sequence conflicti | 225 | F → S in BAF84705 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 645 | G → EFIER in BAA11621 (PubMed:8812506).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046545 | 646 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78155 mRNA Translation: BAA11230.1 D78156 Genomic DNA Translation: BAA11231.1 D82880 mRNA Translation: BAA11621.1 D82881 Genomic DNA Translation: BAA11622.1 AF115573 mRNA Translation: AAD09821.1 AC010184 Genomic DNA No translation available. AC092977 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78999.1 AK292016 mRNA Translation: BAF84705.1 |
CCDSi | CCDS3117.1 [Q15283-2] |
PIRi | JC5047 |
RefSeqi | NP_001290174.1, NM_001303245.1 [Q15283-1] NP_001290175.1, NM_001303246.1 NP_006497.2, NM_006506.3 [Q15283-2] |
Genome annotation databases
Ensembli | ENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2] |
GeneIDi | 5922 |
KEGGi | hsa:5922 |
UCSCi | uc003etz.2, human [Q15283-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78155 mRNA Translation: BAA11230.1 D78156 Genomic DNA Translation: BAA11231.1 D82880 mRNA Translation: BAA11621.1 D82881 Genomic DNA Translation: BAA11622.1 AF115573 mRNA Translation: AAD09821.1 AC010184 Genomic DNA No translation available. AC092977 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78999.1 AK292016 mRNA Translation: BAF84705.1 |
CCDSi | CCDS3117.1 [Q15283-2] |
PIRi | JC5047 |
RefSeqi | NP_001290174.1, NM_001303245.1 [Q15283-1] NP_001290175.1, NM_001303246.1 NP_006497.2, NM_006506.3 [Q15283-2] |
3D structure databases
SMRi | Q15283 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111857, 5 interactors |
STRINGi | 9606.ENSP00000286364 |
PTM databases
iPTMneti | Q15283 |
PhosphoSitePlusi | Q15283 |
Polymorphism and mutation databases
BioMutai | RASA2 |
DMDMi | 519668674 |
Proteomic databases
jPOSTi | Q15283 |
MassIVEi | Q15283 |
MaxQBi | Q15283 |
PaxDbi | Q15283 |
PeptideAtlasi | Q15283 |
PRIDEi | Q15283 |
ProteomicsDBi | 32185 60511 [Q15283-1] |
Protocols and materials databases
Antibodypediai | 18019, 42 antibodies |
DNASUi | 5922 |
Genome annotation databases
Ensembli | ENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2] |
GeneIDi | 5922 |
KEGGi | hsa:5922 |
UCSCi | uc003etz.2, human [Q15283-1] |
Organism-specific databases
CTDi | 5922 |
DisGeNETi | 5922 |
EuPathDBi | HostDB:ENSG00000155903.11 |
GeneCardsi | RASA2 |
HGNCi | HGNC:9872, RASA2 |
HPAi | ENSG00000155903, Low tissue specificity |
MalaCardsi | RASA2 |
MIMi | 601589, gene |
neXtProti | NX_Q15283 |
OpenTargetsi | ENSG00000155903 |
Orphaneti | 648, Noonan syndrome |
PharmGKBi | PA34233 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2059, Eukaryota |
GeneTreei | ENSGT00940000158201 |
HOGENOMi | CLU_008096_1_1_1 |
InParanoidi | Q15283 |
OrthoDBi | 145372at2759 |
PhylomeDBi | Q15283 |
TreeFami | TF105302 |
Enzyme and pathway databases
PathwayCommonsi | Q15283 |
Reactomei | R-HSA-5658442, Regulation of RAS by GAPs |
Miscellaneous databases
BioGRID-ORCSi | 5922, 22 hits in 843 CRISPR screens |
ChiTaRSi | RASA2, human |
GenomeRNAii | 5922 |
Pharosi | Q15283, Tdark |
PROi | PR:Q15283 |
RNActi | Q15283, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155903, Expressed in blood and 223 other tissues |
ExpressionAtlasi | Q15283, baseline and differential |
Genevisiblei | Q15283, HS |
Family and domain databases
CDDi | cd13370, PH_GAP1m_mammal-like, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039360, Ras_GTPase IPR037773, RASA2_PH IPR023152, RasGAP_CS IPR001936, RasGAP_dom IPR008936, Rho_GTPase_activation_prot IPR001562, Znf_Btk_motif |
PANTHERi | PTHR10194, PTHR10194, 1 hit |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00168, C2, 2 hits PF00169, PH, 1 hit PF00616, RasGAP, 2 hits |
PRINTSi | PR00402, TECBTKDOMAIN |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00239, C2, 2 hits SM00233, PH, 1 hit SM00323, RasGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50003, PH_DOMAIN, 1 hit PS00509, RAS_GTPASE_ACTIV_1, 1 hit PS50018, RAS_GTPASE_ACTIV_2, 1 hit PS51113, ZF_BTK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RASA2_HUMAN | |
Accessioni | Q15283Primary (citable) accession number: Q15283 Secondary accession number(s): A8K7K1 Q9UEQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 4, 2001 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot