RASA2

Functionⁱ

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	708 – 744	Btk-typePROSITE-ProRule annotationAdd BLAST		37

GO - Molecular functionⁱ

GTPase activator activity Source: GO_Central
metal ion binding Source: UniProtKB-KW
phospholipid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

MAPK cascade Source: Reactome
negative regulation of Ras protein signal transduction Source: GO_Central
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8699317
- 8812506

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5658442 Regulation of RAS by GAPs R-HSA-6802949 Signaling by RAS mutants

Reactomeⁱ

R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras GTPase-activating protein 2 Alternative name(s): GTPase-activating protein 1m Short name: GAP1m
Gene namesⁱ	Name:RASA2 Synonyms:GAP1M, RASGAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155903.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9872 RASA2
MIMⁱ	601589 gene
neXtProtⁱ	NX_Q15283

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5922
MalaCards human disease database More...MalaCardsⁱ	RASA2
Open Targets More...OpenTargetsⁱ	ENSG00000155903
Orphanetⁱ	648 Noonan syndrome
PharmGKBⁱ	PA34233

Polymorphism and mutation databases

BioMutaⁱ	RASA2
DMDMⁱ	519668674

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000056638	2 – 850	Ras GTPase-activating protein 2Add BLAST		849

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	555	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15283
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15283
PaxDbⁱ	Q15283
PeptideAtlas More...PeptideAtlasⁱ	Q15283
PRIDEⁱ	Q15283
ProteomicsDBⁱ	60511

PTM databases

iPTMnetⁱ	Q15283
PhosphoSitePlusⁱ	Q15283

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000155903 Expressed in 210 organ(s), highest expression level in blood
CleanExⁱ	HS_RASA2
ExpressionAtlasⁱ	Q15283 baseline and differential
Genevisibleⁱ	Q15283 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035374 HPA035375

HPAⁱ

HPA035374
HPA035375

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111857, 2 interactors
STRINGⁱ	9606.ENSP00000286364

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15283
SMRⁱ	Q15283
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 122	C2 1PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	158 – 273	C2 2PROSITE-ProRule annotationAdd BLAST	116
Domainⁱ	356 – 550	Ras-GAPPROSITE-ProRule annotationAdd BLAST	195
Domainⁱ	604 – 706	PHPROSITE-ProRule annotationAdd BLAST	103

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	2 – 26	Ala-richAdd BLAST		25

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	708 – 744	Btk-typePROSITE-ProRule annotationAdd BLAST		37

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2059 Eukaryota ENOG410Y128 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119092
HOGENOMⁱ	HOG000007183
HOVERGENⁱ	HBG055643
InParanoidⁱ	Q15283
KEGG Orthology (KO) More...KOⁱ	K08053
PhylomeDBⁱ	Q15283
TreeFamⁱ	TF105302

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13370 PH_GAP1m_mammal-like, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR039360 Ras_GTPase IPR037773 RASA2_PH IPR023152 RasGAP_CS IPR001936 RasGAP_dom IPR008936 Rho_GTPase_activation_prot IPR001562 Znf_Btk_motif
PANTHERⁱ	PTHR10194 PTHR10194, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00779 BTK, 1 hit PF00168 C2, 2 hits PF00169 PH, 1 hit PF00616 RasGAP, 2 hits
PRINTSⁱ	PR00402 TECBTKDOMAIN
SMARTⁱ	View protein in SMART SM00107 BTK, 1 hit SM00239 C2, 2 hits SM00233 PH, 1 hit SM00323 RasGAP, 1 hit
SUPFAMⁱ	SSF48350 SSF48350, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits PS50003 PH_DOMAIN, 1 hit PS00509 RAS_GTPASE_ACTIV_1, 1 hit PS50018 RAS_GTPASE_ACTIV_2, 1 hit PS51113 ZF_BTK, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q15283-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL 
        60         70         80         90        100
LPYLGPHKMR DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ 
       110        120        130        140        150
YLSFYVYDKN VLQRDLRIGK VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ 
       160        170        180        190        200
GKVHLELKLN ELITENGTVC QQLVVHIKAC HGLPLINGQS CDPYATVSLV 
       210        220        230        240        250
GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ FQVEEEDIEK 
       260        270        280        290        300
LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS 
       310        320        330        340        350
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL 
       360        370        380        390        400
SEICRDKNDA VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS 
       410        420        430        440        450
LATRCLDEMM KIVGGHYLKV TLKPILDEIC DSSKSCEIDP IKLKEGDNVE 
       460        470        480        490        500
NNKENLRYYV DKLFNTIVKS SMSCPTVMCD IFYSLRQMAT QRFPNDPHVQ 
       510        520        530        540        550
YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL ISKTIQTLGS 
       560        570        580        590        600
WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT 
       610        620        630        640        650
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI 
       660        670        680        690        700
YTIPVKNILA VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV 
       710        720        730        740        750
LCRVSRCNQN RLSFYHPSVY LNGNWLCCQE TGENTLGCKP CTAGVPADIQ 
       760        770        780        790        800
IDIDEDRETE RIYSLFTLSL LKLQKMEEAC GTIAVYQGPQ KEPDDYSNFV 
       810        820        830        840        850
IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS KENPIVGKAS

Length:850

Mass (Da):96,614

Last modified:June 26, 2013 - v3

Checksum:ⁱ1F357940CA106E5E

GO

Isoform 2 (identifier: Q15283-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
646-646: Missing.

« Hide

        10         20         30         40         50
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL 
        60         70         80         90        100
LPYLGPHKMR DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ 
       110        120        130        140        150
YLSFYVYDKN VLQRDLRIGK VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ 
       160        170        180        190        200
GKVHLELKLN ELITENGTVC QQLVVHIKAC HGLPLINGQS CDPYATVSLV 
       210        220        230        240        250
GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ FQVEEEDIEK 
       260        270        280        290        300
LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS 
       310        320        330        340        350
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL 
       360        370        380        390        400
SEICRDKNDA VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS 
       410        420        430        440        450
LATRCLDEMM KIVGGHYLKV TLKPILDEIC DSSKSCEIDP IKLKEGDNVE 
       460        470        480        490        500
NNKENLRYYV DKLFNTIVKS SMSCPTVMCD IFYSLRQMAT QRFPNDPHVQ 
       510        520        530        540        550
YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL ISKTIQTLGS 
       560        570        580        590        600
WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT 
       610        620        630        640        650
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGKDAIY 
       660        670        680        690        700
TIPVKNILAV EKLEESSFNK KNMFQVIHTE KPLYVQANNC VEANEWIDVL 
       710        720        730        740        750
CRVSRCNQNR LSFYHPSVYL NGNWLCCQET GENTLGCKPC TAGVPADIQI 
       760        770        780        790        800
DIDEDRETER IYSLFTLSLL KLQKMEEACG TIAVYQGPQK EPDDYSNFVI 
       810        820        830        840 
EDSVTTFKTI QQIKSIIEKL DEPHEKYRKK RSSSAKYGSK ENPIVGKAS

Show »

Length:849

Mass (Da):96,527

Checksum:ⁱA4B491DFF5C4CB76

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A0A0MSJ9	A0A0A0MSJ9_HUMAN		Ras GTPase-activating protein 2 Ras GTPase-activating protein 2	RASA2	853	Annotation score:
	D6RBA9	D6RBA9_HUMAN		Ras GTPase-activating protein 2 Ras GTPase-activating protein 2	RASA2	47	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	216	T → A in BAA11230 (PubMed:8917095).Curated	1
Sequence conflictⁱ	225	F → S in BAF84705 (PubMed:14702039).Curated	1
Sequence conflictⁱ	645	G → EFIER in BAA11621 (PubMed:8812506).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046545	646	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D78155 mRNA Translation: BAA11230.1 D78156 Genomic DNA Translation: BAA11231.1 D82880 mRNA Translation: BAA11621.1 D82881 Genomic DNA Translation: BAA11622.1 AF115573 mRNA Translation: AAD09821.1 AC010184 Genomic DNA No translation available. AC092977 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78999.1 AK292016 mRNA Translation: BAF84705.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3117.1 [Q15283-2]
PIRⁱ	JC5047
NCBI Reference Sequences More...RefSeqⁱ	NP_001290174.1, NM_001303245.1 [Q15283-1] NP_001290175.1, NM_001303246.1 NP_006497.2, NM_006506.3 [Q15283-2]
UniGeneⁱ	Hs.655941 Hs.98445

Genome annotation databases

Ensemblⁱ	ENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2]
GeneIDⁱ	5922
KEGGⁱ	hsa:5922
UCSC genome browser More...UCSCⁱ	uc003etz.2 human [Q15283-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15283	RAS p21 protein activator 2		MACFA		860	UniRef90_Q15283
RAS p21 protein activator 2		MACNE		860
RAS p21 protein activator 2		MACMU		856
RAS p21 protein activator 2		CERAT		856
Ras GTPase-activating protein 2		HUMAN		853
+185

Protein	Similar proteins		Species	Score	Length	Source
Q15283	RAS p21 protein activator 2		MACNE		860	UniRef50_Q15283
RAS p21 protein activator 2		MACFA		860
RAS p21 protein activator 2		MACMU		856
RAS p21 protein activator 2		CERAT		856
RASA2 isoform 2		PANTR		853
+277

Entry informationⁱ

Entry nameⁱ	RASA2_HUMAN
Accessionⁱ	Q15283Primary (citable) accession number: Q15283 Secondary accession number(s): A8K7K1 Q9UEQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
	Last sequence update:	June 26, 2013
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15283 (RASA2_HUMAN)

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Ras GTPase-activating protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ