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UniProtKB - Q15283 (RASA2_HUMAN)

Entry version 175 (12 Aug 2020)
Sequence version 3 (26 Jun 2013)
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Protein

Ras GTPase-activating protein 2

Gene

RASA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri708 – 744Btk-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15283

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5658442, Regulation of RAS by GAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GTPase-activating protein 1m
Short name:
GAP1m
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASA2
Synonyms:GAP1M, RASGAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000155903.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:9872, RASA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601589, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5922

MalaCards human disease database

More...MalaCardsi		RASA2

Open Targets

More...OpenTargetsi		ENSG00000155903

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		648, Noonan syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34233

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15283, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RASA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		519668674

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566382 – 850Ras GTPase-activating protein 2Add BLAST849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15283

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15283

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15283

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15283

PeptideAtlas

More...PeptideAtlasi		Q15283

PRoteomics IDEntifications database

More...PRIDEi		Q15283

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32185
60511 [Q15283-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155903, Expressed in blood and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15283, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15283, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155903, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111857, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286364

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15283, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15283

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 138C2 1PROSITE-ProRule annotationAdd BLAST119
Domaini149 – 289C2 2PROSITE-ProRule annotationAdd BLAST141
Domaini356 – 550Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini604 – 706PHPROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 26Ala-richAdd BLAST25

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri708 – 744Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2059, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008096_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15283

KEGG Orthology (KO)

More...KOi		K08053

Database of Orthologous Groups

More...OrthoDBi		145372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15283

TreeFam database of animal gene trees

More...TreeFami		TF105302

Family and domain databases

Conserved Domains Database

More...CDDi		cd13370, PH_GAP1m_mammal-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR037773, RASA2_PH
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif

The PANTHER Classification System

More...PANTHERi		PTHR10194, PTHR10194, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00402, TECBTKDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL 
        60         70         80         90        100
LPYLGPHKMR DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ 
       110        120        130        140        150
YLSFYVYDKN VLQRDLRIGK VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ 
       160        170        180        190        200
GKVHLELKLN ELITENGTVC QQLVVHIKAC HGLPLINGQS CDPYATVSLV 
       210        220        230        240        250
GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ FQVEEEDIEK 
       260        270        280        290        300
LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS 
       310        320        330        340        350
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL 
       360        370        380        390        400
SEICRDKNDA VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS 
       410        420        430        440        450
LATRCLDEMM KIVGGHYLKV TLKPILDEIC DSSKSCEIDP IKLKEGDNVE 
       460        470        480        490        500
NNKENLRYYV DKLFNTIVKS SMSCPTVMCD IFYSLRQMAT QRFPNDPHVQ 
       510        520        530        540        550
YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL ISKTIQTLGS 
       560        570        580        590        600
WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT 
       610        620        630        640        650
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI 
       660        670        680        690        700
YTIPVKNILA VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV 
       710        720        730        740        750
LCRVSRCNQN RLSFYHPSVY LNGNWLCCQE TGENTLGCKP CTAGVPADIQ 
       760        770        780        790        800
IDIDEDRETE RIYSLFTLSL LKLQKMEEAC GTIAVYQGPQ KEPDDYSNFV 
       810        820        830        840        850
IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS KENPIVGKAS
Length:850
Mass (Da):96,614
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F357940CA106E5E
GO
Isoform 2 (identifier: Q15283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-646: Missing.

Show »
Length:849
Mass (Da):96,527
Checksum:iA4B491DFF5C4CB76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSJ9A0A0A0MSJ9_HUMAN
Ras GTPase-activating protein 2
RASA2
853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBA9D6RBA9_HUMAN
Ras GTPase-activating protein 2
RASA2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216T → A in BAA11230 (PubMed:8917095).Curated1
Sequence conflicti225F → S in BAF84705 (PubMed:14702039).Curated1
Sequence conflicti645G → EFIER in BAA11621 (PubMed:8812506).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046545646Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D78155 mRNA Translation: BAA11230.1
D78156 Genomic DNA Translation: BAA11231.1
D82880 mRNA Translation: BAA11621.1
D82881 Genomic DNA Translation: BAA11622.1
AF115573 mRNA Translation: AAD09821.1
AC010184 Genomic DNA No translation available.
AC092977 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78999.1
AK292016 mRNA Translation: BAF84705.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3117.1 [Q15283-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5047

NCBI Reference Sequences

More...RefSeqi		NP_001290174.1, NM_001303245.1 [Q15283-1]
NP_001290175.1, NM_001303246.1
NP_006497.2, NM_006506.3 [Q15283-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5922

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5922

UCSC genome browser

More...UCSCi		uc003etz.2, human [Q15283-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78155 mRNA Translation: BAA11230.1
D78156 Genomic DNA Translation: BAA11231.1
D82880 mRNA Translation: BAA11621.1
D82881 Genomic DNA Translation: BAA11622.1
AF115573 mRNA Translation: AAD09821.1
AC010184 Genomic DNA No translation available.
AC092977 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78999.1
AK292016 mRNA Translation: BAF84705.1
CCDSiCCDS3117.1 [Q15283-2]
PIRiJC5047
RefSeqiNP_001290174.1, NM_001303245.1 [Q15283-1]
NP_001290175.1, NM_001303246.1
NP_006497.2, NM_006506.3 [Q15283-2]

3D structure databases

SMRiQ15283
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111857, 5 interactors
STRINGi9606.ENSP00000286364

PTM databases

iPTMnetiQ15283
PhosphoSitePlusiQ15283

Polymorphism and mutation databases

BioMutaiRASA2
DMDMi519668674

Proteomic databases

jPOSTiQ15283
MassIVEiQ15283
MaxQBiQ15283
PaxDbiQ15283
PeptideAtlasiQ15283
PRIDEiQ15283
ProteomicsDBi32185
60511 [Q15283-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18019, 42 antibodies

The DNASU plasmid repository

More...DNASUi		5922

Genome annotation databases

EnsembliENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2]
GeneIDi5922
KEGGihsa:5922
UCSCiuc003etz.2, human [Q15283-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5922
DisGeNETi5922
EuPathDBiHostDB:ENSG00000155903.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		RASA2
HGNCiHGNC:9872, RASA2
HPAiENSG00000155903, Low tissue specificity
MalaCardsiRASA2
MIMi601589, gene
neXtProtiNX_Q15283
OpenTargetsiENSG00000155903
Orphaneti648, Noonan syndrome
PharmGKBiPA34233

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2059, Eukaryota
GeneTreeiENSGT00940000158201
HOGENOMiCLU_008096_1_1_1
InParanoidiQ15283
KOiK08053
OrthoDBi145372at2759
PhylomeDBiQ15283
TreeFamiTF105302

Enzyme and pathway databases

PathwayCommonsiQ15283
ReactomeiR-HSA-5658442, Regulation of RAS by GAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5922, 22 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RASA2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5922
PharosiQ15283, Tdark

Protein Ontology

More...PROi		PR:Q15283
RNActiQ15283, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155903, Expressed in blood and 223 other tissues
ExpressionAtlasiQ15283, baseline and differential
GenevisibleiQ15283, HS

Family and domain databases

CDDicd13370, PH_GAP1m_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR037773, RASA2_PH
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif
PANTHERiPTHR10194, PTHR10194, 1 hit
PfamiView protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 2 hits
PRINTSiPR00402, TECBTKDOMAIN
SMARTiView protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15283
Secondary accession number(s): A8K7K1
, G3V0F9, O00695, Q15284, Q92594, Q99577, Q9UEQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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