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Entry version 188 (17 Jun 2020)
Sequence version 2 (17 Oct 2006)
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Protein

Rab GTPase-binding effector protein 1

Gene

RABEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Endocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8854214 TBC/RABGAPs

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15276

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab GTPase-binding effector protein 1
Alternative name(s):
Rabaptin-4
Rabaptin-5
Rabaptin-5alpha
Renal carcinoma antigen NY-REN-17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RABEP1
Synonyms:RAB5EP, RABPT5, RABPT5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000029725.16

Human Gene Nomenclature Database

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HGNCi
HGNC:17677 RABEP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603616 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q15276

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi812D → K: No effect on RAB5A binding affinity. 1 Publication1
Mutagenesisi815E → K: No effect on RAB5A binding affinity. 1 Publication1
Mutagenesisi818Q → W: Strongly decreases RAB5A binding affinity. 1 Publication1
Mutagenesisi820D → K: Strongly decreases RAB5A binding affinity. 1 Publication1
Mutagenesisi821F → R: Strongly decreases RAB5A binding affinity. 1 Publication1
Mutagenesisi822V → D: Strongly decreases RAB5A binding affinity. 1 Publication1
Mutagenesisi826Q → A: Strongly decreases RAB5A binding affinity. 1 Publication1
Mutagenesisi829Q → A: Strongly decreases RAB5A binding affinity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9135

Open Targets

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OpenTargetsi
ENSG00000029725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884097

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15276 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RABEP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242743

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001875562 – 862Rab GTPase-binding effector protein 1Add BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei282N6-acetyllysineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei408PhosphothreonineCombined sources1
Modified residuei410PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15276

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15276

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15276

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15276

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15276

PeptideAtlas

More...
PeptideAtlasi
Q15276

PRoteomics IDEntifications database

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PRIDEi
Q15276

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60509 [Q15276-1]
60510 [Q15276-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15276

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q15276

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000029725 Expressed in corpus callosum and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15276 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15276 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000029725 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer when bound to RAB5A (PubMed:15378032). Heterodimer with RABGEF1 (PubMed:11452015, PubMed:9323142). The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding (PubMed:10698684, PubMed:8521472, PubMed:20098723). Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 (PubMed:12505986, PubMed:12773381, PubMed:9045618).

Interacts with ECPAS (PubMed:20682791).

Interacts with KCNH1 (By similarity).

Interacts with PKD1 (via C-terminal domain) and GGA1; the interactions recruit PKD1:PKD2 complex to GGA1 and ARL3 at trans-Golgi network (By similarity).

Interacts with KCNH1 (By similarity).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q15276
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-447043,EBI-11096309
AIMP2 [Q13155]3EBI-447043,EBI-745226
AP1G1 [O43747]2EBI-447043,EBI-447609
AP1G2 [O75843]2EBI-447043,EBI-373637
BARD1 [Q99728]3EBI-447043,EBI-473181
CCDC120 [Q96HB5]3EBI-447043,EBI-744556
CCDC151 [A5D8V7]3EBI-447043,EBI-8466445
CDC73 [Q6P1J9]3EBI-447043,EBI-930143
CDK18 [Q07002]3EBI-447043,EBI-746238
CDKL3 [Q8IVW4]3EBI-447043,EBI-3919850
CEP57 - isoform 3 [Q86XR8-3]3EBI-447043,EBI-11752486
CFAP53 [Q96M91]3EBI-447043,EBI-742422
ELOA [Q14241]3EBI-447043,EBI-742350
ESCO2 [Q56NI9]3EBI-447043,EBI-3951849
FAM50B [Q9Y247]3EBI-447043,EBI-742802
FAM90A1 [Q86YD7]3EBI-447043,EBI-6658203
GGA1 [Q9UJY5]8EBI-447043,EBI-447141
GGA2 [Q9UJY4]7EBI-447043,EBI-447646
GGA3 [Q9NZ52]4EBI-447043,EBI-447404
LENG1 [Q96BZ8]3EBI-447043,EBI-726510
MAT2B [Q9NZL9]3EBI-447043,EBI-10317491
MCRS1 [Q96EZ8]3EBI-447043,EBI-348259
PELI2 [Q9HAT8]3EBI-447043,EBI-448407
PKP2 - isoform 1 [Q99959-2]3EBI-447043,EBI-10987518
PRPF3 [O43395]3EBI-447043,EBI-744322
RAB4A [P20338]3EBI-447043,EBI-722284
RAB4B [P61018]3EBI-447043,EBI-10218066
RABGEF1 - isoform 1 [Q9UJ41-2]2EBI-447043,EBI-6448458
RNF39 [Q9H2S5]3EBI-447043,EBI-12235180
SNW1 [Q13573]3EBI-447043,EBI-632715
STAR [P49675]3EBI-447043,EBI-722932
TNS4 [Q8IZW8]3EBI-447043,EBI-7543499
TRAPPC2L - isoform 2 [Q9UL33-2]3EBI-447043,EBI-11119202
TSHZ2 [Q9NRE2]3EBI-447043,EBI-10687282
UBTFL1 [P0CB47]3EBI-447043,EBI-17208936
USP2 [O75604]3EBI-447043,EBI-743272
UTP14C [Q5TAP6]3EBI-447043,EBI-11737646
WASHC3 [Q9Y3C0]3EBI-447043,EBI-712969
ZNF438 [Q7Z4V0]3EBI-447043,EBI-11962468
ZNF512B [Q96KM6]3EBI-447043,EBI-1049952
ZNF774 [Q6NX45]3EBI-447043,EBI-10251462
yscH [P68590] from Yersinia pestis.2EBI-447043,EBI-2845098

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114583, 83 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15276

Database of interacting proteins

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DIPi
DIP-29350N

Protein interaction database and analysis system

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IntActi
Q15276, 76 interactors

Molecular INTeraction database

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MINTi
Q15276

STRING: functional protein association networks

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STRINGi
9606.ENSP00000445408

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q15276 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1862
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15276

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15276

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 345Sequence analysisAdd BLAST335
Coiled coili534 – 816Sequence analysisAdd BLAST283

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rabaptin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0993 Eukaryota
ENOG410XSZ1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_016882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15276

KEGG Orthology (KO)

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KOi
K12480

Identification of Orthologs from Complete Genome Data

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OMAi
SENDMFK

Database of Orthologous Groups

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OrthoDBi
1369937at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15276

TreeFam database of animal gene trees

More...
TreeFami
TF329365

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003914 Rabaptin
IPR029880 Rabaptin-5
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR31179 PTHR31179, 1 hit
PTHR31179:SF5 PTHR31179:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09311 Rab5-bind, 1 hit
PF03528 Rabaptin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01432 RABAPTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15276-1) [UniParc]FASTAAdd to basket
Also known as: Rabaptin-5

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQPGPASQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY
60 70 80 90 100
LAKEEDLKRQ NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ
110 120 130 140 150
EAIDEVKRQW REEVASLQAV MKETVRDYEH QFHLRLEQER TQWAQYRESA
160 170 180 190 200
EREIADLRRR LSEGQEEENL ENEMKKAQED AEKLRSVVMP MEKEIAALKD
210 220 230 240 250
KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV LNTQKSVLQE
260 270 280 290 300
DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR
310 320 330 340 350
MEIVLTSEQL RQVEELKKKD QEDDEQQRLN KRKDHKKADV EEEIKIPVVC
360 370 380 390 400
ALTQEESSAQ LSNEEEHLDS TRGSVHSLDA GLLLPSGDPF SKSDNDMFKD
410 420 430 440 450
GLRRAQSTDS LGTSGSLQSK ALGYNYKAKS AGNLDESDFG PLVGADSVSE
460 470 480 490 500
NFDTASLGSL QMPSGFMLTK DQERAIKAMT PEQEETASLL SSVTQGMESA
510 520 530 540 550
YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE KQLQGIQIQE
560 570 580 590 600
AETRDQVKKL QLMLRQANDQ LEKTMKDKQE LEDFIKQSSE DSSHQISALV
610 620 630 640 650
LRAQASEILL EELQQGLSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND
660 670 680 690 700
SLQGKHSLHV SLQQAEDFIL PDTTEALREL VLKYREDIIN VRTAADHVEE
710 720 730 740 750
KLKAEILFLK EQIQAEQCLK ENLEETLQLE IENCKEEIAS ISSLKAELER
760 770 780 790 800
IKVEKGQLES TLREKSQQLE SLQEIKISLE EQLKKETAAK ATVEQLMFEE
810 820 830 840 850
KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS LERIRAILND
860
TKLTDINQLP ET
Length:862
Mass (Da):99,290
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAAF91638B8ED516
GO
Isoform 2 (identifier: Q15276-2) [UniParc]FASTAAdd to basket
Also known as: Rabaptin-4

The sequence of this isoform differs from the canonical sequence as follows:
     758-790: Missing.

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Length:829
Mass (Da):95,479
Checksum:i5B9D6E6BDF9627CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2B8I3L2B8_HUMAN
Rab GTPase-binding effector protein...
RABEP1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZZ3A0A087WZZ3_HUMAN
Rab GTPase-binding effector protein...
RABEP1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENJ9K7ENJ9_HUMAN
Rab GTPase-binding effector protein...
RABEP1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L456I3L456_HUMAN
Rab GTPase-binding effector protein...
RABEP1
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149S → Y in CAA62580 (PubMed:8521472).Curated1
Sequence conflicti149S → Y in AAC70781 (PubMed:10698684).Curated1
Sequence conflicti628M → I in BAG36864 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028106640E → G. Corresponds to variant dbSNP:rs3026099Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010451758 – 790Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X91141 mRNA Translation: CAA62580.1
AF098638 mRNA Translation: AAC70781.1
AK314183 mRNA Translation: BAG36864.1
BC041700 mRNA Translation: AAH41700.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42243.1 [Q15276-2]
CCDS45592.1 [Q15276-1]

NCBI Reference Sequences

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RefSeqi
NP_001077054.1, NM_001083585.2 [Q15276-2]
NP_001278510.1, NM_001291581.1
NP_004694.2, NM_004703.5 [Q15276-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000341923; ENSP00000339569; ENSG00000029725 [Q15276-2]
ENST00000537505; ENSP00000445408; ENSG00000029725 [Q15276-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9135

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9135

UCSC genome browser

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UCSCi
uc032ery.2 human [Q15276-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91141 mRNA Translation: CAA62580.1
AF098638 mRNA Translation: AAC70781.1
AK314183 mRNA Translation: BAG36864.1
BC041700 mRNA Translation: AAH41700.1
CCDSiCCDS42243.1 [Q15276-2]
CCDS45592.1 [Q15276-1]
RefSeqiNP_001077054.1, NM_001083585.2 [Q15276-2]
NP_001278510.1, NM_001291581.1
NP_004694.2, NM_004703.5 [Q15276-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P4UX-ray2.20B435-447[»]
1TU3X-ray2.31F/G/H/I/J789-862[»]
1X79X-ray2.41B/C551-661[»]
4N3YX-ray2.20B/C552-642[»]
4N3ZX-ray3.10B/C552-642[»]
4Q9UX-ray4.62C/D/G/H552-642[»]
SMRiQ15276
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114583, 83 interactors
CORUMiQ15276
DIPiDIP-29350N
IntActiQ15276, 76 interactors
MINTiQ15276
STRINGi9606.ENSP00000445408

PTM databases

iPTMnetiQ15276
MetOSiteiQ15276
PhosphoSitePlusiQ15276

Polymorphism and mutation databases

BioMutaiRABEP1
DMDMi116242743

Proteomic databases

EPDiQ15276
jPOSTiQ15276
MassIVEiQ15276
MaxQBiQ15276
PaxDbiQ15276
PeptideAtlasiQ15276
PRIDEiQ15276
ProteomicsDBi60509 [Q15276-1]
60510 [Q15276-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3875 108 antibodies

Genome annotation databases

EnsembliENST00000341923; ENSP00000339569; ENSG00000029725 [Q15276-2]
ENST00000537505; ENSP00000445408; ENSG00000029725 [Q15276-1]
GeneIDi9135
KEGGihsa:9135
UCSCiuc032ery.2 human [Q15276-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9135
DisGeNETi9135
EuPathDBiHostDB:ENSG00000029725.16

GeneCards: human genes, protein and diseases

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GeneCardsi
RABEP1
HGNCiHGNC:17677 RABEP1
HPAiENSG00000029725 Low tissue specificity
MIMi603616 gene
neXtProtiNX_Q15276
OpenTargetsiENSG00000029725
PharmGKBiPA134884097

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0993 Eukaryota
ENOG410XSZ1 LUCA
GeneTreeiENSGT00530000063743
HOGENOMiCLU_016882_0_0_1
InParanoidiQ15276
KOiK12480
OMAiSENDMFK
OrthoDBi1369937at2759
PhylomeDBiQ15276
TreeFamiTF329365

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
SIGNORiQ15276

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9135 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RABEP1 human
EvolutionaryTraceiQ15276

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RABEP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9135
PharosiQ15276 Tbio

Protein Ontology

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PROi
PR:Q15276
RNActiQ15276 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000029725 Expressed in corpus callosum and 216 other tissues
ExpressionAtlasiQ15276 baseline and differential
GenevisibleiQ15276 HS

Family and domain databases

InterProiView protein in InterPro
IPR003914 Rabaptin
IPR029880 Rabaptin-5
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom
PANTHERiPTHR31179 PTHR31179, 1 hit
PTHR31179:SF5 PTHR31179:SF5, 1 hit
PfamiView protein in Pfam
PF09311 Rab5-bind, 1 hit
PF03528 Rabaptin, 1 hit
PRINTSiPR01432 RABAPTIN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRABE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15276
Secondary accession number(s): B2RAG7, O95369, Q8IVX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 17, 2006
Last modified: June 17, 2020
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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