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Entry version 184 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Periodic tryptophan protein 2 homolog

Gene

PWP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q15269

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periodic tryptophan protein 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PWP2
Synonyms:PWP2H
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9711 PWP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601475 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15269

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000241945

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400451

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15269

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PWP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242740

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000511751 – 919Periodic tryptophan protein 2 homologAdd BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei898PhosphoserineBy similarity1
Modified residuei902PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15269

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15269

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15269

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15269

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15269

PeptideAtlas

More...
PeptideAtlasi
Q15269

PRoteomics IDEntifications database

More...
PRIDEi
Q15269

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60506

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q15269

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15269

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241945 Expressed in 89 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15269 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15269 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024573

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111780, 59 interactors
3195276, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q15269, 31 interactors

Molecular INTeraction database

More...
MINTi
Q15269

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291576

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15269

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati12 – 50WD 1Add BLAST39
Repeati53 – 93WD 2Add BLAST41
Repeati94 – 132WD 3Add BLAST39
Repeati142 – 181WD 4Add BLAST40
Repeati186 – 225WD 5Add BLAST40
Repeati286 – 325WD 6Add BLAST40
Repeati328 – 368WD 7Add BLAST41
Repeati371 – 410WD 8Add BLAST40
Repeati413 – 452WD 9Add BLAST40
Repeati456 – 498WD 10Add BLAST43
Repeati499 – 538WD 11Add BLAST40
Repeati541 – 580WD 12Add BLAST40
Repeati603 – 642WD 13Add BLAST40
Repeati700 – 740WD 14Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi240 – 247Poly-Glu8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat PWP2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0291 Eukaryota
ENOG410XP2P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000160363

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15269

KEGG Orthology (KO)

More...
KOi
K14558

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIMKQQG

Database of Orthologous Groups

More...
OrthoDBi
290630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15269

TreeFam database of animal gene trees

More...
TreeFami
TF300853

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR027145 PWP2
IPR011047 Quinoprotein_ADH-like_supfam
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR19858 PTHR19858, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL
60 70 80 90 100
PLATRYNVKC VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH
110 120 130 140 150
SVSFSPDGRK FVVTKGNIAQ MYHAPGKKRE FNAFVLDKTY FGPYDETTCI
160 170 180 190 200
DWTDDSRCFV VGSKDMSTWV FGAERWDNLI YYALGGHKDA IVACFFESNS
210 220 230 240 250
LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE EEEEEEEDQE
260 270 280 290 300
GDRETTIRGK ATPAEEEKTG KVKYSRLAKY FFNKEGDFNN LTAAAFHKKS
310 320 330 340 350
HLLVTGFASG IFHLHELPEF NLIHSLSISD QSIASVAINS SGDWIAFGCS
360 370 380 390 400
GLGQLLVWEW QSESYVLKQQ GHFNSMVALA YSPDGQYIVT GGDDGKVKVW
410 420 430 440 450
NTLSGFCFVT FTEHSSGVTG VTFTATGYVV VTSSMDGTVR AFDLHRYRNF
460 470 480 490 500
RTFTSPRPTQ FSCVAVDASG EIVSAGAQDS FEIFVWSMQT GRLLDVLSGH
510 520 530 540 550
EGPISGLCFN PMKSVLASAS WDKTVRLWDM FDSWRTKETL ALTSDALAVT
560 570 580 590 600
FRPDGAELAV ATLNSQITFW DPENAVQTGS IEGRHDLKTG RKELDKITAK
610 620 630 640 650
HAAKGKAFTA LCYSADGHSI LAGGMSKFVC IYHVREQILM KRFEISCNLS
660 670 680 690 700
LDAMEEFLNR RKMTEFGNLA LIDQDAGQED GVAIPLPGVR KGDMSSRHFK
710 720 730 740 750
PEIRVTSLRF SPTGRCWAAT TTEGLLIYSL DTRVLFDPFE LDTSVTPGRV
760 770 780 790 800
REALRQQDFT RAILMALRLN ESKLVQEALE AVPRGEIEVV TSSLPELYVE
810 820 830 840 850
KVLEFLASSF EVSRHLEFYL LWTHKLLMLH GQKLKSRAGT LLPVIQFLQK
860 870 880 890 900
SIQRHLDDLS KLCSWNHYNM QYALAVSKQR GTKRSLDPLG SEEEAEASED
910
DSLHLLGGGG RDSEEEMLA
Length:919
Mass (Da):102,452
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2A94C5595DF4380
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J544C9J544_HUMAN
Periodic tryptophan protein 2 homol...
PWP2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti719A → G in CAA64560 (PubMed:8661145).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02810425D → N7 PublicationsCorresponds to variant dbSNP:rs2020945Ensembl.1
Natural variantiVAR_053412174E → K. Corresponds to variant dbSNP:rs35001460Ensembl.1
Natural variantiVAR_028105551F → I1 PublicationCorresponds to variant dbSNP:rs17856422Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95263 mRNA Translation: CAA64560.1
X96424 Genomic DNA Translation: CAA65284.1
X96425 Genomic DNA Translation: CAA65285.1
U53346 mRNA Translation: AAB08084.1
U56085 mRNA Translation: AAC50904.1
U56089
, U56086, U56087, U56088 Genomic DNA Translation: AAC50905.1
AB001517 Genomic DNA Translation: BAA21137.1
AK314184 mRNA Translation: BAG36865.1
AP001753 Genomic DNA Translation: BAA95553.1
CH471079 Genomic DNA Translation: EAX09458.1
BC013309 mRNA Translation: AAH13309.1
BC014988 mRNA Translation: AAH14988.1
AB001523 Genomic DNA Translation: BAA21100.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33579.1

NCBI Reference Sequences

More...
RefSeqi
NP_005040.2, NM_005049.2
XP_006723973.1, XM_006723910.1
XP_011507205.1, XM_011508903.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291576; ENSP00000291576; ENSG00000241945

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5822

UCSC genome browser

More...
UCSCi
uc002zeb.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95263 mRNA Translation: CAA64560.1
X96424 Genomic DNA Translation: CAA65284.1
X96425 Genomic DNA Translation: CAA65285.1
U53346 mRNA Translation: AAB08084.1
U56085 mRNA Translation: AAC50904.1
U56089
, U56086, U56087, U56088 Genomic DNA Translation: AAC50905.1
AB001517 Genomic DNA Translation: BAA21137.1
AK314184 mRNA Translation: BAG36865.1
AP001753 Genomic DNA Translation: BAA95553.1
CH471079 Genomic DNA Translation: EAX09458.1
BC013309 mRNA Translation: AAH13309.1
BC014988 mRNA Translation: AAH14988.1
AB001523 Genomic DNA Translation: BAA21100.1
CCDSiCCDS33579.1
RefSeqiNP_005040.2, NM_005049.2
XP_006723973.1, XM_006723910.1
XP_011507205.1, XM_011508903.2

3D structure databases

SMRiQ15269
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111780, 59 interactors
3195276, 3 interactors
IntActiQ15269, 31 interactors
MINTiQ15269
STRINGi9606.ENSP00000291576

PTM databases

iPTMnetiQ15269
PhosphoSitePlusiQ15269
SwissPalmiQ15269

Polymorphism and mutation databases

BioMutaiPWP2
DMDMi116242740

2D gel databases

SWISS-2DPAGEiQ15269

Proteomic databases

EPDiQ15269
jPOSTiQ15269
MassIVEiQ15269
MaxQBiQ15269
PaxDbiQ15269
PeptideAtlasiQ15269
PRIDEiQ15269
ProteomicsDBi60506

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5822

Genome annotation databases

EnsembliENST00000291576; ENSP00000291576; ENSG00000241945
GeneIDi5822
KEGGihsa:5822
UCSCiuc002zeb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5822

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PWP2
HGNCiHGNC:9711 PWP2
HPAiHPA024573
MIMi601475 gene
neXtProtiNX_Q15269
OpenTargetsiENSG00000241945
PharmGKBiPA162400451

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0291 Eukaryota
ENOG410XP2P LUCA
GeneTreeiENSGT00550000074981
HOGENOMiHOG000160363
InParanoidiQ15269
KOiK14558
OMAiYIMKQQG
OrthoDBi290630at2759
PhylomeDBiQ15269
TreeFamiTF300853

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ15269

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PWP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PWP2
PharosiQ15269

Protein Ontology

More...
PROi
PR:Q15269

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241945 Expressed in 89 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ15269 baseline and differential
GenevisibleiQ15269 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR027145 PWP2
IPR011047 Quinoprotein_ADH-like_supfam
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PANTHERiPTHR19858 PTHR19858, 1 hit
PfamiView protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 13 hits
SUPFAMiSSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPWP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15269
Secondary accession number(s): B2RAG8, Q96A77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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