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Entry version 192 (13 Feb 2019)
Sequence version 2 (01 May 2007)
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Protein

Receptor-type tyrosine-protein phosphatase kappa

Gene

PTPRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1050SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1082Phosphocysteine intermediateBy similarity1
Binding sitei1126SubstrateBy similarity1
Active sitei1376Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-182971 EGFR downregulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q15262

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15262

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase kappa (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase kappa
Short name:
R-PTP-kappa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRK
Synonyms:PTPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152894.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9674 PTPRK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602545 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15262

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 752ExtracellularSequence analysisAdd BLAST726
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei753 – 774HelicalSequence analysisAdd BLAST22
Topological domaini775 – 1439CytoplasmicSequence analysisAdd BLAST665

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5796

Open Targets

More...
OpenTargetsi
ENSG00000152894

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34019

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPRK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146345496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002544627 – 1439Receptor-type tyrosine-protein phosphatase kappaAdd BLAST1413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi216 ↔ 270PROSITE-ProRule annotation
Glycosylationi416N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei856PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

This protein undergoes proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei643 – 644CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15262

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15262

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15262

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15262

PeptideAtlas

More...
PeptideAtlasi
Q15262

PRoteomics IDEntifications database

More...
PRIDEi
Q15262

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60503
60504 [Q15262-2]
60505 [Q15262-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q15262

GlyConnect protein glycosylation platform

More...
GlyConnecti
1709

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15262

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15262

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152894 Expressed in 232 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15262 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15262 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054056
HPA054822

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111760, 121 interactors

Protein interaction database and analysis system

More...
IntActi
Q15262, 25 interactors

Molecular INTeraction database

More...
MINTi
Q15262

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357196

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7SX-ray1.95A865-1154[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15262

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15262

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15262

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 194MAMPROSITE-ProRule annotationAdd BLAST164
Domaini196 – 281Ig-like C2-typeAdd BLAST86
Domaini294 – 389Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini392 – 488Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini491 – 595Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST105
Domaini597 – 680Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST84
Domaini887 – 1141Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1173 – 1435Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1082 – 1088Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4228 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156249

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049029

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG062785

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15262

KEGG Orthology (KO)

More...
KOi
K06776

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15262

TreeFam database of animal gene trees

More...
TreeFami
TF312900

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd06263 MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 1 hit
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 1 hit
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15262-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD
60 70 80 90 100
LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE
110 120 130 140 150
NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL
160 170 180 190 200
RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR
210 220 230 240 250
LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR
260 270 280 290 300
FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL
310 320 330 340 350
LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL
360 370 380 390 400
WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE
410 420 430 440 450
IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP
460 470 480 490 500
QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG
510 520 530 540 550
TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL
560 570 580 590 600
WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE
610 620 630 640 650
GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME
660 670 680 690 700
CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP
710 720 730 740 750
LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV
760 770 780 790 800
VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA
810 820 830 840 850
MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL
860 870 880 890 900
CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA
910 920 930 940 950
SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ
960 970 980 990 1000
RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP
1010 1020 1030 1040 1050
DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD
1060 1070 1080 1090 1100
HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD
1110 1120 1130 1140 1150
MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP
1160 1170 1180 1190 1200
VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN
1210 1220 1230 1240 1250
HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP
1260 1270 1280 1290 1300
LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE
1310 1320 1330 1340 1350
CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS
1360 1370 1380 1390 1400
FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN
1410 1420 1430
VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS
Length:1,439
Mass (Da):162,102
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE1EA6EA3CCA31ED
GO
Isoform 2 (identifier: Q15262-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA

Show »
Length:1,440
Mass (Da):162,173
Checksum:i41B5AD638EE63969
GO
Isoform 3 (identifier: Q15262-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,446
Mass (Da):163,020
Checksum:i43919D3BA33C84C4
GO
Isoform 4 (identifier: Q15262-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     831-831: Y → LPNDPLVPTAVLVPITD
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):164,613
Checksum:iC3CEA4670A00B758
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TG12Q5TG12_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
1,458Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGC5E9PGC5_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
1,472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6P5H0Y6P5_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
343Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRW2E9PRW2_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQF6A0A0G2JQF6_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6V4H0Y6V4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6P493Q6P493_HUMAN
PTPRK protein
PTPRK
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMV4E9PMV4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDP9H0YDP9_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD44H0YD44_HUMAN
Receptor-type tyrosine-protein phos...
PTPRK
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9L → V in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti158T → S in CAA94519 (PubMed:8663237).Curated1
Sequence conflicti284A → P in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti422T → S in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti672 – 674AEL → CRT in AAC37599 (PubMed:9047348).Curated3
Sequence conflicti715S → T in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti1366E → K in AAC37599 (PubMed:9047348).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024819732A → AA in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_054480831Y → LPNDPLVPTAVLVPITD in isoform 4. 1 Publication1
Alternative sequenceiVSP_042049946I → IDIWLYR in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z70660 mRNA Translation: CAA94519.1
L77886 mRNA Translation: AAC37599.1
AL035470 Genomic DNA No translation available.
AL034349 Genomic DNA No translation available.
AL590006 Genomic DNA No translation available.
AL451073 Genomic DNA No translation available.
AL357621 Genomic DNA No translation available.
AL035465 Genomic DNA No translation available.
AL035594 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48086.1
BC140775 mRNA Translation: AAI40776.1
BC144512 mRNA Translation: AAI44513.1
BC144513 mRNA Translation: AAI44514.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47473.1 [Q15262-3]
CCDS5137.1 [Q15262-2]
CCDS75517.1 [Q15262-1]
CCDS78179.1 [Q15262-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC6312

NCBI Reference Sequences

More...
RefSeqi
NP_001129120.1, NM_001135648.2 [Q15262-3]
NP_001278910.1, NM_001291981.1 [Q15262-4]
NP_001278913.1, NM_001291984.1 [Q15262-1]
NP_002835.2, NM_002844.3 [Q15262-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.155919

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368213; ENSP00000357196; ENSG00000152894 [Q15262-3]
ENST00000368215; ENSP00000357198; ENSG00000152894 [Q15262-1]
ENST00000368226; ENSP00000357209; ENSG00000152894 [Q15262-2]
ENST00000532331; ENSP00000432973; ENSG00000152894 [Q15262-4]
ENST00000618215; ENSP00000484742; ENSG00000273993 [Q15262-3]
ENST00000618924; ENSP00000483766; ENSG00000273993 [Q15262-2]
ENST00000619256; ENSP00000477791; ENSG00000273993 [Q15262-4]
ENST00000628183; ENSP00000486442; ENSG00000273993 [Q15262-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5796

UCSC genome browser

More...
UCSCi
uc003qbj.4 human [Q15262-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70660 mRNA Translation: CAA94519.1
L77886 mRNA Translation: AAC37599.1
AL035470 Genomic DNA No translation available.
AL034349 Genomic DNA No translation available.
AL590006 Genomic DNA No translation available.
AL451073 Genomic DNA No translation available.
AL357621 Genomic DNA No translation available.
AL035465 Genomic DNA No translation available.
AL035594 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48086.1
BC140775 mRNA Translation: AAI40776.1
BC144512 mRNA Translation: AAI44513.1
BC144513 mRNA Translation: AAI44514.1
CCDSiCCDS47473.1 [Q15262-3]
CCDS5137.1 [Q15262-2]
CCDS75517.1 [Q15262-1]
CCDS78179.1 [Q15262-4]
PIRiJC6312
RefSeqiNP_001129120.1, NM_001135648.2 [Q15262-3]
NP_001278910.1, NM_001291981.1 [Q15262-4]
NP_001278913.1, NM_001291984.1 [Q15262-1]
NP_002835.2, NM_002844.3 [Q15262-2]
UniGeneiHs.155919

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7SX-ray1.95A865-1154[»]
ProteinModelPortaliQ15262
SMRiQ15262
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111760, 121 interactors
IntActiQ15262, 25 interactors
MINTiQ15262
STRINGi9606.ENSP00000357196

PTM databases

DEPODiQ15262
GlyConnecti1709
iPTMnetiQ15262
PhosphoSitePlusiQ15262

Polymorphism and mutation databases

BioMutaiPTPRK
DMDMi146345496

Proteomic databases

EPDiQ15262
jPOSTiQ15262
MaxQBiQ15262
PaxDbiQ15262
PeptideAtlasiQ15262
PRIDEiQ15262
ProteomicsDBi60503
60504 [Q15262-2]
60505 [Q15262-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5796
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368213; ENSP00000357196; ENSG00000152894 [Q15262-3]
ENST00000368215; ENSP00000357198; ENSG00000152894 [Q15262-1]
ENST00000368226; ENSP00000357209; ENSG00000152894 [Q15262-2]
ENST00000532331; ENSP00000432973; ENSG00000152894 [Q15262-4]
ENST00000618215; ENSP00000484742; ENSG00000273993 [Q15262-3]
ENST00000618924; ENSP00000483766; ENSG00000273993 [Q15262-2]
ENST00000619256; ENSP00000477791; ENSG00000273993 [Q15262-4]
ENST00000628183; ENSP00000486442; ENSG00000273993 [Q15262-1]
GeneIDi5796
KEGGihsa:5796
UCSCiuc003qbj.4 human [Q15262-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5796
DisGeNETi5796
EuPathDBiHostDB:ENSG00000152894.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRK

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006208
HIX0033189
HGNCiHGNC:9674 PTPRK
HPAiHPA054056
HPA054822
MIMi602545 gene
neXtProtiNX_Q15262
OpenTargetsiENSG00000152894
PharmGKBiPA34019

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000156249
HOGENOMiHOG000049029
HOVERGENiHBG062785
InParanoidiQ15262
KOiK06776
OrthoDBi411281at2759
PhylomeDBiQ15262
TreeFamiTF312900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-182971 EGFR downregulation
SignaLinkiQ15262
SIGNORiQ15262

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRK human
EvolutionaryTraceiQ15262

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPRK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5796

Protein Ontology

More...
PROi
PR:Q15262

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152894 Expressed in 232 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ15262 baseline and differential
GenevisibleiQ15262 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 1 hit
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 1 hit
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15262
Secondary accession number(s): B2RTQ8
, B7ZMG0, Q14763, Q5TG10, Q5TG11
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: February 13, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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