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Entry version 179 (16 Oct 2019)
Sequence version 3 (17 Oct 2006)
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Protein

Serine/threonine-protein phosphatase 2A activator

Gene

PTPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg2+ (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi183 – 189ATP7
Nucleotide bindingi240 – 242ATP3
Nucleotide bindingi342 – 343ATP2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15257

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator (EC:5.2.1.8)
Alternative name(s):
PP2A, subunit B', PR53 isoform
Phosphotyrosyl phosphatase activator
Short name:
PTPA
Serine/threonine-protein phosphatase 2A regulatory subunit 4
Serine/threonine-protein phosphatase 2A regulatory subunit B'
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPAImported
Synonyms:PPP2R4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9308 PTPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600756 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15257

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi185D → A: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi239A → D: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi240G → D: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi244V → D: Impairs interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi305E → A: Abolishes interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi316V → D: Impairs interaction with the PP2A(D) complex. 1
Mutagenesisi325G → D: Abolishes interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi329M → D: Abolishes interaction with the PP2A(D) complex. 1 Publication1
Mutagenesisi337K → G: Impairs interaction with the PP2A(D) complex. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5524

Open Targets

More...
OpenTargetsi
ENSG00000119383

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33671

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15257

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2505

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715242 – 358Serine/threonine-protein phosphatase 2A activatorAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-259
CPTAC-260

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15257

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15257

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15257

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15257

PeptideAtlas

More...
PeptideAtlasi
Q15257

PRoteomics IDEntifications database

More...
PRIDEi
Q15257

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60499 [Q15257-1]
60500 [Q15257-2]
60501 [Q15257-3]
60502 [Q15257-4]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q15257

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15257

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15257

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15257

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119383 Expressed in 235 organ(s), highest expression level in endometrium epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15257 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15257 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022068
CAB035999
HPA005695

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A) (PubMed:16916641).

Interacts with PPP2CB (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTQ4VCS5-23EBI-1774121,EBI-3891843

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111516, 75 interactors

Protein interaction database and analysis system

More...
IntActi
Q15257, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377036

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15257

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15257

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15257

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011500

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15257

KEGG Orthology (KO)

More...
KOi
K17605

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGWGDCC

Database of Orthologous Groups

More...
OrthoDBi
1165705at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15257

TreeFam database of animal gene trees

More...
TreeFami
TF105555

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04087 PTPA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004327 Phstyr_phstse_ac
IPR037218 PTPA_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10012 PTHR10012, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03095 PTPA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016325 Phstyr_phstse_ac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140984 SSF140984, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q15257-1) [UniParc]FASTAAdd to basket
Also known as: Beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG
60 70 80 90 100
FILTLNEGVK GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA
110 120 130 140 150
GHCAPSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE
160 170 180 190 200
AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC
210 220 230 240 250
LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF
260 270 280 290 300
QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT
310 320 330 340 350
GPFAEHSNQL WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL

PIHPVTSG
Length:358
Mass (Da):40,668
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A962521AF5B4CF7
GO
Isoform 1 (identifier: Q15257-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     73-107: Missing.

Show »
Length:323
Mass (Da):36,775
Checksum:iEA0D7B96FB88CC01
GO
Isoform 3 (identifier: Q15257-3) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     45-108: Missing.

Show »
Length:294
Mass (Da):33,467
Checksum:i12C8B0D3D96A490B
GO
Isoform 4 (identifier: Q15257-4) [UniParc]FASTAAdd to basket
Also known as: Epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     73-149: Missing.

Show »
Length:281
Mass (Da):31,859
Checksum:i9C554DF39A3436B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVN5A6PVN5_HUMAN
Serine/threonine-protein phosphatas...
PTPA
329Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WIT2F6WIT2_HUMAN
Serine/threonine-protein phosphatas...
PTPA
288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVN9A6PVN9_HUMAN
Serine/threonine-protein phosphatas...
PTPA
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVN6A6PVN6_HUMAN
Serine/threonine-protein phosphatas...
PTPA
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6E5H0Y6E5_HUMAN
Serine/threonine-protein phosphatas...
PTPA
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q68CR8Q68CR8_HUMAN
Serine/threonine-protein phosphatas...
PTPA DKFZp781M17165
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T949Q5T949_HUMAN
Serine/threonine-protein phosphatas...
PTPA
250Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBP7B7ZBP7_HUMAN
Serine/threonine-protein phosphatas...
PTPA
77Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T948Q5T948_HUMAN
Serine/threonine-protein phosphatas...
PTPA
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DDQ6B4DDQ6_HUMAN
Serine/threonine-protein phosphatas...
PTPA
151Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113V → L in CAA51873 (PubMed:8195217).Curated1
Sequence conflicti113V → L in CAA60163 (PubMed:8530035).Curated1
Sequence conflicti113V → L in CAB77601 (PubMed:10880964).Curated1
Sequence conflicti113V → L in CAB77602 (PubMed:10880964).Curated1
Sequence conflicti297Missing in CAA60163 (PubMed:8530035).Curated1
Sequence conflicti297Missing in CAB77601 (PubMed:10880964).Curated1
Sequence conflicti297Missing in CAB77602 (PubMed:10880964).Curated1
Sequence conflicti297Missing in CAB77603 (PubMed:10880964).Curated1
Sequence conflicti357S → V AA sequence (PubMed:8195217).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02810128K → R. Corresponds to variant dbSNP:rs17481693Ensembl.1
Natural variantiVAR_028102208R → Q. Corresponds to variant dbSNP:rs4836639Ensembl.1
Natural variantiVAR_028103357S → L1 PublicationCorresponds to variant dbSNP:rs2480452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00512245 – 108Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_00512473 – 149Missing in isoform 4. CuratedAdd BLAST77
Alternative sequenceiVSP_00512373 – 107Missing in isoform 1. 4 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X73478 mRNA Translation: CAA51873.1
X86428
, X86429, X86430, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAA60163.1
X86428
, X86429, X86430, X86431, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77601.1
X86428
, X86429, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77602.1
X86428
, X86429, X86430, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77603.1
AK302043 mRNA Translation: BAG63436.1
BT020119 mRNA Translation: AAV38922.1
AK222788 mRNA Translation: BAD96508.1
AL158151 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87876.1
CH471090 Genomic DNA Translation: EAW87882.1
BC002545 mRNA Translation: AAH02545.1
BC011605 mRNA Translation: AAH11605.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS65156.1 [Q15257-3]
CCDS6920.1 [Q15257-2]

Protein sequence database of the Protein Information Resource

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PIRi
A54021

NCBI Reference Sequences

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RefSeqi
NP_001180326.1, NM_001193397.1
NP_001258761.1, NM_001271832.1 [Q15257-3]
NP_066954.2, NM_021131.4 [Q15257-2]
NP_821067.1, NM_178000.2 [Q15257-2]
NP_821068.1, NM_178001.2 [Q15257-1]
NP_821070.1, NM_178003.2 [Q15257-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337738; ENSP00000337448; ENSG00000119383 [Q15257-1]
ENST00000355007; ENSP00000347109; ENSG00000119383 [Q15257-4]
ENST00000357197; ENSP00000349726; ENSG00000119383 [Q15257-3]
ENST00000358994; ENSP00000351885; ENSG00000119383 [Q15257-2]
ENST00000393370; ENSP00000377036; ENSG00000119383 [Q15257-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5524

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5524

UCSC genome browser

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UCSCi
uc004bxl.3 human [Q15257-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73478 mRNA Translation: CAA51873.1
X86428
, X86429, X86430, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAA60163.1
X86428
, X86429, X86430, X86431, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77601.1
X86428
, X86429, X86432, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77602.1
X86428
, X86429, X86430, X86434, X86435, X86436, X86437, X86438, X86439 Genomic DNA Translation: CAB77603.1
AK302043 mRNA Translation: BAG63436.1
BT020119 mRNA Translation: AAV38922.1
AK222788 mRNA Translation: BAD96508.1
AL158151 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87876.1
CH471090 Genomic DNA Translation: EAW87882.1
BC002545 mRNA Translation: AAH02545.1
BC011605 mRNA Translation: AAH11605.1
CCDSiCCDS65156.1 [Q15257-3]
CCDS6920.1 [Q15257-2]
PIRiA54021
RefSeqiNP_001180326.1, NM_001193397.1
NP_001258761.1, NM_001271832.1 [Q15257-3]
NP_066954.2, NM_021131.4 [Q15257-2]
NP_821067.1, NM_178000.2 [Q15257-2]
NP_821068.1, NM_178001.2 [Q15257-1]
NP_821070.1, NM_178003.2 [Q15257-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G62X-ray1.60A22-358[»]
2HV6X-ray1.90A/B1-358[»]
2HV7X-ray2.50A/B/C/D/E/F/G/H1-358[»]
2IXMX-ray1.50A20-357[»]
4LACX-ray2.82B19-358[»]
4NY3X-ray1.80A/B22-358[»]
SMRiQ15257
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111516, 75 interactors
IntActiQ15257, 21 interactors
STRINGi9606.ENSP00000377036

Chemistry databases

BindingDBiQ15257
ChEMBLiCHEMBL2505

PTM databases

iPTMnetiQ15257
PhosphoSitePlusiQ15257
SwissPalmiQ15257

Polymorphism and mutation databases

BioMutaiPTPA
DMDMi116242737

2D gel databases

OGPiQ15257

Proteomic databases

CPTACiCPTAC-259
CPTAC-260
EPDiQ15257
jPOSTiQ15257
MassIVEiQ15257
MaxQBiQ15257
PeptideAtlasiQ15257
PRIDEiQ15257
ProteomicsDBi60499 [Q15257-1]
60500 [Q15257-2]
60501 [Q15257-3]
60502 [Q15257-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5524

Genome annotation databases

EnsembliENST00000337738; ENSP00000337448; ENSG00000119383 [Q15257-1]
ENST00000355007; ENSP00000347109; ENSG00000119383 [Q15257-4]
ENST00000357197; ENSP00000349726; ENSG00000119383 [Q15257-3]
ENST00000358994; ENSP00000351885; ENSG00000119383 [Q15257-2]
ENST00000393370; ENSP00000377036; ENSG00000119383 [Q15257-2]
GeneIDi5524
KEGGihsa:5524
UCSCiuc004bxl.3 human [Q15257-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5524
DisGeNETi5524

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPA
HGNCiHGNC:9308 PTPA
HPAiCAB022068
CAB035999
HPA005695
MIMi600756 gene
neXtProtiNX_Q15257
OpenTargetsiENSG00000119383
PharmGKBiPA33671

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000011500
InParanoidiQ15257
KOiK17605
OMAiTGWGDCC
OrthoDBi1165705at2759
PhylomeDBiQ15257
TreeFamiTF105555

Enzyme and pathway databases

SIGNORiQ15257

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPA human
EvolutionaryTraceiQ15257

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPP2R4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5524
PharosiQ15257

Protein Ontology

More...
PROi
PR:Q15257

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119383 Expressed in 235 organ(s), highest expression level in endometrium epithelium
ExpressionAtlasiQ15257 baseline and differential
GenevisibleiQ15257 HS

Family and domain databases

CDDicd04087 PTPA, 1 hit
InterProiView protein in InterPro
IPR004327 Phstyr_phstse_ac
IPR037218 PTPA_sf
PANTHERiPTHR10012 PTHR10012, 1 hit
PfamiView protein in Pfam
PF03095 PTPA, 1 hit
PIRSFiPIRSF016325 Phstyr_phstse_ac, 1 hit
SUPFAMiSSF140984 SSF140984, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15257
Secondary accession number(s): A2A347
, A9IZU4, B4DXM4, Q15258, Q53GZ3, Q5TZQ2, Q9BUK1, Q9NNZ7, Q9NNZ8, Q9NNZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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