Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pregnancy-specific beta-1-glycoprotein 5

Gene

PSG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 5
Short name:
PS-beta-G-5
Short name:
PSBG-5
Short name:
Pregnancy-specific glycoprotein 5
Alternative name(s):
Fetal liver non-specific cross-reactive antigen 3
Short name:
FL-NCA-3
Gene namesi
Name:PSG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000204941.13
HGNCiHGNC:9522 PSG5
MIMi176394 gene
neXtProtiNX_Q15238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5673
OpenTargetsiENSG00000204941
PharmGKBiPA33867

Polymorphism and mutation databases

BioMutaiPSG5
DMDMi311033414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491235 – 335Pregnancy-specific beta-1-glycoprotein 5Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15238
PeptideAtlasiQ15238
PRIDEiQ15238
ProteomicsDBi60495

PTM databases

iPTMnetiQ15238
PhosphoSitePlusiQ15238

Expressioni

Tissue specificityi

Synthesized by syncytiotrophoblast of the placenta.

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000204941 Expressed in 112 organ(s), highest expression level in chorionic villus
CleanExiHS_PSG5
ExpressionAtlasiQ15238 baseline and differential
GenevisibleiQ15238 HS

Organism-specific databases

HPAiHPA046327

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TIE1P355903EBI-4314891,EBI-2256865

Protein-protein interaction databases

BioGridi111648, 4 interactors
IntActiQ15238, 3 interactors
MINTiQ15238
STRINGi9606.ENSP00000344413

Structurei

3D structure databases

ProteinModelPortaliQ15238
SMRiQ15238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini239 – 317Ig-like C2-type 2Add BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ15238
KOiK06500
PhylomeDBiQ15238
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY
160 170 180 190 200
ITINNSKPRE NKDVLAFTCE PKSENYTYIW WLNGQSLPVS PRVKRPIENR
210 220 230 240 250
ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD LPSIYPSFTY
260 270 280 290 300
YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT
310 320 330
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI
Length:335
Mass (Da):37,713
Last modified:November 2, 2010 - v3
Checksum:iE14EA6E9DAA88296
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1G9M0R1G9_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG5
428Annotation score:
E7EQY3E7EQY3_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG5
333Annotation score:
E9PC55E9PC55_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG5
157Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15W → C in AAA60205 (PubMed:1922019).Curated1
Sequence conflicti20L → V in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti195R → Q no nucleotide entry (PubMed:2789512).Curated1
Sequence conflicti195R → Q in AAH12607 (PubMed:15489334).Curated1
Sequence conflicti232T → S in AAA60205 (PubMed:1922019).Curated1
Sequence conflicti232T → S in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti240D → Y in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti288I → M in AAA36514 (PubMed:2735907).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06026018L → V4 PublicationsCorresponds to variant dbSNP:rs8107936Ensembl.1
Natural variantiVAR_016041154N → K2 PublicationsCorresponds to variant dbSNP:rs1058259Ensembl.1
Natural variantiVAR_060261168T → I. Corresponds to variant dbSNP:rs5013158Ensembl.1
Natural variantiVAR_060262227R → H4 PublicationsCorresponds to variant dbSNP:rs1058285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA Translation: AAA60205.1
M25384 mRNA Translation: AAA36514.1
AC005392 Genomic DNA No translation available.
BC012607 mRNA Translation: AAH12607.1
AH007626 Genomic DNA Translation: AAD28500.1
CCDSiCCDS12617.1
PIRiA33514
B33251
C54312
RefSeqiNP_001123486.1, NM_001130014.1
NP_002772.3, NM_002781.3
XP_016882492.1, XM_017027003.1
UniGeneiHs.654415

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941
ENST00000366175; ENSP00000382334; ENSG00000204941
ENST00000407356; ENSP00000386008; ENSG00000204941
GeneIDi5673
KEGGihsa:5673
UCSCiuc002ovu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA Translation: AAA60205.1
M25384 mRNA Translation: AAA36514.1
AC005392 Genomic DNA No translation available.
BC012607 mRNA Translation: AAH12607.1
AH007626 Genomic DNA Translation: AAD28500.1
CCDSiCCDS12617.1
PIRiA33514
B33251
C54312
RefSeqiNP_001123486.1, NM_001130014.1
NP_002772.3, NM_002781.3
XP_016882492.1, XM_017027003.1
UniGeneiHs.654415

3D structure databases

ProteinModelPortaliQ15238
SMRiQ15238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111648, 4 interactors
IntActiQ15238, 3 interactors
MINTiQ15238
STRINGi9606.ENSP00000344413

PTM databases

iPTMnetiQ15238
PhosphoSitePlusiQ15238

Polymorphism and mutation databases

BioMutaiPSG5
DMDMi311033414

Proteomic databases

PaxDbiQ15238
PeptideAtlasiQ15238
PRIDEiQ15238
ProteomicsDBi60495

Protocols and materials databases

DNASUi5673
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941
ENST00000366175; ENSP00000382334; ENSG00000204941
ENST00000407356; ENSP00000386008; ENSG00000204941
GeneIDi5673
KEGGihsa:5673
UCSCiuc002ovu.4 human

Organism-specific databases

CTDi5673
DisGeNETi5673
EuPathDBiHostDB:ENSG00000204941.13
GeneCardsiPSG5
H-InvDBiHIX0096869
HGNCiHGNC:9522 PSG5
HPAiHPA046327
MIMi176394 gene
neXtProtiNX_Q15238
OpenTargetsiENSG00000204941
PharmGKBiPA33867
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ15238
KOiK06500
PhylomeDBiQ15238
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

GeneWikiiPSG5
GenomeRNAii5673
PROiPR:Q15238
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204941 Expressed in 112 organ(s), highest expression level in chorionic villus
CleanExiHS_PSG5
ExpressionAtlasiQ15238 baseline and differential
GenevisibleiQ15238 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG5_HUMAN
AccessioniPrimary (citable) accession number: Q15238
Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: September 12, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again