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Protein

Inorganic pyrophosphatase

Gene

PPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi116Magnesium 1By similarity1
Metal bindingi121Magnesium 1By similarity1
Metal bindingi121Magnesium 2By similarity1
Metal bindingi153Magnesium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-71737 Pyrophosphate hydrolysis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPA1
Synonyms:IOPPP, PP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180817.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9226 PPA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
179030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15181

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5464

Open Targets

More...
OpenTargetsi
ENSG00000180817

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33550

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
8247940

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001375672 – 289Inorganic pyrophosphataseAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1
Modified residuei228N6-acetyllysineCombined sources1
Modified residuei250PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15181

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15181

PeptideAtlas

More...
PeptideAtlasi
Q15181

PRoteomics IDEntifications database

More...
PRIDEi
Q15181

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60485

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q15181

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00015018

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15181

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180817 Expressed in 225 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPA1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15181 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15181 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019878
HPA020096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111460, 46 interactors

Protein interaction database and analysis system

More...
IntActi
Q15181, 16 interactors

Molecular INTeraction database

More...
MINTi
Q15181

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362329

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q15181

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1626 Eukaryota
COG0221 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017004

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000195569

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000491

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15181

KEGG Orthology (KO)

More...
KOi
K01507

Identification of Orthologs from Complete Genome Data

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OMAi
CDSACTV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0KFV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15181

TreeFam database of animal gene trees

More...
TreeFami
TF300887

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00412 pyrophosphatase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10286 PTHR10286, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00719 Pyrophosphatase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50324 SSF50324, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00387 PPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFSTEERA APFSLEYRVF LKNEKGQYIS PFHDIPIYAD KDVFHMVVEV
60 70 80 90 100
PRWSNAKMEI ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT
110 120 130 140 150
WEDPGHNDKH TGCCGDNDPI DVCEIGSKVC ARGEIIGVKV LGILAMIDEG
160 170 180 190 200
ETDWKVIAIN VDDPDAANYN DINDVKRLKP GYLEATVDWF RRYKVPDGKP
210 220 230 240 250
ENEFAFNAEF KDKDFAIDII KSTHDHWKAL VTKKTNGKGI SCMNTTLSES
260 270 280
PFKCDPDAAR AIVDALPPPC ESACTVPTDV DKWFHHQKN
Length:289
Mass (Da):32,660
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3973C9E6F8CA5CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQT6Q5SQT6_HUMAN
Inorganic pyrophosphatase
PPA1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12P → A in AAD24964 (Ref. 8) Curated1
Sequence conflicti84L → I in CAA88494 (Ref. 10) Curated1
Sequence conflicti96 – 97AI → TL in CAA88494 (Ref. 10) Curated2
Sequence conflicti105 – 114GHNDKHTGCC → HEKDKSTNCF in CAA88494 (Ref. 10) Curated10
Sequence conflicti129 – 140VCARG…IGVKV → ILSCGEVIHVKI in CAA88494 (Ref. 10) CuratedAdd BLAST12
Sequence conflicti146M → L in CAA88494 (Ref. 10) Curated1
Sequence conflicti156V → L in CAA88494 (Ref. 10) Curated1
Sequence conflicti161 – 162VD → AN in CAA88494 (Ref. 10) Curated2
Sequence conflicti165 – 173DAANYNDIN → EASKFHDID in CAA88494 (Ref. 10) Curated9
Sequence conflicti177 – 178RL → KF in CAA88494 (Ref. 10) Curated2
Sequence conflicti187 – 188VD → LN in CAA88494 (Ref. 10) Curated2
Sequence conflicti192R → L in CAA88494 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03635857K → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF154065 mRNA Translation: AAD34643.1
AB026723 mRNA Translation: BAA84702.1
AF217186 mRNA Translation: AAG36780.1
AF092439 mRNA Translation: AAP97214.1
AF119665 mRNA Translation: AAF17222.1
AL731540 Genomic DNA No translation available.
BC001022 mRNA Translation: AAH01022.3
BC061581 mRNA Translation: AAH61581.2
BC105034 mRNA Translation: AAI05035.1
BC105036 mRNA Translation: AAI05037.1
BC107882 mRNA Translation: AAI07883.1
AF108211 mRNA Translation: AAD24964.1
Z48605 mRNA Translation: CAA88494.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7299.1

NCBI Reference Sequences

More...
RefSeqi
NP_066952.1, NM_021129.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.437403

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373232; ENSP00000362329; ENSG00000180817

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5464

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154065 mRNA Translation: AAD34643.1
AB026723 mRNA Translation: BAA84702.1
AF217186 mRNA Translation: AAG36780.1
AF092439 mRNA Translation: AAP97214.1
AF119665 mRNA Translation: AAF17222.1
AL731540 Genomic DNA No translation available.
BC001022 mRNA Translation: AAH01022.3
BC061581 mRNA Translation: AAH61581.2
BC105034 mRNA Translation: AAI05035.1
BC105036 mRNA Translation: AAI05037.1
BC107882 mRNA Translation: AAI07883.1
AF108211 mRNA Translation: AAD24964.1
Z48605 mRNA Translation: CAA88494.1
CCDSiCCDS7299.1
RefSeqiNP_066952.1, NM_021129.3
UniGeneiHs.437403

3D structure databases

ProteinModelPortaliQ15181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111460, 46 interactors
IntActiQ15181, 16 interactors
MINTiQ15181
STRINGi9606.ENSP00000362329

PTM databases

iPTMnetiQ15181
PhosphoSitePlusiQ15181

Polymorphism and mutation databases

BioMutaiPPA1
DMDMi8247940

2D gel databases

REPRODUCTION-2DPAGEiIPI00015018

Proteomic databases

EPDiQ15181
PaxDbiQ15181
PeptideAtlasiQ15181
PRIDEiQ15181
ProteomicsDBi60485
TopDownProteomicsiQ15181

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5464
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373232; ENSP00000362329; ENSG00000180817
GeneIDi5464
KEGGihsa:5464

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5464
DisGeNETi5464
EuPathDBiHostDB:ENSG00000180817.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPA1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0032502
HGNCiHGNC:9226 PPA1
HPAiHPA019878
HPA020096
MIMi179030 gene
neXtProtiNX_Q15181
OpenTargetsiENSG00000180817
PharmGKBiPA33550

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1626 Eukaryota
COG0221 LUCA
GeneTreeiENSGT00390000017004
HOGENOMiHOG000195569
HOVERGENiHBG000491
InParanoidiQ15181
KOiK01507
OMAiCDSACTV
OrthoDBiEOG091G0KFV
PhylomeDBiQ15181
TreeFamiTF300887

Enzyme and pathway databases

BRENDAi3.6.1.1 2681
ReactomeiR-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-71737 Pyrophosphate hydrolysis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPA1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5464

Protein Ontology

More...
PROi
PR:Q15181

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180817 Expressed in 225 organ(s), highest expression level in endometrium
CleanExiHS_PPA1
ExpressionAtlasiQ15181 baseline and differential
GenevisibleiQ15181 HS

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPYR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15181
Secondary accession number(s): Q2M348
, Q5SQT7, Q6P7P4, Q9UQJ5, Q9Y5B1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: December 5, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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