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Protein

Serum paraoxonase/lactonase 3

Gene

PON3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.1 Publication

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
3.1.8.1 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/lactonase 3 (EC:3.1.1.2, EC:3.1.1.81, EC:3.1.8.1)
Gene namesi
Name:PON3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105852.10
HGNCiHGNC:9206 PON3
MIMi602720 gene
neXtProtiNX_Q15166

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5446
MalaCardsiPON3
OpenTargetsiENSG00000105852
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33531

Chemistry databases

DrugBankiDB00974 Edetic Acid
DB00227 Lovastatin

Polymorphism and mutation databases

BioMutaiPON3
DMDMi50403778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232901 – 354Serum paraoxonase/lactonase 3Add BLAST354
Signal peptidei1 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 352By similarity
Modified residuei165PhosphoserineCombined sources1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15166
MaxQBiQ15166
PaxDbiQ15166
PeptideAtlasiQ15166
PRIDEiQ15166
ProteomicsDBi60478

PTM databases

iPTMnetiQ15166
PhosphoSitePlusiQ15166

Expressioni

Gene expression databases

BgeeiENSG00000105852 Expressed in 135 organ(s), highest expression level in liver
CleanExiHS_PON3
ExpressionAtlasiQ15166 baseline and differential
GenevisibleiQ15166 HS

Organism-specific databases

HPAiCAB025250
HPA014848

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111442, 2 interactors
IntActiQ15166, 1 interactor
STRINGi9606.ENSP00000265627

Structurei

3D structure databases

ProteinModelPortaliQ15166
SMRiQ15166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOVERGENiHBG003604
InParanoidiQ15166
KOiK01045
OMAiYATRDHY
OrthoDBiEOG091G0AV9
PhylomeDBiQ15166
TreeFamiTF322436

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKLVALVLL GVGLSLVGEM FLAFRERVNA SREVEPVEPE NCHLIEELES
60 70 80 90 100
GSEDIDILPS GLAFISSGLK YPGMPNFAPD EPGKIFLMDL NEQNPRAQAL
110 120 130 140 150
EISGGFDKEL FNPHGISIFI DKDNTVYLYV VNHPHMKSTV EIFKFEEQQR
160 170 180 190 200
SLVYLKTIKH ELLKSVNDIV VLGPEQFYAT RDHYFTNSLL SFFEMILDLR
210 220 230 240 250
WTYVLFYSPR EVKVVAKGFC SANGITVSAD QKYVYVADVA AKNIHIMEKH
260 270 280 290 300
DNWDLTQLKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LNYNPEDPPG
310 320 330 340 350
SEVLRIQNVL SEKPRVSTVY ANNGSVLQGT SVASVYHGKI LIGTVFHKTL

YCEL
Length:354
Mass (Da):39,607
Last modified:July 19, 2004 - v3
Checksum:i1B861B35E8533921
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZ99C9JZ99_HUMAN
Serum paraoxonase/lactonase 3
PON3
245Annotation score:
F8WD41F8WD41_HUMAN
Serum paraoxonase/lactonase 3
PON3
270Annotation score:
F8WBV4F8WBV4_HUMAN
Serum paraoxonase/lactonase 3
PON3
61Annotation score:
F2Z2L3F2Z2L3_HUMAN
Serum paraoxonase/lactonase 3
PON3
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18G → E in AAC41996 (PubMed:8661009).Curated1
Sequence conflicti32R → Q in AAC41996 (PubMed:8661009).Curated1
Sequence conflicti50S → N in AAH70374 (PubMed:15489334).Curated1
Sequence conflicti58 – 59LP → FL in AAK07629 (Ref. 1) Curated2
Sequence conflicti63A → S in AAC41996 (PubMed:8661009).Curated1
Sequence conflicti68G → E in AAC41996 (PubMed:8661009).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021082146E → K1 PublicationCorresponds to variant dbSNP:rs17878827Ensembl.1
Natural variantiVAR_021083179A → D1 PublicationCorresponds to variant dbSNP:rs17883013Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320003 mRNA Translation: AAK07629.1
AF329433 mRNA Translation: AAO15365.1
AY805220 Genomic DNA Translation: AAV50000.1
AC004022 Genomic DNA No translation available.
AC005021 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24132.1
CH471091 Genomic DNA Translation: EAW76768.1
BC070374 mRNA Translation: AAH70374.1
L48516 mRNA Translation: AAC41996.1
CCDSiCCDS5639.1
RefSeqiNP_000931.1, NM_000940.2
UniGeneiHs.440967

Genome annotation databases

EnsembliENST00000265627; ENSP00000265627; ENSG00000105852
GeneIDi5446
KEGGihsa:5446
UCSCiuc003unt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320003 mRNA Translation: AAK07629.1
AF329433 mRNA Translation: AAO15365.1
AY805220 Genomic DNA Translation: AAV50000.1
AC004022 Genomic DNA No translation available.
AC005021 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24132.1
CH471091 Genomic DNA Translation: EAW76768.1
BC070374 mRNA Translation: AAH70374.1
L48516 mRNA Translation: AAC41996.1
CCDSiCCDS5639.1
RefSeqiNP_000931.1, NM_000940.2
UniGeneiHs.440967

3D structure databases

ProteinModelPortaliQ15166
SMRiQ15166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111442, 2 interactors
IntActiQ15166, 1 interactor
STRINGi9606.ENSP00000265627

Chemistry databases

DrugBankiDB00974 Edetic Acid
DB00227 Lovastatin

PTM databases

iPTMnetiQ15166
PhosphoSitePlusiQ15166

Polymorphism and mutation databases

BioMutaiPON3
DMDMi50403778

Proteomic databases

EPDiQ15166
MaxQBiQ15166
PaxDbiQ15166
PeptideAtlasiQ15166
PRIDEiQ15166
ProteomicsDBi60478

Protocols and materials databases

DNASUi5446
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265627; ENSP00000265627; ENSG00000105852
GeneIDi5446
KEGGihsa:5446
UCSCiuc003unt.4 human

Organism-specific databases

CTDi5446
DisGeNETi5446
EuPathDBiHostDB:ENSG00000105852.10
GeneCardsiPON3
HGNCiHGNC:9206 PON3
HPAiCAB025250
HPA014848
MalaCardsiPON3
MIMi602720 gene
neXtProtiNX_Q15166
OpenTargetsiENSG00000105852
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33531
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOVERGENiHBG003604
InParanoidiQ15166
KOiK01045
OMAiYATRDHY
OrthoDBiEOG091G0AV9
PhylomeDBiQ15166
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
3.1.8.1 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids

Miscellaneous databases

GeneWikiiPON3
GenomeRNAii5446
PROiPR:Q15166
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105852 Expressed in 135 organ(s), highest expression level in liver
CleanExiHS_PON3
ExpressionAtlasiQ15166 baseline and differential
GenevisibleiQ15166 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2
ProtoNetiSearch...

Entry informationi

Entry nameiPON3_HUMAN
AccessioniPrimary (citable) accession number: Q15166
Secondary accession number(s): A4D1H8
, O75855, O76060, Q6IRU9, Q8IX97, Q9BZH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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