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Entry version 176 (13 Nov 2019)
Sequence version 4 (28 Mar 2018)
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Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.2 2681
3.1.1.25 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15165

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PON2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9205 PON2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602447 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15165

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5445

MalaCards human disease database

More...
MalaCardsi
PON2

Open Targets

More...
OpenTargetsi
ENSG00000105854

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33530

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15165

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PON2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325511384

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002232871 – 354Serum paraoxonase/arylesterase 2Add BLAST354
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 352By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15165

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15165

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15165

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15165

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15165

PeptideAtlas

More...
PeptideAtlasi
Q15165

PRoteomics IDEntifications database

More...
PRIDEi
Q15165

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60475 [Q15165-2]
60476 [Q15165-1]
60477 [Q15165-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1741

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15165

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15165

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15165

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105854 Expressed in 230 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15165 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15165 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025430
HPA029193

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111441, 98 interactors

Database of interacting proteins

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DIPi
DIP-61136N

Protein interaction database and analysis system

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IntActi
Q15165, 67 interactors

Molecular INTeraction database

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MINTi
Q15165

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15165

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHDV Eukaryota
ENOG4111QK7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008932

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15165

KEGG Orthology (KO)

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KOi
K01045

Database of Orthologous Groups

More...
OrthoDBi
888266at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15165

TreeFam database of animal gene trees

More...
TreeFami
TF322436

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01731 Arylesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01785 PARAOXONASE
PR01787 PARAOXONASE2

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA
60 70 80 90 100
GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL
110 120 130 140 150
RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN
160 170 180 190 200
SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH
260 270 280 290 300
TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS
310 320 330 340 350
SEVLRIQNIL SEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL

YCEL
Length:354
Mass (Da):39,381
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05CEDC91C1B6BC2A
GO
Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

Show »
Length:354
Mass (Da):39,382
Checksum:iAAA198182C01D89D
GO
Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-134: Missing.

Show »
Length:342
Mass (Da):37,980
Checksum:i71F47B2B1C441500
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YXF2A0A0J9YXF2_HUMAN
Paraoxonase 2, isoform CRA_a
PON2 hCG_1640820
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XAK4G3XAK4_HUMAN
Paraoxonase 2, isoform CRA_c
PON2 hCG_1640820
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXU7A0A0J9YXU7_HUMAN
Serum paraoxonase/arylesterase 2
PON2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYJ1A0A0J9YYJ1_HUMAN
Serum paraoxonase/arylesterase 2
PON2
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXM1A0A0J9YXM1_HUMAN
Serum paraoxonase/arylesterase 2
PON2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYF0A0A0J9YYF0_HUMAN
Serum paraoxonase/arylesterase 2
PON2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYF3A0A0J9YYF3_HUMAN
Serum paraoxonase/arylesterase 2
PON2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVW3A0A0J9YVW3_HUMAN
Serum paraoxonase/arylesterase 2
PON2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2SAK4A0A2Q2SAK4_HUMAN
Serum paraoxonase/arylesterase 2
PON2
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49 – 50EA → VW in AAC27945 (PubMed:9714608).Curated2
Sequence conflicti53E → D in BAG37646 (PubMed:14702039).Curated1
Sequence conflicti63A → V in BAG58797 (PubMed:14702039).Curated1
Sequence conflicti194E → G in AAC41995 (PubMed:8661009).Curated1
Sequence conflicti282G → V in AAC27944 (PubMed:9714608).Curated1
Sequence conflicti282G → V in BAD89420 (Ref. 3) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Ser-311 is associated with an increased risk of cornary heart disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_006045148A → G Associated with elevated mean fasting plasma glucose level. 3 PublicationsCorresponds to variant dbSNP:rs12026EnsemblClinVar.1
Natural variantiVAR_020786172V → L1 PublicationCorresponds to variant dbSNP:rs17876152Ensembl.1
Natural variantiVAR_006046311S → C1 PublicationCorresponds to variant dbSNP:rs7493EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0045331 – 16MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040715123 – 134Missing in isoform 3. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L48513 mRNA Translation: AAC41995.1
AF001601 mRNA Translation: AAC27944.1
AF001602 mRNA Translation: AAC27945.1
AF001603 Genomic DNA Translation: AAC27946.1
AB102891 mRNA Translation: BAD89420.1
AK291103 mRNA Translation: BAF83792.1
AK296029 mRNA Translation: BAG58797.1
AK315209 mRNA Translation: BAG37646.1
AY210982 Genomic DNA Translation: AAO18083.1
AC005021 Genomic DNA Translation: AAC62431.1
CH236949 Genomic DNA Translation: EAL24131.1
BC040010 mRNA Translation: AAH40010.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47644.1 [Q15165-3]
CCDS5640.1 [Q15165-2]

NCBI Reference Sequences

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RefSeqi
NP_000296.2, NM_000305.2 [Q15165-2]
NP_001018171.1, NM_001018161.1 [Q15165-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000222572; ENSP00000222572; ENSG00000105854 [Q15165-2]
ENST00000433091; ENSP00000404622; ENSG00000105854 [Q15165-3]
ENST00000633531; ENSP00000488838; ENSG00000105854 [Q15165-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5445

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5445

UCSC genome browser

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UCSCi
uc003unv.4 human [Q15165-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA Translation: AAC41995.1
AF001601 mRNA Translation: AAC27944.1
AF001602 mRNA Translation: AAC27945.1
AF001603 Genomic DNA Translation: AAC27946.1
AB102891 mRNA Translation: BAD89420.1
AK291103 mRNA Translation: BAF83792.1
AK296029 mRNA Translation: BAG58797.1
AK315209 mRNA Translation: BAG37646.1
AY210982 Genomic DNA Translation: AAO18083.1
AC005021 Genomic DNA Translation: AAC62431.1
CH236949 Genomic DNA Translation: EAL24131.1
BC040010 mRNA Translation: AAH40010.1
CCDSiCCDS47644.1 [Q15165-3]
CCDS5640.1 [Q15165-2]
RefSeqiNP_000296.2, NM_000305.2 [Q15165-2]
NP_001018171.1, NM_001018161.1 [Q15165-3]

3D structure databases

SMRiQ15165
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111441, 98 interactors
DIPiDIP-61136N
IntActiQ15165, 67 interactors
MINTiQ15165
STRINGi9606.ENSP00000222572

PTM databases

GlyConnecti1741
iPTMnetiQ15165
PhosphoSitePlusiQ15165
SwissPalmiQ15165

Polymorphism and mutation databases

BioMutaiPON2
DMDMi325511384

Proteomic databases

EPDiQ15165
jPOSTiQ15165
MassIVEiQ15165
MaxQBiQ15165
PaxDbiQ15165
PeptideAtlasiQ15165
PRIDEiQ15165
ProteomicsDBi60475 [Q15165-2]
60476 [Q15165-1]
60477 [Q15165-3]

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854 [Q15165-2]
ENST00000433091; ENSP00000404622; ENSG00000105854 [Q15165-3]
ENST00000633531; ENSP00000488838; ENSG00000105854 [Q15165-2]
GeneIDi5445
KEGGihsa:5445
UCSCiuc003unv.4 human [Q15165-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5445
DisGeNETi5445

GeneCards: human genes, protein and diseases

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GeneCardsi
PON2
HGNCiHGNC:9205 PON2
HPAiCAB025430
HPA029193
MalaCardsiPON2
MIMi602447 gene
neXtProtiNX_Q15165
OpenTargetsiENSG00000105854
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33530

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
InParanoidiQ15165
KOiK01045
OrthoDBi888266at2759
PhylomeDBiQ15165
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
SIGNORiQ15165

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PON2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PON2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5445
PharosiQ15165

Protein Ontology

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PROi
PR:Q15165

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105854 Expressed in 230 organ(s), highest expression level in right lung
ExpressionAtlasiQ15165 baseline and differential
GenevisibleiQ15165 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPON2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15165
Secondary accession number(s): A4D1H7
, B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 28, 2018
Last modified: November 13, 2019
This is version 176 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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