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Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

  • acyl-L-homoserine-lactone lactonohydrolase activity Source: Reactome
  • arylesterase activity Source: GO_Central
  • identical protein binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
SIGNORiQ15165

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:PON2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105854.12
HGNCiHGNC:9205 PON2
MIMi602447 gene
neXtProtiNX_Q15165

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5445
MalaCardsiPON2
OpenTargetsiENSG00000105854
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33530

Polymorphism and mutation databases

BioMutaiPON2
DMDMi325511384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232871 – 354Serum paraoxonase/arylesterase 2Add BLAST354
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi254N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15165
MaxQBiQ15165
PaxDbiQ15165
PeptideAtlasiQ15165
PRIDEiQ15165
ProteomicsDBi60475
60476 [Q15165-1]
60477 [Q15165-3]

PTM databases

GlyConnecti1741
iPTMnetiQ15165
PhosphoSitePlusiQ15165
SwissPalmiQ15165

Expressioni

Tissue specificityi

Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

Gene expression databases

BgeeiENSG00000105854 Expressed in 230 organ(s), highest expression level in right lung
CleanExiHS_PON2
ExpressionAtlasiQ15165 baseline and differential
GenevisibleiQ15165 HS

Organism-specific databases

HPAiCAB025430
HPA029193

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111441, 95 interactors
DIPiDIP-61136N
IntActiQ15165, 15 interactors
MINTiQ15165
STRINGi9606.ENSP00000222572

Structurei

3D structure databases

ProteinModelPortaliQ15165
SMRiQ15165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOVERGENiHBG003604
InParanoidiQ15165
KOiK01045
OrthoDBiEOG091G0AV9
PhylomeDBiQ15165
TreeFamiTF322436

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA
60 70 80 90 100
GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL
110 120 130 140 150
RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN
160 170 180 190 200
SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH
260 270 280 290 300
TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS
310 320 330 340 350
SEVLRIQNIL SEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL

YCEL
Length:354
Mass (Da):39,381
Last modified:March 28, 2018 - v4
Checksum:i05CEDC91C1B6BC2A
GO
Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

Show »
Length:354
Mass (Da):39,382
Checksum:iAAA198182C01D89D
GO
Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-134: Missing.

Show »
Length:342
Mass (Da):37,980
Checksum:i71F47B2B1C441500
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YXF2A0A0J9YXF2_HUMAN
Paraoxonase 2, isoform CRA_a
PON2 hCG_1640820
375Annotation score:
J3QT77J3QT77_HUMAN
Serum paraoxonase/arylesterase 2
PON2
342Annotation score:
A0A0J9YYG4A0A0J9YYG4_HUMAN
Serum paraoxonase/arylesterase 2
PON2
354Annotation score:
G3XAK4G3XAK4_HUMAN
Paraoxonase 2, isoform CRA_c
PON2 hCG_1640820
219Annotation score:
A0A0J9YYJ1A0A0J9YYJ1_HUMAN
Serum paraoxonase/arylesterase 2
PON2
122Annotation score:
A0A0J9YXU7A0A0J9YXU7_HUMAN
Serum paraoxonase/arylesterase 2
PON2
113Annotation score:
A0A0J9YYF0A0A0J9YYF0_HUMAN
Serum paraoxonase/arylesterase 2
PON2
53Annotation score:
A0A0J9YYF3A0A0J9YYF3_HUMAN
Serum paraoxonase/arylesterase 2
PON2
69Annotation score:
A0A0J9YVW3A0A0J9YVW3_HUMAN
Serum paraoxonase/arylesterase 2
PON2
32Annotation score:
A0A0J9YXM1A0A0J9YXM1_HUMAN
Serum paraoxonase/arylesterase 2
PON2
84Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50EA → VW in AAC27945 (PubMed:9714608).Curated2
Sequence conflicti53E → D in BAG37646 (PubMed:14702039).Curated1
Sequence conflicti63A → V in BAG58797 (PubMed:14702039).Curated1
Sequence conflicti194E → G in AAC41995 (PubMed:8661009).Curated1
Sequence conflicti282G → V in AAC27944 (PubMed:9714608).Curated1
Sequence conflicti282G → V in BAD89420 (Ref. 3) Curated1

Polymorphismi

Ser-311 is associated with an increased risk of cornary heart disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006045148A → G Associated with elevated mean fasting plasma glucose level. 3 PublicationsCorresponds to variant dbSNP:rs12026EnsemblClinVar.1
Natural variantiVAR_020786172V → L1 PublicationCorresponds to variant dbSNP:rs17876152Ensembl.1
Natural variantiVAR_006046311S → C1 PublicationCorresponds to variant dbSNP:rs7493EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0045331 – 16MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040715123 – 134Missing in isoform 3. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA Translation: AAC41995.1
AF001601 mRNA Translation: AAC27944.1
AF001602 mRNA Translation: AAC27945.1
AF001603 Genomic DNA Translation: AAC27946.1
AB102891 mRNA Translation: BAD89420.1
AK291103 mRNA Translation: BAF83792.1
AK296029 mRNA Translation: BAG58797.1
AK315209 mRNA Translation: BAG37646.1
AY210982 Genomic DNA Translation: AAO18083.1
AC005021 Genomic DNA Translation: AAC62431.1
CH236949 Genomic DNA Translation: EAL24131.1
BC040010 mRNA Translation: AAH40010.1
CCDSiCCDS47644.1 [Q15165-3]
CCDS5640.1 [Q15165-2]
RefSeqiNP_000296.2, NM_000305.2 [Q15165-2]
UniGeneiHs.514420
Hs.744912

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854 [Q15165-2]
ENST00000433091; ENSP00000404622; ENSG00000105854 [Q15165-3]
ENST00000633531; ENSP00000488838; ENSG00000105854 [Q15165-2]
GeneIDi5445
KEGGihsa:5445
UCSCiuc003unv.4 human [Q15165-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA Translation: AAC41995.1
AF001601 mRNA Translation: AAC27944.1
AF001602 mRNA Translation: AAC27945.1
AF001603 Genomic DNA Translation: AAC27946.1
AB102891 mRNA Translation: BAD89420.1
AK291103 mRNA Translation: BAF83792.1
AK296029 mRNA Translation: BAG58797.1
AK315209 mRNA Translation: BAG37646.1
AY210982 Genomic DNA Translation: AAO18083.1
AC005021 Genomic DNA Translation: AAC62431.1
CH236949 Genomic DNA Translation: EAL24131.1
BC040010 mRNA Translation: AAH40010.1
CCDSiCCDS47644.1 [Q15165-3]
CCDS5640.1 [Q15165-2]
RefSeqiNP_000296.2, NM_000305.2 [Q15165-2]
UniGeneiHs.514420
Hs.744912

3D structure databases

ProteinModelPortaliQ15165
SMRiQ15165
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111441, 95 interactors
DIPiDIP-61136N
IntActiQ15165, 15 interactors
MINTiQ15165
STRINGi9606.ENSP00000222572

PTM databases

GlyConnecti1741
iPTMnetiQ15165
PhosphoSitePlusiQ15165
SwissPalmiQ15165

Polymorphism and mutation databases

BioMutaiPON2
DMDMi325511384

Proteomic databases

EPDiQ15165
MaxQBiQ15165
PaxDbiQ15165
PeptideAtlasiQ15165
PRIDEiQ15165
ProteomicsDBi60475
60476 [Q15165-1]
60477 [Q15165-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854 [Q15165-2]
ENST00000433091; ENSP00000404622; ENSG00000105854 [Q15165-3]
ENST00000633531; ENSP00000488838; ENSG00000105854 [Q15165-2]
GeneIDi5445
KEGGihsa:5445
UCSCiuc003unv.4 human [Q15165-2]

Organism-specific databases

CTDi5445
DisGeNETi5445
EuPathDBiHostDB:ENSG00000105854.12
GeneCardsiPON2
HGNCiHGNC:9205 PON2
HPAiCAB025430
HPA029193
MalaCardsiPON2
MIMi602447 gene
neXtProtiNX_Q15165
OpenTargetsiENSG00000105854
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33530
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOVERGENiHBG003604
InParanoidiQ15165
KOiK01045
OrthoDBiEOG091G0AV9
PhylomeDBiQ15165
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
SIGNORiQ15165

Miscellaneous databases

ChiTaRSiPON2 human
GeneWikiiPON2
GenomeRNAii5445
PROiPR:Q15165
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105854 Expressed in 230 organ(s), highest expression level in right lung
CleanExiHS_PON2
ExpressionAtlasiQ15165 baseline and differential
GenevisibleiQ15165 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2
ProtoNetiSearch...

Entry informationi

Entry nameiPON2_HUMAN
AccessioniPrimary (citable) accession number: Q15165
Secondary accession number(s): A4D1H7
, B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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