UniProtKB - Q15155 (NOMO1_HUMAN)
Nodal modulator 1
NOMO1
Functioni
Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719).
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity).
By similarity1 PublicationCaution
GO - Molecular functioni
- carbohydrate binding Source: InterPro
- ribosome binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q15155 |
SignaLinki | Q15155 |
Names & Taxonomyi
Protein namesi | Recommended name: Nodal modulator 1Alternative name(s): pM5 protein |
Gene namesi | Name:NOMO1 Synonyms:PM5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30060, NOMO1 |
MIMi | 609157, gene |
neXtProti | NX_Q15155 |
VEuPathDBi | HostDB:ENSG00000103512 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 1155 | ExtracellularSequence analysisAdd BLAST | 1124 | |
Transmembranei | 1156 – 1176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1177 – 1222 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23420 |
OpenTargetsi | ENSG00000103512 |
PharmGKBi | PA134934458 |
Miscellaneous databases
Pharosi | Q15155, Tbio |
Chemistry databases
DrugBanki | DB00277, Theophylline |
Genetic variation databases
BioMutai | NOMO1 |
DMDMi | 296439497 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000021819 | 32 – 1222 | Nodal modulator 1Add BLAST | 1191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 618 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 1205 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q15155 |
jPOSTi | Q15155 |
MassIVEi | Q15155 |
MaxQBi | Q15155 |
PaxDbi | Q15155 |
PeptideAtlasi | Q15155 |
PRIDEi | Q15155 |
ProteomicsDBi | 60474 |
PTM databases
GlyConnecti | 1572, 8 N-Linked glycans (3 sites) |
GlyGeni | Q15155, 6 sites, 8 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | Q15155 |
PhosphoSitePlusi | Q15155 |
SwissPalmi | Q15155 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000103512, Expressed in muscle tissue and 120 other tissues |
ExpressionAtlasi | Q15155, baseline and differential |
Genevisiblei | Q15155, HS |
Organism-specific databases
HPAi | ENSG00000103512, Tissue enhanced (pancreas) |
Interactioni
Subunit structurei
Forms a complex with NCLN/Nicalin and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome (PubMed:20538592). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (PubMed:32820719). Due to the strong similarity between NOMO1, NOMO2 and NOMO3, similar interaction pattern probably occur for the three gene copies (PubMed:20538592, PubMed:32820719).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 116991, 203 interactors |
IntActi | Q15155, 28 interactors |
MINTi | Q15155 |
STRINGi | 9606.ENSP00000287667 |
Miscellaneous databases
RNActi | Q15155, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q15155 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1198 – 1222 | DisorderedSequence analysisAdd BLAST | 25 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1948, Eukaryota |
GeneTreei | ENSGT00390000000089 |
HOGENOMi | CLU_007543_2_0_1 |
InParanoidi | Q15155 |
OrthoDBi | 839381at2759 |
PhylomeDBi | Q15155 |
TreeFami | TF313696 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013784, Carb-bd-like_fold IPR008969, CarboxyPept-like_regulatory IPR013783, Ig-like_fold IPR041033, Prealbumin-like |
Pfami | View protein in Pfam PF17802, SpaA, 1 hit |
SUPFAMi | SSF49452, SSF49452, 3 hits SSF49464, SSF49464, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIIATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTN RPMMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDM SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVRALGQA
1210 1220
ASDNSGPEDA KRQAKKQKTR RT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JN29 | A0A0G2JN29_HUMAN | Nodal modulator 1 | NOMO1 | 1,267 | Annotation score: | ||
A0A0G2JP90 | A0A0G2JP90_HUMAN | Nodal modulator 1 | NOMO1 | 1,100 | Annotation score: | ||
H3BUC9 | H3BUC9_HUMAN | Nodal modulator 1 | NOMO1 | 144 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 – 35 | EDI → RDL in CAA40655 (PubMed:1310294).Curated | 3 | |
Sequence conflicti | 200 | R → S in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 513 | D → N in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 618 | N → S in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 620 | S → F in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 650 | T → I in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 659 | L → F in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 1141 | I → T in CAA40655 (PubMed:1310294).Curated | 1 | |
Sequence conflicti | 1196 | A → V in AAH65535 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013312 | 404 | I → V1 PublicationCorresponds to variant dbSNP:rs2561962Ensembl. | 1 | |
Natural variantiVAR_013313 | 458 | K → N1 PublicationCorresponds to variant dbSNP:rs1345150579Ensembl. | 1 | |
Natural variantiVAR_013314 | 490 | N → D1 PublicationCorresponds to variant dbSNP:rs1062412Ensembl. | 1 | |
Natural variantiVAR_022551 | 493 | M → V. Corresponds to variant dbSNP:rs141860762Ensembl. | 1 | |
Natural variantiVAR_056956 | 580 | M → V. Corresponds to variant dbSNP:rs17356851Ensembl. | 1 | |
Natural variantiVAR_060370 | 583 | V → A1 PublicationCorresponds to variant dbSNP:rs17855981Ensembl. | 1 | |
Natural variantiVAR_011496 | 1081 | E → K1 PublicationCorresponds to variant dbSNP:rs200317822Ensembl. | 1 | |
Natural variantiVAR_013315 | 1141 | I → F1 PublicationCorresponds to variant dbSNP:rs376397163Ensembl. | 1 | |
Natural variantiVAR_013316 | 1195 | R → G1 PublicationCorresponds to variant dbSNP:rs9330Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136443 Genomic DNA No translation available. BC065535 mRNA Translation: AAH65535.1 X57398 mRNA Translation: CAA40655.1 |
CCDSi | CCDS10556.1 |
PIRi | S21977 |
RefSeqi | NP_055102.3, NM_014287.3 |
Genome annotation databases
Ensembli | ENST00000287667.12; ENSP00000287667.7; ENSG00000103512.16 ENST00000619292.4; ENSP00000482008.1; ENSG00000274779.4 |
GeneIDi | 23420 |
KEGGi | hsa:23420 |
MANE-Selecti | ENST00000287667.12; ENSP00000287667.7; NM_014287.4; NP_055102.3 |
UCSCi | uc002dcv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136443 Genomic DNA No translation available. BC065535 mRNA Translation: AAH65535.1 X57398 mRNA Translation: CAA40655.1 |
CCDSi | CCDS10556.1 |
PIRi | S21977 |
RefSeqi | NP_055102.3, NM_014287.3 |
3D structure databases
AlphaFoldDBi | Q15155 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116991, 203 interactors |
IntActi | Q15155, 28 interactors |
MINTi | Q15155 |
STRINGi | 9606.ENSP00000287667 |
Chemistry databases
DrugBanki | DB00277, Theophylline |
PTM databases
GlyConnecti | 1572, 8 N-Linked glycans (3 sites) |
GlyGeni | Q15155, 6 sites, 8 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | Q15155 |
PhosphoSitePlusi | Q15155 |
SwissPalmi | Q15155 |
Genetic variation databases
BioMutai | NOMO1 |
DMDMi | 296439497 |
Proteomic databases
EPDi | Q15155 |
jPOSTi | Q15155 |
MassIVEi | Q15155 |
MaxQBi | Q15155 |
PaxDbi | Q15155 |
PeptideAtlasi | Q15155 |
PRIDEi | Q15155 |
ProteomicsDBi | 60474 |
Protocols and materials databases
Antibodypediai | 24899, 340 antibodies from 26 providers |
DNASUi | 23420 |
Genome annotation databases
Ensembli | ENST00000287667.12; ENSP00000287667.7; ENSG00000103512.16 ENST00000619292.4; ENSP00000482008.1; ENSG00000274779.4 |
GeneIDi | 23420 |
KEGGi | hsa:23420 |
MANE-Selecti | ENST00000287667.12; ENSP00000287667.7; NM_014287.4; NP_055102.3 |
UCSCi | uc002dcv.4, human |
Organism-specific databases
CTDi | 23420 |
DisGeNETi | 23420 |
GeneCardsi | NOMO1 |
HGNCi | HGNC:30060, NOMO1 |
HPAi | ENSG00000103512, Tissue enhanced (pancreas) |
MIMi | 609157, gene |
neXtProti | NX_Q15155 |
OpenTargetsi | ENSG00000103512 |
PharmGKBi | PA134934458 |
VEuPathDBi | HostDB:ENSG00000103512 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1948, Eukaryota |
GeneTreei | ENSGT00390000000089 |
HOGENOMi | CLU_007543_2_0_1 |
InParanoidi | Q15155 |
OrthoDBi | 839381at2759 |
PhylomeDBi | Q15155 |
TreeFami | TF313696 |
Enzyme and pathway databases
PathwayCommonsi | Q15155 |
SignaLinki | Q15155 |
Miscellaneous databases
BioGRID-ORCSi | 23420, 46 hits in 990 CRISPR screens |
ChiTaRSi | NOMO1, human |
GeneWikii | NOMO1 |
GenomeRNAii | 23420 |
Pharosi | Q15155, Tbio |
PROi | PR:Q15155 |
RNActi | Q15155, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103512, Expressed in muscle tissue and 120 other tissues |
ExpressionAtlasi | Q15155, baseline and differential |
Genevisiblei | Q15155, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013784, Carb-bd-like_fold IPR008969, CarboxyPept-like_regulatory IPR013783, Ig-like_fold IPR041033, Prealbumin-like |
Pfami | View protein in Pfam PF17802, SpaA, 1 hit |
SUPFAMi | SSF49452, SSF49452, 3 hits SSF49464, SSF49464, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NOMO1_HUMAN | |
Accessioni | Q15155Primary (citable) accession number: Q15155 Secondary accession number(s): P78421, Q8IW21, Q96DG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 194 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot