UniProtKB - Q15131 (CDK10_HUMAN)
Cyclin-dependent kinase 10
CDK10
Functioni
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572).
Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
2 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 68 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 163 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 45 – 53 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cell projection organization Source: UniProtKB-KW
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of cilium assembly Source: UniProtKB
- peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of MAPK cascade Source: Ensembl
- protein phosphorylation Source: GO_Central
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of cell cycle G2/M phase transition Source: ComplexPortal
- regulation of mitotic cell cycle Source: GO_Central
- traversing start control point of mitotic cell cycle Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cilium biogenesis/degradation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | Q15131 |
SignaLinki | Q15131 |
SIGNORi | Q15131 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 10 (EC:2.7.11.22)Alternative name(s): Cell division protein kinase 10 Serine/threonine-protein kinase PISSLRE |
Gene namesi | Name:CDK10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1770, CDK10 |
MIMi | 603464, gene |
neXtProti | NX_Q15131 |
VEuPathDBi | HostDB:ENSG00000185324 |
Subcellular locationi
Cytoskeleton
- cilium basal body 1 Publication
Cytoskeleton
- ciliary basal body Source: UniProtKB
Nucleus
- nucleus Source: MGI
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: ComplexPortal
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Al Kaissi syndrome (ALKAS)1 Publication
Organism-specific databases
DisGeNETi | 8558 |
MalaCardsi | CDK10 |
MIMi | 617694, phenotype |
OpenTargetsi | ENSG00000185324 |
PharmGKBi | PA26307 |
Miscellaneous databases
Pharosi | Q15131, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1795191 |
Genetic variation databases
BioMutai | CDK10 |
DMDMi | 6226784 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085809 | 1 – 360 | Cyclin-dependent kinase 10Add BLAST | 360 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 196 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15131 |
jPOSTi | Q15131 |
MassIVEi | Q15131 |
MaxQBi | Q15131 |
PaxDbi | Q15131 |
PeptideAtlasi | Q15131 |
PRIDEi | Q15131 |
ProteomicsDBi | 60454 [Q15131-1] 60455 [Q15131-2] 60456 [Q15131-3] 60457 [Q15131-4] |
PTM databases
iPTMneti | Q15131 |
PhosphoSitePlusi | Q15131 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185324, Expressed in pituitary gland and 237 other tissues |
ExpressionAtlasi | Q15131, baseline and differential |
Genevisiblei | Q15131, HS |
Organism-specific databases
HPAi | ENSG00000185324, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with CCNQ, the interaction is required for kinase activity.
Interacts with ETS2.
Interacts with PRK2 (PubMed:27104747).
2 PublicationsBinary interactionsi
Q15131
With | #Exp. | IntAct |
---|---|---|
ETS2 [P15036] | 2 | EBI-1646959,EBI-1646991 |
HSP90AB1 [P08238] | 3 | EBI-1646959,EBI-352572 |
PIN1 [Q13526] | 5 | EBI-1646959,EBI-714158 |
Isoform 1 [Q15131-1]
With | #Exp. | IntAct |
---|---|---|
CCNQ [Q8N1B3] | 7 | EBI-11507283,EBI-3925043 |
Protein-protein interaction databases
BioGRIDi | 114128, 21 interactors |
ComplexPortali | CPX-326, Cyclin M-CDK10 complex [Q15131-1] |
IntActi | Q15131, 32 interactors |
MINTi | Q15131 |
STRINGi | 9606.ENSP00000338673 |
Chemistry databases
BindingDBi | Q15131 |
Miscellaneous databases
RNActi | Q15131, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 323 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 334 – 360 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0663, Eukaryota |
GeneTreei | ENSGT00940000158102 |
InParanoidi | Q15131 |
OMAi | TWPGFRS |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q15131 |
TreeFami | TF101026 |
Family and domain databases
CDDi | cd07845, STKc_CDK10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044093, STKc_CDK10 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY
60 70 80 90 100
GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE
110 120 130 140 150
LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIVLQVLRG
160 170 180 190 200
LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV
210 220 230 240 250
TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP GTSEIHQIDL
260 270 280 290 300
IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL
310 320 330 340 350
HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT
360
SEGQSKRCKP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W872 | F8W872_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 313 | Annotation score: | ||
H3BT74 | H3BT74_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 239 | Annotation score: | ||
D6RA59 | D6RA59_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 42 | Annotation score: | ||
Q9UHL7 | Q9UHL7_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 42 | Annotation score: | ||
D6RHH3 | D6RHH3_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 56 | Annotation score: | ||
D6REZ2 | D6REZ2_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 69 | Annotation score: | ||
H3BSN8 | H3BSN8_HUMAN | Cyclin-dependent kinase 10 | CDK10 | 37 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041983 | 96 | P → L1 PublicationCorresponds to variant dbSNP:rs55819627Ensembl. | 1 | |
Natural variantiVAR_041984 | 168 | N → S1 PublicationCorresponds to variant dbSNP:rs56340740Ensembl. | 1 | |
Natural variantiVAR_041985 | 342 | R → H1 PublicationCorresponds to variant dbSNP:rs55757604Ensembl. | 1 | |
Natural variantiVAR_041986 | 358 | C → Y1 PublicationCorresponds to variant dbSNP:rs56242003Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021642 | 1 – 71 | Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 4 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_054969 | 48 – 54 | GTYGIVY → D in isoform 5 and isoform 6. 1 Publication | 7 | |
Alternative sequenceiVSP_054970 | 141 – 160 | KCIVL…RNFII → RGRGAWGGGMGFMGPCGAHL in isoform 6. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_054971 | 161 – 360 | Missing in isoform 6. 1 PublicationAdd BLAST | 200 | |
Alternative sequenceiVSP_054972 | 180 – 194 | ADFGL…VPVKP → GGCNLGQALSLDGTW in isoform 5 and isoform 7. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_054973 | 195 – 360 | Missing in isoform 5. 1 PublicationAdd BLAST | 166 | |
Alternative sequenceiVSP_021643 | 306 – 311 | Missing in isoform 3. 2 Publications | 6 | |
Alternative sequenceiVSP_021644 | 329 – 360 | PCEPE…KRCKP → RLPISGVCEGCREPG in isoform 4. 2 PublicationsAdd BLAST | 32 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000353379.12; ENSP00000338673.7; ENSG00000185324.22 ENST00000505473.5; ENSP00000424415.1; ENSG00000185324.22 [Q15131-4] ENST00000617879.1; ENSP00000484357.1; ENSG00000185324.22 [Q15131-4] |
GeneIDi | 8558 |
KEGGi | hsa:8558 |
MANE-Selecti | ENST00000353379.12; ENSP00000338673.7; NM_052988.5; NP_443714.3 |
UCSCi | uc002fod.4, human [Q15131-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
AlphaFoldDBi | Q15131 |
SMRi | Q15131 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114128, 21 interactors |
ComplexPortali | CPX-326, Cyclin M-CDK10 complex [Q15131-1] |
IntActi | Q15131, 32 interactors |
MINTi | Q15131 |
STRINGi | 9606.ENSP00000338673 |
Chemistry databases
BindingDBi | Q15131 |
ChEMBLi | CHEMBL1795191 |
PTM databases
iPTMneti | Q15131 |
PhosphoSitePlusi | Q15131 |
Genetic variation databases
BioMutai | CDK10 |
DMDMi | 6226784 |
Proteomic databases
EPDi | Q15131 |
jPOSTi | Q15131 |
MassIVEi | Q15131 |
MaxQBi | Q15131 |
PaxDbi | Q15131 |
PeptideAtlasi | Q15131 |
PRIDEi | Q15131 |
ProteomicsDBi | 60454 [Q15131-1] 60455 [Q15131-2] 60456 [Q15131-3] 60457 [Q15131-4] |
Protocols and materials databases
Antibodypediai | 30892, 324 antibodies from 35 providers |
DNASUi | 8558 |
Genome annotation databases
Ensembli | ENST00000353379.12; ENSP00000338673.7; ENSG00000185324.22 ENST00000505473.5; ENSP00000424415.1; ENSG00000185324.22 [Q15131-4] ENST00000617879.1; ENSP00000484357.1; ENSG00000185324.22 [Q15131-4] |
GeneIDi | 8558 |
KEGGi | hsa:8558 |
MANE-Selecti | ENST00000353379.12; ENSP00000338673.7; NM_052988.5; NP_443714.3 |
UCSCi | uc002fod.4, human [Q15131-1] |
Organism-specific databases
CTDi | 8558 |
DisGeNETi | 8558 |
GeneCardsi | CDK10 |
HGNCi | HGNC:1770, CDK10 |
HPAi | ENSG00000185324, Low tissue specificity |
MalaCardsi | CDK10 |
MIMi | 603464, gene 617694, phenotype |
neXtProti | NX_Q15131 |
OpenTargetsi | ENSG00000185324 |
PharmGKBi | PA26307 |
VEuPathDBi | HostDB:ENSG00000185324 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0663, Eukaryota |
GeneTreei | ENSGT00940000158102 |
InParanoidi | Q15131 |
OMAi | TWPGFRS |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q15131 |
TreeFami | TF101026 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | Q15131 |
SignaLinki | Q15131 |
SIGNORi | Q15131 |
Miscellaneous databases
BioGRID-ORCSi | 8558, 42 hits in 1120 CRISPR screens |
ChiTaRSi | CDK10, human |
GeneWikii | Cyclin-dependent_kinase_10 |
GenomeRNAii | 8558 |
Pharosi | Q15131, Tchem |
PROi | PR:Q15131 |
RNActi | Q15131, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185324, Expressed in pituitary gland and 237 other tissues |
ExpressionAtlasi | Q15131, baseline and differential |
Genevisiblei | Q15131, HS |
Family and domain databases
CDDi | cd07845, STKc_CDK10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044093, STKc_CDK10 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK10_HUMAN | |
Accessioni | Q15131Primary (citable) accession number: Q15131 Secondary accession number(s): A8K370 Q6PJC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families