CDK10

Functionⁱ

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).2 Publications

Catalytic activityⁱ

ATP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-seryl-[protein]
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=
ADP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
  Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
  Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH CCNQ.
EC:
2.7.11.22
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
  Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
  Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH CCNQ.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-seryl-[protein]
L-serine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-seryl-[protein]
O-phospho-L-serine residue
zoom
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
  Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
  Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH CCNQ.
EC:
2.7.11.22
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
  Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
  Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH CCNQ.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-threonyl-[protein]
L-threonine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-threonyl-[protein]
O-phospho-L-threonine residue
zoom

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	68	ATPPROSITE-ProRule annotation		1
Active siteⁱ	163	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	45 – 53	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cilium biogenesis/degradation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22, 2681
PathwayCommonsⁱ	Q15131
SignaLinkⁱ	Q15131
SIGNORⁱ	Q15131

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 10 (EC:2.7.11.22) Alternative name(s): Cell division protein kinase 10 Serine/threonine-protein kinase PISSLRE
Gene namesⁱ	Name:CDK10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1770, CDK10
MIMⁱ	603464, gene
neXtProtⁱ	NX_Q15131
VEuPathDBⁱ	HostDB:ENSG00000185324.21

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Al Kaissi syndrome (ALKAS)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay.

Related information in OMIM

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8558
MalaCards human disease database More...MalaCardsⁱ	CDK10
MIMⁱ	617694, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000185324
PharmGKBⁱ	PA26307

Miscellaneous databases

Pharosⁱ	Q15131, Tbio

Pharosⁱ

Q15131, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1795191

ChEMBLⁱ

CHEMBL1795191

Genetic variation databases

BioMutaⁱ	CDK10
DMDMⁱ	6226784

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085809	1 – 360	Cyclin-dependent kinase 10Add BLAST		360

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	196	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15131
jPOSTⁱ	Q15131
MassIVEⁱ	Q15131
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15131
PaxDbⁱ	Q15131
PeptideAtlas More...PeptideAtlasⁱ	Q15131
PRIDEⁱ	Q15131
ProteomicsDBⁱ	60454 [Q15131-1] 60455 [Q15131-2] 60456 [Q15131-3] 60457 [Q15131-4]

PTM databases

iPTMnetⁱ	Q15131
PhosphoSitePlusⁱ	Q15131

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185324, Expressed in pituitary gland and 236 other tissues
ExpressionAtlasⁱ	Q15131, baseline and differential
Genevisibleⁱ	Q15131, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000185324, Low tissue specificity

HPAⁱ

ENSG00000185324, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Heterodimer with CCNQ, the interaction is required for kinase activity.

Interacts with ETS2.

Interacts with PRK2 (PubMed:27104747).

2 Publications

Binary interactionsⁱ

Hide details

Q15131

With	#Exp.	IntAct
ETS2 [P15036]	2	EBI-1646959,EBI-1646991
HSP90AB1 [P08238]	2	EBI-1646959,EBI-352572
PIN1 [Q13526]	5	EBI-1646959,EBI-714158

Isoform 1 [Q15131-1]

With	#Exp.	IntAct
CCNQ [Q8N1B3]	7	EBI-11507283,EBI-3925043

Protein-protein interaction databases

BioGRIDⁱ	114128, 19 interactors
ComplexPortalⁱ	CPX-326, Cyclin M-CDK10 complex [Q15131-1]
IntActⁱ	Q15131, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q15131
STRINGⁱ	9606.ENSP00000338673

Miscellaneous databases

RNActⁱ	Q15131, protein

RNActⁱ

Q15131, protein

Structureⁱ

3D structure databases

SMRⁱ	Q15131
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 323	Protein kinasePROSITE-ProRule annotationAdd BLAST		285

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0663, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158102
InParanoidⁱ	Q15131
OMAⁱ	MTDKGCI
Database of Orthologous Groups More...OrthoDBⁱ	925637at2759
PhylomeDBⁱ	Q15131
TreeFamⁱ	TF101026

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07845, STKc_CDK10, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044093, STKc_CDK10
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15131-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY 
        60         70         80         90        100
GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE 
       110        120        130        140        150
LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIVLQVLRG 
       160        170        180        190        200
LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV 
       210        220        230        240        250
TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP GTSEIHQIDL 
       260        270        280        290        300
IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 
       310        320        330        340        350
HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT 
       360
SEGQSKRCKP

Length:360

Mass (Da):41,038

Last modified:November 1, 1996 - v1

Checksum:ⁱ25B28560961103F4

GO

Isoform 2 (identifier: Q15131-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.

« Hide

        10         20         30         40         50
MDKEKDGIPI SSLREITLLL RLRHPNIVEL KEVVVGNHLE SIFLVMGYCE 
        60         70         80         90        100
QDLASLLENM PTPFSEAQVK CIVLQVLRGL QYLHRNFIIH RDLKVSNLLM 
       110        120        130        140        150
TDKGCVKTAD FGLARAYGVP VKPMTPKVVT LWYRAPELLL GTTTQTTSID 
       160        170        180        190        200
MWAVGCILAE LLAHRPLLPG TSEIHQIDLI VQLLGTPSEN IWPGFSKLPL 
       210        220        230        240        250
VGQYSLRKQP YNNLKHKFPW LSEAGLRLLH FLFMYDPKKR ATAGDCLESS 
       260        270        280 
YFKEKPLPCE PELMPTFPHH RNKRAAPATS EGQSKRCKP

Show »

Length:289

Mass (Da):32,731

Checksum:ⁱ4C1854D5E1858B32

GO

Isoform 3 (identifier: Q15131-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.
306-311: Missing.

« Hide

        10         20         30         40         50
MDKEKDGIPI SSLREITLLL RLRHPNIVEL KEVVVGNHLE SIFLVMGYCE 
        60         70         80         90        100
QDLASLLENM PTPFSEAQVK CIVLQVLRGL QYLHRNFIIH RDLKVSNLLM 
       110        120        130        140        150
TDKGCVKTAD FGLARAYGVP VKPMTPKVVT LWYRAPELLL GTTTQTTSID 
       160        170        180        190        200
MWAVGCILAE LLAHRPLLPG TSEIHQIDLI VQLLGTPSEN IWPGFSKLPL 
       210        220        230        240        250
VGQYSLRKQP YNNLKHKFPW LSEAGLRLLH FLFMATAGDC LESSYFKEKP 
       260        270        280 
LPCEPELMPT FPHHRNKRAA PATSEGQSKR CKP

Show »

Length:283

Mass (Da):31,944

Checksum:ⁱC6B5F44BF84F9B88

GO

Isoform 4 (identifier: Q15131-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.
329-360: PCEPELMPTFPHHRNKRAAPATSEGQSKRCKP → RLPISGVCEGCREPG

« Hide

        10         20         30         40         50
MDKEKDGIPI SSLREITLLL RLRHPNIVEL KEVVVGNHLE SIFLVMGYCE 
        60         70         80         90        100
QDLASLLENM PTPFSEAQVK CIVLQVLRGL QYLHRNFIIH RDLKVSNLLM 
       110        120        130        140        150
TDKGCVKTAD FGLARAYGVP VKPMTPKVVT LWYRAPELLL GTTTQTTSID 
       160        170        180        190        200
MWAVGCILAE LLAHRPLLPG TSEIHQIDLI VQLLGTPSEN IWPGFSKLPL 
       210        220        230        240        250
VGQYSLRKQP YNNLKHKFPW LSEAGLRLLH FLFMYDPKKR ATAGDCLESS 
       260        270 
YFKEKPLRLP ISGVCEGCRE PG

Show »

Length:272

Mass (Da):30,702

Checksum:ⁱ6F30BB76F69F772D

GO

Isoform 5 (identifier: Q15131-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-54: GTYGIVY → D
     180-194: ADFGLARAYGVPVKP → GGCNLGQALSLDGTW
     195-360: Missing.

« Hide

        10         20         30         40         50
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEDRA 
        60         70         80         90        100
RDTQTDEIVA LKKVRMDKEK DGIPISSLRE ITLLLRLRHP NIVELKEVVV 
       110        120        130        140        150
GNHLESIFLV MGYCEQDLAS LLENMPTPFS EAQVKCIVLQ VLRGLQYLHR 
       160        170        180 
NFIIHRDLKV SNLLMTDKGC VKTGGCNLGQ ALSLDGTW

Show »

Length:188

Mass (Da):21,512

Checksum:ⁱ05E92EF153FC1303

GO

Isoform 6 (identifier: Q15131-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-54: GTYGIVY → D
     141-160: KCIVLQVLRGLQYLHRNFII → RGRGAWGGGMGFMGPCGAHL
     161-360: Missing.

« Hide

        10         20         30         40         50
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEDRA 
        60         70         80         90        100
RDTQTDEIVA LKKVRMDKEK DGIPISSLRE ITLLLRLRHP NIVELKEVVV 
       110        120        130        140        150
GNHLESIFLV MGYCEQDLAS LLENMPTPFS EAQVRGRGAW GGGMGFMGPC 

GAHL

Show »

Length:154

Mass (Da):17,446

Checksum:ⁱADC10B30602C2148

GO

Isoform 7 (identifier: Q15131-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.
180-194: ADFGLARAYGVPVKP → GGCNLGQALSLDGTW

« Hide

        10         20         30         40         50
MDKEKDGIPI SSLREITLLL RLRHPNIVEL KEVVVGNHLE SIFLVMGYCE 
        60         70         80         90        100
QDLASLLENM PTPFSEAQVK CIVLQVLRGL QYLHRNFIIH RDLKVSNLLM 
       110        120        130        140        150
TDKGCVKTGG CNLGQALSLD GTWMTPKVVT LWYRAPELLL GTTTQTTSID 
       160        170        180        190        200
MWAVGCILAE LLAHRPLLPG TSEIHQIDLI VQLLGTPSEN IWPGFSKLPL 
       210        220        230        240        250
VGQYSLRKQP YNNLKHKFPW LSEAGLRLLH FLFMYDPKKR ATAGDCLESS 
       260        270        280 
YFKEKPLPCE PELMPTFPHH RNKRAAPATS EGQSKRCKP

Show »

Length:289

Mass (Da):32,662

Checksum:ⁱ30C4754ACDF5A8EE

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W872	F8W872_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	313	Annotation score:
H3BT74	H3BT74_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	239	Annotation score:
Q9UHL7	Q9UHL7_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10 (Cyclin-dependent kinase related protein)	CDK10	42	Annotation score:
D6RA59	D6RA59_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	42	Annotation score:
D6RHH3	D6RHH3_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	56	Annotation score:
D6REZ2	D6REZ2_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	69	Annotation score:
H3BSN8	H3BSN8_HUMAN	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	CDK10	37	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041983	96	P → L1 PublicationCorresponds to variant dbSNP:rs55819627Ensembl.	1
Natural variantⁱVAR_041984	168	N → S1 PublicationCorresponds to variant dbSNP:rs56340740Ensembl.	1
Natural variantⁱVAR_041985	342	R → H1 PublicationCorresponds to variant dbSNP:rs55757604Ensembl.	1
Natural variantⁱVAR_041986	358	C → Y1 PublicationCorresponds to variant dbSNP:rs56242003Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021642	1 – 71	Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 4 PublicationsAdd BLAST	71
Alternative sequenceⁱVSP_054969	48 – 54	GTYGIVY → D in isoform 5 and isoform 6. 1 Publication	7
Alternative sequenceⁱVSP_054970	141 – 160	KCIVL…RNFII → RGRGAWGGGMGFMGPCGAHL in isoform 6. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_054971	161 – 360	Missing in isoform 6. 1 PublicationAdd BLAST	200
Alternative sequenceⁱVSP_054972	180 – 194	ADFGL…VPVKP → GGCNLGQALSLDGTW in isoform 5 and isoform 7. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_054973	195 – 360	Missing in isoform 5. 1 PublicationAdd BLAST	166
Alternative sequenceⁱVSP_021643	306 – 311	Missing in isoform 3. 2 Publications	6
Alternative sequenceⁱVSP_021644	329 – 360	PCEPE…KRCKP → RLPISGVCEGCREPG in isoform 4. 2 PublicationsAdd BLAST	32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33264 mRNA Translation: AAA60092.2 X78342 mRNA Translation: CAA55137.1 AJ010341 AJ010344 Genomic DNA Translation: CAB37619.1 AM392903 mRNA Translation: CAL37781.1 AK075036 mRNA Translation: BAG52055.1 AK290485 mRNA Translation: BAF83174.1 AK292351 mRNA Translation: BAF85040.1 AK296631 mRNA Translation: BAH12406.1 AM393177 mRNA Translation: CAL38055.1 AM393204 mRNA Translation: CAL38082.1 AC010538 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66701.1 CH471184 Genomic DNA Translation: EAW66703.1 CH471184 Genomic DNA Translation: EAW66704.1 CH471184 Genomic DNA Translation: EAW66705.1 CH471184 Genomic DNA Translation: EAW66706.1 CH471184 Genomic DNA Translation: EAW66707.1 CH471184 Genomic DNA Translation: EAW66708.1 CH471184 Genomic DNA Translation: EAW66710.1 BC017342 mRNA Translation: AAH17342.1 BC025301 mRNA Translation: AAH25301.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10984.2 [Q15131-1] CCDS32514.2 [Q15131-4]
PIRⁱ	S49330
NCBI Reference Sequences More...RefSeqⁱ	NP_001092003.2, NM_001098533.2 [Q15131-3] NP_001153839.1, NM_001160367.1 [Q15131-2] NP_443713.2, NM_052987.3 [Q15131-4] NP_443714.3, NM_052988.4 [Q15131-1] XP_016879297.1, XM_017023808.1 [Q15131-2] XP_016879298.1, XM_017023809.1 [Q15131-3] XP_016879299.1, XM_017023810.1 [Q15131-4]

Genome annotation databases

Ensemblⁱ	ENST00000353379; ENSP00000338673; ENSG00000185324 [Q15131-1] ENST00000505473; ENSP00000424415; ENSG00000185324 [Q15131-4] ENST00000617879; ENSP00000484357; ENSG00000185324 [Q15131-4]
GeneIDⁱ	8558
KEGGⁱ	hsa:8558
UCSC genome browser More...UCSCⁱ	uc002fod.4, human [Q15131-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15131	CDK10 isoform 1		PANTR		360	UniRef100_Q15131
Protein kinase domain-containing protein		PANPA		360
Q15131-4	CDK10 isoform 5		PANTR		272	UniRef100_A0A2J8J082
+1
Q15131-5	cDNA FLJ53790, highly similar to Cell division protein kinase 10		HUMAN		188	UniRef100_Q15131-5

Protein	Similar proteins		Species	Score	Length	Source
Q15131	CDK10 isoform 1		PANTR		360	UniRef90_Q15131
Protein kinase domain-containing protein		PANPA		360
Cyclin dependent kinase 10		LOXAF		366
Cyclin-dependent kinase 10		PIG		361
Cyclin-dependent kinase 10		FUKDA		360
+50
Q15131-3	Cyclin dependent kinase 10		MACMU		361	UniRef90_Q15131-3
Protein kinase domain-containing protein		PAPAN		361
Protein kinase domain-containing protein		MACFA		361
Protein kinase domain-containing protein		MACNE		361
Cyclin dependent kinase 10		PIPKU		360
+26
Q15131-4	cyclin-dependent kinase 10 isoform X4		SAPAP		283	UniRef90_A0A6J3IE46
CDK10 isoform 5		PANTR		272
+2
Q15131-5	cDNA FLJ53790, highly similar to Cell division protein kinase 10		HUMAN		188	UniRef90_Q15131-5
Q15131-7	Protein kinase domain-containing protein		NOMLE		358	UniRef90_Q15131-7
Cyclin dependent kinase 10		GORGO		315
Cyclin-dependent kinase 10		HUMAN		313
CDK10 isoform 4		PANTR		313
Protein kinase domain-containing protein		AOTNA		313
+5

Protein	Similar proteins		Species	Score	Length	Source
Q15131	Cyclin-dependent kinase 10		MOUSE		360	UniRef50_Q15131
CDK10 isoform 1		PANTR		360
Protein kinase domain-containing protein		PANPA		360
Cyclin dependent kinase 10		LOXAF		366
Cyclin-dependent kinase 10		PIG		361
+851
Q15131-4	Protein kinase domain-containing protein		CEBIM		353	UniRef50_A0A2K5R1X5
cyclin-dependent kinase 10 isoform X3		PTEVA		283
Protein kinase domain-containing protein (Fragment)		OXYMA		365
Cyclin dependent kinase 10		PHACC		353
Protein kinase domain-containing protein (Fragment)		Amphidinium massartii		326
+58
Q15131-5	cDNA FLJ53790, highly similar to Cell division protein kinase 10		HUMAN		188	UniRef50_Q15131-5
Cyclin-dependent kinase 10 isoform 3 variant (Fragment)		HUMAN		214
Q15131-6	Cyclin-dependent kinase 10		Sinocyclocheilus anshuiensis		159	UniRef50_Q15131-6
Q15131-7	Protein kinase domain-containing protein		NOMLE		358	UniRef50_Q15131-7
Cyclin dependent kinase 10		GORGO		315
CDK10 isoform 5		PONAB		313
Protein kinase domain-containing protein		PAPAN		313
CDK10 isoform 4		PANTR		313
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L33264 mRNA Translation: AAA60092.2 X78342 mRNA Translation: CAA55137.1 AJ010341 AJ010344 Genomic DNA Translation: CAB37619.1 AM392903 mRNA Translation: CAL37781.1 AK075036 mRNA Translation: BAG52055.1 AK290485 mRNA Translation: BAF83174.1 AK292351 mRNA Translation: BAF85040.1 AK296631 mRNA Translation: BAH12406.1 AM393177 mRNA Translation: CAL38055.1 AM393204 mRNA Translation: CAL38082.1 AC010538 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66701.1 CH471184 Genomic DNA Translation: EAW66703.1 CH471184 Genomic DNA Translation: EAW66704.1 CH471184 Genomic DNA Translation: EAW66705.1 CH471184 Genomic DNA Translation: EAW66706.1 CH471184 Genomic DNA Translation: EAW66707.1 CH471184 Genomic DNA Translation: EAW66708.1 CH471184 Genomic DNA Translation: EAW66710.1 BC017342 mRNA Translation: AAH17342.1 BC025301 mRNA Translation: AAH25301.1
CCDSⁱ	CCDS10984.2 [Q15131-1] CCDS32514.2 [Q15131-4]
PIRⁱ	S49330
RefSeqⁱ	NP_001092003.2, NM_001098533.2 [Q15131-3] NP_001153839.1, NM_001160367.1 [Q15131-2] NP_443713.2, NM_052987.3 [Q15131-4] NP_443714.3, NM_052988.4 [Q15131-1] XP_016879297.1, XM_017023808.1 [Q15131-2] XP_016879298.1, XM_017023809.1 [Q15131-3] XP_016879299.1, XM_017023810.1 [Q15131-4]

3D structure databases

SMRⁱ	Q15131
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	114128, 19 interactors
ComplexPortalⁱ	CPX-326, Cyclin M-CDK10 complex [Q15131-1]
IntActⁱ	Q15131, 22 interactors
MINTⁱ	Q15131
STRINGⁱ	9606.ENSP00000338673

Chemistry databases

ChEMBLⁱ	CHEMBL1795191

ChEMBLⁱ

CHEMBL1795191

PTM databases

iPTMnetⁱ	Q15131
PhosphoSitePlusⁱ	Q15131

Genetic variation databases

BioMutaⁱ	CDK10
DMDMⁱ	6226784

Proteomic databases

EPDⁱ	Q15131
jPOSTⁱ	Q15131
MassIVEⁱ	Q15131
MaxQBⁱ	Q15131
PaxDbⁱ	Q15131
PeptideAtlasⁱ	Q15131
PRIDEⁱ	Q15131
ProteomicsDBⁱ	60454 [Q15131-1] 60455 [Q15131-2] 60456 [Q15131-3] 60457 [Q15131-4]

Protocols and materials databases

Antibodypediaⁱ	30892, 317 antibodies
The DNASU plasmid repository More...DNASUⁱ	8558

Genome annotation databases

Ensemblⁱ	ENST00000353379; ENSP00000338673; ENSG00000185324 [Q15131-1] ENST00000505473; ENSP00000424415; ENSG00000185324 [Q15131-4] ENST00000617879; ENSP00000484357; ENSG00000185324 [Q15131-4]
GeneIDⁱ	8558
KEGGⁱ	hsa:8558
UCSCⁱ	uc002fod.4, human [Q15131-1]

Organism-specific databases

CTDⁱ	8558
DisGeNETⁱ	8558
GeneCardsⁱ	CDK10
HGNCⁱ	HGNC:1770, CDK10
HPAⁱ	ENSG00000185324, Low tissue specificity
MalaCardsⁱ	CDK10
MIMⁱ	603464, gene 617694, phenotype
neXtProtⁱ	NX_Q15131
OpenTargetsⁱ	ENSG00000185324
PharmGKBⁱ	PA26307
VEuPathDBⁱ	HostDB:ENSG00000185324.21
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0663, Eukaryota
GeneTreeⁱ	ENSGT00940000158102
InParanoidⁱ	Q15131
OMAⁱ	MTDKGCI
OrthoDBⁱ	925637at2759
PhylomeDBⁱ	Q15131
TreeFamⁱ	TF101026

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22, 2681
PathwayCommonsⁱ	Q15131
SignaLinkⁱ	Q15131
SIGNORⁱ	Q15131

Miscellaneous databases

BioGRID-ORCSⁱ	8558, 32 hits in 1033 CRISPR screens
ChiTaRSⁱ	CDK10, human
GeneWikiⁱ	Cyclin-dependent_kinase_10
GenomeRNAiⁱ	8558
Pharosⁱ	Q15131, Tbio
Protein Ontology More...PROⁱ	PR:Q15131
RNActⁱ	Q15131, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185324, Expressed in pituitary gland and 236 other tissues
ExpressionAtlasⁱ	Q15131, baseline and differential
Genevisibleⁱ	Q15131, HS

Family and domain databases

CDDⁱ	cd07845, STKc_CDK10, 1 hit
InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044093, STKc_CDK10
Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDK10_HUMAN
Accessionⁱ	Q15131Primary (citable) accession number: Q15131 Secondary accession number(s): A8K370 Q6PJC0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	April 7, 2021
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q15131 (CDK10_HUMAN)

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Cyclin-dependent kinase 10

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q15131

Isoform 1 [Q15131-1]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Keywords - Technical termⁱ