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Protein

Procollagen C-endopeptidase enhancer 1

Gene

PCOLCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: Ensembl
  • multicellular organism development Source: ProtInc
  • proteolysis Source: Ensembl

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2243919 Crosslinking of collagen fibrils

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 1
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 1
Short name:
PCPE-1
Short name:
Procollagen C-proteinase enhancer 1
Type 1 procollagen C-proteinase enhancer protein
Type I procollagen COOH-terminal proteinase enhancer
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCOLCE
Synonyms:PCPE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106333.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8738 PCOLCE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600270 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15113

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5118

Open Targets

More...
OpenTargetsi
ENSG00000106333

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33083

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCOLCE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6919941

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002202326 – 449Procollagen C-endopeptidase enhancer 1Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 63PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Disulfide bondi90 ↔ 112PROSITE-ProRule annotation
Disulfide bondi159 ↔ 186PROSITE-ProRule annotation
Disulfide bondi213 ↔ 236PROSITE-ProRule annotation
Disulfide bondi318 ↔ 3861 Publication
Disulfide bondi322 ↔ 3891 Publication
Disulfide bondi333 ↔ 4371 Publication
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

C-terminally processed at multiple positions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei287 – 288Cleavage1 Publication2
Sitei288 – 289Cleavage1 Publication2
Sitei293 – 294Cleavage1 Publication2
Sitei299 – 300Cleavage1 Publication2
Sitei303 – 304Cleavage1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15113

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15113

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15113

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15113

PeptideAtlas

More...
PeptideAtlasi
Q15113

PRoteomics IDEntifications database

More...
PRIDEi
Q15113

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60442

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15113

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15113

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106333 Expressed in 185 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

More...
CleanExi
HS_PCOLCE

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15113 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017623
HPA042927

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111147, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q15113, 22 interactors

Molecular INTeraction database

More...
MINTi
Q15113

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000223061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UAPNMR-A313-442[»]
6FZVX-ray2.70D26-278[»]
6FZWX-ray2.78D26-278[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15113

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15113

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15113

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 149CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini159 – 273CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini318 – 437NTRPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPS8 Eukaryota
ENOG410Y9AW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159264

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059592

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053528

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15113

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPLKFYV

Database of Orthologous Groups

More...
OrthoDBi
862783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15113

TreeFam database of animal gene trees

More...
TreeFami
TF316506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR028870 PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR44264:SF2 PTHR44264:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q15113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAATASLL GPLLTACALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS
60 70 80 90 100
EGFPNLYPPN KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG
110 120 130 140 150
SGTSGQRLGR FCGTFRPAPL VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA
160 170 180 190 200
TSGTEHQFCG GRLEKAQGTL TTPNWPESDY PPGISCSWHI IAPPDQVIAL
210 220 230 240 250
TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV PGSISSEGNE
260 270 280 290 300
LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS
310 320 330 340 350
QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP
360 370 380 390 400
GEGLAVTVSL IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL
410 420 430 440
MGQVEENRGP VLPPESFVVL HRPNQDQILT NLSKRKCPSQ PVRAAASQD
Length:449
Mass (Da):47,972
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D88430158648796
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L33799 mRNA Translation: AAA61949.1 Sequence problems.
AB008549 mRNA Translation: BAA23281.1
AF053356 Genomic DNA Translation: AAC78800.1
AF083655 Genomic DNA Translation: AAD16041.1
AK313748 mRNA Translation: BAG36488.1
CH471091 Genomic DNA Translation: EAW76515.1
BC000574 mRNA Translation: AAH00574.1
BC033205 mRNA Translation: AAH33205.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5700.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55362

NCBI Reference Sequences

More...
RefSeqi
NP_002584.2, NM_002593.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.202097

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223061; ENSP00000223061; ENSG00000106333

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5118

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5118

UCSC genome browser

More...
UCSCi
uc003uvo.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33799 mRNA Translation: AAA61949.1 Sequence problems.
AB008549 mRNA Translation: BAA23281.1
AF053356 Genomic DNA Translation: AAC78800.1
AF083655 Genomic DNA Translation: AAD16041.1
AK313748 mRNA Translation: BAG36488.1
CH471091 Genomic DNA Translation: EAW76515.1
BC000574 mRNA Translation: AAH00574.1
BC033205 mRNA Translation: AAH33205.1
CCDSiCCDS5700.1
PIRiA55362
RefSeqiNP_002584.2, NM_002593.3
UniGeneiHs.202097

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UAPNMR-A313-442[»]
6FZVX-ray2.70D26-278[»]
6FZWX-ray2.78D26-278[»]
ProteinModelPortaliQ15113
SMRiQ15113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111147, 1 interactor
IntActiQ15113, 22 interactors
MINTiQ15113
STRINGi9606.ENSP00000223061

PTM databases

iPTMnetiQ15113
PhosphoSitePlusiQ15113

Polymorphism and mutation databases

BioMutaiPCOLCE
DMDMi6919941

Proteomic databases

EPDiQ15113
jPOSTiQ15113
MaxQBiQ15113
PaxDbiQ15113
PeptideAtlasiQ15113
PRIDEiQ15113
ProteomicsDBi60442

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5118
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223061; ENSP00000223061; ENSG00000106333
GeneIDi5118
KEGGihsa:5118
UCSCiuc003uvo.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5118
DisGeNETi5118
EuPathDBiHostDB:ENSG00000106333.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCOLCE
HGNCiHGNC:8738 PCOLCE
HPAiCAB017623
HPA042927
MIMi600270 gene
neXtProtiNX_Q15113
OpenTargetsiENSG00000106333
PharmGKBiPA33083

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPS8 Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00940000159264
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ15113
OMAiTPLKFYV
OrthoDBi862783at2759
PhylomeDBiQ15113
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2243919 Crosslinking of collagen fibrils

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCOLCE human
EvolutionaryTraceiQ15113

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCOLCE

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5118

Protein Ontology

More...
PROi
PR:Q15113

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106333 Expressed in 185 organ(s), highest expression level in tibia
CleanExiHS_PCOLCE
GenevisibleiQ15113 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR028870 PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR44264:SF2 PTHR44264:SF2, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCOC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15113
Secondary accession number(s): B2R9E1, O14550
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 16, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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