UniProtKB - Q15111 (PLCL1_HUMAN)
Inactive phospholipase C-like protein 1
PLCL1
Functioni
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity).
Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
By similarity1 PublicationCaution
GO - Molecular functioni
- GABA receptor binding Source: InterPro
- inositol 1,4,5 trisphosphate binding Source: InterPro
- phosphatidylinositol phospholipase C activity Source: InterPro
- phospholipase C activity Source: ProtInc
GO - Biological processi
- gamma-aminobutyric acid signaling pathway Source: Ensembl
- intracellular signal transduction Source: ProtInc
- lipid metabolic process Source: InterPro
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- phosphatidylinositol-mediated signaling Source: GO_Central
- positive regulation of receptor binding Source: Ensembl
- regulation of peptidyl-serine phosphorylation Source: Ensembl
- regulation of synaptic transmission, GABAergic Source: Ensembl
Keywordsi
Molecular function | Transducer |
Enzyme and pathway databases
BRENDAi | 2.7.11.10, 2681 |
PathwayCommonsi | Q15111 |
SignaLinki | Q15111 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive phospholipase C-like protein 1Short name: PLC-L1 Alternative name(s): Phospholipase C-deleted in lung carcinoma Phospholipase C-related but catalytically inactive protein Short name: PRIP |
Gene namesi | Name:PLCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9063, PLCL1 |
MIMi | 600597, gene |
neXtProti | NX_Q15111 |
VEuPathDBi | HostDB:ENSG00000115896 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 5334 |
OpenTargetsi | ENSG00000115896 |
PharmGKBi | PA33394 |
Miscellaneous databases
Pharosi | Q15111, Tbio |
Chemistry databases
DrugBanki | DB01103, Quinacrine |
Genetic variation databases
BioMutai | PLCL1 |
DMDMi | 226694170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319414 | 1 – 1095 | Inactive phospholipase C-like protein 1Add BLAST | 1095 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | PhosphoserineBy similarity | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 93 | Phosphothreonine; by PKABy similarity | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 556 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 569 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1079 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q15111 |
MaxQBi | Q15111 |
PaxDbi | Q15111 |
PeptideAtlasi | Q15111 |
PRIDEi | Q15111 |
ProteomicsDBi | 60440 [Q15111-1] 60441 [Q15111-2] |
PTM databases
GlyGeni | Q15111, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15111 |
PhosphoSitePlusi | Q15111 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115896, Expressed in corpus callosum and 224 other tissues |
ExpressionAtlasi | Q15111, baseline and differential |
Genevisiblei | Q15111, HS |
Organism-specific databases
HPAi | ENSG00000115896, Tissue enhanced (brain, tongue) |
Interactioni
Subunit structurei
Interacts with PPP2CA (By similarity).
Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination.
By similarity5 PublicationsGO - Molecular functioni
- GABA receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 111350, 2 interactors |
IntActi | Q15111, 2 interactors |
STRINGi | 9606.ENSP00000402861 |
Miscellaneous databases
RNActi | Q15111, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 113 – 223 | PHPROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 398 – 542 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 585 – 701 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 701 – 830 | C2PROSITE-ProRule annotationAdd BLAST | 130 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 83 – 222 | Interaction with PPP1CAdd BLAST | 140 | |
Regioni | 543 – 567 | Interaction with GABA A beta subunitBy similarityAdd BLAST | 25 | |
Regioni | 1066 – 1095 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 894 – 914 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1034 – 1059 | Sequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1077 – 1095 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158407 |
InParanoidi | Q15111 |
OMAi | FLWVYTH |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q15111 |
TreeFami | TF313216 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR042124, PLCL1 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF102, PTHR10336:SF102, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEGAAGRED PAPPDAAGGE DDPRVGPDAA GDCVTAASGG RMRDRRSGVA
60 70 80 90 100
LPGAAGTPAD SEAGLLEAAR ATPRRSSIIK DPSNQKCGGR KKTVSFSSMP
110 120 130 140 150
SEKKISSAND CISFMQAGCE LKKVRPNSRI YNRFFTLDTD LQALRWEPSK
160 170 180 190 200
KDLEKAKLDI SAIKEIRLGK NTETFRNNGL ADQICEDCAF SILHGENYES
210 220 230 240 250
LDLVANSADV ANIWVSGLRY LVSRSKQPLD FMEGNQNTPR FMWLKTVFEA
260 270 280 290 300
ADVDGNGIML EDTSVELIKQ LNPTLKEAKI RLKFKEIQKS KEKLTTRVTE
310 320 330 340 350
EEFCEAFCEL CTRPEVYFLL VQISKNKEYL DANDLMLFLE AEQGVTHITE
360 370 380 390 400
DICLDIIRRY ELSEEGRQKG FLAIDGFTQY LLSSECDIFD PEQKKVAQDM
410 420 430 440 450
TQPLSHYYIN ASHNTYLIED QFRGPADING YIRALKMGCR SVELDVSDGS
460 470 480 490 500
DNEPILCNRN NMTTHVSFRS VIEVINKFAF VASEYPLILC LGNHCSLPQQ
510 520 530 540 550
KVMAQQMKKV FGNKLYTEAP LPSESYLPSP EKLKRMIIVK GKKLPSDPDV
560 570 580 590 600
LEGEVTDEDE EAEMSRRMSV DYNGEQKQIR LCRELSDLVS ICKSVQYRDF
610 620 630 640 650
ELSMKSQNYW EMCSFSETEA SRIANEYPED FVNYNKKFLS RIYPSAMRID
660 670 680 690 700
SSNLNPQDFW NCGCQIVAMN FQTPGPMMDL HTGWFLQNGG CGYVLRPSIM
710 720 730 740 750
RDEVSYFSAN TKGILPGVSP LALHIKIISG QNFPKPKGAC AKGDVIDPYV
760 770 780 790 800
CIEIHGIPAD CSEQRTKTVQ QNSDNPIFDE TFEFQVNLPE LAMIRFVVLD
810 820 830 840 850
DDYIGDEFIG QYTIPFECLQ PGYRHVPLRS FVGDIMEHVT LFVHIAITNR
860 870 880 890 900
SGGGKAQKRS LSVRMGKKVR EYTMLRNIGL KTIDDIFKIA VHPLREAIDM
910 920 930 940 950
RENMQNAIVS IKELCGLPPI ASLKQCLLTL SSRLITSDNT PSVSLVMKDS
960 970 980 990 1000
FPYLEPLGAI PDVQKKMLTA YDLMIQESRF LIEMADTVQE KIVQCQKAGM
1010 1020 1030 1040 1050
EFHEELHNLG AKEGLKGRKL NKATESFAWN ITVLKGQGDL LKNAKNEAIE
1060 1070 1080 1090
NMKQIQLACL SCGLSKAPSS SAEAKSKRSL EAIEEKESSE ENGKL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MT40 | A0A0A0MT40_HUMAN | Phosphoinositide phospholipase C | PLCL1 | 1,018 | Annotation score: | ||
H3BUD4 | H3BUD4_HUMAN | Phosphoinositide phospholipase C | PLCL1 | 1,012 | Annotation score: | ||
F8WAR2 | F8WAR2_HUMAN | Inactive phospholipase C-like prote... | PLCL1 | 94 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | R → T in BAA07688 (PubMed:7633416).Curated | 1 | |
Sequence conflicti | 563 | E → Q in BAA07688 (PubMed:7633416).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038993 | 445 | D → N. Corresponds to variant dbSNP:rs45506698Ensembl. | 1 | |
Natural variantiVAR_038994 | 454 | P → S. Corresponds to variant dbSNP:rs45506696Ensembl. | 1 | |
Natural variantiVAR_038995 | 546 | S → F. Corresponds to variant dbSNP:rs45596936Ensembl. | 1 | |
Natural variantiVAR_038996 | 667 | V → I1 PublicationCorresponds to variant dbSNP:rs1064213Ensembl. | 1 | |
Natural variantiVAR_038997 | 684 | W → C. Corresponds to variant dbSNP:rs6741084Ensembl. | 1 | |
Natural variantiVAR_038998 | 937 | S → N. Corresponds to variant dbSNP:rs45452996Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031475 | 1 – 98 | Missing in isoform 2. 2 PublicationsAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D42108 mRNA Translation: BAA07688.1 AC011997 Genomic DNA No translation available. AC013478 Genomic DNA No translation available. AC020719 Genomic DNA Translation: AAY14733.1 BC101531 mRNA Translation: AAI01532.1 BC111985 mRNA Translation: AAI11986.1 BX537442 mRNA Translation: CAD97684.1 |
CCDSi | CCDS2326.2 [Q15111-1] |
PIRi | I54390 |
RefSeqi | NP_006217.3, NM_006226.3 [Q15111-1] XP_016859829.1, XM_017004340.1 [Q15111-2] |
Genome annotation databases
Ensembli | ENST00000428675; ENSP00000402861; ENSG00000115896 |
GeneIDi | 5334 |
KEGGi | hsa:5334 |
MANE-Selecti | ENST00000428675.6; ENSP00000402861.1; NM_006226.4; NP_006217.3 |
UCSCi | uc010fsp.4, human [Q15111-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D42108 mRNA Translation: BAA07688.1 AC011997 Genomic DNA No translation available. AC013478 Genomic DNA No translation available. AC020719 Genomic DNA Translation: AAY14733.1 BC101531 mRNA Translation: AAI01532.1 BC111985 mRNA Translation: AAI11986.1 BX537442 mRNA Translation: CAD97684.1 |
CCDSi | CCDS2326.2 [Q15111-1] |
PIRi | I54390 |
RefSeqi | NP_006217.3, NM_006226.3 [Q15111-1] XP_016859829.1, XM_017004340.1 [Q15111-2] |
3D structure databases
SMRi | Q15111 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111350, 2 interactors |
IntActi | Q15111, 2 interactors |
STRINGi | 9606.ENSP00000402861 |
Chemistry databases
DrugBanki | DB01103, Quinacrine |
PTM databases
GlyGeni | Q15111, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15111 |
PhosphoSitePlusi | Q15111 |
Genetic variation databases
BioMutai | PLCL1 |
DMDMi | 226694170 |
Proteomic databases
MassIVEi | Q15111 |
MaxQBi | Q15111 |
PaxDbi | Q15111 |
PeptideAtlasi | Q15111 |
PRIDEi | Q15111 |
ProteomicsDBi | 60440 [Q15111-1] 60441 [Q15111-2] |
Protocols and materials databases
Antibodypediai | 34073, 156 antibodies from 25 providers |
DNASUi | 5334 |
Genome annotation databases
Ensembli | ENST00000428675; ENSP00000402861; ENSG00000115896 |
GeneIDi | 5334 |
KEGGi | hsa:5334 |
MANE-Selecti | ENST00000428675.6; ENSP00000402861.1; NM_006226.4; NP_006217.3 |
UCSCi | uc010fsp.4, human [Q15111-1] |
Organism-specific databases
CTDi | 5334 |
DisGeNETi | 5334 |
GeneCardsi | PLCL1 |
HGNCi | HGNC:9063, PLCL1 |
HPAi | ENSG00000115896, Tissue enhanced (brain, tongue) |
MIMi | 600597, gene |
neXtProti | NX_Q15111 |
OpenTargetsi | ENSG00000115896 |
PharmGKBi | PA33394 |
VEuPathDBi | HostDB:ENSG00000115896 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158407 |
InParanoidi | Q15111 |
OMAi | FLWVYTH |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q15111 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 2.7.11.10, 2681 |
PathwayCommonsi | Q15111 |
SignaLinki | Q15111 |
Miscellaneous databases
BioGRID-ORCSi | 5334, 3 hits in 1046 CRISPR screens |
ChiTaRSi | PLCL1, human |
GenomeRNAii | 5334 |
Pharosi | Q15111, Tbio |
PROi | PR:Q15111 |
RNActi | Q15111, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115896, Expressed in corpus callosum and 224 other tissues |
ExpressionAtlasi | Q15111, baseline and differential |
Genevisiblei | Q15111, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR042124, PLCL1 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF102, PTHR10336:SF102, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCL1_HUMAN | |
Accessioni | Q15111Primary (citable) accession number: Q15111 Secondary accession number(s): Q3MJ90, Q53SD3, Q7Z3S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | April 14, 2009 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot