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Entry version 200 (05 Jun 2019)
Sequence version 1 (01 Nov 1997)
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Protein

Advanced glycosylation end product-specific receptor

Gene

AGER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15109

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.23.1.19 the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGER
Synonyms:RAGE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:320 AGER

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600214 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 342ExtracellularSequence analysisAdd BLAST320
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 404CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
177

Open Targets

More...
OpenTargetsi
ENSG00000204305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24617

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176846

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2843

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGER

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2497317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001492323 – 404Advanced glycosylation end product-specific receptorAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 994 Publications
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 2084 Publications
Disulfide bondi259Interchain1 Publication
Disulfide bondi301Interchain1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei391PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15109

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15109

PeptideAtlas

More...
PeptideAtlasi
Q15109

PRoteomics IDEntifications database

More...
PRIDEi
Q15109

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60436
60437 [Q15109-2]
60438 [Q15109-3]
60439 [Q15109-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15109

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15109

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Endothelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204305 Expressed in 111 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15109 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15109 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011682
HPA064436

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with S100A1 and APP (By similarity).

Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106685, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-40658N

Protein interaction database and analysis system

More...
IntActi
Q15109, 21 interactors

Molecular INTeraction database

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MINTi
Q15109

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364210

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q15109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15109

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15109

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 116Ig-like V-typeAdd BLAST94
Domaini124 – 221Ig-like C2-type 1Add BLAST98
Domaini227 – 317Ig-like C2-type 2Add BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi380 – 384Poly-Glu5

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVT2 Eukaryota
ENOG4111C4I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00890000139566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232122

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15109

KEGG Orthology (KO)

More...
KOi
K19722

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHTAPIQ

Database of Orthologous Groups

More...
OrthoDBi
845400at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15109

TreeFam database of animal gene trees

More...
TreeFami
TF337155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15109-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ
110 120 130 140 150
AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY
160 170 180 190 200
PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH PETGLFTLQS ELMVTPARGG
210 220 230 240 250
DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA
260 270 280 290 300
PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS
310 320 330 340 350
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG
360 370 380 390 400
LGTAALLIGV ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS

TGGP
Length:404
Mass (Da):42,803
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D584C436C30CCE7
GO
Isoform 2 (identifier: Q15109-2) [UniParc]FASTAAdd to basket
Also known as: RAGESEC

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.
     275-404: GVPLPLPPSP...EAGESSTGGP → VSDLERGAGR...ACRTESVGGT

Show »
Length:342
Mass (Da):36,193
Checksum:i35DDF66A13E39B38
GO
Isoform 3 (identifier: Q15109-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:347
Mass (Da):37,050
Checksum:i519E377C4D6AC62C
GO
Isoform 4 (identifier: Q15109-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:363
Mass (Da):39,020
Checksum:i82CC2FB0B9F209EA
GO
Isoform 5 (identifier: Q15109-5) [UniParc]FASTAAdd to basket
Also known as: del exon3-7

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: YRVRVYQIP → WWWSQKVEQ
     122-404: Missing.

Show »
Length:121
Mass (Da):13,192
Checksum:iE97FC3AF05656A12
GO
Isoform 6 (identifier: Q15109-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE

Show »
Length:420
Mass (Da):44,773
Checksum:i5C7E88B8E689D4E5
GO
Isoform 7 (identifier: Q15109-7) [UniParc]FASTAAdd to basket
Also known as: del exon3

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.

Show »
Length:390
Mass (Da):41,234
Checksum:i45A848CAF877F023
GO
Isoform 8 (identifier: Q15109-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-325: GVPLPLPPSP...VSISIIEPGE → NQARRGQLQV...TRRKRRSVQN
     326-404: Missing.

Show »
Length:325
Mass (Da):35,322
Checksum:iF69D13970D2A81B6
GO
Isoform 9 (identifier: Q15109-9) [UniParc]FASTAAdd to basket
Also known as: del exon8-9

The sequence of this isoform differs from the canonical sequence as follows:
     276-355: VPLPLPPSPV...GILGGLGTAA → LRTREPTAVW...TRRKRRSVQN
     356-404: Missing.

Show »
Length:355
Mass (Da):38,379
Checksum:i728DA303F36B4175
GO
Isoform 10 (identifier: Q15109-10) [UniParc]FASTAAdd to basket
Also known as: delta-ICD, variant 20

The sequence of this isoform differs from the canonical sequence as follows:
     374-404: KAPENQEEEEERAELNQSEEPEAGESSTGGP → PQKTRRKRRSVQN

Note: Detected in lung, brain, heart and kidney.
Show »
Length:386
Mass (Da):41,098
Checksum:i4D3BCF036D55A052
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SSZ2Q5SSZ2_HUMAN
Advanced glycosylation end product-...
AGER
233Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3L1R2Q3L1R2_HUMAN
Advanced glycosylation end product-...
AGER
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JL65A0A0G2JL65_HUMAN
Advanced glycosylation end product-...
AGER
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JL21A0A0G2JL21_HUMAN
Advanced glycosylation end product-...
AGER
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MS87A8MS87_HUMAN
Advanced glycosylation end product-...
AGER
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C0IP14C0IP14_HUMAN
Advanced glycosylation end product-...
AGER
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JL37A0A0G2JL37_HUMAN
Advanced glycosylation end product-...
AGER
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJF5A0A0G2JJF5_HUMAN
Advanced glycosylation end product-...
AGER
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JID9A0A0G2JID9_HUMAN
Advanced glycosylation end product-...
AGER
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5A982B5A982_HUMAN
Advanced glycosylation end product-...
AGER RAGE
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → G in AAA03574 (PubMed:1378843).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02450082G → S1 PublicationCorresponds to variant dbSNP:rs2070600Ensembl.1
Natural variantiVAR_011338100Q → R1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00255154 – 67Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_047884113 – 121YRVRVYQIP → WWWSQKVEQ in isoform 5. 1 Publication9
Alternative sequenceiVSP_047885122 – 404Missing in isoform 5. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_043528140K → KVVEESRRSRKRPCEQE in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_002552275 – 404GVPLP…STGGP → VSDLERGAGRTRRGGANCRL CGRIRAGNSSPGPGDPGRPG DSRPAHWGHLVAKAATPRRG EEGPRKPGGRGGACRTESVG GT in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_047886275 – 325GVPLP…IEPGE → NQARRGQLQVRGLIKSGKQK IAPNTCDWGDGQQERNGRPQ KTRRKRRSVQN in isoform 8. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_047887276 – 355VPLPL…LGTAA → LRTREPTAVWPPIPATGPRK AVLSASASSNQARRGQLQVR GLIKSGKQKIAPNTCDWGDG QQERNGRPQKTRRKRRSVQN in isoform 9. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_047888326 – 404Missing in isoform 8. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_042011332 – 404SVGGS…STGGP → EGFDKVREAEDSPQHM in isoform 3 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_047889356 – 404Missing in isoform 9. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055321374 – 404KAPEN…STGGP → PQKTRRKRRSVQN in isoform 10. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M91211 mRNA Translation: AAA03574.1
D28769 Genomic DNA Translation: BAA05958.1
AB036432 mRNA Translation: BAA89369.1
AJ133822 mRNA Translation: CAB43108.1
AB061668 mRNA Translation: BAC65465.1
U89336 Genomic DNA Translation: AAB47491.1
AY755619 mRNA Translation: AAX07272.1
AY755620 mRNA Translation: AAX07273.1
AY755621 mRNA Translation: AAX07274.1
AY755622 mRNA Translation: AAX07275.1
AY755623 mRNA Translation: AAX07276.1
AY755624 mRNA Translation: AAX07277.1
AY755625 mRNA Translation: AAX07278.1
AY755628 mRNA Translation: AAX07281.1
DQ104252 mRNA Translation: AAZ32413.1
EU117141 mRNA Translation: ABV03807.1
KC692917 mRNA Translation: AHB30241.1
AK313178 mRNA Translation: BAG35995.1
AL662830 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03610.1
CH471081 Genomic DNA Translation: EAX03611.1
BC020669 mRNA Translation: AAH20669.1
AF208289 Genomic DNA Translation: AAG35728.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4746.1 [Q15109-1]
CCDS4747.1 [Q15109-2]
CCDS56417.1 [Q15109-4]
CCDS56418.1 [Q15109-3]
CCDS75429.1 [Q15109-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
I61596

NCBI Reference Sequences

More...
RefSeqi
NP_001127.1, NM_001136.4 [Q15109-1]
NP_001193858.1, NM_001206929.1 [Q15109-6]
NP_001193861.1, NM_001206932.1 [Q15109-7]
NP_001193863.1, NM_001206934.1 [Q15109-4]
NP_001193865.1, NM_001206936.1 [Q15109-9]
NP_001193869.1, NM_001206940.1 [Q15109-3]
NP_001193883.1, NM_001206954.1 [Q15109-8]
NP_001193895.1, NM_001206966.1 [Q15109-3]
NP_751947.1, NM_172197.2 [Q15109-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375055; ENSP00000364195; ENSG00000204305 [Q15109-3]
ENST00000375067; ENSP00000364208; ENSG00000204305 [Q15109-2]
ENST00000375069; ENSP00000364210; ENSG00000204305 [Q15109-6]
ENST00000375076; ENSP00000364217; ENSG00000204305 [Q15109-1]
ENST00000383275; ENSP00000372762; ENSG00000206320 [Q15109-3]
ENST00000383279; ENSP00000372766; ENSG00000206320 [Q15109-2]
ENST00000412470; ENSP00000387853; ENSG00000229058 [Q15109-2]
ENST00000426138; ENSP00000415144; ENSG00000230514
ENST00000427822; ENSP00000416042; ENSG00000231268
ENST00000432831; ENSP00000413391; ENSG00000237405 [Q15109-3]
ENST00000436456; ENSP00000397227; ENSG00000234729 [Q15109-1]
ENST00000438221; ENSP00000387887; ENSG00000204305 [Q15109-4]
ENST00000441180; ENSP00000388462; ENSG00000234729 [Q15109-2]
ENST00000441804; ENSP00000391743; ENSG00000237405 [Q15109-2]
ENST00000447921; ENSP00000395812; ENSG00000237405 [Q15109-1]
ENST00000449037; ENSP00000400667; ENSG00000229058 [Q15109-3]
ENST00000451115; ENSP00000401068; ENSG00000206320 [Q15109-1]
ENST00000453588; ENSP00000399686; ENSG00000234729 [Q15109-3]
ENST00000456918; ENSP00000409457; ENSG00000229058 [Q15109-1]
ENST00000547328; ENSP00000448579; ENSG00000206320 [Q15109-6]
ENST00000547651; ENSP00000449708; ENSG00000229058 [Q15109-4]
ENST00000548464; ENSP00000450134; ENSG00000234729 [Q15109-6]
ENST00000549758; ENSP00000447301; ENSG00000229058 [Q15109-6]
ENST00000550562; ENSP00000446835; ENSG00000234729 [Q15109-4]
ENST00000551254; ENSP00000449226; ENSG00000206320 [Q15109-4]
ENST00000551381; ENSP00000448979; ENSG00000237405 [Q15109-6]
ENST00000551827; ENSP00000449042; ENSG00000237405 [Q15109-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:177

UCSC genome browser

More...
UCSCi
uc003oal.3 human [Q15109-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91211 mRNA Translation: AAA03574.1
D28769 Genomic DNA Translation: BAA05958.1
AB036432 mRNA Translation: BAA89369.1
AJ133822 mRNA Translation: CAB43108.1
AB061668 mRNA Translation: BAC65465.1
U89336 Genomic DNA Translation: AAB47491.1
AY755619 mRNA Translation: AAX07272.1
AY755620 mRNA Translation: AAX07273.1
AY755621 mRNA Translation: AAX07274.1
AY755622 mRNA Translation: AAX07275.1
AY755623 mRNA Translation: AAX07276.1
AY755624 mRNA Translation: AAX07277.1
AY755625 mRNA Translation: AAX07278.1
AY755628 mRNA Translation: AAX07281.1
DQ104252 mRNA Translation: AAZ32413.1
EU117141 mRNA Translation: ABV03807.1
KC692917 mRNA Translation: AHB30241.1
AK313178 mRNA Translation: BAG35995.1
AL662830 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03610.1
CH471081 Genomic DNA Translation: EAX03611.1
BC020669 mRNA Translation: AAH20669.1
AF208289 Genomic DNA Translation: AAG35728.1
CCDSiCCDS4746.1 [Q15109-1]
CCDS4747.1 [Q15109-2]
CCDS56417.1 [Q15109-4]
CCDS56418.1 [Q15109-3]
CCDS75429.1 [Q15109-6]
PIRiI61596
RefSeqiNP_001127.1, NM_001136.4 [Q15109-1]
NP_001193858.1, NM_001206929.1 [Q15109-6]
NP_001193861.1, NM_001206932.1 [Q15109-7]
NP_001193863.1, NM_001206934.1 [Q15109-4]
NP_001193865.1, NM_001206936.1 [Q15109-9]
NP_001193869.1, NM_001206940.1 [Q15109-3]
NP_001193883.1, NM_001206954.1 [Q15109-8]
NP_001193895.1, NM_001206966.1 [Q15109-3]
NP_751947.1, NM_172197.2 [Q15109-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWImodel-A1-404[»]
2BJPmodel-A1-404[»]
2E5ENMR-A23-121[»]
2ENSNMR-A235-323[»]
2L7UNMR-A23-125[»]
2LE9NMR-A/D235-327[»]
2LMBNMR-A363-404[»]
2M1KNMR-A/C23-121[»]
2MJWNMR-A/C23-121[»]
2MOVNMR-A23-125[»]
3CJJX-ray1.85A23-240[»]
3O3UX-ray1.50N23-231[»]
4LP4X-ray2.40A/B23-231[»]
4LP5X-ray3.80A/B23-323[»]
4OF5X-ray2.80A/B23-237[»]
4OFVX-ray3.10A/B23-235[»]
4OI7X-ray3.10A/B23-237[»]
4OI8X-ray3.10A/B23-237[»]
4P2YX-ray2.30A23-323[»]
4XYNX-ray2.55P54-68[»]
4YBHX-ray2.40A23-323[»]
5D7FX-ray1.30P65-79[»]
SMRiQ15109
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106685, 12 interactors
DIPiDIP-40658N
IntActiQ15109, 21 interactors
MINTiQ15109
STRINGi9606.ENSP00000364210

Chemistry databases

BindingDBiQ15109
ChEMBLiCHEMBL2176846
GuidetoPHARMACOLOGYi2843

Protein family/group databases

TCDBi8.A.23.1.19 the basigin (basigin) family

PTM databases

iPTMnetiQ15109
PhosphoSitePlusiQ15109

Polymorphism and mutation databases

BioMutaiAGER
DMDMi2497317

Proteomic databases

jPOSTiQ15109
PaxDbiQ15109
PeptideAtlasiQ15109
PRIDEiQ15109
ProteomicsDBi60436
60437 [Q15109-2]
60438 [Q15109-3]
60439 [Q15109-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
177
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375055; ENSP00000364195; ENSG00000204305 [Q15109-3]
ENST00000375067; ENSP00000364208; ENSG00000204305 [Q15109-2]
ENST00000375069; ENSP00000364210; ENSG00000204305 [Q15109-6]
ENST00000375076; ENSP00000364217; ENSG00000204305 [Q15109-1]
ENST00000383275; ENSP00000372762; ENSG00000206320 [Q15109-3]
ENST00000383279; ENSP00000372766; ENSG00000206320 [Q15109-2]
ENST00000412470; ENSP00000387853; ENSG00000229058 [Q15109-2]
ENST00000426138; ENSP00000415144; ENSG00000230514
ENST00000427822; ENSP00000416042; ENSG00000231268
ENST00000432831; ENSP00000413391; ENSG00000237405 [Q15109-3]
ENST00000436456; ENSP00000397227; ENSG00000234729 [Q15109-1]
ENST00000438221; ENSP00000387887; ENSG00000204305 [Q15109-4]
ENST00000441180; ENSP00000388462; ENSG00000234729 [Q15109-2]
ENST00000441804; ENSP00000391743; ENSG00000237405 [Q15109-2]
ENST00000447921; ENSP00000395812; ENSG00000237405 [Q15109-1]
ENST00000449037; ENSP00000400667; ENSG00000229058 [Q15109-3]
ENST00000451115; ENSP00000401068; ENSG00000206320 [Q15109-1]
ENST00000453588; ENSP00000399686; ENSG00000234729 [Q15109-3]
ENST00000456918; ENSP00000409457; ENSG00000229058 [Q15109-1]
ENST00000547328; ENSP00000448579; ENSG00000206320 [Q15109-6]
ENST00000547651; ENSP00000449708; ENSG00000229058 [Q15109-4]
ENST00000548464; ENSP00000450134; ENSG00000234729 [Q15109-6]
ENST00000549758; ENSP00000447301; ENSG00000229058 [Q15109-6]
ENST00000550562; ENSP00000446835; ENSG00000234729 [Q15109-4]
ENST00000551254; ENSP00000449226; ENSG00000206320 [Q15109-4]
ENST00000551381; ENSP00000448979; ENSG00000237405 [Q15109-6]
ENST00000551827; ENSP00000449042; ENSG00000237405 [Q15109-4]
GeneIDi177
KEGGihsa:177
UCSCiuc003oal.3 human [Q15109-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177
DisGeNETi177

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AGER
HGNCiHGNC:320 AGER
HPAiCAB011682
HPA064436
MIMi600214 gene
neXtProtiNX_Q15109
OpenTargetsiENSG00000204305
PharmGKBiPA24617

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
GeneTreeiENSGT00890000139566
HOGENOMiHOG000232122
InParanoidiQ15109
KOiK19722
OMAiLHTAPIQ
OrthoDBi845400at2759
PhylomeDBiQ15109
TreeFamiTF337155

Enzyme and pathway databases

ReactomeiR-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
SIGNORiQ15109

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AGER human
EvolutionaryTraceiQ15109

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAGE_(receptor)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
177

Protein Ontology

More...
PROi
PR:Q15109

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204305 Expressed in 111 organ(s), highest expression level in right lung
ExpressionAtlasiQ15109 baseline and differential
GenevisibleiQ15109 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAGE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15109
Secondary accession number(s): A2BFI7
, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 5, 2019
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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