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Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

PAFAH1B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47By similarity1
Active sitei192By similarity1
Active sitei195By similarity1

GO - Molecular functioni

GO - Biological processi

  • brain development Source: GO_Central
  • lipid catabolic process Source: UniProtKB-KW
  • lipid metabolic process Source: ProtInc
  • nervous system development Source: ProtInc
  • spermatogenesis Source: Ensembl

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Gene namesi
Name:PAFAH1B3
Synonyms:PAFAHG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000079462.7
HGNCiHGNC:8576 PAFAH1B3
MIMi603074 gene
neXtProtiNX_Q15102

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5050
OpenTargetsiENSG00000079462
PharmGKBiPA32907

Chemistry databases

ChEMBLiCHEMBL5108

Polymorphism and mutation databases

BioMutaiPAFAH1B3
DMDMi3024344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000581552 – 231Platelet-activating factor acetylhydrolase IB subunit gammaAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15102
MaxQBiQ15102
PaxDbiQ15102
PeptideAtlasiQ15102
PRIDEiQ15102
ProteomicsDBi60435

2D gel databases

REPRODUCTION-2DPAGEiIPI00014808

PTM databases

iPTMnetiQ15102
PhosphoSitePlusiQ15102
SwissPalmiQ15102

Expressioni

Tissue specificityi

In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain.

Gene expression databases

BgeeiENSG00000079462
CleanExiHS_PAFAH1B3
ExpressionAtlasiQ15102 baseline and differential
GenevisibleiQ15102 HS

Organism-specific databases

HPAiHPA035639

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi111087, 46 interactors
IntActiQ15102, 40 interactors
MINTiQ15102
STRINGi9606.ENSP00000262890

Structurei

3D structure databases

ProteinModelPortaliQ15102
SMRiQ15102
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IMK6 Eukaryota
ENOG410XPWQ LUCA
GeneTreeiENSGT00390000016520
HOGENOMiHOG000232143
HOVERGENiHBG053477
InParanoidiQ15102
KOiK16795
OMAiHQDMYDY
OrthoDBiEOG091G0OII
PhylomeDBiQ15102
TreeFamiTF323955

Family and domain databases

Gene3Di3.40.50.1110, 1 hit
InterProiView protein in InterPro
IPR013830 SGNH_hydro
IPR036514 SGNH_hydro_sf
PfamiView protein in Pfam
PF13472 Lipase_GDSL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ
60 70 80 90 100
LMHQCEIWRE LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW
110 120 130 140 150
VGTNNHGHTA EQVTGGIKAI VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE
160 170 180 190 200
KNRQVNELVR AALAGHPRAH FLDADPGFVH SDGTISHHDM YDYLHLSRLG
210 220 230
YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P
Length:231
Mass (Da):25,734
Last modified:November 1, 1996 - v1
Checksum:i58A4CB8E7076AE23
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051261214R → G. Corresponds to variant dbSNP:rs1043818Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63391 mRNA Translation: BAA09706.1
CR407626 mRNA Translation: CAG28554.1
AC006486 Genomic DNA Translation: AAD11989.1
CH471126 Genomic DNA Translation: EAW57122.1
BC003016 mRNA Translation: AAH03016.1
BC007863 mRNA Translation: AAH07863.1
CCDSiCCDS12602.1
PIRiJC4246
RefSeqiNP_001139411.1, NM_001145939.1
NP_001139412.1, NM_001145940.1
NP_002564.1, NM_002573.3
UniGeneiHs.466831

Genome annotation databases

EnsembliENST00000262890; ENSP00000262890; ENSG00000079462
ENST00000538771; ENSP00000444935; ENSG00000079462
GeneIDi5050
KEGGihsa:5050
UCSCiuc002otg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPA1B3_HUMAN
AccessioniPrimary (citable) accession number: Q15102
Secondary accession number(s): Q53X88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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