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Entry version 192 (13 Feb 2019)
Sequence version 2 (30 May 2006)
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Protein

Neutrophil cytosol factor 4

Gene

NCF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: UniProtKB
  • phosphatidylinositol binding Source: GO_Central
  • protein dimerization activity Source: UniProtKB
  • superoxide-generating NADPH oxidase activator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutrophil cytosol factor 4
Short name:
NCF-4
Alternative name(s):
Neutrophil NADPH oxidase factor 4
SH3 and PX domain-containing protein 4
p40-phox
Short name:
p40phox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCF4
Synonyms:SH3PXD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100365.14

Human Gene Nomenclature Database

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HGNCi
HGNC:7662 NCF4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601488 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15080

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive (CGD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
See also OMIM:613960
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065949105R → Q in CGD3; the protein remains cytosolic, does not localize to phagosomes or endosomes and is unable to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) in a lipid-binding assay; unable to rescue the NADPH-oxidase defect of NCF4 functionally null cells. 1 PublicationCorresponds to variant dbSNP:rs387906808EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58R → Q: Abolishes interaction with membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi60R → A: Strongly reduces interaction with membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi92K → A: Abolishes interaction with membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi94Y → A: Slightly reduces interaction with membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi105R → A: Abolishes interaction with membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi154T → A: Reduces phosphorylation. 1 Publication1
Mutagenesisi211T → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi251T → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi274T → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi315S → A: Reduces phosphorylation. 1 Publication1
Mutagenesisi327T → A: No effect on phosphorylation. 1 Publication1

Keywords - Diseasei

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4689

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
NCF4

MalaCards human disease database

More...
MalaCardsi
NCF4
MIMi613960 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100365

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
379 Chronic granulomatous disease
206 NON RARE IN EUROPE: Crohn disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31465

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00514 Dextromethorphan

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108884815

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967641 – 339Neutrophil cytosol factor 4Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei154Phosphothreonine1 Publication1
Modified residuei315Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15080

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15080

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15080

PeptideAtlas

More...
PeptideAtlasi
Q15080

PRoteomics IDEntifications database

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PRIDEi
Q15080

ProteomicsDB human proteome resource

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ProteomicsDBi
60430
60432 [Q15080-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15080

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15080

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is restricted to hematopoietic cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100365 Expressed in 162 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15080 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15080 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010146
HPA036156
HPA057975

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. NCF4 interacts primarily with NCF2 to form a complex with NCF1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110769, 6 interactors

Database of interacting proteins

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DIPi
DIP-17019N

Protein interaction database and analysis system

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IntActi
Q15080, 5 interactors

Molecular INTeraction database

More...
MINTi
Q15080

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380334

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H6HX-ray1.70A2-144[»]
1OEYX-ray2.00J/K/L/M237-339[»]
1W6XX-ray2.00A/B174-228[»]
1W70X-ray1.46A/B174-228[»]
1Z9QNMR-A168-233[»]
2DYBX-ray3.15A/B1-339[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q15080

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15080

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15080

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 140PXPROSITE-ProRule annotationAdd BLAST122
Domaini170 – 229SH3PROSITE-ProRule annotationAdd BLAST60
Domaini237 – 329PB1PROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 60Phosphatidylinositol 3-phosphate binding3
Regioni92 – 94Phosphatidylinositol 3-phosphate binding3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PB1 domain mediates the association with NCF2/p67-PHOX.
The PX domain mediates interaction with membranes enriched in phosphatidylnositol 3-phosphate.

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4773 Eukaryota
ENOG410YBFF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013076

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006452

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15080

KEGG Orthology (KO)

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KOi
K08012

Identification of Orthologs from Complete Genome Data

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OMAi
FPWKLHV

Database of Orthologous Groups

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OrthoDBi
824942at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15080

Family and domain databases

Conserved Domains Database

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CDDi
cd06399 PB1_P40, 1 hit
cd06882 PX_p40phox, 1 hit
cd11869 SH3_p40phox, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000919 p40phox
IPR035541 p40phox_SH3
IPR000270 PB1_dom
IPR034853 PB1_P40
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034912 PX_p40phox
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR44898 PTHR44898, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00564 PB1, 1 hit
PF00787 PX, 1 hit
PF00018 SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00497 P40PHOX

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15080-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAQQLRAE SDFEQLPDDV AISANIADIE EKRGFTSHFV FVIEVKTKGG
60 70 80 90 100
SKYLIYRRYR QFHALQSKLE ERFGPDSKSS ALACTLPTLP AKVYVGVKQE
110 120 130 140 150
IAEMRIPALN AYMKSLLSLP VWVLMDEDVR IFFYQSPYDS EQVPQALRRL
160 170 180 190 200
RPRTRKVKSV SPQGNSVDRM AAPRAEALFD FTGNSKLELN FKAGDVIFLL
210 220 230 240 250
SRINKDWLEG TVRGATGIFP LSFVKILKDF PEEDDPTNWL RCYYYEDTIS
260 270 280 290 300
TIKDIAVEED LSSTPLLKDL LELTRREFQR EDIALNYRDA EGDLVRLLSD
310 320 330
EDVALMVRQA RGLPSQKRLF PWKLHITQKD NYRVYNTMP
Length:339
Mass (Da):39,032
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD82FE9E5BA12890B
GO
Isoform 3 (identifier: Q15080-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-339: DIAVEEDLSS...DNYRVYNTMP → SVAWEGGACP...WRKISAALPY

Show »
Length:348
Mass (Da):39,017
Checksum:i0C787E82434C16C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QY04B0QY04_HUMAN
Neutrophil cytosol factor 4
NCF4
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A217FLJ2A0A217FLJ2_HUMAN
Neutrophil cytosol factor 4
NCF4 hCG_40038
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JR51A0A0G2JR51_HUMAN
Neutrophil cytosol factor 4
NCF4
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065949105R → Q in CGD3; the protein remains cytosolic, does not localize to phagosomes or endosomes and is unable to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) in a lipid-binding assay; unable to rescue the NADPH-oxidase defect of NCF4 functionally null cells. 1 PublicationCorresponds to variant dbSNP:rs387906808EnsemblClinVar.1
Natural variantiVAR_009314147L → I2 Publications1
Natural variantiVAR_034136153R → H. Corresponds to variant dbSNP:rs35160112Ensembl.1
Isoform 3 (identifier: Q15080-3)
Natural varianti272L → P. Corresponds to variant dbSNP:rs2075939Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042681254 – 339DIAVE…YNTMP → SVAWEGGACPAFLPSLRPLP LTSPSHGSLSHSKAPSGSQM SHNAVTSHQRPGWPGQPHSP FPHPTPHFQPDASLLQPVTP LGTSRWRKISAALPY in isoform 3. 4 PublicationsAdd BLAST86

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X77094 mRNA Translation: CAA54372.1
U50729
, U50720, U50721, U50722, U50723, U50724, U50725, U50726, U50727, U50728 Genomic DNA Translation: AAB39970.1
AB025220 mRNA Translation: BAA89792.1
AB025219 mRNA Translation: BAA89791.1
CR456528 mRNA Translation: CAG30414.1
BT007346 mRNA Translation: AAP36010.1
AK290924 mRNA Translation: BAF83613.1
DQ314880 Genomic DNA Translation: ABC40739.1
AL008637 Genomic DNA No translation available.
BC002798 mRNA Translation: AAH02798.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13934.1 [Q15080-1]
CCDS13935.1 [Q15080-3]

Protein sequence database of the Protein Information Resource

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PIRi
S39768

NCBI Reference Sequences

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RefSeqi
NP_000622.2, NM_000631.4 [Q15080-1]
NP_038202.2, NM_013416.3 [Q15080-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.474781

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000248899; ENSP00000248899; ENSG00000100365 [Q15080-1]
ENST00000397147; ENSP00000380334; ENSG00000100365 [Q15080-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4689

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4689

UCSC genome browser

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UCSCi
uc003apy.5 human [Q15080-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77094 mRNA Translation: CAA54372.1
U50729
, U50720, U50721, U50722, U50723, U50724, U50725, U50726, U50727, U50728 Genomic DNA Translation: AAB39970.1
AB025220 mRNA Translation: BAA89792.1
AB025219 mRNA Translation: BAA89791.1
CR456528 mRNA Translation: CAG30414.1
BT007346 mRNA Translation: AAP36010.1
AK290924 mRNA Translation: BAF83613.1
DQ314880 Genomic DNA Translation: ABC40739.1
AL008637 Genomic DNA No translation available.
BC002798 mRNA Translation: AAH02798.1
CCDSiCCDS13934.1 [Q15080-1]
CCDS13935.1 [Q15080-3]
PIRiS39768
RefSeqiNP_000622.2, NM_000631.4 [Q15080-1]
NP_038202.2, NM_013416.3 [Q15080-3]
UniGeneiHs.474781

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H6HX-ray1.70A2-144[»]
1OEYX-ray2.00J/K/L/M237-339[»]
1W6XX-ray2.00A/B174-228[»]
1W70X-ray1.46A/B174-228[»]
1Z9QNMR-A168-233[»]
2DYBX-ray3.15A/B1-339[»]
ProteinModelPortaliQ15080
SMRiQ15080
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110769, 6 interactors
DIPiDIP-17019N
IntActiQ15080, 5 interactors
MINTiQ15080
STRINGi9606.ENSP00000380334

Chemistry databases

DrugBankiDB00514 Dextromethorphan

PTM databases

iPTMnetiQ15080
PhosphoSitePlusiQ15080

Polymorphism and mutation databases

BioMutaiNCF4
DMDMi108884815

Proteomic databases

jPOSTiQ15080
MaxQBiQ15080
PaxDbiQ15080
PeptideAtlasiQ15080
PRIDEiQ15080
ProteomicsDBi60430
60432 [Q15080-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4689
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248899; ENSP00000248899; ENSG00000100365 [Q15080-1]
ENST00000397147; ENSP00000380334; ENSG00000100365 [Q15080-3]
GeneIDi4689
KEGGihsa:4689
UCSCiuc003apy.5 human [Q15080-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4689
DisGeNETi4689
EuPathDBiHostDB:ENSG00000100365.14

GeneCards: human genes, protein and diseases

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GeneCardsi
NCF4
GeneReviewsiNCF4
HGNCiHGNC:7662 NCF4
HPAiCAB010146
HPA036156
HPA057975
MalaCardsiNCF4
MIMi601488 gene
613960 phenotype
neXtProtiNX_Q15080
OpenTargetsiENSG00000100365
Orphaneti379 Chronic granulomatous disease
206 NON RARE IN EUROPE: Crohn disease
PharmGKBiPA31465

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4773 Eukaryota
ENOG410YBFF LUCA
GeneTreeiENSGT00510000048561
HOGENOMiHOG000013076
HOVERGENiHBG006452
InParanoidiQ15080
KOiK08012
OMAiFPWKLHV
OrthoDBi824942at2759
PhylomeDBiQ15080

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORiQ15080

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCF4 human
EvolutionaryTraceiQ15080

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4689

Protein Ontology

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PROi
PR:Q15080

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100365 Expressed in 162 organ(s), highest expression level in blood
ExpressionAtlasiQ15080 baseline and differential
GenevisibleiQ15080 HS

Family and domain databases

CDDicd06399 PB1_P40, 1 hit
cd06882 PX_p40phox, 1 hit
cd11869 SH3_p40phox, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR000919 p40phox
IPR035541 p40phox_SH3
IPR000270 PB1_dom
IPR034853 PB1_P40
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034912 PX_p40phox
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR44898 PTHR44898, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00787 PX, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00497 P40PHOX
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15080
Secondary accession number(s): A8K4F9
, O60808, Q86U56, Q9BU98, Q9NP45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2006
Last modified: February 13, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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