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UniProtKB - Q15078 (CD5R1_HUMAN)

Entry version 211 (25 May 2022)
Sequence version 1 (01 Nov 1997)
Previous versions | rss
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Protein

Cyclin-dependent kinase 5 activator 1

Gene

CDK5R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

1 Publication

Miscellaneous

Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15078

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-399956, CRMPs in Sema3A signaling
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9031628, NGF-stimulated transcription
R-HSA-9032845, Activated NTRK2 signals through CDK5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15078

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15078

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 5 activator 1
Short name:
CDK5 activator 1
Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 1
TPKII regulatory subunit
Cleaved into the following 2 chains:
Cyclin-dependent kinase 5 activator 1, p35
Short name:
p35
Cyclin-dependent kinase 5 activator 1, p25
Short name:
p25
Alternative name(s):
Tau protein kinase II 23 kDa subunit
Short name:
p23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5R1
Synonyms:CDK5R, NCK5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1775, CDK5R1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603460, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15078

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Absent from the cell periphery. 2 Publications1
Mutagenesisi8S → A: Increased susceptibility to calpain. 1 Publication1
Mutagenesisi8S → E: Reduced susceptibility to calpain. 1 Publication1
Mutagenesisi138T → A: Increased susceptibility to calpain. 1 Publication1
Mutagenesisi138T → E: Reduced susceptibility to calpain. 1 Publication1
Mutagenesisi305L → A in L-3A mutant; abolished recognition and ubiquitination by the CRL2(FEM1B) complex. 1 Publication1
Mutagenesisi305L → R in L-3R mutant; abolished recognition and ubiquitination by the CRL2(FEM1B) complex, while promoting recognition and ubiquitination by the CRL2(FEM1B) complex. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8851

Open Targets

More...OpenTargetsi		ENSG00000176749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26311

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15078, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2783

Drug and drug target database

More...DrugBanki		DB07364, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
DB02052, Indirubin-3'-monoxime

DrugCentral

More...DrugCentrali		Q15078

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDK5R1

Domain mapping of disease mutations (DMDM)

More...DMDMi		2498217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000047942 – 307Cyclin-dependent kinase 5 activator 1, p35Add BLAST306
ChainiPRO_000000479599 – 307Cyclin-dependent kinase 5 activator 1, p25Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8Phosphoserine; by CDK51 Publication1
Modified residuei138Phosphothreonine; by CDK51 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).By similarity
Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.2 Publications
Ubiquitinated, leading to its degradation: degradation of p35 by proteasome results in down-regulation of CDK5 activity (PubMed:12393264). During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation (PubMed:12393264). Ubiquitinated by the CRL2(FEM1B) complex, which recognizes the -Gly-Leu-Asp-Arg C-degron at the C-terminus, leading to its degradation (PubMed:33398170, PubMed:33398168).3 Publications
Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei98 – 99Cleavage; by calpainBy similarity2

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15078

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15078

PeptideAtlas

More...PeptideAtlasi		Q15078

PRoteomics IDEntifications database

More...PRIDEi		Q15078

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60429

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15078

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15078

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain and neuron specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176749, Expressed in neocortex and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15078, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15078, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176749, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3 (PubMed:16039528, PubMed:17671990, PubMed:15689152). Only the heterodimer shows kinase activity (PubMed:16039528, PubMed:17671990, PubMed:15689152).

Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity).

Interacts with RASGRF2 (PubMed:15128856). The complex p35/CDK5 interacts with CLOCK (PubMed:24235147).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114376, 54 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2201, Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
CPX-3142, Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant

Database of interacting proteins

More...DIPi		DIP-24222N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q15078

Protein interaction database and analysis system

More...IntActi		Q15078, 42 interactors

Molecular INTeraction database

More...MINTi		Q15078

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318486

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15078, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q15078

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15078

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15078

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 136DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 129Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin-dependent kinase 5 activator family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3932, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008812

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034132_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15078

Identification of Orthologs from Complete Genome Data

More...OMAi		EVATDHE

Database of Orthologous Groups

More...OrthoDBi		1492547at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15078

TreeFam database of animal gene trees

More...TreeFami		TF101036

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004944, CDK5_activator
IPR036915, Cyclin-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR23401, PTHR23401, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03261, CDK5_activator, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF009324, Cdk5_activator, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q15078-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL 
        60         70         80         90        100
PWKRIVAVSA KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ 
       110        120        130        140        150
PPPAQPPAPP ASQLSGSQTG GSSSVKKAPH PAVTSAGTPK RVIVQASTSE 
       160        170        180        190        200
LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN 
       210        220        230        240        250
VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV 
       260        270        280        290        300
ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 

LLLGLDR
Length:307
Mass (Da):34,060
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1C29A07AFF1B644
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRB5J3QRB5_HUMAN
Cyclin-dependent kinase 5 activator...
CDK5R1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X80343 mRNA Translation: CAA56587.1
AY376350 Genomic DNA Translation: AAQ74776.1
BT019573 mRNA Translation: AAV38380.1
CH471147 Genomic DNA Translation: EAW80227.1
CH471147 Genomic DNA Translation: EAW80228.1
BC020580 mRNA Translation: AAH20580.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11273.1

Protein sequence database of the Protein Information Resource

More...PIRi		S50861

NCBI Reference Sequences

More...RefSeqi		NP_003876.1, NM_003885.2
XP_011523740.1, XM_011525438.2
XP_016880770.1, XM_017025281.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313401.4; ENSP00000318486.3; ENSG00000176749.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8851

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000313401.4; ENSP00000318486.3; NM_003885.3; NP_003876.1

UCSC genome browser

More...UCSCi		uc002hhn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80343 mRNA Translation: CAA56587.1
AY376350 Genomic DNA Translation: AAQ74776.1
BT019573 mRNA Translation: AAV38380.1
CH471147 Genomic DNA Translation: EAW80227.1
CH471147 Genomic DNA Translation: EAW80228.1
BC020580 mRNA Translation: AAH20580.1
CCDSiCCDS11273.1
PIRiS50861
RefSeqiNP_003876.1, NM_003885.2
XP_011523740.1, XM_011525438.2
XP_016880770.1, XM_017025281.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4LX-ray2.65D/E147-293[»]
1UNGX-ray2.30D/E100-307[»]
1UNHX-ray2.35D/E100-307[»]
1UNLX-ray2.20D/E100-307[»]
3O0GX-ray1.95D/E145-293[»]
6LDPX-ray2.35A/B298-307[»]
7CNGX-ray3.49A/B298-307[»]
AlphaFoldDBiQ15078
SMRiQ15078
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114376, 54 interactors
ComplexPortaliCPX-2201, Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
CPX-3142, Cyclin-dependent protein kinase 5 holoenzyme complex, p25 variant
DIPiDIP-24222N
ELMiQ15078
IntActiQ15078, 42 interactors
MINTiQ15078
STRINGi9606.ENSP00000318486

Chemistry databases

BindingDBiQ15078
ChEMBLiCHEMBL2783
DrugBankiDB07364, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
DB02052, Indirubin-3'-monoxime
DrugCentraliQ15078

PTM databases

iPTMnetiQ15078
PhosphoSitePlusiQ15078

Genetic variation databases

BioMutaiCDK5R1
DMDMi2498217

Proteomic databases

MassIVEiQ15078
PaxDbiQ15078
PeptideAtlasiQ15078
PRIDEiQ15078
ProteomicsDBi60429

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q15078, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15411, 284 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		8851

Genome annotation databases

EnsembliENST00000313401.4; ENSP00000318486.3; ENSG00000176749.9
GeneIDi8851
KEGGihsa:8851
MANE-SelectiENST00000313401.4; ENSP00000318486.3; NM_003885.3; NP_003876.1
UCSCiuc002hhn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8851
DisGeNETi8851

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDK5R1
HGNCiHGNC:1775, CDK5R1
HPAiENSG00000176749, Tissue enriched (brain)
MIMi603460, gene
neXtProtiNX_Q15078
OpenTargetsiENSG00000176749
PharmGKBiPA26311
VEuPathDBiHostDB:ENSG00000176749

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3932, Eukaryota
GeneTreeiENSGT00390000008812
HOGENOMiCLU_034132_2_0_1
InParanoidiQ15078
OMAiEVATDHE
OrthoDBi1492547at2759
PhylomeDBiQ15078
TreeFamiTF101036

Enzyme and pathway databases

PathwayCommonsiQ15078
ReactomeiR-HSA-399956, CRMPs in Sema3A signaling
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9031628, NGF-stimulated transcription
R-HSA-9032845, Activated NTRK2 signals through CDK5
SignaLinkiQ15078
SIGNORiQ15078

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8851, 7 hits in 1078 CRISPR screens
EvolutionaryTraceiQ15078

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDK5R1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8851
PharosiQ15078, Tchem

Protein Ontology

More...PROi		PR:Q15078
RNActiQ15078, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000176749, Expressed in neocortex and 195 other tissues
ExpressionAtlasiQ15078, baseline and differential
GenevisibleiQ15078, HS

Family and domain databases

InterProiView protein in InterPro
IPR004944, CDK5_activator
IPR036915, Cyclin-like_sf
PANTHERiPTHR23401, PTHR23401, 1 hit
PfamiView protein in Pfam
PF03261, CDK5_activator, 1 hit
PIRSFiPIRSF009324, Cdk5_activator, 1 hit
SUPFAMiSSF47954, SSF47954, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD5R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15078
Secondary accession number(s): E1P664, Q5U0G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 25, 2022
This is version 211 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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