Cyclin-dependent kinase 5 activator 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin filament binding Source: Ensembl
• alpha-tubulin binding Source: ARUK-UCL
• beta-tubulin binding Source: ARUK-UCL
• cadherin binding Source: UniProtKB
• calcium ion binding Source: UniProtKB
• cyclin-dependent protein serine/threonine kinase activator activity Source: ARUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Microtubule association of the neuronal p35 activator of Cdk5."
    Hou Z., Li Q., He L., Lim H.Y., Fu X., Cheung N.S., Qi D.X., Qi R.Z.
    J. Biol. Chem. 282:18666-18670(2007) [PubMed] [Europe PMC] [Abstract]
• ephrin receptor binding Source: Ensembl
• ionotropic glutamate receptor binding Source: Ensembl
• kinase activity Source: UniProtKB
• protease binding Source: Ensembl
• protein kinase activator activity Source: GO_CentralTraceable author statementⁱ
  • Ref.1

    "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5."
    Tsai L.-H., Delalle I., Caviness V.S. Jr., Chae T., Harlow E.
    Nature 371:419-423(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• protein kinase activity Source: ProtIncTraceable author statementⁱ
  • "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator."
    Tang D., Yeung J., Lee K.-Y., Matsushita M., Matsui H., Tomizawa K., Hatase O., Wang J.H.
    J. Biol. Chem. 270:26897-26903(1995) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase."
    Kesavapany S., Lau K.F., Ackerley S., Banner S.J., Shemilt S.J., Cooper J.D., Leigh P.N., Shaw C.E., McLoughlin D.M., Miller C.C.
    J. Neurosci. 23:4975-4983(2003) [PubMed] [Europe PMC] [Abstract]
• protein serine/threonine kinase activator activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase."
    Kesavapany S., Lau K.F., Ackerley S., Banner S.J., Shemilt S.J., Cooper J.D., Leigh P.N., Shaw C.E., McLoughlin D.M., Miller C.C.
    J. Neurosci. 23:4975-4983(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• axonal fasciculation Source: UniProtKB
• axon guidance Source: UniProtKB
• brain development Source: UniProtKB
• cerebellum development Source: Ensembl
• embryo development ending in birth or egg hatching Source: Ensembl
• ephrin receptor signaling pathway Source: UniProtKB
• G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
• hippocampus development Source: Ensembl
• ionotropic glutamate receptor signaling pathway Source: UniProtKB
• layer formation in cerebral cortex Source: Ensembl
• microtubule cytoskeleton organization Source: ARUK-UCLTraceable author statementⁱ
  • "Microtubule association of the neuronal p35 activator of Cdk5."
    Hou Z., Li Q., He L., Lim H.Y., Fu X., Cheung N.S., Qi D.X., Qi R.Z.
    J. Biol. Chem. 282:18666-18670(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of axon extension Source: Ensembl
• negative regulation of transcription, DNA-templated Source: DFLAT <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor."
    Kino T., Jaffe H., Amin N.D., Chakrabarti M., Zheng Y.L., Chrousos G.P., Pant H.C.
    Mol. Endocrinol. 24:941-952(2010) [PubMed] [Europe PMC] [Abstract]
• neuron cell-cell adhesion Source: UniProtKB
• neuron differentiation Source: UniProtKB
• neuron migration Source: UniProtKB
• neuron projection development Source: UniProtKB
• peptidyl-serine phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase."
    Kesavapany S., Lau K.F., Ackerley S., Banner S.J., Shemilt S.J., Cooper J.D., Leigh P.N., Shaw C.E., McLoughlin D.M., Miller C.C.
    J. Neurosci. 23:4975-4983(2003) [PubMed] [Europe PMC] [Abstract]
• peptidyl-threonine phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase."
    Kesavapany S., Lau K.F., Ackerley S., Banner S.J., Shemilt S.J., Cooper J.D., Leigh P.N., Shaw C.E., McLoughlin D.M., Miller C.C.
    J. Neurosci. 23:4975-4983(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle arrest Source: Ensembl
• positive regulation of MHC class II biosynthetic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution."
    Mathys H., Adaikkan C., Gao F., Young J.Z., Manet E., Hemberg M., De Jager P.L., Ransohoff R.M., Regev A., Tsai L.H.
    Cell Rep 21:366-380(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of microtubule polymerization Source: ARUK-UCL
• positive regulation of neuron apoptotic process Source: UniProtKB
• positive regulation of protein targeting to membrane Source: Ensembl
• positive regulation of receptor biosynthetic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution."
    Mathys H., Adaikkan C., Gao F., Young J.Z., Manet E., Hemberg M., De Jager P.L., Ransohoff R.M., Regev A., Tsai L.H.
    Cell Rep 21:366-380(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of actin cytoskeleton organization Source: Ensembl
• regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtIncTraceable author statementⁱ
  • "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator."
    Tang D., Yeung J., Lee K.-Y., Matsushita M., Matsui H., Tomizawa K., Hatase O., Wang J.H.
    J. Biol. Chem. 270:26897-26903(1995) [PubMed] [Europe PMC] [Abstract]
• regulation of dendritic spine morphogenesis Source: UniProtKB
• regulation of macroautophagy Source: ParkinsonsUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease."
    Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., Ip N.Y.
    Nat. Cell Biol. 13:568-579(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of neuron differentiation Source: UniProtKBNon-traceable author statementⁱ
  • "Cloning of three novel neuronal Cdk5 activator binding proteins."
    Ching Y.-P., Qi Z., Wang J.H.
    Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of signal transduction by p53 class mediator Source: Reactome
• regulation of synaptic vesicle cycle Source: Ensembl
• rhythmic process Source: UniProtKB-KW
• serine phosphorylation of STAT protein Source: Ensembl
• superior olivary nucleus maturation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• actin filament binding Source: Ensembl
• alpha-tubulin binding Source: ARUK-UCL
• beta-tubulin binding Source: ARUK-UCL
• cadherin binding Source: UniProtKB
• ephrin receptor binding Source: Ensembl
• ionotropic glutamate receptor binding Source: Ensembl
• protease binding Source: Ensembl
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase."
    Kesavapany S., Lau K.F., Ackerley S., Banner S.J., Shemilt S.J., Cooper J.D., Leigh P.N., Shaw C.E., McLoughlin D.M., Miller C.C.
    J. Neurosci. 23:4975-4983(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL 
        60         70         80         90        100
PWKRIVAVSA KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ 
       110        120        130        140        150
PPPAQPPAPP ASQLSGSQTG GSSSVKKAPH PAVTSAGTPK RVIVQASTSE 
       160        170        180        190        200
LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN 
       210        220        230        240        250
VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV 
       260        270        280        290        300
ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 

LLLGLDR                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM