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UniProtKB - Q15077 (P2RY6_HUMAN)

Entry version 181 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

P2Y purinoceptor 6

Gene

P2RY6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15077

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416476, G alpha (q) signalling events
R-HSA-417957, P2Y receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15077

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RY6
ORF Names:PP2891
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8543, P2RY6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602451, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15077

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171631.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5031

Open Targets

More...OpenTargetsi		ENSG00000171631

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32872

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15077, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4714

DrugCentral

More...DrugCentrali		Q15077

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		326

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		P2RY6

Domain mapping of disease mutations (DMDM)

More...DMDMi		2495018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700281 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15077

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15077

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15077

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15077

PeptideAtlas

More...PeptideAtlasi		Q15077

PRoteomics IDEntifications database

More...PRIDEi		Q15077

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60428

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15077, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15077

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15077

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171631, Expressed in left coronary artery and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15077, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15077, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171631, Group enriched (blood, lymphoid tissue, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111070, 383 interactors

Protein interaction database and analysis system

More...IntActi		Q15077, 376 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480966

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15077

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15077, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRYJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234746

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15077

Identification of Orthologs from Complete Genome Data

More...OMAi		AWLVCGA

Database of Orthologous Groups

More...OrthoDBi		925903at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15077

TreeFam database of animal gene trees

More...TreeFami		TF330775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR001973, P2Y6_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01068, P2Y6PRNOCPTR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q15077-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ 
        60         70         80         90        100
ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR 
       110        120        130        140        150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA 
       160        170        180        190        200
VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG 
       210        220        230        240        250
FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI 
       260        270        280        290        300
SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 
       310        320 
FYFTQKKFRR RPHELLQKLT AKWQRQGR
Length:328
Mass (Da):36,429
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAD6C55A43818107
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYF3F5GYF3_HUMAN
P2Y purinoceptor 6
P2RY6
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX90F5GX90_HUMAN
P2Y purinoceptor 6
P2RY6
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7H9F5H7H9_HUMAN
P2Y purinoceptor 6
P2RY6
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TA46A0A7P0TA46_HUMAN
P2Y purinoceptor 6
P2RY6
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 3Missing (PubMed:9286708).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X97058 mRNA Translation: CAA65770.1
U52464 mRNA Translation: AAB03572.1
AF007892 mRNA Translation: AAB80713.1
AF007891 mRNA Translation: AAB80712.1
AF218005 mRNA Translation: AAG17247.1
AF498920 mRNA Translation: AAM18129.1
BT006771 mRNA Translation: AAP35417.1
BC000571 mRNA Translation: AAH00571.1
BC009391 mRNA Translation: AAH09391.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8220.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC4800

NCBI Reference Sequences

More...RefSeqi		NP_001264133.1, NM_001277204.1
NP_001264134.1, NM_001277205.1
NP_001264135.1, NM_001277206.1
NP_001264136.1, NM_001277207.1
NP_001264137.1, NM_001277208.1
NP_789766.1, NM_176796.2
NP_789767.1, NM_176797.2
NP_789768.1, NM_176798.2
XP_005274079.1, XM_005274022.3
XP_006718634.1, XM_006718571.3
XP_011543379.1, XM_011545077.2
XP_011543381.1, XM_011545079.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000349767; ENSP00000309771; ENSG00000171631
ENST00000393590; ENSP00000377215; ENSG00000171631
ENST00000393591; ENSP00000377216; ENSG00000171631
ENST00000393592; ENSP00000377217; ENSG00000171631
ENST00000535931; ENSP00000440770; ENSG00000171631
ENST00000538328; ENSP00000442990; ENSG00000171631
ENST00000540124; ENSP00000442551; ENSG00000171631
ENST00000540342; ENSP00000443427; ENSG00000171631
ENST00000542092; ENSP00000445652; ENSG00000171631
ENST00000544437; ENSP00000441079; ENSG00000171631
ENST00000618468; ENSP00000480966; ENSG00000171631
ENST00000679753; ENSP00000504879; ENSG00000171631
ENST00000680955; ENSP00000505646; ENSG00000171631

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5031

UCSC genome browser

More...UCSCi		uc001otm.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA Translation: CAA65770.1
U52464 mRNA Translation: AAB03572.1
AF007892 mRNA Translation: AAB80713.1
AF007891 mRNA Translation: AAB80712.1
AF218005 mRNA Translation: AAG17247.1
AF498920 mRNA Translation: AAM18129.1
BT006771 mRNA Translation: AAP35417.1
BC000571 mRNA Translation: AAH00571.1
BC009391 mRNA Translation: AAH09391.1
CCDSiCCDS8220.1
PIRiJC4800
RefSeqiNP_001264133.1, NM_001277204.1
NP_001264134.1, NM_001277205.1
NP_001264135.1, NM_001277206.1
NP_001264136.1, NM_001277207.1
NP_001264137.1, NM_001277208.1
NP_789766.1, NM_176796.2
NP_789767.1, NM_176797.2
NP_789768.1, NM_176798.2
XP_005274079.1, XM_005274022.3
XP_006718634.1, XM_006718571.3
XP_011543379.1, XM_011545077.2
XP_011543381.1, XM_011545079.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111070, 383 interactors
IntActiQ15077, 376 interactors
STRINGi9606.ENSP00000480966

Chemistry databases

BindingDBiQ15077
ChEMBLiCHEMBL4714
DrugCentraliQ15077
GuidetoPHARMACOLOGYi326

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ15077, 1 site
iPTMnetiQ15077
PhosphoSitePlusiQ15077

Genetic variation databases

BioMutaiP2RY6
DMDMi2495018

Proteomic databases

jPOSTiQ15077
MassIVEiQ15077
MaxQBiQ15077
PaxDbiQ15077
PeptideAtlasiQ15077
PRIDEiQ15077
ProteomicsDBi60428

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17126, 263 antibodies

The DNASU plasmid repository

More...DNASUi		5031

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631
ENST00000393590; ENSP00000377215; ENSG00000171631
ENST00000393591; ENSP00000377216; ENSG00000171631
ENST00000393592; ENSP00000377217; ENSG00000171631
ENST00000535931; ENSP00000440770; ENSG00000171631
ENST00000538328; ENSP00000442990; ENSG00000171631
ENST00000540124; ENSP00000442551; ENSG00000171631
ENST00000540342; ENSP00000443427; ENSG00000171631
ENST00000542092; ENSP00000445652; ENSG00000171631
ENST00000544437; ENSP00000441079; ENSG00000171631
ENST00000618468; ENSP00000480966; ENSG00000171631
ENST00000679753; ENSP00000504879; ENSG00000171631
ENST00000680955; ENSP00000505646; ENSG00000171631
GeneIDi5031
KEGGihsa:5031
UCSCiuc001otm.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5031
DisGeNETi5031

GeneCards: human genes, protein and diseases

More...GeneCardsi		P2RY6
HGNCiHGNC:8543, P2RY6
HPAiENSG00000171631, Group enriched (blood, lymphoid tissue, placenta)
MIMi602451, gene
neXtProtiNX_Q15077
OpenTargetsiENSG00000171631
PharmGKBiPA32872
VEuPathDBiHostDB:ENSG00000171631.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRYJ, Eukaryota
GeneTreeiENSGT01030000234746
InParanoidiQ15077
OMAiAWLVCGA
OrthoDBi925903at2759
PhylomeDBiQ15077
TreeFamiTF330775

Enzyme and pathway databases

PathwayCommonsiQ15077
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-417957, P2Y receptors
SIGNORiQ15077

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5031, 16 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		P2RY6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		P2RY6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5031
PharosiQ15077, Tchem

Protein Ontology

More...PROi		PR:Q15077
RNActiQ15077, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171631, Expressed in left coronary artery and 135 other tissues
ExpressionAtlasiQ15077, baseline and differential
GenevisibleiQ15077, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR001973, P2Y6_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01068, P2Y6PRNOCPTR
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RY6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15077
Secondary accession number(s): Q15754
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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