UniProtKB - Q15077 (P2RY6_HUMAN)
Protein
P2Y purinoceptor 6
Gene
P2RY6
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- ADP receptor activity Source: ARUK-UCL
- G protein-coupled receptor activity Source: ProtInc
- UDP-activated nucleotide receptor activity Source: ARUK-UCL
- UTP-activated nucleotide receptor activity Source: ARUK-UCL
GO - Biological processi
- activation of phospholipase C activity Source: ARUK-UCL
- cellular response to prostaglandin E stimulus Source: Ensembl
- cellular response to purine-containing compound Source: ARUK-UCL
- cellular response to pyrimidine ribonucleotide Source: ARUK-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- phagocytosis Source: ARUK-UCL
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: ARUK-UCL
- positive regulation of inositol trisphosphate biosynthetic process Source: ARUK-UCL
- positive regulation of smooth muscle cell migration Source: Ensembl
- positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
- transepithelial chloride transport Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-416476 G alpha (q) signalling events R-HSA-417957 P2Y receptors |
Names & Taxonomyi
Protein namesi | Recommended name: P2Y purinoceptor 6Short name: P2Y6 |
Gene namesi | Name:P2RY6 ORF Names:PP2891 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171631.14 |
HGNCi | HGNC:8543 P2RY6 |
MIMi | 602451 gene |
neXtProti | NX_Q15077 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- apical plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 62 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 63 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 101 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 144 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 145 – 165 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 194 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 195 – 215 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 236 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 280 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 281 – 303 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 304 – 328 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5031 |
OpenTargetsi | ENSG00000171631 |
PharmGKBi | PA32872 |
Chemistry databases
ChEMBLi | CHEMBL4714 |
GuidetoPHARMACOLOGYi | 326 |
Polymorphism and mutation databases
BioMutai | P2RY6 |
DMDMi | 2495018 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070028 | 1 – 328 | P2Y purinoceptor 6Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 177 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q15077 |
MaxQBi | Q15077 |
PaxDbi | Q15077 |
PeptideAtlasi | Q15077 |
PRIDEi | Q15077 |
ProteomicsDBi | 60428 |
PTM databases
iPTMneti | Q15077 |
PhosphoSitePlusi | Q15077 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171631 Expressed in 100 organ(s), highest expression level in left coronary artery |
ExpressionAtlasi | Q15077 baseline and differential |
Genevisiblei | Q15077 HS |
Organism-specific databases
HPAi | CAB022740 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 111070, 3 interactors |
IntActi | Q15077, 12 interactors |
STRINGi | 9606.ENSP00000309771 |
Chemistry databases
BindingDBi | Q15077 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B6R | model | - | A | 1-318 | [»] | |
ProteinModelPortali | Q15077 | |||||
SMRi | Q15077 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJR4 Eukaryota ENOG410YAZW LUCA |
GeneTreei | ENSGT00940000154812 |
HOGENOMi | HOG000231307 |
HOVERGENi | HBG101120 |
InParanoidi | Q15077 |
KOi | K04272 |
OMAi | HWPFGDL |
OrthoDBi | 1203363at2759 |
PhylomeDBi | Q15077 |
TreeFami | TF330775 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001973 P2Y6_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01068 P2Y6PRNOCPTR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q15077-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ
60 70 80 90 100
ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR
110 120 130 140 150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA
160 170 180 190 200
VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG
210 220 230 240 250
FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL
310 320
FYFTQKKFRR RPHELLQKLT AKWQRQGR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GX90 | F5GX90_HUMAN | P2Y purinoceptor 6 | P2RY6 | 128 | Annotation score: | ||
F5GYF3 | F5GYF3_HUMAN | P2Y purinoceptor 6 | P2RY6 | 245 | Annotation score: | ||
F5H7H9 | F5H7H9_HUMAN | P2Y purinoceptor 6 | P2RY6 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 – 3 | Missing (PubMed:9286708).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97058 mRNA Translation: CAA65770.1 U52464 mRNA Translation: AAB03572.1 AF007892 mRNA Translation: AAB80713.1 AF007891 mRNA Translation: AAB80712.1 AF218005 mRNA Translation: AAG17247.1 AF498920 mRNA Translation: AAM18129.1 BT006771 mRNA Translation: AAP35417.1 BC000571 mRNA Translation: AAH00571.1 BC009391 mRNA Translation: AAH09391.1 |
CCDSi | CCDS8220.1 |
PIRi | JC4800 |
RefSeqi | NP_001264133.1, NM_001277204.1 NP_001264134.1, NM_001277205.1 NP_001264135.1, NM_001277206.1 NP_001264136.1, NM_001277207.1 NP_001264137.1, NM_001277208.1 NP_789766.1, NM_176796.2 NP_789767.1, NM_176797.2 NP_789768.1, NM_176798.2 XP_005274079.1, XM_005274022.3 XP_006718634.1, XM_006718571.3 XP_011543379.1, XM_011545077.2 XP_011543381.1, XM_011545079.2 |
UniGenei | Hs.16362 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97058 mRNA Translation: CAA65770.1 U52464 mRNA Translation: AAB03572.1 AF007892 mRNA Translation: AAB80713.1 AF007891 mRNA Translation: AAB80712.1 AF218005 mRNA Translation: AAG17247.1 AF498920 mRNA Translation: AAM18129.1 BT006771 mRNA Translation: AAP35417.1 BC000571 mRNA Translation: AAH00571.1 BC009391 mRNA Translation: AAH09391.1 |
CCDSi | CCDS8220.1 |
PIRi | JC4800 |
RefSeqi | NP_001264133.1, NM_001277204.1 NP_001264134.1, NM_001277205.1 NP_001264135.1, NM_001277206.1 NP_001264136.1, NM_001277207.1 NP_001264137.1, NM_001277208.1 NP_789766.1, NM_176796.2 NP_789767.1, NM_176797.2 NP_789768.1, NM_176798.2 XP_005274079.1, XM_005274022.3 XP_006718634.1, XM_006718571.3 XP_011543379.1, XM_011545077.2 XP_011543381.1, XM_011545079.2 |
UniGenei | Hs.16362 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B6R | model | - | A | 1-318 | [»] | |
ProteinModelPortali | Q15077 | |||||
SMRi | Q15077 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 111070, 3 interactors |
IntActi | Q15077, 12 interactors |
STRINGi | 9606.ENSP00000309771 |
Chemistry databases
BindingDBi | Q15077 |
ChEMBLi | CHEMBL4714 |
GuidetoPHARMACOLOGYi | 326 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q15077 |
PhosphoSitePlusi | Q15077 |
Polymorphism and mutation databases
BioMutai | P2RY6 |
DMDMi | 2495018 |
Proteomic databases
jPOSTi | Q15077 |
MaxQBi | Q15077 |
PaxDbi | Q15077 |
PeptideAtlasi | Q15077 |
PRIDEi | Q15077 |
ProteomicsDBi | 60428 |
Protocols and materials databases
DNASUi | 5031 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 5031 |
DisGeNETi | 5031 |
EuPathDBi | HostDB:ENSG00000171631.14 |
GeneCardsi | P2RY6 |
HGNCi | HGNC:8543 P2RY6 |
HPAi | CAB022740 |
MIMi | 602451 gene |
neXtProti | NX_Q15077 |
OpenTargetsi | ENSG00000171631 |
PharmGKBi | PA32872 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IJR4 Eukaryota ENOG410YAZW LUCA |
GeneTreei | ENSGT00940000154812 |
HOGENOMi | HOG000231307 |
HOVERGENi | HBG101120 |
InParanoidi | Q15077 |
KOi | K04272 |
OMAi | HWPFGDL |
OrthoDBi | 1203363at2759 |
PhylomeDBi | Q15077 |
TreeFami | TF330775 |
Enzyme and pathway databases
Reactomei | R-HSA-416476 G alpha (q) signalling events R-HSA-417957 P2Y receptors |
Miscellaneous databases
GeneWikii | P2RY6 |
GenomeRNAii | 5031 |
PROi | PR:Q15077 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171631 Expressed in 100 organ(s), highest expression level in left coronary artery |
ExpressionAtlasi | Q15077 baseline and differential |
Genevisiblei | Q15077 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001973 P2Y6_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01068 P2Y6PRNOCPTR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | P2RY6_HUMAN | |
Accessioni | Q15077Primary (citable) accession number: Q15077 Secondary accession number(s): Q15754 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 13, 2019 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries