Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 169 (31 Jul 2019)
Sequence version 2 (05 May 2009)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Early endosome antigen 1

Gene

EEA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

Miscellaneous

Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri41 – 64C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q15075

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Early endosome antigen 1
Alternative name(s):
Endosome-associated protein p162
Zinc finger FYVE domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EEA1
Synonyms:ZFYVE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3185 EEA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605070 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15075

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39E → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi41F → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi42I → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi44P → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi47M → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi60Y → A: Strongly reduces interaction with RAB5C. 1 Publication1
Mutagenesisi1349W → A: Reduces phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1352D → V: Reduces phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1357N → D: Reduces phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1358C → S: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1365F → A: Strongly reduces phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1367 – 1368VT → EE or GG: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication2
Mutagenesisi1370R → A: Abolishes endosomal location. 1 Publication1
Mutagenesisi1371R → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1372H → A: Abolishes endosomal location. Abolishes pH sensitivity of the FYVE-type zinc finger domain; when associated with A-1373. 2 Publications1
Mutagenesisi1373H → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. Abolishes pH sensitivity of the FYVE-type zinc finger domain; when associated with A-1372. 2 Publications1
Mutagenesisi1374C → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1375R → G: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 2 Publications1
Mutagenesisi1377C → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1378G → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1385C → A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1
Mutagenesisi1400R → G: Strongly reduces phosphatidylinositol 3-phosphate binding and abolishes endosomal location. 2 Publications1
Mutagenesisi1405C → S: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8411

Open Targets

More...
OpenTargetsi
ENSG00000102189

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27621

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EEA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462866

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987061 – 1411Early endosome antigen 1Add BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15075

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15075

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15075

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15075

PeptideAtlas

More...
PeptideAtlasi
Q15075

PRoteomics IDEntifications database

More...
PRIDEi
Q15075

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60427

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15075

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15075

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15075

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q15075

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102189 Expressed in 226 organ(s), highest expression level in biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15075 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15075 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005861
CAB018782
HPA038158
HPA038159

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.

Interacts with RAB31.

Interacts with ERBB2.

Interacts with SAMD9 AND SAMD9L (PubMed:24029230). May interact with PLEKHF2.

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113999, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q15075

Protein interaction database and analysis system

More...
IntActi
Q15075, 89 interactors

Molecular INTeraction database

More...
MINTi
Q15075

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317955

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15075

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15075

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 1348Sequence analysisAdd BLAST1275

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi397 – 758Gln/Glu/Lys-richAdd BLAST362
Compositional biasi937 – 1032Gln/Glu/Lys-richAdd BLAST96
Compositional biasi1093 – 1231Glu/Lys-richAdd BLAST139

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 64C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1410FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFA7 Eukaryota
ENOG4111F3Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112329

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15075

KEGG Orthology (KO)

More...
KOi
K12478

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIAVYQH

Database of Orthologous Groups

More...
OrthoDBi
753155at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15075

TreeFam database of animal gene trees

More...
TreeFami
TF329698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15075-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRILQRTP GRVGSQGSDL DSSATPINTV DVNNESSSEG FICPQCMKSL
60 70 80 90 100
GSADELFKHY EAVHDAGNDS GHGGESNLAL KRDDVTLLRQ EVQDLQASLK
110 120 130 140 150
EEKWYSEELK KELEKYQGLQ QQEAKPDGLV TDSSAELQSL EQQLEEAQTE
160 170 180 190 200
NFNIKQMKDL FEQKAAQLAT EIADIKSKYD EERSLREAAE QKVTRLTEEL
210 220 230 240 250
NKEATVIQDL KTELLQRPGI EDVAVLKKEL VQVQTLMDNM TLERERESEK
260 270 280 290 300
LKDECKKLQS QYASSEATIS QLRSELAKGP QEVAVYVQEL QKLKSSVNEL
310 320 330 340 350
TQKNQTLTEN LLKKEQDYTK LEEKHNEESV SKKNIQATLH QKDLDCQQLQ
360 370 380 390 400
SRLSASETSL HRIHVELSEK GEATQKLKEE LSEVETKYQH LKAEFKQLQQ
410 420 430 440 450
QREEKEQHGL QLQSEINQLH SKLLETERQL GEAHGRLKEQ RQLSSEKLMD
460 470 480 490 500
KEQQVADLQL KLSRLEEQLK EKVTNSTELQ HQLDKTKQQH QEQQALQQST
510 520 530 540 550
TAKLREAQND LEQVLRQIGD KDQKIQNLEA LLQKSKENIS LLEKEREDLY
560 570 580 590 600
AKIQAGEGET AVLNQLQEKN HTLQEQVTQL TEKLKNQSES HKQAQENLHD
610 620 630 640 650
QVQEQKAHLR AAQDRVLSLE TSVNELNSQL NESKEKVSQL DIQIKAKTEL
660 670 680 690 700
LLSAEAAKTA QRADLQNHLD TAQNALQDKQ QELNKITTQL DQVTAKLQDK
710 720 730 740 750
QEHCSQLESH LKEYKEKYLS LEQKTEELEG QIKKLEADSL EVKASKEQAL
760 770 780 790 800
QDLQQQRQLN TDLELRATEL SKQLEMEKEI VSSTRLDLQK KSEALESIKQ
810 820 830 840 850
KLTKQEEEKK ILKQDFETLS QETKIQHEEL NNRIQTTVTE LQKVKMEKEA
860 870 880 890 900
LMTELSTVKD KLSKVSDSLK NSKSEFEKEN QKGKAAILDL EKTCKELKHQ
910 920 930 940 950
LQVQMENTLK EQKELKKSLE KEKEASHQLK LELNSMQEQL IQAQNTLKQN
960 970 980 990 1000
EKEEQQLQGN INELKQSSEQ KKKQIEALQG ELKIAVLQKT ELENKLQQQL
1010 1020 1030 1040 1050
TQAAQELAAE KEKISVLQNN YEKSQETFKQ LQSDFYGRES ELLATRQDLK
1060 1070 1080 1090 1100
SVEEKLSLAQ EDLISNRNQI GNQNKLIQEL KTAKATLEQD SAKKEQQLQE
1110 1120 1130 1140 1150
RCKALQDIQK EKSLKEKELV NEKSKLAEIE EIKCRQEKEI TKLNEELKSH
1160 1170 1180 1190 1200
KLESIKEITN LKDAKQLLIQ QKLELQGKAD SLKAAVEQEK RNQQILKDQV
1210 1220 1230 1240 1250
KKEEEELKKE FIEKEAKLHS EIKEKEVGMK KHEENEAKLT MQITALNENL
1260 1270 1280 1290 1300
GTVKKEWQSS QRRVSELEKQ TDDLRGEIAV LEATVQNNQD ERRALLERCL
1310 1320 1330 1340 1350
KGEGEIEKLQ TKVLELQRKL DNTTAAVQEL GRENQSLQIK HTQALNRKWA
1360 1370 1380 1390 1400
EDNEVQNCMA CGKGFSVTVR RHHCRQCGNI FCAECSAKNA LTPSSKKPVR
1410
VCDACFNDLQ G
Length:1,411
Mass (Da):162,466
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51BA418F561E3411
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE79F8WE79_HUMAN
Early endosome antigen 1
EEA1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUZ7F8VUZ7_HUMAN
Early endosome antigen 1
EEA1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W119F8W119_HUMAN
Early endosome antigen 1
EEA1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255C → S in AAA79121 (PubMed:7768953).Curated1
Sequence conflicti258 – 259LQ → FE in AAA79121 (PubMed:7768953).Curated2
Sequence conflicti277A → S in AAA79121 (PubMed:7768953).Curated1
Sequence conflicti284A → R in AAA79121 (PubMed:7768953).Curated1
Sequence conflicti520D → E in AAA79121 (PubMed:7768953).Curated1
Sequence conflicti575 – 576EQ → DE in AAA79121 (PubMed:7768953).Curated2
Sequence conflicti583 – 584KL → NV in AAA79121 (PubMed:7768953).Curated2
Sequence conflicti680Q → H in AAA79121 (PubMed:7768953).Curated1
Sequence conflicti1325Missing in AAA79121 (PubMed:7768953).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052980810K → Q2 PublicationsCorresponds to variant dbSNP:rs10745623Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L40157 mRNA Translation: AAA79121.1
X78998 mRNA Translation: CAA55632.1
AC016136 Genomic DNA No translation available.
AC021646 Genomic DNA No translation available.
AC026111 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31874.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57013

NCBI Reference Sequences

More...
RefSeqi
NP_003557.2, NM_003566.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322349; ENSP00000317955; ENSG00000102189

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8411

UCSC genome browser

More...
UCSCi
uc001tck.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40157 mRNA Translation: AAA79121.1
X78998 mRNA Translation: CAA55632.1
AC016136 Genomic DNA No translation available.
AC021646 Genomic DNA No translation available.
AC026111 Genomic DNA No translation available.
CCDSiCCDS31874.1
PIRiA57013
RefSeqiNP_003557.2, NM_003566.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HYINMR-A1347-1411[»]
1HYJNMR-A1347-1411[»]
1JOCX-ray2.20A/B1287-1324[»]
A/B1326-1411[»]
3MJHX-ray2.03B/D36-69[»]
SMRiQ15075
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113999, 52 interactors
CORUMiQ15075
IntActiQ15075, 89 interactors
MINTiQ15075
STRINGi9606.ENSP00000317955

PTM databases

iPTMnetiQ15075
PhosphoSitePlusiQ15075
SwissPalmiQ15075

Polymorphism and mutation databases

BioMutaiEEA1
DMDMi229462866

Proteomic databases

EPDiQ15075
jPOSTiQ15075
MaxQBiQ15075
PaxDbiQ15075
PeptideAtlasiQ15075
PRIDEiQ15075
ProteomicsDBi60427

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8411
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322349; ENSP00000317955; ENSG00000102189
GeneIDi8411
KEGGihsa:8411
UCSCiuc001tck.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8411
DisGeNETi8411

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EEA1
HGNCiHGNC:3185 EEA1
HPAiCAB005861
CAB018782
HPA038158
HPA038159
MIMi605070 gene
neXtProtiNX_Q15075
OpenTargetsiENSG00000102189
PharmGKBiPA27621

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFA7 Eukaryota
ENOG4111F3Q LUCA
GeneTreeiENSGT00940000156910
HOGENOMiHOG000112329
InParanoidiQ15075
KOiK12478
OMAiFIAVYQH
OrthoDBi753155at2759
PhylomeDBiQ15075
TreeFamiTF329698

Enzyme and pathway databases

ReactomeiR-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
SIGNORiQ15075

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EEA1 human
EvolutionaryTraceiQ15075

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EEA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8411
PMAP-CutDBiQ15075

Protein Ontology

More...
PROi
PR:Q15075

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102189 Expressed in 226 organ(s), highest expression level in biceps brachii
ExpressionAtlasiQ15075 baseline and differential
GenevisibleiQ15075 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEEA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15075
Secondary accession number(s): Q14221
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: May 5, 2009
Last modified: July 31, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again