ZNF146

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	16 – 38	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	44 – 66	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	72 – 94	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	100 – 122	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	128 – 150	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 206	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 8665923
DNA-binding transcription factor activity Source: GO_Central
heparin binding
Source: ProtInc
Traceable author statementⁱ
- 8665923
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 8665923

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: ProtInc
Traceable author statementⁱ
- 8107129

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein OZF Alternative name(s): Only zinc finger protein Zinc finger protein 146
Gene namesⁱ	Name:ZNF146 Synonyms:OZF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167635.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12931 ZNF146
MIMⁱ	601505 gene
neXtProtⁱ	NX_Q15072

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	157	K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. 1 Publication		1
Mutagenesisⁱ	169	K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000167635
PharmGKBⁱ	PA37518

Polymorphism and mutation databases

BioMutaⁱ	ZNF146
DMDMⁱ	134048495

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047276	1 – 292	Zinc finger protein OZFAdd BLAST		292

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	28	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	51	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	56	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	157	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	169	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	173	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylated.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q15072
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15072
PaxDbⁱ	Q15072
PeptideAtlas More...PeptideAtlasⁱ	Q15072
PRIDEⁱ	Q15072
ProteomicsDBⁱ	60426

PTM databases

iPTMnetⁱ	Q15072
PhosphoSitePlusⁱ	Q15072

Expressionⁱ

Tissue specificityⁱ

Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000167635 Expressed in 245 organ(s), highest expression level in metanephros
CleanExⁱ	HS_ZNF146
Genevisibleⁱ	Q15072 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003358

HPAⁱ

HPA003358

Interactionⁱ

Subunit structureⁱ

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.2 Publications

Protein-protein interaction databases

BioGridⁱ	113499, 24 interactors
IntActⁱ	Q15072, 3 interactors
STRINGⁱ	9606.ENSP00000392095

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15072
SMRⁱ	Q15072
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	212 – 292	Interaction with TERF2IP1 PublicationAdd BLAST		81

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	16 – 38	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	44 – 66	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	72 – 94	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	100 – 122	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	128 – 150	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 206	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139445
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q15072
OMAⁱ	GFTKNCN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q15072
TreeFamⁱ	TF337055

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 10 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15072-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG 
        60         70         80         90        100
KAFSQKQYVI KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF 
       110        120        130        140        150
ECKDCGKAFI QKSNLIRHQR THTGEKPFVC KECGKTFSGK SNLTEHEKIH 
       160        170        180        190        200
IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI 
       210        220        230        240        250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS 
       260        270        280        290 
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH

Length:292

Mass (Da):33,308

Last modified:March 6, 2007 - v2

Checksum:ⁱD5062375D261B971

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023746	8	R → K3 PublicationsCorresponds to variant dbSNP:rs2070132Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X70394 mRNA Translation: CAA49844.1 AJ011806 Genomic DNA Translation: CAB41967.1 AC012617 Genomic DNA No translation available. BC110500 mRNA Translation: AAI10501.1 BC110501 mRNA Translation: AAI10502.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12492.1
PIRⁱ	S43826
NCBI Reference Sequences More...RefSeqⁱ	NP_001093108.1, NM_001099638.1 NP_001093109.1, NM_001099639.1 NP_009076.2, NM_007145.2 XP_005259271.1, XM_005259214.2 XP_016882733.1, XM_017027244.1 XP_016882734.1, XM_017027245.1 XP_016882735.1, XM_017027246.1 XP_016882736.1, XM_017027247.1
UniGeneⁱ	Hs.643436

Genome annotation databases

Ensemblⁱ	ENST00000443387; ENSP00000392095; ENSG00000167635 ENST00000456324; ENSP00000400391; ENSG00000167635
GeneIDⁱ	7705
KEGGⁱ	hsa:7705
UCSC genome browser More...UCSCⁱ	uc002odq.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15072	Zinc finger protein OZF		PONAB		292	UniRef100_Q15072
Zinc finger protein 146		CHLSB		404
ZNF146 isoform 1		PANTR		292
Uncharacterized protein		COLAP		292
Uncharacterized protein		RHIRO		292
+8

Protein	Similar proteins		Species	Score	Length	Source
Q15072	Zinc finger protein OZF		PONAB		292	UniRef90_Q15072
Zinc finger protein 146		CHLSB		404
ZNF146 isoform 1		PANTR		292
Uncharacterized protein		COLAP		292
Uncharacterized protein		RHIRO		292
+10

Protein	Similar proteins		Species	Score	Length	Source
Q15072	Zinc finger protein OZF		PONAB		292	UniRef50_Q15072
Zinc finger protein 146		CHLSB		404
ZNF146 isoform 1		PANTR		292
Uncharacterized protein		COLAP		292
Uncharacterized protein		RHIRO		292
+74

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X70394 mRNA Translation: CAA49844.1 AJ011806 Genomic DNA Translation: CAB41967.1 AC012617 Genomic DNA No translation available. BC110500 mRNA Translation: AAI10501.1 BC110501 mRNA Translation: AAI10502.1
CCDSⁱ	CCDS12492.1
PIRⁱ	S43826
RefSeqⁱ	NP_001093108.1, NM_001099638.1 NP_001093109.1, NM_001099639.1 NP_009076.2, NM_007145.2 XP_005259271.1, XM_005259214.2 XP_016882733.1, XM_017027244.1 XP_016882734.1, XM_017027245.1 XP_016882735.1, XM_017027246.1 XP_016882736.1, XM_017027247.1
UniGeneⁱ	Hs.643436

3D structure databases

ProteinModelPortalⁱ	Q15072
SMRⁱ	Q15072
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113499, 24 interactors
IntActⁱ	Q15072, 3 interactors
STRINGⁱ	9606.ENSP00000392095

PTM databases

iPTMnetⁱ	Q15072
PhosphoSitePlusⁱ	Q15072

Polymorphism and mutation databases

BioMutaⁱ	ZNF146
DMDMⁱ	134048495

Proteomic databases

EPDⁱ	Q15072
MaxQBⁱ	Q15072
PaxDbⁱ	Q15072
PeptideAtlasⁱ	Q15072
PRIDEⁱ	Q15072
ProteomicsDBⁱ	60426

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7705
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000443387; ENSP00000392095; ENSG00000167635 ENST00000456324; ENSP00000400391; ENSG00000167635
GeneIDⁱ	7705
KEGGⁱ	hsa:7705
UCSCⁱ	uc002odq.5 human

Organism-specific databases

CTDⁱ	7705
EuPathDBⁱ	HostDB:ENSG00000167635.11
GeneCardsⁱ	ZNF146
HGNCⁱ	HGNC:12931 ZNF146
HPAⁱ	HPA003358
MIMⁱ	601505 gene
neXtProtⁱ	NX_Q15072
OpenTargetsⁱ	ENSG00000167635
PharmGKBⁱ	PA37518
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00890000139445
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q15072
OMAⁱ	GFTKNCN
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q15072
TreeFamⁱ	TF337055

Miscellaneous databases

ChiTaRSⁱ	ZNF146 human
GeneWikiⁱ	ZNF146
GenomeRNAiⁱ	7705
Protein Ontology More...PROⁱ	PR:Q15072
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167635 Expressed in 245 organ(s), highest expression level in metanephros
CleanExⁱ	HS_ZNF146
Genevisibleⁱ	Q15072 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 10 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OZF_HUMAN
Accessionⁱ	Q15072Primary (citable) accession number: Q15072 Secondary accession number(s): Q2TB94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	March 6, 2007
	Last modified:	October 10, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15072 (OZF_HUMAN)

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Zinc finger protein OZF

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ