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Protein

Zinc finger protein OZF

Gene

ZNF146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri44 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene namesi
Name:ZNF146
Synonyms:OZF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167635.11
HGNCiHGNC:12931 ZNF146
MIMi601505 gene
neXtProtiNX_Q15072

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. 1 Publication1
Mutagenesisi169K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000167635
PharmGKBiPA37518

Polymorphism and mutation databases

BioMutaiZNF146
DMDMi134048495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472761 – 292Zinc finger protein OZFAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ15072
MaxQBiQ15072
PaxDbiQ15072
PeptideAtlasiQ15072
PRIDEiQ15072
ProteomicsDBi60426

PTM databases

iPTMnetiQ15072
PhosphoSitePlusiQ15072

Expressioni

Tissue specificityi

Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.2 Publications

Gene expression databases

BgeeiENSG00000167635 Expressed in 245 organ(s), highest expression level in metanephros
CleanExiHS_ZNF146
GenevisibleiQ15072 HS

Organism-specific databases

HPAiHPA003358

Interactioni

Subunit structurei

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.2 Publications

Protein-protein interaction databases

BioGridi113499, 24 interactors
IntActiQ15072, 3 interactors
STRINGi9606.ENSP00000392095

Structurei

3D structure databases

ProteinModelPortaliQ15072
SMRiQ15072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 292Interaction with TERF2IP1 PublicationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri44 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139445
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ15072
OMAiGFTKNCN
OrthoDBiEOG091G02KC
PhylomeDBiQ15072
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q15072-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG
60 70 80 90 100
KAFSQKQYVI KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF
110 120 130 140 150
ECKDCGKAFI QKSNLIRHQR THTGEKPFVC KECGKTFSGK SNLTEHEKIH
160 170 180 190 200
IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI
210 220 230 240 250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS
260 270 280 290
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
Length:292
Mass (Da):33,308
Last modified:March 6, 2007 - v2
Checksum:iD5062375D261B971
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0237468R → K3 PublicationsCorresponds to variant dbSNP:rs2070132Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70394 mRNA Translation: CAA49844.1
AJ011806 Genomic DNA Translation: CAB41967.1
AC012617 Genomic DNA No translation available.
BC110500 mRNA Translation: AAI10501.1
BC110501 mRNA Translation: AAI10502.1
CCDSiCCDS12492.1
PIRiS43826
RefSeqiNP_001093108.1, NM_001099638.1
NP_001093109.1, NM_001099639.1
NP_009076.2, NM_007145.2
XP_005259271.1, XM_005259214.2
XP_016882733.1, XM_017027244.1
XP_016882734.1, XM_017027245.1
XP_016882735.1, XM_017027246.1
XP_016882736.1, XM_017027247.1
UniGeneiHs.643436

Genome annotation databases

EnsembliENST00000443387; ENSP00000392095; ENSG00000167635
ENST00000456324; ENSP00000400391; ENSG00000167635
GeneIDi7705
KEGGihsa:7705
UCSCiuc002odq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70394 mRNA Translation: CAA49844.1
AJ011806 Genomic DNA Translation: CAB41967.1
AC012617 Genomic DNA No translation available.
BC110500 mRNA Translation: AAI10501.1
BC110501 mRNA Translation: AAI10502.1
CCDSiCCDS12492.1
PIRiS43826
RefSeqiNP_001093108.1, NM_001099638.1
NP_001093109.1, NM_001099639.1
NP_009076.2, NM_007145.2
XP_005259271.1, XM_005259214.2
XP_016882733.1, XM_017027244.1
XP_016882734.1, XM_017027245.1
XP_016882735.1, XM_017027246.1
XP_016882736.1, XM_017027247.1
UniGeneiHs.643436

3D structure databases

ProteinModelPortaliQ15072
SMRiQ15072
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113499, 24 interactors
IntActiQ15072, 3 interactors
STRINGi9606.ENSP00000392095

PTM databases

iPTMnetiQ15072
PhosphoSitePlusiQ15072

Polymorphism and mutation databases

BioMutaiZNF146
DMDMi134048495

Proteomic databases

EPDiQ15072
MaxQBiQ15072
PaxDbiQ15072
PeptideAtlasiQ15072
PRIDEiQ15072
ProteomicsDBi60426

Protocols and materials databases

DNASUi7705
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443387; ENSP00000392095; ENSG00000167635
ENST00000456324; ENSP00000400391; ENSG00000167635
GeneIDi7705
KEGGihsa:7705
UCSCiuc002odq.5 human

Organism-specific databases

CTDi7705
EuPathDBiHostDB:ENSG00000167635.11
GeneCardsiZNF146
HGNCiHGNC:12931 ZNF146
HPAiHPA003358
MIMi601505 gene
neXtProtiNX_Q15072
OpenTargetsiENSG00000167635
PharmGKBiPA37518
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139445
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ15072
OMAiGFTKNCN
OrthoDBiEOG091G02KC
PhylomeDBiQ15072
TreeFamiTF337055

Miscellaneous databases

ChiTaRSiZNF146 human
GeneWikiiZNF146
GenomeRNAii7705
PROiPR:Q15072
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167635 Expressed in 245 organ(s), highest expression level in metanephros
CleanExiHS_ZNF146
GenevisibleiQ15072 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOZF_HUMAN
AccessioniPrimary (citable) accession number: Q15072
Secondary accession number(s): Q2TB94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: October 10, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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