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UniProtKB - Q15072 (OZF_HUMAN)
Protein
Zinc finger protein OZF
Gene
ZNF146
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 38 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 44 – 66 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 72 – 94 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 100 – 122 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 128 – 150 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- heparin binding Source: ProtInc
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: ProtInc
GO - Biological processi
- regulation of transcription, DNA-templated Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15072 |
SignaLinki | Q15072 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein OZFAlternative name(s): Only zinc finger protein Zinc finger protein 146 |
Gene namesi | Name:ZNF146 Synonyms:OZF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12931, ZNF146 |
MIMi | 601505, gene |
neXtProti | NX_Q15072 |
VEuPathDBi | HostDB:ENSG00000167635 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 157 | K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. 1 Publication | 1 | |
Mutagenesisi | 169 | K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7705 |
OpenTargetsi | ENSG00000167635 |
PharmGKBi | PA37518 |
Miscellaneous databases
Pharosi | Q15072, Tbio |
Genetic variation databases
BioMutai | ZNF146 |
DMDMi | 134048495 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047276 | 1 – 292 | Zinc finger protein OZFAdd BLAST | 292 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 28 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 51 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 56 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 157 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Cross-linki | 169 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Cross-linki | 173 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Sumoylated.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q15072 |
jPOSTi | Q15072 |
MassIVEi | Q15072 |
MaxQBi | Q15072 |
PaxDbi | Q15072 |
PeptideAtlasi | Q15072 |
PRIDEi | Q15072 |
ProteomicsDBi | 60426 |
PTM databases
iPTMneti | Q15072 |
PhosphoSitePlusi | Q15072 |
Expressioni
Tissue specificityi
Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.2 Publications
Gene expression databases
Bgeei | ENSG00000167635, Expressed in metanephros and 255 other tissues |
Genevisiblei | Q15072, HS |
Organism-specific databases
HPAi | ENSG00000167635, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA.
Interacts with SUMO conjugating enzyme UBC9/UBE2I.
Interacts with the telomeric protein TERF2IP.
2 PublicationsBinary interactionsi
Q15072
With | #Exp. | IntAct |
---|---|---|
CIB3 [Q96Q77] | 3 | EBI-11914212,EBI-10292696 |
Protein-protein interaction databases
BioGRIDi | 113499, 62 interactors |
IntActi | Q15072, 17 interactors |
MINTi | Q15072 |
STRINGi | 9606.ENSP00000400391 |
Miscellaneous databases
RNActi | Q15072, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 212 – 292 | Interaction with TERF2IP1 PublicationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 38 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 44 – 66 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 72 – 94 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 100 – 122 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 128 – 150 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162671 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q15072 |
OMAi | GGSPFAC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15072 |
TreeFami | TF337055 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
i Sequence
Sequence statusi: Complete.
Q15072-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG
60 70 80 90 100
KAFSQKQYVI KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF
110 120 130 140 150
ECKDCGKAFI QKSNLIRHQR THTGEKPFVC KECGKTFSGK SNLTEHEKIH
160 170 180 190 200
IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI
210 220 230 240 250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS
260 270 280 290
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023746 | 8 | R → K3 PublicationsCorresponds to variant dbSNP:rs2070132Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70394 mRNA Translation: CAA49844.1 AJ011806 Genomic DNA Translation: CAB41967.1 AC012617 Genomic DNA No translation available. BC110500 mRNA Translation: AAI10501.1 BC110501 mRNA Translation: AAI10502.1 |
CCDSi | CCDS12492.1 |
PIRi | S43826 |
RefSeqi | NP_001093108.1, NM_001099638.1 NP_001093109.1, NM_001099639.1 NP_009076.2, NM_007145.2 XP_005259271.1, XM_005259214.2 XP_016882733.1, XM_017027244.1 XP_016882734.1, XM_017027245.1 XP_016882735.1, XM_017027246.1 XP_016882736.1, XM_017027247.1 |
Genome annotation databases
Ensembli | ENST00000443387; ENSP00000392095; ENSG00000167635 ENST00000456324; ENSP00000400391; ENSG00000167635 |
GeneIDi | 7705 |
KEGGi | hsa:7705 |
MANE-Selecti | ENST00000443387.3; ENSP00000392095.1; NM_007145.3; NP_009076.2 |
UCSCi | uc002odq.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70394 mRNA Translation: CAA49844.1 AJ011806 Genomic DNA Translation: CAB41967.1 AC012617 Genomic DNA No translation available. BC110500 mRNA Translation: AAI10501.1 BC110501 mRNA Translation: AAI10502.1 |
CCDSi | CCDS12492.1 |
PIRi | S43826 |
RefSeqi | NP_001093108.1, NM_001099638.1 NP_001093109.1, NM_001099639.1 NP_009076.2, NM_007145.2 XP_005259271.1, XM_005259214.2 XP_016882733.1, XM_017027244.1 XP_016882734.1, XM_017027245.1 XP_016882735.1, XM_017027246.1 XP_016882736.1, XM_017027247.1 |
3D structure databases
SMRi | Q15072 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113499, 62 interactors |
IntActi | Q15072, 17 interactors |
MINTi | Q15072 |
STRINGi | 9606.ENSP00000400391 |
PTM databases
iPTMneti | Q15072 |
PhosphoSitePlusi | Q15072 |
Genetic variation databases
BioMutai | ZNF146 |
DMDMi | 134048495 |
Proteomic databases
EPDi | Q15072 |
jPOSTi | Q15072 |
MassIVEi | Q15072 |
MaxQBi | Q15072 |
PaxDbi | Q15072 |
PeptideAtlasi | Q15072 |
PRIDEi | Q15072 |
ProteomicsDBi | 60426 |
Protocols and materials databases
Antibodypediai | 929, 161 antibodies from 24 providers |
DNASUi | 7705 |
Genome annotation databases
Ensembli | ENST00000443387; ENSP00000392095; ENSG00000167635 ENST00000456324; ENSP00000400391; ENSG00000167635 |
GeneIDi | 7705 |
KEGGi | hsa:7705 |
MANE-Selecti | ENST00000443387.3; ENSP00000392095.1; NM_007145.3; NP_009076.2 |
UCSCi | uc002odq.5, human |
Organism-specific databases
CTDi | 7705 |
DisGeNETi | 7705 |
GeneCardsi | ZNF146 |
HGNCi | HGNC:12931, ZNF146 |
HPAi | ENSG00000167635, Low tissue specificity |
MIMi | 601505, gene |
neXtProti | NX_Q15072 |
OpenTargetsi | ENSG00000167635 |
PharmGKBi | PA37518 |
VEuPathDBi | HostDB:ENSG00000167635 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162671 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q15072 |
OMAi | GGSPFAC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q15072 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q15072 |
SignaLinki | Q15072 |
Miscellaneous databases
BioGRID-ORCSi | 7705, 6 hits in 1036 CRISPR screens |
ChiTaRSi | ZNF146, human |
GeneWikii | ZNF146 |
GenomeRNAii | 7705 |
Pharosi | Q15072, Tbio |
PROi | PR:Q15072 |
RNActi | Q15072, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167635, Expressed in metanephros and 255 other tissues |
Genevisiblei | Q15072, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OZF_HUMAN | |
Accessioni | Q15072Primary (citable) accession number: Q15072 Secondary accession number(s): Q2TB94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families