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Entry version 197 (16 Oct 2019)
Sequence version 3 (20 Feb 2007)
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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (PubMed:17458872, PubMed:17603022). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (PubMed:17603022). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (PubMed:17603022). Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA (PubMed:17603022).2 Publications

Miscellaneous

Isoform 1 and isoform 2 can reverse the Acox1 null phenotype in mouse which is characterized by severe microvesicular hepatic steatosis, sustained activation of Ppara, spontaneous massive peroxisome proliferation and eventual development of hepatocellular carcinomas. Isoform 2 is more effective in reversal of the phenotype than isoform 1 (PubMed:20195242).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=73 µM for palmitoyl-CoA (isoform 1)1 Publication
  2. KM=90 µM for palmitoyl-CoA (isoform 2)1 Publication

    pH dependencei

    Optimum pH is 8.5 for isoform 1 and 7.5-8.5 for isoform 2.1 Publication

    Temperature dependencei

    Optimum temperature for isoform 1 at pH 7.5 is 40 degrees Celsius with no activity at 50 degrees Celsius. Optimum temperature for isoform 2 at pH 7.5 is 47.5 degrees Celsius with 57% activity retained at 50 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peroxisomal fatty acid beta-oxidation

    This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
    View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei139FADBy similarity1
    Binding sitei178FAD; via amide nitrogenBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei421Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processFatty acid metabolism, Lipid metabolism
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS08589-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.3.3.6 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1989781 PPARA activates gene expression [Q15067-1]
    R-HSA-2046106 alpha-linolenic acid (ALA) metabolism [Q15067-2]
    R-HSA-390247 Beta-oxidation of very long chain fatty acids [Q15067-2]
    R-HSA-9033241 Peroxisomal protein import
    R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q15067

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00661

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000536 [Q15067-1]
    SLP:000000537 [Q15067-2]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 11 Publication (EC:1.3.3.61 Publication)
    Short name:
    AOX1 Publication
    Alternative name(s):
    Palmitoyl-CoA oxidase1 Publication
    Straight-chain acyl-CoA oxidase
    Short name:
    SCOX
    Cleaved into the following 3 chains:
    Peroxisomal acyl-CoA oxidase 1, A chainBy similarity
    Peroxisomal acyl-CoA oxidase 1, B chainBy similarity
    Peroxisomal acyl-CoA oxidase 1, C chainBy similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ACOX1Imported
    Synonyms:ACOX
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:119 ACOX1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609751 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q15067

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Peroxisome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Adrenoleukodystrophy, pseudoneonatal (Pseudo-NALD)3 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA peroxisomal single-enzyme disorder of fatty acid beta-oxidation, resulting in clinical manifestations that remind neonatal adrenoleukodystrophy. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty acids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning.
    Related information in OMIM

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51

    MalaCards human disease database

    More...
    MalaCardsi
    ACOX1
    MIMi264470 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000161533

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    2971 Peroxisomal acyl-CoA oxidase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA21

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q15067

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4105748

    Drug and drug target database

    More...
    DrugBanki
    DB07930 (3R)-3-HYDROXYDODECANOIC ACID
    DB03147 Flavin adenine dinucleotide

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ACOX1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    126302511

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002046771 – 660Peroxisomal acyl-CoA oxidase 1, A chainAdd BLAST660
    ChainiPRO_00004475001 – 468Peroxisomal acyl-CoA oxidase 1, B chainBy similarityAdd BLAST468
    ChainiPRO_0000447501469 – 660Peroxisomal acyl-CoA oxidase 1, C chainBy similarityAdd BLAST192

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineCombined sources1
    Modified residuei89N6-succinyllysineBy similarity1
    Modified residuei90N6-succinyllysineBy similarity1
    Modified residuei216N6-acetyllysineBy similarity1
    Modified residuei241N6-succinyllysineBy similarity1
    Modified residuei255N6-acetyllysineCombined sources1
    Modified residuei267N6-acetyllysineCombined sources1
    Modified residuei272N6-acetyllysineBy similarity1
    Modified residuei349N6-succinyllysineBy similarity1
    Modified residuei437N6-acetyllysine; alternateCombined sources1
    Modified residuei437N6-succinyllysine; alternateBy similarity1
    Modified residuei446N6-acetyllysine; alternateBy similarity1
    Modified residuei446N6-succinyllysine; alternateBy similarity1
    Modified residuei500N6-acetyllysineCombined sources1
    Modified residuei504N6-acetyllysineCombined sources1
    Modified residuei512N6-acetyllysine; alternateBy similarity1
    Modified residuei512N6-succinyllysine; alternateBy similarity1
    Modified residuei542N6-succinyllysineBy similarity1
    Modified residuei637N6-acetyllysine; alternateBy similarity1
    Modified residuei637N6-succinyllysine; alternateBy similarity1
    Modified residuei643N6-succinyllysineBy similarity1
    Modified residuei649PhosphoserineBy similarity1
    Modified residuei651N6-acetyllysineBy similarity1
    Modified residuei654N6-succinyllysineBy similarity1

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei468 – 469CleavageBy similarity2

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q15067

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q15067

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q15067

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q15067

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q15067

    PeptideAtlas

    More...
    PeptideAtlasi
    Q15067

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q15067

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    24812
    60421 [Q15067-1]
    60422 [Q15067-2]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q15067-1 [Q15067-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q15067

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q15067

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q15067

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000161533 Expressed in 225 organ(s), highest expression level in liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q15067 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q15067 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB021094
    HPA021192
    HPA021195
    HPA028759

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (By similarity).

    Interacts with LONP2 (PubMed:18281296).

    By similarity1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    106567, 45 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q15067, 29 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000293217

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q15067

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi658 – 660Microbody targeting signal3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0136 Eukaryota
    COG1960 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157287

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q15067

    KEGG Orthology (KO)

    More...
    KOi
    K00232

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GRRFFTM

    Database of Orthologous Groups

    More...
    OrthoDBi
    416859at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q15067

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300672

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01150 AXO, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.540.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR034171 ACO
    IPR029320 Acyl-CoA_ox_N
    IPR006091 Acyl-CoA_Oxase/DH_cen-dom
    IPR012258 Acyl-CoA_oxidase
    IPR002655 Acyl-CoA_oxidase_C
    IPR036250 AcylCo_DH-like_C
    IPR037069 AcylCoA_DH/ox_N_sf
    IPR009100 AcylCoA_DH/oxidase_NM_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01756 ACOX, 1 hit
    PF02770 Acyl-CoA_dh_M, 1 hit
    PF14749 Acyl-CoA_ox_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000168 Acyl-CoA_oxidase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47203 SSF47203, 2 hits
    SSF56645 SSF56645, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q15067-1) [UniParc]FASTAAdd to basket
    Also known as: ACOX1a, SCOX-exon 3I

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED
    60 70 80 90 100
    LNFLTRSQRY EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV
    110 120 130 140 150
    GLNYSMFIPT LLNQGTTAQK EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL
    160 170 180 190 200
    ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITKGKCY
    210 220 230 240 250
    GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL KMDNHRIPRE
    260 270 280 290 300
    NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA
    310 320 330 340 350
    IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE
    360 370 380 390 400
    TYHRINEGIG QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG
    410 420 430 440 450
    YSHCSGLPNI YVNFTPSCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG
    460 470 480 490 500
    MVSYLNDLPS QRIQPQQVAV WPTMVDINSP ESLTEAYKLR AARLVEIAAK
    510 520 530 540 550
    NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS EKLLKIQDKA
    560 570 580 590 600
    IQAVLRSLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR
    610 620 630 640 650
    SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY
    660
    KHLKSLQSKL
    Length:660
    Mass (Da):74,424
    Last modified:February 20, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD713768A47374EA1
    GO
    Isoform 2 (identifier: Q15067-2) [UniParc]FASTAAdd to basket
    Also known as: ACOX1b, SCOX-exon 3II

    The sequence of this isoform differs from the canonical sequence as follows:
         90-131: KLHLVNFVEP...KWLLSSKGLQ → NFVHRGRPEP...RFFMPAWNLE

    Show »
    Length:660
    Mass (Da):74,668
    Checksum:i761C97B5043F9068
    GO
    Isoform 3 (identifier: Q15067-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: Missing.
         90-131: KLHLVNFVEP...KWLLSSKGLQ → NFVHRGRPEP...RFFMPAWNLE

    Note: No experimental confirmation available.
    Show »
    Length:622
    Mass (Da):70,136
    Checksum:iFE52A881C050EB78
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7ELT1K7ELT1_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    156Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ENF1K7ENF1_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    132Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ESC7K7ESC7_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    153Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L2U4I3L2U4_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    71Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L0T4I3L0T4_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    223Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L4S5I3L4S5_HUMAN
    Peroxisomal acyl-coenzyme A oxidase...
    ACOX1
    108Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAD97622 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27P → L in CAA50574 (PubMed:8040306).Curated1
    Sequence conflicti80A → R in CAA50574 (PubMed:8040306).Curated1
    Sequence conflicti84E → D in CAD97622 (PubMed:17974005).Curated1
    Sequence conflicti119Q → E in AAB30019 (PubMed:8117268).Curated1
    Sequence conflicti200Y → H in AAA18595 (PubMed:7876265).Curated1
    Sequence conflicti212 – 213IG → NR in AAA19113 (PubMed:8159712).Curated2
    Sequence conflicti212 – 213IG → NR in AAA19114 (PubMed:8159712).Curated2
    Sequence conflicti212 – 213IG → NR in AAA18595 (PubMed:7876265).Curated2
    Sequence conflicti264T → P in AAA19113 (PubMed:8159712).Curated1
    Sequence conflicti264T → P in AAA19114 (PubMed:8159712).Curated1
    Sequence conflicti264T → P in AAA18595 (PubMed:7876265).Curated1
    Sequence conflicti332F → L in AAA18595 (PubMed:7876265).Curated1
    Sequence conflicti449C → R in AAA18595 (PubMed:7876265).Curated1
    Sequence conflicti490R → L in BAF85654 (PubMed:14702039).Curated1
    Sequence conflicti531C → L in AAA19113 (PubMed:8159712).Curated1
    Sequence conflicti531C → L in AAA19114 (PubMed:8159712).Curated1
    Sequence conflicti531C → L in AAA18595 (PubMed:7876265).Curated1
    Sequence conflicti534 – 535VV → GL in AAA19113 (PubMed:8159712).Curated2
    Sequence conflicti534 – 535VV → GL in AAA19114 (PubMed:8159712).Curated2
    Sequence conflicti534 – 535VV → GL in AAA18595 (PubMed:7876265).Curated2
    Sequence conflicti615V → A in CAA50574 (PubMed:8040306).Curated1
    Sequence conflicti650Y → YH in AAB30019 (PubMed:8117268).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06704064Missing in pseudo-NALD. 1 Publication1
    Natural variantiVAR_048182101G → S. Corresponds to variant dbSNP:rs3744032Ensembl.1
    Natural variantiVAR_030619153T → I1 PublicationCorresponds to variant dbSNP:rs17855420EnsemblClinVar.1
    Natural variantiVAR_025789178G → C in pseudo-NALD. 2 PublicationsCorresponds to variant dbSNP:rs118204091EnsemblClinVar.1
    Natural variantiVAR_067041184S → L in pseudo-NALD. 1 PublicationCorresponds to variant dbSNP:rs780887410Ensembl.1
    Natural variantiVAR_067042231G → V in pseudo-NALD. 1 Publication1
    Natural variantiVAR_025790278M → V in pseudo-NALD. 2 PublicationsCorresponds to variant dbSNP:rs118204090EnsemblClinVar.1
    Natural variantiVAR_067043309Q → R in pseudo-NALD. 1 PublicationCorresponds to variant dbSNP:rs118204092EnsemblClinVar.1
    Natural variantiVAR_067044310S → P in pseudo-NALD. 1 PublicationCorresponds to variant dbSNP:rs758962364Ensembl.1
    Natural variantiVAR_021529312I → M5 PublicationsCorresponds to variant dbSNP:rs1135640EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0461291 – 38Missing in isoform 3. 1 PublicationAdd BLAST38
    Alternative sequenceiVSP_00014690 – 131KLHLV…SKGLQ → NFVHRGRPEPLDLHLGMFLP TLLHQATAEQQERFFMPAWN LE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST42

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U03268
    , U03254, U03255, U03256, U03258, U03259, U03260, U03261, U03263, U03264, U03265, U03266, U03267 Genomic DNA Translation: AAA19113.1
    U03268
    , U03254, U03255, U03257, U03258, U03259, U03260, U03261, U03263, U03264, U03265, U03266, U03267 Genomic DNA Translation: AAA19114.1
    U07866 mRNA Translation: AAA18595.1
    X71440 mRNA Translation: CAA50574.1
    S69189 mRNA Translation: AAB30019.2
    AK291793 mRNA Translation: BAF84482.1
    AK292965 mRNA Translation: BAF85654.1
    AK296409 mRNA Translation: BAG59073.1
    BX537380 mRNA Translation: CAD97622.1 Different initiation.
    AC040980 Genomic DNA No translation available.
    AC087289 Genomic DNA No translation available.
    CH471099 Genomic DNA Translation: EAW89351.1
    BC008767 mRNA Translation: AAH08767.1
    BC010425 mRNA Translation: AAH10425.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11734.1 [Q15067-2]
    CCDS11735.1 [Q15067-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A54942
    B54942
    I38095

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001171968.1, NM_001185039.1 [Q15067-3]
    NP_004026.2, NM_004035.6 [Q15067-2]
    NP_009223.2, NM_007292.5 [Q15067-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000293217; ENSP00000293217; ENSG00000161533 [Q15067-2]
    ENST00000301608; ENSP00000301608; ENSG00000161533 [Q15067-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51

    UCSC genome browser

    More...
    UCSCi
    uc002jqe.5 human [Q15067-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U03268
    , U03254, U03255, U03256, U03258, U03259, U03260, U03261, U03263, U03264, U03265, U03266, U03267 Genomic DNA Translation: AAA19113.1
    U03268
    , U03254, U03255, U03257, U03258, U03259, U03260, U03261, U03263, U03264, U03265, U03266, U03267 Genomic DNA Translation: AAA19114.1
    U07866 mRNA Translation: AAA18595.1
    X71440 mRNA Translation: CAA50574.1
    S69189 mRNA Translation: AAB30019.2
    AK291793 mRNA Translation: BAF84482.1
    AK292965 mRNA Translation: BAF85654.1
    AK296409 mRNA Translation: BAG59073.1
    BX537380 mRNA Translation: CAD97622.1 Different initiation.
    AC040980 Genomic DNA No translation available.
    AC087289 Genomic DNA No translation available.
    CH471099 Genomic DNA Translation: EAW89351.1
    BC008767 mRNA Translation: AAH08767.1
    BC010425 mRNA Translation: AAH10425.1
    CCDSiCCDS11734.1 [Q15067-2]
    CCDS11735.1 [Q15067-1]
    PIRiA54942
    B54942
    I38095
    RefSeqiNP_001171968.1, NM_001185039.1 [Q15067-3]
    NP_004026.2, NM_004035.6 [Q15067-2]
    NP_009223.2, NM_007292.5 [Q15067-1]

    3D structure databases

    SMRiQ15067
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi106567, 45 interactors
    IntActiQ15067, 29 interactors
    STRINGi9606.ENSP00000293217

    Chemistry databases

    ChEMBLiCHEMBL4105748
    DrugBankiDB07930 (3R)-3-HYDROXYDODECANOIC ACID
    DB03147 Flavin adenine dinucleotide
    SwissLipidsiSLP:000000536 [Q15067-1]
    SLP:000000537 [Q15067-2]

    PTM databases

    iPTMnetiQ15067
    PhosphoSitePlusiQ15067
    SwissPalmiQ15067

    Polymorphism and mutation databases

    BioMutaiACOX1
    DMDMi126302511

    Proteomic databases

    EPDiQ15067
    jPOSTiQ15067
    MassIVEiQ15067
    MaxQBiQ15067
    PaxDbiQ15067
    PeptideAtlasiQ15067
    PRIDEiQ15067
    ProteomicsDBi24812
    60421 [Q15067-1]
    60422 [Q15067-2]
    TopDownProteomicsiQ15067-1 [Q15067-1]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    51

    Genome annotation databases

    EnsembliENST00000293217; ENSP00000293217; ENSG00000161533 [Q15067-2]
    ENST00000301608; ENSP00000301608; ENSG00000161533 [Q15067-1]
    GeneIDi51
    KEGGihsa:51
    UCSCiuc002jqe.5 human [Q15067-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51
    DisGeNETi51

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ACOX1
    HGNCiHGNC:119 ACOX1
    HPAiCAB021094
    HPA021192
    HPA021195
    HPA028759
    MalaCardsiACOX1
    MIMi264470 phenotype
    609751 gene
    neXtProtiNX_Q15067
    OpenTargetsiENSG00000161533
    Orphaneti2971 Peroxisomal acyl-CoA oxidase deficiency
    PharmGKBiPA21

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0136 Eukaryota
    COG1960 LUCA
    GeneTreeiENSGT00940000157287
    InParanoidiQ15067
    KOiK00232
    OMAiGRRFFTM
    OrthoDBi416859at2759
    PhylomeDBiQ15067
    TreeFamiTF300672

    Enzyme and pathway databases

    UniPathwayiUPA00661
    BioCyciMetaCyc:HS08589-MONOMER
    BRENDAi1.3.3.6 2681
    ReactomeiR-HSA-1989781 PPARA activates gene expression [Q15067-1]
    R-HSA-2046106 alpha-linolenic acid (ALA) metabolism [Q15067-2]
    R-HSA-390247 Beta-oxidation of very long chain fatty acids [Q15067-2]
    R-HSA-9033241 Peroxisomal protein import
    R-HSA-9033500 TYSND1 cleaves peroxisomal proteins
    SABIO-RKiQ15067

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ACOX1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ACOX1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51
    PharosiQ15067

    Protein Ontology

    More...
    PROi
    PR:Q15067

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000161533 Expressed in 225 organ(s), highest expression level in liver
    ExpressionAtlasiQ15067 baseline and differential
    GenevisibleiQ15067 HS

    Family and domain databases

    CDDicd01150 AXO, 1 hit
    Gene3Di1.10.540.10, 1 hit
    InterProiView protein in InterPro
    IPR034171 ACO
    IPR029320 Acyl-CoA_ox_N
    IPR006091 Acyl-CoA_Oxase/DH_cen-dom
    IPR012258 Acyl-CoA_oxidase
    IPR002655 Acyl-CoA_oxidase_C
    IPR036250 AcylCo_DH-like_C
    IPR037069 AcylCoA_DH/ox_N_sf
    IPR009100 AcylCoA_DH/oxidase_NM_dom
    PfamiView protein in Pfam
    PF01756 ACOX, 1 hit
    PF02770 Acyl-CoA_dh_M, 1 hit
    PF14749 Acyl-CoA_ox_N, 1 hit
    PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
    SUPFAMiSSF47203 SSF47203, 2 hits
    SSF56645 SSF56645, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOX1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15067
    Secondary accession number(s): A8K6X8
    , A8KAA0, B4DK61, F5GYQ8, Q12863, Q15068, Q15101, Q16131, Q7Z3W5, Q9UD31
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 20, 2007
    Last modified: October 16, 2019
    This is version 197 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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