Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 43

Gene

WDR43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ15061

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 43
Alternative name(s):
U3 small nucleolar RNA-associated protein 5 homolog
Gene namesi
Name:WDR43
Synonyms:KIAA0007, UTP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163811.11
HGNCiHGNC:28945 WDR43
MIMi616195 gene
neXtProtiNX_Q15061

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23160
OpenTargetsiENSG00000163811
PharmGKBiPA134914163

Polymorphism and mutation databases

BioMutaiWDR43
DMDMi158518532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513921 – 677WD repeat-containing protein 43Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Cross-linki309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei321PhosphothreonineCombined sources1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei394PhosphothreonineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei656PhosphothreonineCombined sources1
Modified residuei658PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15061
MaxQBiQ15061
PaxDbiQ15061
PeptideAtlasiQ15061
PRIDEiQ15061
ProteomicsDBi60416

2D gel databases

SWISS-2DPAGEiQ15061

PTM databases

iPTMnetiQ15061
PhosphoSitePlusiQ15061
SwissPalmiQ15061

Expressioni

Gene expression databases

BgeeiENSG00000163811 Expressed in 224 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_WDR43
ExpressionAtlasiQ15061 baseline and differential
GenevisibleiQ15061 HS

Organism-specific databases

HPAiHPA044733

Interactioni

Subunit structurei

Interacts directly with UTP4 and UTP15 (PubMed:24219289). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).2 Publications1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP4Q969X62EBI-2563523,EBI-2602591

Protein-protein interaction databases

BioGridi116772, 26 interactors
IntActiQ15061, 14 interactors
MINTiQ15061
STRINGi9606.ENSP00000384302

Structurei

3D structure databases

ProteinModelPortaliQ15061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 51WD 1Add BLAST41
Repeati57 – 119WD 2Add BLAST63
Repeati124 – 163WD 3Add BLAST40
Repeati166 – 205WD 4Add BLAST40
Repeati207 – 259WD 5Add BLAST53
Repeati267 – 309WD 6Add BLAST43

Sequence similaritiesi

Belongs to the UTP5 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4547 Eukaryota
ENOG410XRY4 LUCA
GeneTreeiENSGT00390000004254
HOGENOMiHOG000006569
HOVERGENiHBG060012
InParanoidiQ15061
KOiK14546
OMAiWQVRSEN
OrthoDBiEOG091G0K58
PhylomeDBiQ15061
TreeFamiTF313160

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGGGSCD PLAPAGVPCA FSPHSQAYFA LASTDGHLRV WETANNRLHQ
60 70 80 90 100
EYVPSAHLSG TCTCLAWAPA RLQAKESPQR KKRKSEAVGM SNQTDLLALG
110 120 130 140 150
TAVGSILLYS TVKGELHSKL ISGGHDNRVN CIQWHQDSGC LYSCSDDKHI
160 170 180 190 200
VEWNVQTCKV KCKWKGDNSS VSSLCISPDG KMLLSAGRTI KLWVLETKEV
210 220 230 240 250
YRHFTGHATP VSSLMFTTIR PPNESQPFDG ITGLYFLSGA VHDRLLNVWQ
260 270 280 290 300
VRSENKEKSA VMSFTVTDEP VYIDLTLSEN KEEPVKLAVV CRDGQVHLFE
310 320 330 340 350
HILNGYCKKP LTSNCTIQIA TPGKGKKSTP KPIPILAAGF CSDKMSLLLV
360 370 380 390 400
YGSWFQPTIE RVALNSREPH MCLVRDISNC WAPKVETAIT KVRTPVMNSE
410 420 430 440 450
AKVLVPGIPG HHAAIKPAPP QTEQVESKRK SGGNEVSIEE RLGAMDIDTH
460 470 480 490 500
KKGKEDLQTN SFPVLLTQGL ESNDFEMLNK VLQTRNVNLI KKTVLRMPLH
510 520 530 540 550
TIIPLLQELT KRLQGHPNSA VLMVQWLKCV LTVHASYLST LPDLVPQLGT
560 570 580 590 600
LYQLMESRVK TFQKLSHLHG KLILLITQVT ASEKTKGATS PGQKAKLVYE
610 620 630 640 650
EESSEEESDD EIADKDSEDN WDEDEEESES EKDEDVEEED EDAEGKDEEN
660 670
GEDRDTASEK ELNGDSDLDP ENESEEE
Length:677
Mass (Da):74,891
Last modified:July 24, 2007 - v3
Checksum:i4EEAD92C30118ACD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JEE7C9JEE7_HUMAN
WD repeat-containing protein 43
WDR43
147Annotation score:
C9IZK7C9IZK7_HUMAN
WD repeat-containing protein 43
WDR43
187Annotation score:
C9JH61C9JH61_HUMAN
WD repeat-containing protein 43
WDR43
25Annotation score:

Sequence cautioni

The sequence BAA05499 differs from that shown. Reason: Frameshift at positions 614 and 617.Curated
The sequence BAA05499 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26488 mRNA Translation: BAA05499.1 Different initiation.
D87716 mRNA Translation: BAA13441.1 Frameshift.
CCDSiCCDS46251.1
RefSeqiNP_055946.1, NM_015131.2
UniGeneiHs.622982
Hs.709228

Genome annotation databases

EnsembliENST00000407426; ENSP00000384302; ENSG00000163811
GeneIDi23160
KEGGihsa:23160
UCSCiuc002rmo.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26488 mRNA Translation: BAA05499.1 Different initiation.
D87716 mRNA Translation: BAA13441.1 Frameshift.
CCDSiCCDS46251.1
RefSeqiNP_055946.1, NM_015131.2
UniGeneiHs.622982
Hs.709228

3D structure databases

ProteinModelPortaliQ15061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116772, 26 interactors
IntActiQ15061, 14 interactors
MINTiQ15061
STRINGi9606.ENSP00000384302

PTM databases

iPTMnetiQ15061
PhosphoSitePlusiQ15061
SwissPalmiQ15061

Polymorphism and mutation databases

BioMutaiWDR43
DMDMi158518532

2D gel databases

SWISS-2DPAGEiQ15061

Proteomic databases

EPDiQ15061
MaxQBiQ15061
PaxDbiQ15061
PeptideAtlasiQ15061
PRIDEiQ15061
ProteomicsDBi60416

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407426; ENSP00000384302; ENSG00000163811
GeneIDi23160
KEGGihsa:23160
UCSCiuc002rmo.3 human

Organism-specific databases

CTDi23160
DisGeNETi23160
EuPathDBiHostDB:ENSG00000163811.11
GeneCardsiWDR43
HGNCiHGNC:28945 WDR43
HPAiHPA044733
MIMi616195 gene
neXtProtiNX_Q15061
OpenTargetsiENSG00000163811
PharmGKBiPA134914163
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4547 Eukaryota
ENOG410XRY4 LUCA
GeneTreeiENSGT00390000004254
HOGENOMiHOG000006569
HOVERGENiHBG060012
InParanoidiQ15061
KOiK14546
OMAiWQVRSEN
OrthoDBiEOG091G0K58
PhylomeDBiQ15061
TreeFamiTF313160

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ15061

Miscellaneous databases

ChiTaRSiWDR43 human
GenomeRNAii23160
PROiPR:Q15061
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163811 Expressed in 224 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_WDR43
ExpressionAtlasiQ15061 baseline and differential
GenevisibleiQ15061 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR007148 SSU_processome_Utp12
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04003 Utp12, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR43_HUMAN
AccessioniPrimary (citable) accession number: Q15061
Secondary accession number(s): Q15395, Q92577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 24, 2007
Last modified: October 10, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again