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UniProtKB - Q15059 (BRD3_HUMAN)

Entry version 194 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Bromodomain-containing protein 3

Gene

BRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114).

Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q15059

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q15059

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q15059

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain-containing protein 3
Alternative name(s):
RING3-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRD3
Synonyms:KIAA0043, RING3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1104, BRD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601541, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15059

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169925

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei647 – 648Breakpoint for translocation to form BDR3-NUTM1 fusion protein1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		8019

Open Targets

More...OpenTargetsi		ENSG00000169925

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25415

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15059, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795186

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2725

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BRD3

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643726

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111812 – 726Bromodomain-containing protein 3Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei563PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15059

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15059

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15059

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15059

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15059

PeptideAtlas

More...PeptideAtlasi		Q15059

PRoteomics IDEntifications database

More...PRIDEi		Q15059

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60414 [Q15059-1]
60415 [Q15059-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q15059, 5 sites, 1 O-linked glycan (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169925, Expressed in forebrain and 259 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15059, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15059, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169925, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'.

Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity).

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113715, 230 interactors

Database of interacting proteins

More...DIPi		DIP-39755N

Protein interaction database and analysis system

More...IntActi		Q15059, 23 interactors

Molecular INTeraction database

More...MINTi		Q15059

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000305918

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q15059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15059, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1726
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q15059

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q15059

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q15059

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 123Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini326 – 398Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini562 – 644NETPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni78 – 80Acetylated histone H3 binding1 Publication3
Regioni149 – 169DisorderedSequence analysisAdd BLAST21
Regioni237 – 305DisorderedSequence analysisAdd BLAST69
Regioni421 – 462DisorderedSequence analysisAdd BLAST42
Regioni477 – 575DisorderedSequence analysisAdd BLAST99
Regioni637 – 726DisorderedSequence analysisAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili453 – 524Sequence analysisAdd BLAST72
Coiled coili645 – 684Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 29Pro residuesSequence analysisAdd BLAST16
Compositional biasi247 – 266Polar residuesSequence analysisAdd BLAST20
Compositional biasi273 – 305Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi498 – 524Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi535 – 551Polar residuesSequence analysisAdd BLAST17
Compositional biasi652 – 673Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi697 – 726Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Bromo domains specifically recognize and bind acetylated histones.1 Publication

Keywords - Domaini

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1474, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001499_0_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15059

Identification of Orthologs from Complete Genome Data

More...OMAi		CYAFNPD

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15059

TreeFam database of animal gene trees

More...TreeFami		TF317345

Family and domain databases

Conserved Domains Database

More...CDDi		cd05497, Bromo_Brdt_I_like, 1 hit
cd05498, Bromo_Brdt_II_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.220, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043508, Bromo_Brdt_I
IPR043509, Bromo_Brdt_II
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR027353, NET_dom
IPR038336, NET_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17035, BET, 1 hit
PF00439, Bromodomain, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297, BROMO, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits
PS51525, NET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15059-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL 
        60         70         80         90        100
WKHQFAWPFY QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE 
       110        120        130        140        150
CMQDFNTMFT NCYIYNKPTD DIVLMAQALE KIFLQKVAQM PQEEVELLPP 
       160        170        180        190        200
APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA TPFQSVPPTV SQTPVIAATP 
       210        220        230        240        250
VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK GVKRKADTTT 
       260        270        280        290        300
PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 
       310        320        330        340        350
HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD 
       360        370        380        390        400
IIKHPMDLST VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM 
       410        420        430        440        450
ARKLQDVFEM RFAKMPDEPV EAPALPAPAA PMVSKGAESS RSSEESSSDS 
       460        470        480        490        500
GSSDSEEERA TRLAELQEQL KAVHEQLAAL SQAPVNKPKK KKEKKEKEKK 
       510        520        530        540        550
KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA NSTTTAGRQL 
       560        570        580        590        600
KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 
       610        620        630        640        650
SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK 
       660        670        680        690        700
KQAAKSKEEL AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS 
       710        720 
RLSSSSSSES GSSSSSGSSS DSSDSE
Length:726
Mass (Da):79,542
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64F526FC3C1033AA
GO
Isoform 2 (identifier: Q15059-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-556: QLKKGGKQ → DHFLTCGV
     557-726: Missing.

Show »
Length:556
Mass (Da):60,942
Checksum:i8352F5DF1801A793
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9J571A9J571_HUMAN
Bromodomain-containing protein 3
BRD3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A9J575A9J575_HUMAN
Bromodomain-containing protein 3
BRD3
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA05393 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04191336T → N in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041914161A → T in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041915172A → V1 PublicationCorresponds to variant dbSNP:rs34609592Ensembl.1
Natural variantiVAR_041916435K → Q1 PublicationCorresponds to variant dbSNP:rs36093130Ensembl.1
Natural variantiVAR_041917441R → H1 PublicationCorresponds to variant dbSNP:rs56017928Ensembl.1
Natural variantiVAR_041918447S → P1 PublicationCorresponds to variant dbSNP:rs55754444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010247549 – 556QLKKGGKQ → DHFLTCGV in isoform 2. 1 Publication8
Alternative sequenceiVSP_010248557 – 726Missing in isoform 2. 1 PublicationAdd BLAST170

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D26362 mRNA Translation: BAA05393.2 Different initiation.
AY513270 mRNA Translation: AAS82952.1
AL445931 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88113.1
CH471090 Genomic DNA Translation: EAW88114.1
BC032124 mRNA Translation: AAH32124.1
Z81330 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6980.1 [Q15059-1]

NCBI Reference Sequences

More...RefSeqi		NP_031397.1, NM_007371.3 [Q15059-1]
XP_006717354.1, XM_006717291.2 [Q15059-1]
XP_011517354.1, XM_011519052.2 [Q15059-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303407; ENSP00000305918; ENSG00000169925
ENST00000371834; ENSP00000360900; ENSG00000169925 [Q15059-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8019

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000303407.12; ENSP00000305918.6; NM_007371.4; NP_031397.1

UCSC genome browser

More...UCSCi		uc004cew.4, human [Q15059-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26362 mRNA Translation: BAA05393.2 Different initiation.
AY513270 mRNA Translation: AAS82952.1
AL445931 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88113.1
CH471090 Genomic DNA Translation: EAW88114.1
BC032124 mRNA Translation: AAH32124.1
Z81330 Genomic DNA No translation available.
CCDSiCCDS6980.1 [Q15059-1]
RefSeqiNP_031397.1, NM_007371.3 [Q15059-1]
XP_006717354.1, XM_006717291.2 [Q15059-1]
XP_011517354.1, XM_011519052.2 [Q15059-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7NNMR-A306-415[»]
2NXBX-ray1.40A/B24-144[»]
2OO1X-ray1.70A/B/C/D307-416[»]
2YW5NMR-A25-155[»]
3S91X-ray2.06A24-144[»]
3S92X-ray1.36A306-416[»]
5A7CX-ray1.90A/B/C/D306-416[»]
5HFRX-ray1.70A/B/C/D306-416[»]
5HJCX-ray2.60A307-416[»]
6BGGNMR-B557-644[»]
6BGHNMR-A557-643[»]
6I41X-ray1.90B245-253[»]
6I5PX-ray1.81B/D/F/H245-253[»]
6I68X-ray1.85B/D/F/H245-253[»]
6I7AX-ray2.20B/D/F/H245-253[»]
6QJUX-ray1.20A/B24-144[»]
6U4AX-ray1.88A/B25-147[»]
6ULPX-ray2.80A/B307-419[»]
7JMYNMR-A554-640[»]
7JQ8NMR-A554-640[»]
7JYNNMR-A554-640[»]
7JYZNMR-B554-640[»]
7L9LX-ray1.55A306-416[»]
7LAYX-ray1.45A/B24-144[»]
7LAZX-ray2.30A/B24-144[»]
7LB4X-ray2.00A/B306-416[»]
7LBTX-ray2.70A/B/C/D306-416[»]
SASBDBiQ15059
SMRiQ15059
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113715, 230 interactors
DIPiDIP-39755N
IntActiQ15059, 23 interactors
MINTiQ15059
STRINGi9606.ENSP00000305918

Chemistry databases

BindingDBiQ15059
ChEMBLiCHEMBL1795186
GuidetoPHARMACOLOGYi2725

PTM databases

GlyGeniQ15059, 5 sites, 1 O-linked glycan (5 sites)
iPTMnetiQ15059
PhosphoSitePlusiQ15059

Genetic variation databases

BioMutaiBRD3
DMDMi12643726

Proteomic databases

EPDiQ15059
jPOSTiQ15059
MassIVEiQ15059
MaxQBiQ15059
PaxDbiQ15059
PeptideAtlasiQ15059
PRIDEiQ15059
ProteomicsDBi60414 [Q15059-1]
60415 [Q15059-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q15059, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31966, 387 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		8019

Genome annotation databases

EnsembliENST00000303407; ENSP00000305918; ENSG00000169925
ENST00000371834; ENSP00000360900; ENSG00000169925 [Q15059-2]
GeneIDi8019
KEGGihsa:8019
MANE-SelectiENST00000303407.12; ENSP00000305918.6; NM_007371.4; NP_031397.1
UCSCiuc004cew.4, human [Q15059-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8019
DisGeNETi8019

GeneCards: human genes, protein and diseases

More...GeneCardsi		BRD3
HGNCiHGNC:1104, BRD3
HPAiENSG00000169925, Low tissue specificity
MIMi601541, gene
neXtProtiNX_Q15059
OpenTargetsiENSG00000169925
PharmGKBiPA25415
VEuPathDBiHostDB:ENSG00000169925

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1474, Eukaryota
GeneTreeiENSGT00940000153385
HOGENOMiCLU_001499_0_4_1
InParanoidiQ15059
OMAiCYAFNPD
PhylomeDBiQ15059
TreeFamiTF317345

Enzyme and pathway databases

PathwayCommonsiQ15059
SignaLinkiQ15059
SIGNORiQ15059

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8019, 6 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BRD3, human
EvolutionaryTraceiQ15059

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BRD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8019
PharosiQ15059, Tchem

Protein Ontology

More...PROi		PR:Q15059
RNActiQ15059, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169925, Expressed in forebrain and 259 other tissues
ExpressionAtlasiQ15059, baseline and differential
GenevisibleiQ15059, HS

Family and domain databases

CDDicd05497, Bromo_Brdt_I_like, 1 hit
cd05498, Bromo_Brdt_II_like, 1 hit
Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR043508, Bromo_Brdt_I
IPR043509, Bromo_Brdt_II
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR027353, NET_dom
IPR038336, NET_sf
PfamiView protein in Pfam
PF17035, BET, 1 hit
PF00439, Bromodomain, 2 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SUPFAMiSSF47370, SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits
PS51525, NET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15059
Secondary accession number(s): B1APD9
, Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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