UniProtKB - Q15059 (BRD3_HUMAN)

BLAST

>sp|Q15059|BRD3_HUMAN Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE

Align

Format
Add to basket Added to basket
History
Entry version 172 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Bromodomain-containing protein 3

Gene

BRD3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization Source: UniProtKB-KW
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 18406326

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q15059

SIGNORⁱ

Q15059

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bromodomain-containing protein 3 Alternative name(s): RING3-like protein
Gene namesⁱ	Name:BRD3 Synonyms:KIAA0043, RING3L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169925.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1104 BRD3
MIMⁱ	601541 gene
neXtProtⁱ	NX_Q15059

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	647 – 648	Breakpoint for translocation to form BDR3-NUT fusion protein1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8019
Open Targets More...OpenTargetsⁱ	ENSG00000169925
PharmGKBⁱ	PA25415

Chemistry databases

ChEMBLⁱ	CHEMBL1795186
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2725

Polymorphism and mutation databases

BioMutaⁱ	BRD3
DMDMⁱ	12643726

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000211181	2 – 726	Bromodomain-containing protein 3Add BLAST		725

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1
Modified residueⁱ	281	PhosphoserineCombined sources	1
Cross-linkⁱ	414	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	563	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q15059
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15059
PaxDbⁱ	Q15059
PeptideAtlas More...PeptideAtlasⁱ	Q15059
PRIDEⁱ	Q15059
ProteomicsDBⁱ	60414 60415 [Q15059-2]

PTM databases

iPTMnetⁱ	Q15059
PhosphoSitePlusⁱ	Q15059

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000169925 Expressed in 248 organ(s), highest expression level in forebrain
CleanExⁱ	HS_BRD3
ExpressionAtlasⁱ	Q15059 baseline and differential
Genevisibleⁱ	Q15059 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051830

HPAⁱ

HPA051830

Interactionⁱ

Subunit structureⁱ

Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MYC	P01106	3	EBI-1383460,EBI-447544

With

Entry

#Exp.

IntAct

Notes

MYC

P01106

EBI-1383460,EBI-447544

GO - Molecular functionⁱ

lysine-acetylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22464331
- 27105114

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113715, 33 interactors
Database of interacting proteins More...DIPⁱ	DIP-39755N
IntActⁱ	Q15059, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q15059
STRINGⁱ	9606.ENSP00000305918

Chemistry databases

BindingDBⁱ

Q15059

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 31	Combined sources	3
Helixⁱ	37 – 44	Combined sources	8
Helixⁱ	46 – 52	Combined sources	7
Helixⁱ	57 – 59	Combined sources	3
Turnⁱ	65 – 69	Combined sources	5
Helixⁱ	73 – 76	Combined sources	4
Helixⁱ	83 – 91	Combined sources	9
Helixⁱ	98 – 115	Combined sources	18
Helixⁱ	121 – 137	Combined sources	17
Helixⁱ	310 – 323	Combined sources	14
Helixⁱ	325 – 327	Combined sources	3
Helixⁱ	328 – 331	Combined sources	4
Helixⁱ	332 – 334	Combined sources	3
Turnⁱ	340 – 344	Combined sources	5
Helixⁱ	348 – 351	Combined sources	4
Helixⁱ	358 – 366	Combined sources	9
Helixⁱ	373 – 390	Combined sources	18
Helixⁱ	396 – 413	Combined sources	18
Helixⁱ	558 – 561	Combined sources	4
Helixⁱ	567 – 569	Combined sources	3
Helixⁱ	574 – 585	Combined sources	12
Helixⁱ	589 – 602	Combined sources	14
Helixⁱ	604 – 608	Combined sources	5
Beta strandⁱ	611 – 613	Combined sources	3
Beta strandⁱ	615 – 617	Combined sources	3
Turnⁱ	618 – 620	Combined sources	3
Helixⁱ	623 – 636	Combined sources	14
Turnⁱ	640 – 642	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15059
SMRⁱ	Q15059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15059

EvolutionaryTraceⁱ

Q15059

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	51 – 123	Bromo 1PROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	326 – 398	Bromo 2PROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	562 – 644	NETPROSITE-ProRule annotationAdd BLAST	83

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	78 – 80	Acetylated histone H3 binding1 Publication		3

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	453 – 524	Sequence analysisAdd BLAST		72
Coiled coilⁱ	645 – 684	Sequence analysisAdd BLAST		40

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	487 – 555	Lys-richAdd BLAST		69
Compositional biasⁱ	676 – 725	Ser-richAdd BLAST		50

Domainⁱ

The Bromo domains specifically recognize and bind acetylated histones.1 Publication

Keywords - Domainⁱ

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1474 Eukaryota COG5076 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150866
HOGENOMⁱ	HOG000231200
HOVERGENⁱ	HBG004896
InParanoidⁱ	Q15059
KEGG Orthology (KO) More...KOⁱ	K11721
OMAⁱ	EGLPMTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01QC
PhylomeDBⁱ	Q15059
TreeFamⁱ	TF317345

Family and domain databases

Gene3Dⁱ	1.20.1270.220, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR027353 NET_dom IPR038336 NET_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17035 BET, 1 hit PF00439 Bromodomain, 2 hits
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 2 hits
SUPFAMⁱ	SSF47370 SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 2 hits PS50014 BROMODOMAIN_2, 2 hits PS51525 NET, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15059-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL 
        60         70         80         90        100
WKHQFAWPFY QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE 
       110        120        130        140        150
CMQDFNTMFT NCYIYNKPTD DIVLMAQALE KIFLQKVAQM PQEEVELLPP 
       160        170        180        190        200
APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA TPFQSVPPTV SQTPVIAATP 
       210        220        230        240        250
VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK GVKRKADTTT 
       260        270        280        290        300
PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 
       310        320        330        340        350
HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD 
       360        370        380        390        400
IIKHPMDLST VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM 
       410        420        430        440        450
ARKLQDVFEM RFAKMPDEPV EAPALPAPAA PMVSKGAESS RSSEESSSDS 
       460        470        480        490        500
GSSDSEEERA TRLAELQEQL KAVHEQLAAL SQAPVNKPKK KKEKKEKEKK 
       510        520        530        540        550
KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA NSTTTAGRQL 
       560        570        580        590        600
KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 
       610        620        630        640        650
SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK 
       660        670        680        690        700
KQAAKSKEEL AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS 
       710        720 
RLSSSSSSES GSSSSSGSSS DSSDSE

Length:726

Mass (Da):79,542

Last modified:November 1, 1996 - v1

Checksum:ⁱ64F526FC3C1033AA

Isoform 2 (identifier: Q15059-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
549-556: QLKKGGKQ → DHFLTCGV
557-726: Missing.

« Hide

        10         20         30         40         50
MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL 
        60         70         80         90        100
WKHQFAWPFY QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE 
       110        120        130        140        150
CMQDFNTMFT NCYIYNKPTD DIVLMAQALE KIFLQKVAQM PQEEVELLPP 
       160        170        180        190        200
APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA TPFQSVPPTV SQTPVIAATP 
       210        220        230        240        250
VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK GVKRKADTTT 
       260        270        280        290        300
PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 
       310        320        330        340        350
HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD 
       360        370        380        390        400
IIKHPMDLST VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM 
       410        420        430        440        450
ARKLQDVFEM RFAKMPDEPV EAPALPAPAA PMVSKGAESS RSSEESSSDS 
       460        470        480        490        500
GSSDSEEERA TRLAELQEQL KAVHEQLAAL SQAPVNKPKK KKEKKEKEKK 
       510        520        530        540        550
KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA NSTTTAGRDH 

FLTCGV

Note: No experimental confirmation available.

Show »

Length:556

Mass (Da):60,942

Checksum:ⁱ8352F5DF1801A793

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A9J571	A9J571_HUMAN	Bromodomain-containing protein 3 Bromodomain-containing protein 3	BRD3	74	Annotation score:
A9J575	A9J575_HUMAN	Bromodomain-containing protein 3 Bromodomain-containing protein 3	BRD3	20	Annotation score:

Sequence cautionⁱ

The sequence BAA05393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041913	36	T → N in a renal clear cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041914	161	A → T in a gastric adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041915	172	A → V1 PublicationCorresponds to variant dbSNP:rs34609592Ensembl.	1
Natural variantⁱVAR_041916	435	K → Q1 PublicationCorresponds to variant dbSNP:rs36093130Ensembl.	1
Natural variantⁱVAR_041917	441	R → H1 PublicationCorresponds to variant dbSNP:rs56017928Ensembl.	1
Natural variantⁱVAR_041918	447	S → P1 PublicationCorresponds to variant dbSNP:rs55754444Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010247	549 – 556	QLKKGGKQ → DHFLTCGV in isoform 2. 1 Publication		8
Alternative sequenceⁱVSP_010248	557 – 726	Missing in isoform 2. 1 PublicationAdd BLAST		170

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26362 mRNA Translation: BAA05393.2 Different initiation. AY513270 mRNA Translation: AAS82952.1 AL445931 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88113.1 CH471090 Genomic DNA Translation: EAW88114.1 BC032124 mRNA Translation: AAH32124.1 Z81330 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6980.1 [Q15059-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_031397.1, NM_007371.3 [Q15059-1] XP_006717354.1, XM_006717291.2 [Q15059-1] XP_011517354.1, XM_011519052.2 [Q15059-1]
UniGeneⁱ	Hs.522472 Hs.654869

Genome annotation databases

Ensemblⁱ	ENST00000303407; ENSP00000305918; ENSG00000169925 [Q15059-1] ENST00000371834; ENSP00000360900; ENSG00000169925 [Q15059-2]
GeneIDⁱ	8019
KEGGⁱ	hsa:8019
UCSC genome browser More...UCSCⁱ	uc004cew.4 human [Q15059-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15059	Bromodomain containing 3, isoform CRA_a		HUMAN		726	UniRef100_Q15059
cDNA FLJ61365, highly similar to Bromodomain-containing protein 3		HUMAN		405
Bromodomain-containing protein 3 (Fragment)		HUMAN		74
Bromodomain-containing protein 3 (Fragment)		HUMAN		20
Q15059-2	Bromodomain-containing protein 3 short isoform		HUMAN		556	UniRef100_A0A140F1N4

Protein	Similar proteins		Species	Score	Length	Source
Q15059	Bromodomain-containing protein 3	)	MOUSE		726	UniRef90_Q15059
Bromodomain containing 3, isoform CRA_a		HUMAN		726
Bromodomain-containing protein 3		FUKDA		825
Uncharacterized protein		LOXAF		744
Brd3 protein		RAT		742
+137
Q15059-2	Uncharacterized protein		MACMU		554	UniRef90_F7G2U4
Bromodomain-containing protein 3 short isoform		HUMAN		556
BRD3 isoform 1		PANTR		556
Bromodomain containing 3		SAIBB		556
Uncharacterized protein		COLAP		556
+10

Protein	Similar proteins		Species	Score	Length	Source
Q15059	Bromodomain-containing protein 3	)	MOUSE		726	UniRef50_Q15059
Bromodomain containing 3, isoform CRA_a		HUMAN		726
Bromodomain-containing protein 3		FUKDA		825
Uncharacterized protein		LOXAF		744
Brd3 protein		RAT		742
+485
Q15059-2	Uncharacterized protein		MACMU		554	UniRef50_F7G2U4
Bromodomain containing 3		SAIBB		556
Bromodomain-containing protein 3 short isoform		HUMAN		556
BRD3 isoform 1		PONAB		556
Uncharacterized protein		RHIRO		556
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D26362 mRNA Translation: BAA05393.2 Different initiation. AY513270 mRNA Translation: AAS82952.1 AL445931 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88113.1 CH471090 Genomic DNA Translation: EAW88114.1 BC032124 mRNA Translation: AAH32124.1 Z81330 Genomic DNA No translation available.
CCDSⁱ	CCDS6980.1 [Q15059-1]
RefSeqⁱ	NP_031397.1, NM_007371.3 [Q15059-1] XP_006717354.1, XM_006717291.2 [Q15059-1] XP_011517354.1, XM_011519052.2 [Q15059-1]
UniGeneⁱ	Hs.522472 Hs.654869

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2E7N	NMR	-	A	306-415	[»]
	2NXB	X-ray	1.40	A/B	24-144	[»]
	2OO1	X-ray	1.70	A/B/C/D	307-416	[»]
	2YW5	NMR	-	A	25-155	[»]
	3S91	X-ray	2.06	A	24-144	[»]
	3S92	X-ray	1.36	A	306-416	[»]
	5A7C	X-ray	1.90	A/B/C/D	306-416	[»]
	5HFR	X-ray	1.70	A/B/C/D	306-416	[»]
	5HJC	X-ray	2.60	A	307-416	[»]
	6BGG	NMR	-	B	557-644	[»]
	6BGH	NMR	-	A	557-643	[»]
ProteinModelPortalⁱ	Q15059
SMRⁱ	Q15059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113715, 33 interactors
DIPⁱ	DIP-39755N
IntActⁱ	Q15059, 11 interactors
MINTⁱ	Q15059
STRINGⁱ	9606.ENSP00000305918

Chemistry databases

BindingDBⁱ	Q15059
ChEMBLⁱ	CHEMBL1795186
GuidetoPHARMACOLOGYⁱ	2725

PTM databases

iPTMnetⁱ	Q15059
PhosphoSitePlusⁱ	Q15059

Polymorphism and mutation databases

BioMutaⁱ	BRD3
DMDMⁱ	12643726

Proteomic databases

EPDⁱ	Q15059
MaxQBⁱ	Q15059
PaxDbⁱ	Q15059
PeptideAtlasⁱ	Q15059
PRIDEⁱ	Q15059
ProteomicsDBⁱ	60414 60415 [Q15059-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8019
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303407; ENSP00000305918; ENSG00000169925 [Q15059-1] ENST00000371834; ENSP00000360900; ENSG00000169925 [Q15059-2]
GeneIDⁱ	8019
KEGGⁱ	hsa:8019
UCSCⁱ	uc004cew.4 human [Q15059-1]

Organism-specific databases

CTDⁱ	8019
DisGeNETⁱ	8019
EuPathDBⁱ	HostDB:ENSG00000169925.16
GeneCardsⁱ	BRD3
HGNCⁱ	HGNC:1104 BRD3
HPAⁱ	HPA051830
MIMⁱ	601541 gene
neXtProtⁱ	NX_Q15059
OpenTargetsⁱ	ENSG00000169925
PharmGKBⁱ	PA25415
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1474 Eukaryota COG5076 LUCA
GeneTreeⁱ	ENSGT00930000150866
HOGENOMⁱ	HOG000231200
HOVERGENⁱ	HBG004896
InParanoidⁱ	Q15059
KOⁱ	K11721
OMAⁱ	EGLPMTY
OrthoDBⁱ	EOG091G01QC
PhylomeDBⁱ	Q15059
TreeFamⁱ	TF317345

Enzyme and pathway databases

SIGNORⁱ	Q15059

SIGNORⁱ

Q15059

Miscellaneous databases

ChiTaRSⁱ	BRD3 human
EvolutionaryTraceⁱ	Q15059
GeneWikiⁱ	BRD3
GenomeRNAiⁱ	8019
Protein Ontology More...PROⁱ	PR:Q15059
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169925 Expressed in 248 organ(s), highest expression level in forebrain
CleanExⁱ	HS_BRD3
ExpressionAtlasⁱ	Q15059 baseline and differential
Genevisibleⁱ	Q15059 HS

Family and domain databases

Gene3Dⁱ	1.20.1270.220, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR027353 NET_dom IPR038336 NET_sf
Pfamⁱ	View protein in Pfam PF17035 BET, 1 hit PF00439 Bromodomain, 2 hits
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 2 hits
SUPFAMⁱ	SSF47370 SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 2 hits PS50014 BROMODOMAIN_2, 2 hits PS51525 NET, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BRD3_HUMAN
Accessionⁱ	Q15059Primary (citable) accession number: Q15059 Secondary accession number(s): B1APD9 , Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15059 (BRD3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Bromodomain-containing protein 3

BRD3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Sites

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ