UniProtKB - Q15058 (KIF14_HUMAN)
Kinesin-like protein KIF14
KIF14
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 447 – 454 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB
- ATP-dependent microtubule motor activity, plus-end-directed Source: UniProtKB
- microtubule binding Source: UniProtKB
- microtubule motor activity Source: GO_Central
- PDZ domain binding Source: MGI
- protein kinase binding Source: UniProtKB
- tubulin binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: UniProtKB
- cell division Source: Ensembl
- cell proliferation in forebrain Source: UniProtKB
- cerebellar cortex development Source: UniProtKB
- cerebellar granular layer structural organization Source: UniProtKB
- cerebellar Purkinje cell layer structural organization Source: UniProtKB
- cerebral cortex development Source: UniProtKB
- establishment of protein localization Source: MGI
- hippocampus development Source: UniProtKB
- microtubule-based movement Source: GO_Central
- mitotic metaphase plate congression Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of integrin activation Source: MGI
- negative regulation of neuron apoptotic process Source: UniProtKB
- olfactory bulb development Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cytokinesis Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- regulation of cell adhesion Source: MGI
- regulation of cell growth Source: UniProtKB
- regulation of cell maturation Source: Ensembl
- regulation of cell migration Source: MGI
- regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- regulation of myelination Source: UniProtKB
- regulation of neuron apoptotic process Source: UniProtKB
- regulation of Rap protein signal transduction Source: MGI
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- substrate adhesion-dependent cell spreading Source: MGI
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q15058 |
Reactomei | R-HSA-5625900, RHO GTPases activate CIT |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF14Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000118193.11 |
HGNCi | HGNC:19181, KIF14 |
MIMi | 611279, gene |
neXtProti | NX_Q15058 |
Subcellular locationi
Cytoskeleton
- spindle 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
Note: Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring.2 Publications
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: MGI
- spindle midzone Source: UniProtKB
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- Flemming body Source: HPA
- membrane Source: UniProtKB
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Microtubule, NucleusPathology & Biotechi
Involvement in diseasei
Meckel syndrome 12 (MKS12)1 Publication
Microcephaly 20, primary, autosomal recessive (MCPH20)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080623 | 88 – 1648 | Missing in MCPH20; drastically decreased expression at the mRNA level; loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody. 1 PublicationAdd BLAST | 1561 | |
Natural variantiVAR_080624 | 459 | G → R in MCPH20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_080625 | 827 | Missing in MCPH20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_080626 | 841 | S → F in MCPH20; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139385693Ensembl. | 1 | |
Natural variantiVAR_080627 | 849 | H → D in MCPH20; Decreased expression at the mRNA level and loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody, when analyzed in primary fibroblasts from a patient who is a compound heterozygous with variant V-1221. 1 PublicationCorresponds to variant dbSNP:rs1553259528EnsemblClinVar. | 1 | |
Natural variantiVAR_080628 | 1221 | G → V in MCPH20; Decreased expression at the mRNA level and loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody, when analyzed in primary fibroblasts from a patient who is a compound heterozygous with variant D-849. 1 Publication | 1 |
Keywords - Diseasei
Ciliopathy, Disease mutation, Meckel syndrome, Primary microcephalyOrganism-specific databases
DisGeNETi | 9928 |
MalaCardsi | KIF14 |
MIMi | 616258, phenotype 617914, phenotype |
OpenTargetsi | ENSG00000118193 |
Orphaneti | 2512, Autosomal recessive primary microcephaly 439897, Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome |
PharmGKBi | PA38820 |
Miscellaneous databases
Pharosi | Q15058, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5576 |
Polymorphism and mutation databases
BioMutai | KIF14 |
DMDMi | 23396633 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125449 | 1 – 1648 | Kinesin-like protein KIF14Add BLAST | 1648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 | |
Modified residuei | 277 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 346 | PhosphoserineCombined sources | 1 | |
Modified residuei | 915 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 937 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1292 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15058 |
jPOSTi | Q15058 |
MassIVEi | Q15058 |
MaxQBi | Q15058 |
PaxDbi | Q15058 |
PeptideAtlasi | Q15058 |
PRIDEi | Q15058 |
ProteomicsDBi | 60413 |
PTM databases
iPTMneti | Q15058 |
MetOSitei | Q15058 |
PhosphoSitePlusi | Q15058 |
SwissPalmi | Q15058 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000118193, Expressed in bone marrow and 117 other tissues |
Genevisiblei | Q15058, HS |
Organism-specific databases
HPAi | ENSG00000118193, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23; targets to the central spindle. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form); targets to the midbody.
Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.
Interacts with AKT1; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation.
Interacts with SVIL; at midbody during cytokinesis.
Interacts with RADIL (via PDZ domain); recruits RADIL to the microtubule network restricting RADIL from interaction with activated RAP1A (PubMed:23209302).
5 PublicationsBinary interactionsi
Q15058
With | #Exp. | IntAct |
---|---|---|
SVIL [O46385] from Bos taurus. | 3 | EBI-1045252,EBI-6995105 |
GO - Molecular functioni
- microtubule binding Source: UniProtKB
- PDZ domain binding Source: MGI
- protein kinase binding Source: UniProtKB
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115256, 107 interactors |
IntActi | Q15058, 61 interactors |
MINTi | Q15058 |
STRINGi | 9606.ENSP00000356319 |
Chemistry databases
BindingDBi | Q15058 |
Miscellaneous databases
RNActi | Q15058, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 358 – 701 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 344 | |
Domaini | 825 – 891 | FHAAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 356 | Required for PRC1-bindingAdd BLAST | 356 | |
Regioni | 356 – 737 | Required for microtubule-binding with high affinityBy similarityAdd BLAST | 382 | |
Regioni | 901 – 1648 | Required for CIT-bindingAdd BLAST | 748 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 705 – 791 | Sequence analysisAdd BLAST | 87 | |
Coiled coili | 922 – 1079 | Sequence analysisAdd BLAST | 158 | |
Coiled coili | 1332 – 1348 | Sequence analysisAdd BLAST | 17 | |
Coiled coili | 1468 – 1500 | Sequence analysisAdd BLAST | 33 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000156834 |
HOGENOMi | CLU_003253_0_0_1 |
InParanoidi | Q15058 |
OMAi | DDHCTIK |
OrthoDBi | 76316at2759 |
PhylomeDBi | Q15058 |
TreeFami | TF105221 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSLHSTHNRN NSGDILDIPS SQNSSSLNAL THSSRLKLHL KSDMSECEND
60 70 80 90 100
DPLLRSAGKV RDINRTYVIS ASRKTADMPL TPNPVGRLAL QRRTTRNKES
110 120 130 140 150
SLLVSELEDT TEKTAETRLT LQRRAKTDSA EKWKTAEIDS VKMTLNVGGE
160 170 180 190 200
TENNGVSKES RTNVRIVNNA KNSFVASSVP LDEDPQVIEM MADKKYKETF
210 220 230 240 250
SAPSRANENV ALKYSSNRPP IASLSQTEVV RSGHLTTKPT QSKLDIKVLG
260 270 280 290 300
TGNLYHRSIG KEIAKTSNKF GSLEKRTPTK CTTEHKLTTK CSLPQLKSPA
310 320 330 340 350
PSILKNRMSN LQVKQRPKSS FLANKQERSA ENTILPEEET VVQNTSAGKD
360 370 380 390 400
PLKVENSQVT VAVRVRPFTK REKIEKASQV VFMSGKEITV EHPDTKQVYN
410 420 430 440 450
FIYDVSFWSF DECHPHYASQ TTVYEKLAAP LLERAFEGFN TCLFAYGQTG
460 470 480 490 500
SGKSYTMMGF SEEPGIIPRF CEDLFSQVAR KQTQEVSYHI EMSFFEVYNE
510 520 530 540 550
KIHDLLVCKD ENGQRKQPLR VREHPVYGPY VEALSMNIVS SYADIQSWLE
560 570 580 590 600
LGNKQRATAA TGMNDKSSRS HSVFTLVMTQ TKTEFVEGEE HDHRITSRIN
610 620 630 640 650
LIDLAGSERC STAHTNGDRL KEGVSINKSL LTLGKVISAL SEQANQRSVF
660 670 680 690 700
IPYRESVLTW LLKESLGGNS KTAMIATISP AASNIEETLS TLRYANQARL
710 720 730 740 750
IVNIAKVNED MNAKLIRELK AEIAKLKAAQ RNSRNIDPER YRLCRQEITS
760 770 780 790 800
LRMKLHQQER DMAEMQRVWK EKFEQAEKRK LQETKELQKA GIMFQMDNHL
810 820 830 840 850
PNLVNLNEDP QLSEMLLYMI KEGTTTVGKY KPNSSHDIQL SGVLIADDHC
860 870 880 890 900
TIKNFGGTVS IIPVGEAKTY VNGKHILEIT VLRHGDRVIL GGDHYFRFNH
910 920 930 940 950
PVEVQKGKRP SGRDTPISEG PKDFEFAKNE LLMAQRSQLE AEIKEAQLKA
960 970 980 990 1000
KEEMMQGIQI AKEMAQQELS SQKAAYESKI KALEAELREE SQRKKMQEIN
1010 1020 1030 1040 1050
NQKANHKIEE LEKAKQHLEQ EIYVNKKRLE METLATKQAL EDHSIRHARI
1060 1070 1080 1090 1100
LEALETEKQK IAKEVQILQQ NRNNRDKTFT VQTTWSSMKL SMMIQEANAI
1110 1120 1130 1140 1150
SSKLKTYYVF GRHDISDKSS SDTSIRVRNL KLGISTFWSL EKFESKLAAM
1160 1170 1180 1190 1200
KELYESNGSN RGEDAFCDPE DEWEPDITDA PVSSLSRRRS RSLMKNRRIS
1210 1220 1230 1240 1250
GCLHDIQVHP IKNLHSSHSS GLMDKSSTIY SNSAESFLPG ICKELIGSSL
1260 1270 1280 1290 1300
DFFGQSYDEE RTIADSLINS FLKIYNGLFA ISKAHEEQDE ESQDNLFSSD
1310 1320 1330 1340 1350
RAIQSLTIQT ACAFEQLVVL MKHWLSDLLP CTNIARLEDE LRQEVKKLGG
1360 1370 1380 1390 1400
YLQLFLQGCC LDISSMIKEA QKNAIQIVQQ AVKYVGQLAV LKGSKLHFLE
1410 1420 1430 1440 1450
NGNNKAASVQ EEFMDAVCDG VGLGMKILLD SGLEKAKELQ HELFRQCTKN
1460 1470 1480 1490 1500
EVTKEMKTNA MGLIRSLENI FAESKIKSFR RQVQEENFEY QDFKRMVNRA
1510 1520 1530 1540 1550
PEFLKLKHCL EKAIEIIISA LKGCHSDINL LQTCVESIRN LASDFYSDFS
1560 1570 1580 1590 1600
VPSTSVGSYE SRVTHIVHQE LESLAKSLLF CFESEESPDL LKPWETYNQN
1610 1620 1630 1640
TKEEHQQSKS SGIDGSKNKG VPKRVYELHG SSPAVSSEEC TPSRIQWV
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 660 | W → C in AAH98582 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080623 | 88 – 1648 | Missing in MCPH20; drastically decreased expression at the mRNA level; loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody. 1 PublicationAdd BLAST | 1561 | |
Natural variantiVAR_080624 | 459 | G → R in MCPH20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_080625 | 827 | Missing in MCPH20; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_080626 | 841 | S → F in MCPH20; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139385693Ensembl. | 1 | |
Natural variantiVAR_080627 | 849 | H → D in MCPH20; Decreased expression at the mRNA level and loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody, when analyzed in primary fibroblasts from a patient who is a compound heterozygous with variant V-1221. 1 PublicationCorresponds to variant dbSNP:rs1553259528EnsemblClinVar. | 1 | |
Natural variantiVAR_080628 | 1221 | G → V in MCPH20; Decreased expression at the mRNA level and loss of localization at the midbody during cytokinesis and consequently loss of CIT/CRIK recruitment to the midbody, when analyzed in primary fibroblasts from a patient who is a compound heterozygous with variant D-849. 1 Publication | 1 | |
Natural variantiVAR_037777 | 1633 | P → A1 PublicationCorresponds to variant dbSNP:rs12120084Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26361 mRNA Translation: BAA05392.2 Different initiation. AL445483 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91316.1 BC098582 mRNA Translation: AAH98582.1 BC113742 mRNA Translation: AAI13743.1 |
CCDSi | CCDS30963.1 |
RefSeqi | NP_001292721.1, NM_001305792.1 NP_055690.1, NM_014875.2 XP_011508533.1, XM_011510231.2 XP_011508534.1, XM_011510232.2 XP_016858494.1, XM_017003005.1 |
Genome annotation databases
Ensembli | ENST00000367350; ENSP00000356319; ENSG00000118193 ENST00000614960; ENSP00000483069; ENSG00000118193 |
GeneIDi | 9928 |
KEGGi | hsa:9928 |
UCSCi | uc010ppk.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26361 mRNA Translation: BAA05392.2 Different initiation. AL445483 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91316.1 BC098582 mRNA Translation: AAH98582.1 BC113742 mRNA Translation: AAI13743.1 |
CCDSi | CCDS30963.1 |
RefSeqi | NP_001292721.1, NM_001305792.1 NP_055690.1, NM_014875.2 XP_011508533.1, XM_011510231.2 XP_011508534.1, XM_011510232.2 XP_016858494.1, XM_017003005.1 |
3D structure databases
SMRi | Q15058 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115256, 107 interactors |
IntActi | Q15058, 61 interactors |
MINTi | Q15058 |
STRINGi | 9606.ENSP00000356319 |
Chemistry databases
BindingDBi | Q15058 |
ChEMBLi | CHEMBL5576 |
PTM databases
iPTMneti | Q15058 |
MetOSitei | Q15058 |
PhosphoSitePlusi | Q15058 |
SwissPalmi | Q15058 |
Polymorphism and mutation databases
BioMutai | KIF14 |
DMDMi | 23396633 |
Proteomic databases
EPDi | Q15058 |
jPOSTi | Q15058 |
MassIVEi | Q15058 |
MaxQBi | Q15058 |
PaxDbi | Q15058 |
PeptideAtlasi | Q15058 |
PRIDEi | Q15058 |
ProteomicsDBi | 60413 |
Protocols and materials databases
Antibodypediai | 20633, 135 antibodies |
DNASUi | 9928 |
Genome annotation databases
Ensembli | ENST00000367350; ENSP00000356319; ENSG00000118193 ENST00000614960; ENSP00000483069; ENSG00000118193 |
GeneIDi | 9928 |
KEGGi | hsa:9928 |
UCSCi | uc010ppk.2, human |
Organism-specific databases
CTDi | 9928 |
DisGeNETi | 9928 |
EuPathDBi | HostDB:ENSG00000118193.11 |
GeneCardsi | KIF14 |
HGNCi | HGNC:19181, KIF14 |
HPAi | ENSG00000118193, Group enriched (bone marrow, lymphoid tissue) |
MalaCardsi | KIF14 |
MIMi | 611279, gene 616258, phenotype 617914, phenotype |
neXtProti | NX_Q15058 |
OpenTargetsi | ENSG00000118193 |
Orphaneti | 2512, Autosomal recessive primary microcephaly 439897, Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome |
PharmGKBi | PA38820 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000156834 |
HOGENOMi | CLU_003253_0_0_1 |
InParanoidi | Q15058 |
OMAi | DDHCTIK |
OrthoDBi | 76316at2759 |
PhylomeDBi | Q15058 |
TreeFami | TF105221 |
Enzyme and pathway databases
PathwayCommonsi | Q15058 |
Reactomei | R-HSA-5625900, RHO GTPases activate CIT |
Miscellaneous databases
BioGRID-ORCSi | 9928, 385 hits in 850 CRISPR screens |
ChiTaRSi | KIF14, human |
GeneWikii | KIF14 |
GenomeRNAii | 9928 |
Pharosi | Q15058, Tbio |
PROi | PR:Q15058 |
RNActi | Q15058, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118193, Expressed in bone marrow and 117 other tissues |
Genevisiblei | Q15058, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF14_HUMAN | |
Accessioni | Q15058Primary (citable) accession number: Q15058 Secondary accession number(s): Q14CI8, Q4G0A5, Q5T1W3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations