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Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Gene

ACAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).1 Publication

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 437C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-beta-2
Short name:
Cnt-b2
Gene namesi
Name:ACAP2
Synonyms:CENTB2, KIAA0041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114331.13
HGNCiHGNC:16469 ACAP2
MIMi607766 gene
neXtProtiNX_Q15057

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi442R → Q: Loss of GAP activity. 1 Publication1

Organism-specific databases

DisGeNETi23527
OpenTargetsiENSG00000114331
PharmGKBiPA26407

Polymorphism and mutation databases

BioMutaiACAP2
DMDMi39932727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742101 – 778Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384PhosphoserineCombined sources1
Modified residuei387PhosphoserineBy similarity1
Modified residuei521PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei584PhosphoserineBy similarity1
Modified residuei742PhosphotyrosineCombined sources1
Modified residuei775PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15057
MaxQBiQ15057
PaxDbiQ15057
PeptideAtlasiQ15057
PRIDEiQ15057
ProteomicsDBi60412

PTM databases

iPTMnetiQ15057
PhosphoSitePlusiQ15057

Expressioni

Tissue specificityi

Widely expressed. Highest level in lung.1 Publication

Gene expression databases

BgeeiENSG00000114331
CleanExiHS_ACAP2
ExpressionAtlasiQ15057 baseline and differential
GenevisibleiQ15057 HS

Organism-specific databases

HPAiHPA034807
HPA034808

Interactioni

Subunit structurei

Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).By similarity

Protein-protein interaction databases

BioGridi117073, 18 interactors
IntActiQ15057, 13 interactors
STRINGi9606.ENSP00000324287

Structurei

3D structure databases

ProteinModelPortaliQ15057
SMRiQ15057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 226BARAdd BLAST226
Domaini266 – 361PHPROSITE-ProRule annotationAdd BLAST96
Domaini399 – 520Arf-GAPPROSITE-ProRule annotationAdd BLAST122
Repeati640 – 669ANK 1Add BLAST30
Repeati673 – 702ANK 2Add BLAST30
Repeati706 – 735ANK 3Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 437C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000220815
HOVERGENiHBG050889
InParanoidiQ15057
KOiK12489
OMAiKAMQNRH
OrthoDBiEOG091G029F
PhylomeDBiQ15057
TreeFamiTF318315

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.25.40.20, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q15057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK
60 70 80 90 100
AFCVANKQFM NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ
110 120 130 140 150
TQRSIKAQLQ NFVKEDLRKF KDAKKQFEKV SEEKENALVK NAQVQRNKQH
160 170 180 190 200
EVEEATNILT ATRKCFRHIA LDYVLQINVL QSKRRSEILK SMLSFMYAHL
210 220 230 240 250
AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ KHSTIQQKDF
260 270 280 290 300
SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK
310 320 330 340 350
KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ
360 370 380 390 400
AWIKAVQTSI ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES
410 420 430 440 450
ALQRVQCIPG NASCCDCGLA DPRWASINLG ITLCIECSGI HRSLGVHFSK
460 470 480 490 500
VRSLTLDTWE PELLKLMCEL GNDVINRVYE ANVEKMGIKK PQPGQRQEKE
510 520 530 540 550
AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS ISKFGPGDQV
560 570 580 590 600
RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD
610 620 630 640 650
SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL
660 670 680 690 700
GGSLVTCEFL LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ
710 720 730 740 750
HATDEEGKDP LSIAVEAANA DIVTLLRLAR MNEEMRESEG LYGQPGDETY
760 770
QDIFRDFSQM ASNNPEKLNR FQQDSQKF
Length:778
Mass (Da):88,029
Last modified:December 15, 2003 - v3
Checksum:i64B620957FEE6195
GO

Sequence cautioni

The sequence BAA05064 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB41450 differs from that shown. Reason: Frameshift at positions 98, 106 and 111.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → G in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti42C → G in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti229V → G in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti252S → R in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti258E → K in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti296L → V in CAB41450 (PubMed:11062263).Curated1
Sequence conflicti564G → E in AAH60767 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238248 mRNA Translation: CAB41450.1 Frameshift.
D26069 mRNA Translation: BAA05064.2 Different initiation.
AK290369 mRNA Translation: BAF83058.1
CH471052 Genomic DNA Translation: EAW78027.1
BC031005 mRNA Translation: AAH31005.1
BC060767 mRNA Translation: AAH60767.1
CCDSiCCDS33924.1
RefSeqiNP_036419.3, NM_012287.5
UniGeneiHs.593373

Genome annotation databases

EnsembliENST00000326793; ENSP00000324287; ENSG00000114331
GeneIDi23527
KEGGihsa:23527
UCSCiuc003fun.5 human

Similar proteinsi

Entry informationi

Entry nameiACAP2_HUMAN
AccessioniPrimary (citable) accession number: Q15057
Secondary accession number(s): A8K2V4, Q8N5Z8, Q9UQR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 2003
Last modified: July 18, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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