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Protein

Ribosome biogenesis regulatory protein homolog

Gene

RRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.1 Publication

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:RRS1
Synonyms:KIAA0112, RRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000179041.3
HGNCiHGNC:17083 RRS1
neXtProtiNX_Q15050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23212
OpenTargetsiENSG00000179041
PharmGKBiPA134993138

Polymorphism and mutation databases

BioMutaiRRS1
DMDMi21431847

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853741 – 365Ribosome biogenesis regulatory protein homologAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei5PhosphoserineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei273CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15050
MaxQBiQ15050
PaxDbiQ15050
PeptideAtlasiQ15050
PRIDEiQ15050
ProteomicsDBi60402
TopDownProteomicsiQ15050

2D gel databases

SWISS-2DPAGEiQ15050

PTM databases

iPTMnetiQ15050
PhosphoSitePlusiQ15050

Expressioni

Gene expression databases

BgeeiENSG00000179041 Expressed in 111 organ(s), highest expression level in left coronary artery
CleanExiHS_RRS1
GenevisibleiQ15050 HS

Organism-specific databases

HPAiHPA055549
HPA060937

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926246EBI-749186,EBI-743771

Protein-protein interaction databases

BioGridi116819, 194 interactors
IntActiQ15050, 9 interactors
MINTiQ15050
STRINGi9606.ENSP00000322396

Structurei

3D structure databases

ProteinModelPortaliQ15050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi302 – 365Arg/Gly/Lys-richAdd BLAST64

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

eggNOGiKOG1765 Eukaryota
COG5225 LUCA
GeneTreeiENSGT00390000005213
HOGENOMiHOG000017552
HOVERGENiHBG036121
InParanoidiQ15050
KOiK14852
OMAiKWEKFAK
OrthoDBiEOG091G0I2Z
PhylomeDBiQ15050
TreeFamiTF313067

Family and domain databases

InterProiView protein in InterPro
IPR007023 Ribosom_reg
PANTHERiPTHR17602 PTHR17602, 1 hit
PfamiView protein in Pfam
PF04939 RRS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q15050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL
60 70 80 90 100
RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR
160 170 180 190 200
DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG
360
GKRKGGQRPG GKRRK
Length:365
Mass (Da):41,193
Last modified:June 6, 2002 - v2
Checksum:i061C3A6174C2E7C2
GO

Sequence cautioni

The sequence BAA04948 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051887116Q → H. Corresponds to variant dbSNP:rs34077648Ensembl.1
Natural variantiVAR_051888126K → R. Corresponds to variant dbSNP:rs3739335Ensembl.1
Natural variantiVAR_020484191R → L. Corresponds to variant dbSNP:rs3739336Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25218 mRNA Translation: BAA04948.1 Different initiation.
BC001811 mRNA Translation: AAH01811.1
BC013043 mRNA Translation: AAH13043.1
CCDSiCCDS6189.1
RefSeqiNP_055984.1, NM_015169.3
UniGeneiHs.71827

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041
GeneIDi23212
KEGGihsa:23212
UCSCiuc003xwa.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25218 mRNA Translation: BAA04948.1 Different initiation.
BC001811 mRNA Translation: AAH01811.1
BC013043 mRNA Translation: AAH13043.1
CCDSiCCDS6189.1
RefSeqiNP_055984.1, NM_015169.3
UniGeneiHs.71827

3D structure databases

ProteinModelPortaliQ15050
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116819, 194 interactors
IntActiQ15050, 9 interactors
MINTiQ15050
STRINGi9606.ENSP00000322396

PTM databases

iPTMnetiQ15050
PhosphoSitePlusiQ15050

Polymorphism and mutation databases

BioMutaiRRS1
DMDMi21431847

2D gel databases

SWISS-2DPAGEiQ15050

Proteomic databases

EPDiQ15050
MaxQBiQ15050
PaxDbiQ15050
PeptideAtlasiQ15050
PRIDEiQ15050
ProteomicsDBi60402
TopDownProteomicsiQ15050

Protocols and materials databases

DNASUi23212
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041
GeneIDi23212
KEGGihsa:23212
UCSCiuc003xwa.3 human

Organism-specific databases

CTDi23212
DisGeNETi23212
EuPathDBiHostDB:ENSG00000179041.3
GeneCardsiRRS1
HGNCiHGNC:17083 RRS1
HPAiHPA055549
HPA060937
neXtProtiNX_Q15050
OpenTargetsiENSG00000179041
PharmGKBiPA134993138
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1765 Eukaryota
COG5225 LUCA
GeneTreeiENSGT00390000005213
HOGENOMiHOG000017552
HOVERGENiHBG036121
InParanoidiQ15050
KOiK14852
OMAiKWEKFAK
OrthoDBiEOG091G0I2Z
PhylomeDBiQ15050
TreeFamiTF313067

Miscellaneous databases

GeneWikiiRRS1
GenomeRNAii23212
PROiPR:Q15050

Gene expression databases

BgeeiENSG00000179041 Expressed in 111 organ(s), highest expression level in left coronary artery
CleanExiHS_RRS1
GenevisibleiQ15050 HS

Family and domain databases

InterProiView protein in InterPro
IPR007023 Ribosom_reg
PANTHERiPTHR17602 PTHR17602, 1 hit
PfamiView protein in Pfam
PF04939 RRS1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q15050
Secondary accession number(s): Q9BUX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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