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Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of toll-like receptor signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14Curated
Gene namesi
Name:LRRC14Imported
Synonyms:KIAA00141 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000160959.7
HGNCiHGNC:20419 LRRC14
neXtProtiNX_Q15048

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160959
PharmGKBiPA134914089

Polymorphism and mutation databases

DMDMi6686102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569741 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

EPDiQ15048
MaxQBiQ15048
PaxDbiQ15048
PeptideAtlasiQ15048
PRIDEiQ15048
ProteomicsDBi60400
TopDownProteomicsiQ15048

PTM databases

iPTMnetiQ15048
PhosphoSitePlusiQ15048

Expressioni

Inductioni

Down-regulated in response to toll-like receptor ligand.1 Publication

Gene expression databases

BgeeiENSG00000160959
CleanExiHS_LRRC14
ExpressionAtlasiQ15048 baseline and differential
GenevisibleiQ15048 HS

Organism-specific databases

HPAiHPA021047

Interactioni

Subunit structurei

Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation (PubMed:27426725). Interacts with CHUK (PubMed:27426725).1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115037, 9 interactors
IntActiQ15048, 2 interactors
STRINGi9606.ENSP00000292524

Structurei

3D structure databases

ProteinModelPortaliQ15048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 146LRR 1; degenerateBy similarityAdd BLAST36
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 246LRR 3; degenerateBy similarityAdd BLAST28
Repeati247 – 282LRR 4; degenerateBy similarityAdd BLAST36
Repeati283 – 307LRR 5By similarityAdd BLAST25
Repeati308 – 339LRR 6By similarityAdd BLAST32
Repeati340 – 360LRR 7By similarityAdd BLAST21
Repeati364 – 391LRR 8By similarityAdd BLAST28
Repeati392 – 416LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA Eukaryota
ENOG4111FCX LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000113363
HOVERGENiHBG052342
InParanoidiQ15048
OMAiVTECELM
OrthoDBiEOG091G05TB
PhylomeDBiQ15048
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR026292 LRRC14
PANTHERiPTHR14224:SF9 PTHR14224:SF9, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 2 hits

Sequencei

Sequence statusi: Complete.

Q15048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE
110 120 130 140 150
PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG
360 370 380 390 400
SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,513
Last modified:November 1, 1996 - v1
Checksum:i1B02E6D0FAF06A88
GO

Sequence cautioni

The sequence BAA04946 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230N → S in BAF82162 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053603437G → D. Corresponds to variant dbSNP:rs3735854Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25216 mRNA Translation: BAA04946.2 Different initiation.
AK289473 mRNA Translation: BAF82162.1
CH471162 Genomic DNA Translation: EAW82066.1
CH471162 Genomic DNA Translation: EAW82067.1
CH471162 Genomic DNA Translation: EAW82068.1
CH471162 Genomic DNA Translation: EAW82069.1
BC011377 mRNA Translation: AAH11377.1
CCDSiCCDS6432.1
RefSeqiNP_001258965.1, NM_001272036.1
NP_055480.1, NM_014665.3
XP_005272415.1, XM_005272358.4
XP_005272416.1, XM_005272359.4
UniGeneiHs.459391

Genome annotation databases

EnsembliENST00000292524; ENSP00000292524; ENSG00000160959
ENST00000529022; ENSP00000434768; ENSG00000160959
GeneIDi9684
KEGGihsa:9684
UCSCiuc003zdk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRC14_HUMAN
AccessioniPrimary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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