Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 160 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q15048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC14Imported
Synonyms:KIAA00141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160959.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20419, LRRC14

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15048

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9684

Open Targets

More...
OpenTargetsi
ENSG00000160959

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134914089

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15048, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6686102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001569741 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15048

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15048

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15048

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15048

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15048

PeptideAtlas

More...
PeptideAtlasi
Q15048

PRoteomics IDEntifications database

More...
PRIDEi
Q15048

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60400

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q15048

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15048

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15048

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in response to toll-like receptor ligand.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160959, Expressed in mammary gland and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15048, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15048, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160959, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation (PubMed:27426725).

Interacts with CHUK (PubMed:27426725).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115037, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q15048, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q15048, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati111 – 146LRR 1; degenerateBy similarityAdd BLAST36
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 246LRR 3; degenerateBy similarityAdd BLAST28
Repeati247 – 282LRR 4; degenerateBy similarityAdd BLAST36
Repeati283 – 307LRR 5By similarityAdd BLAST25
Repeati308 – 339LRR 6By similarityAdd BLAST32
Repeati340 – 360LRR 7By similarityAdd BLAST21
Repeati364 – 391LRR 8By similarityAdd BLAST28
Repeati392 – 416LRR 9By similarityAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWSJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203605

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039635_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15048

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTECELM

Database of Orthologous Groups

More...
OrthoDBi
563553at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15048

TreeFam database of animal gene trees

More...
TreeFami
TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR026292, LRRC14

The PANTHER Classification System

More...
PANTHERi
PTHR14224:SF9, PTHR14224:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15048-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE
110 120 130 140 150
PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG
360 370 380 390 400
SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,513
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B02E6D0FAF06A88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP40E9PP40_HUMAN
Leucine-rich repeat-containing prot...
LRRC14
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNL0E9PNL0_HUMAN
Leucine-rich repeat-containing prot...
LRRC14
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRP5E9PRP5_HUMAN
Leucine-rich repeat-containing prot...
LRRC14
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA04946 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230N → S in BAF82162 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053603437G → D. Corresponds to variant dbSNP:rs3735854Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D25216 mRNA Translation: BAA04946.2 Different initiation.
AK289473 mRNA Translation: BAF82162.1
CH471162 Genomic DNA Translation: EAW82066.1
CH471162 Genomic DNA Translation: EAW82067.1
CH471162 Genomic DNA Translation: EAW82068.1
CH471162 Genomic DNA Translation: EAW82069.1
BC011377 mRNA Translation: AAH11377.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6432.1

NCBI Reference Sequences

More...
RefSeqi
NP_001258965.1, NM_001272036.1
NP_055480.1, NM_014665.3
XP_005272415.1, XM_005272358.4
XP_005272416.1, XM_005272359.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292524; ENSP00000292524; ENSG00000160959
ENST00000529022; ENSP00000434768; ENSG00000160959

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9684

UCSC genome browser

More...
UCSCi
uc003zdk.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25216 mRNA Translation: BAA04946.2 Different initiation.
AK289473 mRNA Translation: BAF82162.1
CH471162 Genomic DNA Translation: EAW82066.1
CH471162 Genomic DNA Translation: EAW82067.1
CH471162 Genomic DNA Translation: EAW82068.1
CH471162 Genomic DNA Translation: EAW82069.1
BC011377 mRNA Translation: AAH11377.1
CCDSiCCDS6432.1
RefSeqiNP_001258965.1, NM_001272036.1
NP_055480.1, NM_014665.3
XP_005272415.1, XM_005272358.4
XP_005272416.1, XM_005272359.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115037, 11 interactors
IntActiQ15048, 5 interactors
STRINGi9606.ENSP00000292524

PTM databases

iPTMnetiQ15048
PhosphoSitePlusiQ15048

Polymorphism and mutation databases

BioMutaiLRRC14
DMDMi6686102

Proteomic databases

EPDiQ15048
jPOSTiQ15048
MassIVEiQ15048
MaxQBiQ15048
PaxDbiQ15048
PeptideAtlasiQ15048
PRIDEiQ15048
ProteomicsDBi60400
TopDownProteomicsiQ15048

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14965, 57 antibodies

The DNASU plasmid repository

More...
DNASUi
9684

Genome annotation databases

EnsembliENST00000292524; ENSP00000292524; ENSG00000160959
ENST00000529022; ENSP00000434768; ENSG00000160959
GeneIDi9684
KEGGihsa:9684
UCSCiuc003zdk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9684
DisGeNETi9684
EuPathDBiHostDB:ENSG00000160959.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC14
HGNCiHGNC:20419, LRRC14
HPAiENSG00000160959, Low tissue specificity
neXtProtiNX_Q15048
OpenTargetsiENSG00000160959
PharmGKBiPA134914089

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QWSJ, Eukaryota
GeneTreeiENSGT00990000203605
HOGENOMiCLU_039635_0_1_1
InParanoidiQ15048
OMAiVTECELM
OrthoDBi563553at2759
PhylomeDBiQ15048
TreeFamiTF332708

Enzyme and pathway databases

PathwayCommonsiQ15048

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9684, 4 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC14, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9684
PharosiQ15048, Tbio

Protein Ontology

More...
PROi
PR:Q15048
RNActiQ15048, protein

Gene expression databases

BgeeiENSG00000160959, Expressed in mammary gland and 204 other tissues
ExpressionAtlasiQ15048, baseline and differential
GenevisibleiQ15048, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR026292, LRRC14
PANTHERiPTHR14224:SF9, PTHR14224:SF9, 1 hit
PfamiView protein in Pfam
PF13516, LRR_6, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again