UniProtKB - Q15047 (SETB1_HUMAN)
Histone-lysine N-methyltransferase SETDB1
SETDB1
Functioni
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583).
Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:27732843, PubMed:14536086).
Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086,).
SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306).
Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306).
In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity).
Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306).
The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).
By similarity5 PublicationsMiscellaneous
Caution
Catalytic activityi
- N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteinePROSITE-ProRule annotation1 PublicationEC:2.1.1.366PROSITE-ProRule annotation1 PublicationThis reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=1.78 µM for S-adenosyl-L-methionine1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 729 | Zinc 1By similarity | 1 | |
Metal bindingi | 729 | Zinc 2By similarity | 1 | |
Metal bindingi | 731 | Zinc 1By similarity | 1 | |
Metal bindingi | 735 | Zinc 1By similarity | 1 | |
Metal bindingi | 735 | Zinc 3By similarity | 1 | |
Metal bindingi | 741 | Zinc 1By similarity | 1 | |
Metal bindingi | 743 | Zinc 2By similarity | 1 | |
Metal bindingi | 781 | Zinc 2By similarity | 1 | |
Metal bindingi | 781 | Zinc 3By similarity | 1 | |
Metal bindingi | 785 | Zinc 2By similarity | 1 | |
Metal bindingi | 787 | Zinc 3By similarity | 1 | |
Metal bindingi | 792 | Zinc 3By similarity | 1 | |
Binding sitei | 851 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 853 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 1220 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Metal bindingi | 1226 | Zinc 4By similarity | 1 | |
Metal bindingi | 1279 | Zinc 4By similarity | 1 | |
Metal bindingi | 1281 | Zinc 4By similarity | 1 | |
Metal bindingi | 1286 | Zinc 4By similarity | 1 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- DNA binding Source: InterPro
- histone-lysine N-methyltransferase activity Source: UniProtKB
- histone methyltransferase activity (H3-K9 specific) Source: UniProtKB
- promoter-specific chromatin binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- heterochromatin organization Source: GO_Central
- histone H3-K9 methylation Source: GO_Central
- negative regulation of gene expression Source: GO_Central
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
- positive regulation of DNA methylation-dependent heterochromatin assembly Source: UniProtKB
- Ras protein signal transduction Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Methyltransferase, Repressor, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Enzyme and pathway databases
BRENDAi | 2.1.1.355, 2681 2.1.1.366, 2681 |
PathwayCommonsi | Q15047 |
Reactomei | R-HSA-3214841, PKMTs methylate histone lysines |
SignaLinki | Q15047 |
SIGNORi | Q15047 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase SETDB1Curated (EC:2.1.1.3661 Publication)Alternative name(s): ERG-associated protein with SET domain Short name: ESET1 Publication Histone H3-K9 methyltransferase 4 Short name: H3-K9-HMTase 4 Lysine N-methyltransferase 1E SET domain bifurcated 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10761, SETDB1 |
MIMi | 604396, gene |
neXtProti | NX_Q15047 |
VEuPathDBi | HostDB:ENSG00000143379 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 729 – 731 | CDC → LDP: Abolishes methyltransferase activity. 1 Publication | 3 | |
Mutagenesisi | 1224 | H → K: Abolishes methyltransferase activity. 1 Publication | 1 | |
Mutagenesisi | 1226 | C → A: Abolishes methyltransferase activity. 1 Publication | 1 | |
Mutagenesisi | 1279 | C → Y: Abolishes methyltransferase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9869 |
OpenTargetsi | ENSG00000143379 |
PharmGKBi | PA35679 |
Miscellaneous databases
Pharosi | Q15047, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2321646 |
Genetic variation databases
BioMutai | SETDB1 |
DMDMi | 25091210 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186064 | 1 – 1291 | Histone-lysine N-methyltransferase SETDB1Add BLAST | 1291 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 112 | PhosphoserineBy similarity | 1 | |
Modified residuei | 117 | PhosphoserineBy similarity | 1 | |
Modified residuei | 120 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | ||
Modified residuei | 1025 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1032 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 1032 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 1038 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1066 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1069 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1170 | N6,N6,N6-trimethyllysine; alternateCombined sources | 1 | |
Modified residuei | 1170 | N6,N6-dimethyllysine; alternateCombined sources | 1 | |
Modified residuei | 1178 | N6,N6,N6-trimethyllysine; alternateCombined sources | 1 | |
Modified residuei | 1178 | N6,N6-dimethyllysine; alternateCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15047 |
jPOSTi | Q15047 |
MassIVEi | Q15047 |
MaxQBi | Q15047 |
PaxDbi | Q15047 |
PeptideAtlasi | Q15047 |
PRIDEi | Q15047 |
ProteomicsDBi | 60397 [Q15047-1] 60398 [Q15047-2] 60399 [Q15047-3] |
PTM databases
GlyGeni | Q15047, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15047 |
PhosphoSitePlusi | Q15047 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000143379, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q15047, baseline and differential |
Genevisiblei | Q15047, HS |
Organism-specific databases
HPAi | ENSG00000143379, Low tissue specificity |
Interactioni
Subunit structurei
Part of a complex containing at least CDYL, REST, WIZ, SETDB1, EHMT1 and EHMT2 (PubMed:19061646).
Forms a complex with ATRX, TRIM28 and ZNF274 (PubMed:27029610). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306).
Interacts with TRIM28/TIF1B (PubMed:11959841).
Interacts with ATF7IP and ATF7IP2; the interaction with ATF7IP protects SETDB1 from proteasomal degradation and is required to stimulate histone methyltransferase activity and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (PubMed:14536086, PubMed:15691849).
Interacts with CBX1 and CBX5 (PubMed:15899859).
Interacts with DNMT3A and DNMT3B (PubMed:16682412).
Interacts with SUMO2.
Interacts with MPHOSPH8 (PubMed:20871592).
Interacts with ERG (By similarity).
Interacts with HDAC1, HDAC2, SIN3A and SIN3B (By similarity).
Interacts with ATRX.
Interacts with RESF1 (By similarity).
Interacts with ZNF638 (PubMed:30487602).
Interacts with TASOR (By similarity).
Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (PubMed:32051553).
By similarity14 PublicationsBinary interactionsi
Q15047
With | #Exp. | IntAct |
---|---|---|
AKT1 [P31749] | 9 | EBI-79691,EBI-296087 |
CDC73 [Q6P1J9] | 3 | EBI-79691,EBI-930143 |
DNMT3A [Q9Y6K1] | 7 | EBI-79691,EBI-923653 |
MBD1 [Q9UIS9] | 3 | EBI-79691,EBI-867196 |
MPHOSPH8 [Q99549] | 3 | EBI-79691,EBI-2653928 |
Isoform 2 [Q15047-2]
Isoform 3 [Q15047-3]
With | #Exp. | IntAct |
---|---|---|
HSF2BP [O75031] | 3 | EBI-11149962,EBI-7116203 |
TRIP6 [Q15654] | 3 | EBI-11149962,EBI-742327 |
Protein-protein interaction databases
BioGRIDi | 115202, 162 interactors |
CORUMi | Q15047 |
DIPi | DIP-31029N |
IntActi | Q15047, 260 interactors |
MINTi | Q15047 |
STRINGi | 9606.ENSP00000271640 |
Chemistry databases
BindingDBi | Q15047 |
Miscellaneous databases
RNActi | Q15047, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15047 |
SMRi | Q15047 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15047 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 257 – 320 | Tudor 1Add BLAST | 64 | |
Domaini | 347 – 403 | Tudor 2Add BLAST | 57 | |
Domaini | 594 – 665 | MBDPROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 727 – 800 | Pre-SETPROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 803 – 1266 | SETPROSITE-ProRule annotationAdd BLAST | 464 | |
Domaini | 1275 – 1291 | Post-SETPROSITE-ProRule annotationAdd BLAST | 17 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 108 – 147 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 404 – 545 | DisorderedSequence analysisAdd BLAST | 142 | |
Regioni | 813 – 815 | S-adenosyl-L-methionine bindingBy similarity | 3 | |
Regioni | 868 – 1160 | DisorderedSequence analysisAdd BLAST | 293 | |
Regioni | 1223 – 1224 | S-adenosyl-L-methionine bindingBy similarity | 2 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 18 – 64 | Sequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 123 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 432 – 448 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 449 – 469 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 472 – 535 | Polar residuesSequence analysisAdd BLAST | 64 | |
Compositional biasi | 893 – 910 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 915 – 947 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 951 – 967 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 972 – 1007 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 1034 – 1053 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1078 – 1140 | Polar residuesSequence analysisAdd BLAST | 63 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1141, Eukaryota |
GeneTreei | ENSGT00940000157471 |
HOGENOMi | CLU_003279_1_0_1 |
InParanoidi | Q15047 |
OMAi | IRAVTNC |
OrthoDBi | 183716at2759 |
PhylomeDBi | Q15047 |
TreeFami | TF106411 |
Family and domain databases
Gene3Di | 2.170.270.10, 2 hits |
InterProi | View protein in InterPro IPR016177, DNA-bd_dom_sf IPR040880, DUF5604 IPR025796, Hist-Lys_N-MeTrfase_SETDB1 IPR001739, Methyl_CpG_DNA-bd IPR003616, Post-SET_dom IPR007728, Pre-SET_dom IPR001214, SET_dom IPR046341, SET_dom_sf IPR002999, Tudor IPR041292, Tudor_4 IPR041291, TUDOR_5 |
Pfami | View protein in Pfam PF18300, DUF5604, 1 hit PF01429, MBD, 1 hit PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit PF18358, Tudor_4, 1 hit PF18359, Tudor_5, 1 hit |
SMARTi | View protein in SMART SM00391, MBD, 1 hit SM00468, PreSET, 1 hit SM00317, SET, 1 hit SM00333, TUDOR, 2 hits |
SUPFAMi | SSF54171, SSF54171, 1 hit SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50982, MBD, 1 hit PS50868, POST_SET, 1 hit PS50867, PRE_SET, 1 hit PS51573, SAM_MT43_SUVAR39_1, 1 hit PS50280, SET, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSLPGCIGL DAATATVESE EIAELQQAVV EELGISMEEL RHFIDEELEK
60 70 80 90 100
MDCVQQRKKQ LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY
110 120 130 140 150
SKLGLQYRDS SSEDESSRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLSQMSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYVTAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASALE KKQGQLRTRP NMGAVRSKGP VVQYTQDLTG TGTQFKPVEP
460 470 480 490 500
PQPTAPPAPP FPPAPPLSPQ AGDSDLESQL AQSRKQVAKK STSFRPGSVG
510 520 530 540 550
SGHSSPTSPA LSENVSGGKP GINQTYRSPL GSTASAPAPS ALPAPPAPPV
560 570 580 590 600
FHGMLERAPA EPSYRAPMEK LFYLPHVCSY TCLSRVRPMR NEQYRGKNPL
610 620 630 640 650
LVPLLYDFRR MTARRRVNRK MGFHVIYKTP CGLCLRTMQE IERYLFETGC
660 670 680 690 700
DFLFLEMFCL DPYVLVDRKF QPYKPFYYIL DITYGKEDVP LSCVNEIDTT
710 720 730 740 750
PPPQVAYSKE RIPGKGVFIN TGPEFLVGCD CKDGCRDKSK CACHQLTIQA
760 770 780 790 800
TACTPGGQIN PNSGYQYKRL EECLPTGVYE CNKRCKCDPN MCTNRLVQHG
810 820 830 840 850
LQVRLQLFKT QNKGWGIRCL DDIAKGSFVC IYAGKILTDD FADKEGLEMG
860 870 880 890 900
DEYFANLDHI ESVENFKEGY ESDAPCSSDS SGVDLKDQED GNSGTEDPEE
910 920 930 940 950
SNDDSSDDNF CKDEDFSTSS VWRSYATRRQ TRGQKENGLS ETTSKDSHPP
960 970 980 990 1000
DLGPPHIPVP PSIPVGGCNP PSSEETPKNK VASWLSCNSV SEGGFADSDS
1010 1020 1030 1040 1050
HSSFKTNEGG EGRAGGSRME AEKASTSGLG IKDEGDIKQA KKEDTDDRNK
1060 1070 1080 1090 1100
MSVVTESSRN YGYNPSPVKP EGLRRPPSKT SMHQSRRLMA SAQSNPDDVL
1110 1120 1130 1140 1150
TLSSSTESEG ESGTSRKPTA GQTSATAVDS DDIQTISSGS EGDDFEDKKN
1160 1170 1180 1190 1200
MTGPMKRQVA VKSTRGFALK STHGIAIKST NMASVDKGES APVRKNTRQF
1210 1220 1230 1240 1250
YDGEESCYII DAKLEGNLGR YLNHSCSPNL FVQNVFVDTH DLRFPWVAFF
1260 1270 1280 1290
ASKRIRAGTE LTWDYNYEVG SVEGKELLCC CGAIECRGRL L
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PRF4 | E9PRF4_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 1,259 | Annotation score: | ||
E9PQM8 | E9PQM8_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 636 | Annotation score: | ||
B0QZE6 | B0QZE6_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 156 | Annotation score: | ||
X6R732 | X6R732_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 249 | Annotation score: | ||
E9PS59 | E9PS59_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 163 | Annotation score: | ||
X6RHV1 | X6RHV1_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 150 | Annotation score: | ||
E9PAP1 | E9PAP1_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 | 111 | Annotation score: | ||
A0A8I5KT93 | A0A8I5KT93_HUMAN | Histone-lysine N-methyltransferase ... | SETDB1 hCG_39375 | 1,292 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014284 | 236 | N → S. Corresponds to variant dbSNP:rs2271075Ensembl. | 1 | |
Natural variantiVAR_031281 | 506 | P → S1 PublicationCorresponds to variant dbSNP:rs17852587Ensembl. | 1 | |
Natural variantiVAR_014286 | 824 | A → G. Corresponds to variant dbSNP:rs2691551Ensembl. | 1 | |
Natural variantiVAR_014285 | 824 | A → P. Corresponds to variant dbSNP:rs2814054Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002217 | 381 – 397 | DDKRC…TRLEP → VLFFSTILEAEVGGGGT in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_002218 | 398 – 1291 | Missing in isoform 2. 1 PublicationAdd BLAST | 894 | |
Alternative sequenceiVSP_034600 | 1254 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31891 mRNA Translation: BAA06689.2 Different initiation. AL590133 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53506.1 BC009362 mRNA Translation: AAH09362.1 BC028671 mRNA Translation: AAH28671.1 |
CCDSi | CCDS44217.1 [Q15047-1] CCDS58026.1 [Q15047-2] CCDS972.1 [Q15047-3] |
RefSeqi | NP_001138887.1, NM_001145415.1 [Q15047-1] NP_001230420.1, NM_001243491.1 [Q15047-2] NP_036564.3, NM_012432.3 [Q15047-3] XP_016858444.1, XM_017002955.1 [Q15047-2] |
Genome annotation databases
Ensembli | ENST00000271640.9; ENSP00000271640.5; ENSG00000143379.13 ENST00000368962.6; ENSP00000357958.2; ENSG00000143379.13 [Q15047-2] ENST00000368969.8; ENSP00000357965.4; ENSG00000143379.13 [Q15047-3] |
GeneIDi | 9869 |
KEGGi | hsa:9869 |
UCSCi | uc001evu.3, human [Q15047-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31891 mRNA Translation: BAA06689.2 Different initiation. AL590133 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53506.1 BC009362 mRNA Translation: AAH09362.1 BC028671 mRNA Translation: AAH28671.1 |
CCDSi | CCDS44217.1 [Q15047-1] CCDS58026.1 [Q15047-2] CCDS972.1 [Q15047-3] |
RefSeqi | NP_001138887.1, NM_001145415.1 [Q15047-1] NP_001230420.1, NM_001243491.1 [Q15047-2] NP_036564.3, NM_012432.3 [Q15047-3] XP_016858444.1, XM_017002955.1 [Q15047-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DLM | X-ray | 1.77 | A | 196-402 | [»] | |
4X3S | X-ray | 1.60 | C/D | 1165-1174 | [»] | |
5KCH | X-ray | 1.70 | A | 196-403 | [»] | |
5KCO | X-ray | 1.47 | A | 196-403 | [»] | |
5KE2 | X-ray | 1.56 | A | 196-402 | [»] | |
5KE3 | X-ray | 1.70 | A | 196-402 | [»] | |
5KH6 | X-ray | 2.05 | A | 196-400 | [»] | |
5QT1 | X-ray | 1.58 | A | 196-397 | [»] | |
5QT2 | X-ray | 1.59 | A | 196-397 | [»] | |
6AU2 | X-ray | 1.63 | A | 196-402 | [»] | |
6AU3 | X-ray | 1.80 | A | 196-402 | [»] | |
6BHD | X-ray | 1.25 | A | 190-410 | [»] | |
6BHE | X-ray | 1.35 | A | 190-410 | [»] | |
6BHG | X-ray | 1.45 | A | 190-410 | [»] | |
6BHH | X-ray | 1.85 | A | 190-410 | [»] | |
6BHI | X-ray | 1.40 | A | 190-410 | [»] | |
6BPI | X-ray | 1.64 | A | 196-402 | [»] | |
7C9N | X-ray | 2.47 | A/B | 190-410 | [»] | |
7CAJ | X-ray | 2.20 | A/D | 190-410 | [»] | |
7CD9 | X-ray | 1.60 | A/B | 190-410 | [»] | |
7CJT | X-ray | 2.47 | A/B/C/D | 190-410 | [»] | |
AlphaFoldDBi | Q15047 | |||||
SMRi | Q15047 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115202, 162 interactors |
CORUMi | Q15047 |
DIPi | DIP-31029N |
IntActi | Q15047, 260 interactors |
MINTi | Q15047 |
STRINGi | 9606.ENSP00000271640 |
Chemistry databases
BindingDBi | Q15047 |
ChEMBLi | CHEMBL2321646 |
PTM databases
GlyGeni | Q15047, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15047 |
PhosphoSitePlusi | Q15047 |
Genetic variation databases
BioMutai | SETDB1 |
DMDMi | 25091210 |
Proteomic databases
EPDi | Q15047 |
jPOSTi | Q15047 |
MassIVEi | Q15047 |
MaxQBi | Q15047 |
PaxDbi | Q15047 |
PeptideAtlasi | Q15047 |
PRIDEi | Q15047 |
ProteomicsDBi | 60397 [Q15047-1] 60398 [Q15047-2] 60399 [Q15047-3] |
Protocols and materials databases
Antibodypediai | 20300, 400 antibodies from 41 providers |
DNASUi | 9869 |
Genome annotation databases
Ensembli | ENST00000271640.9; ENSP00000271640.5; ENSG00000143379.13 ENST00000368962.6; ENSP00000357958.2; ENSG00000143379.13 [Q15047-2] ENST00000368969.8; ENSP00000357965.4; ENSG00000143379.13 [Q15047-3] |
GeneIDi | 9869 |
KEGGi | hsa:9869 |
UCSCi | uc001evu.3, human [Q15047-1] |
Organism-specific databases
CTDi | 9869 |
DisGeNETi | 9869 |
GeneCardsi | SETDB1 |
HGNCi | HGNC:10761, SETDB1 |
HPAi | ENSG00000143379, Low tissue specificity |
MIMi | 604396, gene |
neXtProti | NX_Q15047 |
OpenTargetsi | ENSG00000143379 |
PharmGKBi | PA35679 |
VEuPathDBi | HostDB:ENSG00000143379 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1141, Eukaryota |
GeneTreei | ENSGT00940000157471 |
HOGENOMi | CLU_003279_1_0_1 |
InParanoidi | Q15047 |
OMAi | IRAVTNC |
OrthoDBi | 183716at2759 |
PhylomeDBi | Q15047 |
TreeFami | TF106411 |
Enzyme and pathway databases
BRENDAi | 2.1.1.355, 2681 2.1.1.366, 2681 |
PathwayCommonsi | Q15047 |
Reactomei | R-HSA-3214841, PKMTs methylate histone lysines |
SignaLinki | Q15047 |
SIGNORi | Q15047 |
Miscellaneous databases
BioGRID-ORCSi | 9869, 273 hits in 1124 CRISPR screens |
ChiTaRSi | SETDB1, human |
EvolutionaryTracei | Q15047 |
GeneWikii | SETDB1 |
GenomeRNAii | 9869 |
Pharosi | Q15047, Tbio |
PROi | PR:Q15047 |
RNActi | Q15047, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143379, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q15047, baseline and differential |
Genevisiblei | Q15047, HS |
Family and domain databases
Gene3Di | 2.170.270.10, 2 hits |
InterProi | View protein in InterPro IPR016177, DNA-bd_dom_sf IPR040880, DUF5604 IPR025796, Hist-Lys_N-MeTrfase_SETDB1 IPR001739, Methyl_CpG_DNA-bd IPR003616, Post-SET_dom IPR007728, Pre-SET_dom IPR001214, SET_dom IPR046341, SET_dom_sf IPR002999, Tudor IPR041292, Tudor_4 IPR041291, TUDOR_5 |
Pfami | View protein in Pfam PF18300, DUF5604, 1 hit PF01429, MBD, 1 hit PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit PF18358, Tudor_4, 1 hit PF18359, Tudor_5, 1 hit |
SMARTi | View protein in SMART SM00391, MBD, 1 hit SM00468, PreSET, 1 hit SM00317, SET, 1 hit SM00333, TUDOR, 2 hits |
SUPFAMi | SSF54171, SSF54171, 1 hit SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50982, MBD, 1 hit PS50868, POST_SET, 1 hit PS50867, PRE_SET, 1 hit PS51573, SAM_MT43_SUVAR39_1, 1 hit PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SETB1_HUMAN | |
Accessioni | Q15047Primary (citable) accession number: Q15047 Secondary accession number(s): A6NEW2 Q96GM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 224 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families