UniProtKB - Q15043 (S39AE_HUMAN)
Protein
Metal cation symporter ZIP14
Gene
SLC39A14
Organism
Homo sapiens (Human)
Status
Functioni
Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185).By similarity8 Publications
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- anion:cation symporter activity Source: UniProtKB
- cadmium ion transmembrane transporter activity Source: UniProtKB
- ferrous iron transmembrane transporter activity Source: Ensembl
- iron ion transmembrane transporter activity Source: UniProtKB
- manganese ion transmembrane transporter activity Source: UniProtKB
- zinc ion transmembrane transporter activity Source: BHF-UCL
GO - Biological processi
- cadmium ion transmembrane transport Source: UniProtKB
- cellular response to glucose stimulus Source: UniProtKB
- cellular response to insulin stimulus Source: UniProtKB
- cellular zinc ion homeostasis Source: BHF-UCL
- chondrocyte differentiation Source: UniProtKB
- gluconeogenesis Source: UniProtKB
- import across plasma membrane Source: UniProtKB
- insulin receptor signaling pathway Source: UniProtKB
- iron import into cell Source: UniProtKB
- iron ion transmembrane transport Source: UniProtKB
- manganese ion homeostasis Source: UniProtKB
- manganese ion transmembrane transport Source: UniProtKB
- negative regulation of cyclic-nucleotide phosphodiesterase activity Source: UniProtKB
- positive regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
- regulation of hormone levels Source: UniProtKB
- zinc ion import across plasma membrane Source: UniProtKB
- zinc ion transmembrane transport Source: BHF-UCL
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q15043 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
Protein family/group databases
TCDBi | 2.A.5.4.5, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Metal cation symporter ZIP141 PublicationAlternative name(s): LIV-1 subfamily of ZIP zinc transporter 41 Publication Short name: LZT-Hs41 Publication Solute carrier family 39 member 14Imported Zrt- and Irt-like protein 141 Publication Short name: ZIP-141 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104635.13 |
HGNCi | HGNC:20858, SLC39A14 |
MIMi | 608736, gene |
neXtProti | NX_Q15043 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein Sequence analysis
- Apical cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Basolateral cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endosome
- Early endosome membrane 2 Publications; Multi-pass membrane protein Sequence analysis
- Late endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). Localized at the basolateral membrane of enterocytes (PubMed:31028174). Enriched at the plasma membrane upon glucose uptake (PubMed:27703010).3 Publications
Endosome
- early endosome membrane Source: UniProtKB
- late endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 157 | ExtracellularSequence analysisAdd BLAST | 127 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 186 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 224 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 397 | CytoplasmicSequence analysisAdd BLAST | 152 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 424 | ExtracellularSequence analysis | 6 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 460 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 461 – 481 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 482 – 492 | ExtracellularSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Hypermanganesemia with dystonia 2 (HMNDYT2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic autosomal recessive disorder characterized by increased blood manganese levels, neurodegeneration, and rapidly progressive parkinsonism and dystonia. Affected individuals present with loss of developmental milestones, progressive dystonia and bulbar dysfunction in infancy or early childhood. Towards the end of the first decade, they manifest severe generalized pharmacoresistant dystonia, spasticity, limb contractures and scoliosis, and loss of independent ambulation. Cognition may be impaired, but is better preserved than motor function.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077004 | 98 | F → V in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs879253763EnsemblClinVar. | 1 | |
Natural variantiVAR_077005 | 383 | G → R in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs879253766EnsemblClinVar. | 1 | |
Natural variantiVAR_077006 | 469 | N → K in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs750281602EnsemblClinVar. | 1 |
Hyperostosis cranialis interna (HCIN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Conditional knockin mice overexpressing Arg-438 variant, which is the mouse equivalent of human variant Leu-441, in osteoblasts have a severe skeletal phenotype marked by a drastic increase in cortical thickness due to an enhanced endosteal bone formation, resembling the underlying pathology in HCI patients.1 Publication
Disease descriptionAn autosomal dominant bone disorder characterized by endosteal hyperostosis and osteosclerosis of the calvaria and the skull base. The progressive bone overgrowth causes entrapment and dysfunction of cranial nerves I, II, V, VII, and VIII, its first symptoms often presenting during the second decade of life.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080794 | 441 | L → R in HCIN; loss of localization at the plasma membrane; loss of Zn uptake activity. 1 PublicationCorresponds to variant dbSNP:rs1554520924EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 77 | N → A: Decreased N-glycosylation. 1 Publication | 1 | |
Mutagenesisi | 87 | N → A: Decreased N-glycosylation. 1 Publication | 1 | |
Mutagenesisi | 102 | N → A: Decreased N-glycosylation. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Dystonia, Neurodegeneration, ParkinsonismOrganism-specific databases
DisGeNETi | 23516 |
GeneReviewsi | SLC39A14 |
MalaCardsi | SLC39A14 |
MIMi | 144755, phenotype 617013, phenotype |
OpenTargetsi | ENSG00000104635 |
Orphaneti | 521406, Dystonia-parkinsonism-hypermanganesemia syndrome |
PharmGKBi | PA134863701 |
Miscellaneous databases
Pharosi | Q15043, Tbio |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Polymorphism and mutation databases
BioMutai | SLC39A14 |
DMDMi | 313104191 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000312194 | 31 – 492 | Metal cation symporter ZIP14Add BLAST | 462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 77 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 87 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagine2 Publications | 1 |
Post-translational modificationi
Ubiquitinated. Ubiquitination occurs upon iron depletion. The ubiquitinated form undergoes proteasomal degradation.1 Publication
N-glycosylated. N-glycosylation at Asn-102 is required for iron-regulated extraction of the transporter from membranes and subsequent proteasomal degradation.1 Publication
Keywords - PTMi
Glycoprotein, Ubl conjugationProteomic databases
EPDi | Q15043 |
jPOSTi | Q15043 |
MassIVEi | Q15043 |
MaxQBi | Q15043 |
PaxDbi | Q15043 |
PeptideAtlasi | Q15043 |
PRIDEi | Q15043 |
ProteomicsDBi | 60392 [Q15043-1] 60393 [Q15043-2] 60394 [Q15043-3] |
PTM databases
GlyGeni | Q15043, 2 sites |
iPTMneti | Q15043 |
PhosphoSitePlusi | Q15043 |
SwissPalmi | Q15043 |
Expressioni
Tissue specificityi
Ubiquitously expressed, with higher expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart (PubMed:7584044, PubMed:15642354, PubMed:20682781). Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:7584044). Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Expressed in osteoblasts and giant osteoclast-like cells, but not in osteocytes found osteoblastoma and giant cell tumors (at protein level) (PubMed:29621230). Expressed by microvascular capillary endothelial cells that constitute the blood-brain barrier (at protein level) (PubMed:31699897). Expressed by macrophages (PubMed:23052185).5 Publications
Widely expressed but not detected in brain, heart, skeletal muscle, placenta and fetal skin.1 Publication
Inductioni
Up-regulated by iron (at protein level) (PubMed:24927598). Down-regulation upon iron depletion occurs through proteasomal degradation of the intracellular pool (PubMed:24927598). Up-regulated by tunicamycin, a drug inducing endoplasmic reticulum stress (at protein level) (PubMed:28673968). Up-regulated by lipopolysaccharide/LPS (PubMed:23052185).3 Publications
Gene expression databases
Bgeei | ENSG00000104635, Expressed in right lobe of liver and 238 other tissues |
ExpressionAtlasi | Q15043, baseline and differential |
Genevisiblei | Q15043, HS |
Organism-specific databases
HPAi | ENSG00000104635, Tissue enhanced (liver, pancreas) |
Interactioni
Subunit structurei
Homotrimer.
1 PublicationBinary interactionsi
Hide detailsIsoform 3 [Q15043-2]
With | #Exp. | IntAct |
---|---|---|
LZTS2 [Q9BRK4] | 3 | EBI-12176399,EBI-741037 |
SEPTIN3 [Q9UH03] | 3 | EBI-12176399,EBI-727037 |
Protein-protein interaction databases
BioGRIDi | 117063, 21 interactors |
IntActi | Q15043, 19 interactors |
MINTi | Q15043 |
STRINGi | 9606.ENSP00000352779 |
Miscellaneous databases
RNActi | Q15043, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 251 – 258 | HHHGHXHX-motif1 Publication | 8 | |
Motifi | 376 – 381 | XEXPHE-motif1 Publication | 6 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000157986 |
InParanoidi | Q15043 |
OMAi | PCTERAF |
PhylomeDBi | Q15043 |
TreeFami | TF318470 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q15043-1) [UniParc]FASTAAdd to basket
Also known as: ZIP14B1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR
60 70 80 90 100
YGEGDSLTLQ QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA
110 120 130 140 150
HNFSEQSRIG SSELQEFCPT ILQQLDSRAC TSENQENEEN EQTEEGRPSA
160 170 180 190 200
VEVWGYGLLC VTVISLCSLL GASVVPFMKK TFYKRLLLYF IALAIGTLYS
210 220 230 240 250
NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI LKILLKQKNE
260 270 280 290 300
HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM
310 320 330 340 350
VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI
360 370 380 390 400
DGLAIGASFT VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF
410 420 430 440 450
FNFLSACCCY LGLAFGILAG SHFSANWIFA LAGGMFLYIS LADMFPEMNE
460 470 480 490
VCQEDERKGS ILIPFIIQNL GLLTGFTIMV VLTMYSGQIQ IG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFT1 | E5RFT1_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 201 | Annotation score: | ||
E5RIP4 | E5RIP4_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 155 | Annotation score: | ||
E5RFZ8 | E5RFZ8_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 89 | Annotation score: | ||
E5RGA7 | E5RGA7_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 90 | Annotation score: | ||
E5RJG5 | E5RJG5_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 127 | Annotation score: | ||
E5RFF5 | E5RFF5_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 53 | Annotation score: | ||
E5RJ40 | E5RJ40_HUMAN | Metal cation symporter ZIP14 | SLC39A14 | 122 | Annotation score: |
Sequence cautioni
The sequence BAA06685 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | L → P in BAD18780 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 314 | D → G in BAG58625 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 380 | H → R in BAD18780 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037450 | 33 | L → P1 PublicationCorresponds to variant dbSNP:rs896378Ensembl. | 1 | |
Natural variantiVAR_077004 | 98 | F → V in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs879253763EnsemblClinVar. | 1 | |
Natural variantiVAR_077005 | 383 | G → R in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs879253766EnsemblClinVar. | 1 | |
Natural variantiVAR_080794 | 441 | L → R in HCIN; loss of localization at the plasma membrane; loss of Zn uptake activity. 1 PublicationCorresponds to variant dbSNP:rs1554520924EnsemblClinVar. | 1 | |
Natural variantiVAR_077006 | 469 | N → K in HMNDYT2; no effect on protein abundance; no effect on subcellular localization at the plasma membrane and within the cytoplasm; decreased manganese ion transmembrane transporter activity. 1 PublicationCorresponds to variant dbSNP:rs750281602EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040139 | 156 – 199 | YGLLC…IGTLY → FGFLSVSLINLASLLGVLVL PCTEKAFFSRVLTYFIALSI GTLL in isoform 2. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_029728 | 445 – 492 | FPEMN…QIQIG → MEFCSVAQAGVQWCHLSSLQ PLPLGLKRLSCLSLPSN in isoform 3. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31887 mRNA Translation: BAA06685.1 Different initiation. AK172810 mRNA Translation: BAD18780.1 AK295807 mRNA Translation: BAG58625.1 AC087854 Genomic DNA No translation available. AC105910 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63681.1 CH471080 Genomic DNA Translation: EAW63682.1 CH471080 Genomic DNA Translation: EAW63683.1 BC015770 mRNA Translation: AAH15770.1 |
CCDSi | CCDS47822.1 [Q15043-2] CCDS47823.1 [Q15043-1] CCDS6030.1 [Q15043-3] |
RefSeqi | NP_001121903.1, NM_001128431.2 [Q15043-1] NP_001128625.1, NM_001135153.1 [Q15043-1] NP_056174.2, NM_015359.4 [Q15043-3] XP_005273522.1, XM_005273465.2 XP_005273523.1, XM_005273466.4 [Q15043-1] XP_006716387.1, XM_006716324.2 [Q15043-1] XP_011542780.1, XM_011544478.2 [Q15043-1] XP_016868783.1, XM_017013294.1 XP_016868784.1, XM_017013295.1 |
Genome annotation databases
Ensembli | ENST00000240095; ENSP00000240095; ENSG00000104635 [Q15043-2] ENST00000289952; ENSP00000289952; ENSG00000104635 [Q15043-1] ENST00000359741; ENSP00000352779; ENSG00000104635 [Q15043-3] ENST00000381237; ENSP00000370635; ENSG00000104635 [Q15043-1] |
GeneIDi | 23516 |
KEGGi | hsa:23516 |
UCSCi | uc003xbp.5, human [Q15043-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31887 mRNA Translation: BAA06685.1 Different initiation. AK172810 mRNA Translation: BAD18780.1 AK295807 mRNA Translation: BAG58625.1 AC087854 Genomic DNA No translation available. AC105910 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63681.1 CH471080 Genomic DNA Translation: EAW63682.1 CH471080 Genomic DNA Translation: EAW63683.1 BC015770 mRNA Translation: AAH15770.1 |
CCDSi | CCDS47822.1 [Q15043-2] CCDS47823.1 [Q15043-1] CCDS6030.1 [Q15043-3] |
RefSeqi | NP_001121903.1, NM_001128431.2 [Q15043-1] NP_001128625.1, NM_001135153.1 [Q15043-1] NP_056174.2, NM_015359.4 [Q15043-3] XP_005273522.1, XM_005273465.2 XP_005273523.1, XM_005273466.4 [Q15043-1] XP_006716387.1, XM_006716324.2 [Q15043-1] XP_011542780.1, XM_011544478.2 [Q15043-1] XP_016868783.1, XM_017013294.1 XP_016868784.1, XM_017013295.1 |
3D structure databases
SMRi | Q15043 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117063, 21 interactors |
IntActi | Q15043, 19 interactors |
MINTi | Q15043 |
STRINGi | 9606.ENSP00000352779 |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
TCDBi | 2.A.5.4.5, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
PTM databases
GlyGeni | Q15043, 2 sites |
iPTMneti | Q15043 |
PhosphoSitePlusi | Q15043 |
SwissPalmi | Q15043 |
Polymorphism and mutation databases
BioMutai | SLC39A14 |
DMDMi | 313104191 |
Proteomic databases
EPDi | Q15043 |
jPOSTi | Q15043 |
MassIVEi | Q15043 |
MaxQBi | Q15043 |
PaxDbi | Q15043 |
PeptideAtlasi | Q15043 |
PRIDEi | Q15043 |
ProteomicsDBi | 60392 [Q15043-1] 60393 [Q15043-2] 60394 [Q15043-3] |
Protocols and materials databases
Antibodypediai | 9517, 181 antibodies |
DNASUi | 23516 |
Genome annotation databases
Ensembli | ENST00000240095; ENSP00000240095; ENSG00000104635 [Q15043-2] ENST00000289952; ENSP00000289952; ENSG00000104635 [Q15043-1] ENST00000359741; ENSP00000352779; ENSG00000104635 [Q15043-3] ENST00000381237; ENSP00000370635; ENSG00000104635 [Q15043-1] |
GeneIDi | 23516 |
KEGGi | hsa:23516 |
UCSCi | uc003xbp.5, human [Q15043-1] |
Organism-specific databases
CTDi | 23516 |
DisGeNETi | 23516 |
EuPathDBi | HostDB:ENSG00000104635.13 |
GeneCardsi | SLC39A14 |
GeneReviewsi | SLC39A14 |
HGNCi | HGNC:20858, SLC39A14 |
HPAi | ENSG00000104635, Tissue enhanced (liver, pancreas) |
MalaCardsi | SLC39A14 |
MIMi | 144755, phenotype 608736, gene 617013, phenotype |
neXtProti | NX_Q15043 |
OpenTargetsi | ENSG00000104635 |
Orphaneti | 521406, Dystonia-parkinsonism-hypermanganesemia syndrome |
PharmGKBi | PA134863701 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000157986 |
InParanoidi | Q15043 |
OMAi | PCTERAF |
PhylomeDBi | Q15043 |
TreeFami | TF318470 |
Enzyme and pathway databases
PathwayCommonsi | Q15043 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
Miscellaneous databases
BioGRID-ORCSi | 23516, 8 hits in 854 CRISPR screens |
ChiTaRSi | SLC39A14, human |
GenomeRNAii | 23516 |
Pharosi | Q15043, Tbio |
PROi | PR:Q15043 |
RNActi | Q15043, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104635, Expressed in right lobe of liver and 238 other tissues |
ExpressionAtlasi | Q15043, baseline and differential |
Genevisiblei | Q15043, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S39AE_HUMAN | |
Accessioni | Q15043Primary (citable) accession number: Q15043 Secondary accession number(s): A6NH98 Q96BB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations