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UniProtKB - Q15041 (AR6P1_HUMAN)

Entry version 164 (17 Jun 2020)
Sequence version 2 (20 Jun 2001)
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Protein

ADP-ribosylation factor-like protein 6-interacting protein 1

Gene

ARL6IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).1 PublicationBy similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 1
Short name:
ARL-6-interacting protein 1
Short name:
Aip-1
Alternative name(s):
Apoptotic regulator in the membrane of the endoplasmic reticulum1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARL6IP1
Synonyms:ARL6IP, ARMER1 Publication, KIAA0069
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000170540.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:697 ARL6IP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607669 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q15041

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 65LumenalSequence analysis3
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 133CytoplasmicSequence analysisAdd BLAST47
Transmembranei134 – 175HelicalSequence analysisAdd BLAST42
Topological domaini176 – 203LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 61, autosomal recessive (SPG61)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complicated form of spastic paraplegia with polysensory and motor neuropathy. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08213938 – 203Missing in SPG61; unknown pathological significance. 1 PublicationAdd BLAST166

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		23204

MalaCards human disease database

More...MalaCardsi		ARL6IP1
MIMi615685 phenotype

Open Targets

More...OpenTargetsi		ENSG00000170540

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		401780 Autosomal recessive spastic paraplegia type 61

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162376894

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q15041 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARL6IP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		14424435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646551 – 203ADP-ribosylation factor-like protein 6-interacting protein 1Add BLAST203

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q15041

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q15041

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q15041

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q15041

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q15041

PeptideAtlas

More...PeptideAtlasi		Q15041

PRoteomics IDEntifications database

More...PRIDEi		Q15041

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24482
60389 [Q15041-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q15041

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q15041

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q15041

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Down-regulated during myeloid differentiation.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by apoptotic stimuli.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170540 Expressed in pigmented layer of retina and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q15041 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q15041 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170540 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:24262037). Heterodimer with ARL6IP5.

Interacts with ARL6 (By similarity).

Interacts with TMEM33 (PubMed:25612671).

Interacts with ATL1 (PubMed:24262037).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q15041
With#Exp.IntAct
ACSF2 [Q96CM8]8EBI-714543,EBI-2876502
AQP6 [Q13520]3EBI-714543,EBI-13059134
itself4EBI-714543,EBI-714543
C12orf10 [Q86UA3]3EBI-714543,EBI-10258793
C12orf10 [Q9HB07]3EBI-714543,EBI-709754
C19orf18 [Q8NEA5]3EBI-714543,EBI-18323646
CERT1 [Q9Y5P4]5EBI-714543,EBI-739994
CERT1 - isoform 2 [Q9Y5P4-2]3EBI-714543,EBI-11156432
DIABLO [Q9NR28]9EBI-714543,EBI-517508
EHD3 [Q9NZN3]3EBI-714543,EBI-2870749
EMP1 [P54849]3EBI-714543,EBI-4319440
FXR2 [P51116]3EBI-714543,EBI-740459
GAD2 [Q05329]6EBI-714543,EBI-9304251
GAS8 [O95995]3EBI-714543,EBI-1052570
GOLPH3 [Q9H4A6]3EBI-714543,EBI-2465479
GORASP2 [Q9H8Y8]4EBI-714543,EBI-739467
GPR151 [Q8TDV0]3EBI-714543,EBI-11955647
GPR152 [Q8TDT2]3EBI-714543,EBI-13345167
HSD17B13 [Q7Z5P4]3EBI-714543,EBI-18053395
INPP5K [Q9BT40]5EBI-714543,EBI-749162
MCEMP1 [Q8IX19]3EBI-714543,EBI-2816356
MFSD14B [Q5SR56]3EBI-714543,EBI-373355
MFSD5 [Q6N075]3EBI-714543,EBI-3920969
MGST3 [O14880]3EBI-714543,EBI-724754
MIEF2 - isoform 3 [Q96C03-3]3EBI-714543,EBI-11988931
MTERF3 [Q96E29]3EBI-714543,EBI-7825321
NAPB [Q9H115]3EBI-714543,EBI-3921185
NDRG4 [Q9ULP0]3EBI-714543,EBI-10323810
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-714543,EBI-11978907
PAM16 [Q9Y3D7]3EBI-714543,EBI-721147
PBX3 [Q5JS98]3EBI-714543,EBI-10244393
PICK1 [Q9NRD5]3EBI-714543,EBI-79165
PTPN9 [P43378]3EBI-714543,EBI-742898
RAB33A [Q14088]3EBI-714543,EBI-744685
REEP6 - isoform 2 [Q96HR9-2]3EBI-714543,EBI-14065960
RETREG3 [Q86VR2]7EBI-714543,EBI-10192441
RNF5 [Q99942]3EBI-714543,EBI-348482
RTN4 [Q9NQC3]3EBI-714543,EBI-715945
SDCBP [O00560]3EBI-714543,EBI-727004
SENP2 [Q9HC62]3EBI-714543,EBI-714881
SHISA5 - isoform 3 [Q8N114-3]3EBI-714543,EBI-13369834
SHMT2 [P34897]6EBI-714543,EBI-352908
SLC10A6 [Q3KNW5]3EBI-714543,EBI-18159983
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-714543,EBI-17295964
SNX1 [Q13596]4EBI-714543,EBI-2822329
SNX10 [Q8N5Z3]3EBI-714543,EBI-10266928
SNX10 [Q9Y5X0]6EBI-714543,EBI-10329478
SNX11 [Q9Y5W9]6EBI-714543,EBI-10329449
SNX12 [Q9UMY4]3EBI-714543,EBI-1752602
SNX12 - isoform 1 [Q9UMY4-1]3EBI-714543,EBI-22419305
SNX15 [Q9NRS6]4EBI-714543,EBI-725924
SNX2 [O60749]3EBI-714543,EBI-1046690
SNX3 [O60493]3EBI-714543,EBI-727209
SNX4 [O95219]3EBI-714543,EBI-724909
SNX8 [Q9Y5X2]3EBI-714543,EBI-1752557
SPG21 [Q9NZD8]6EBI-714543,EBI-742688
STARD4 [Q96DR4]3EBI-714543,EBI-17217258
SUCLA2 [E5KS60]3EBI-714543,EBI-10176959
SUCLA2 [Q9P2R7]6EBI-714543,EBI-2269898
TARS2 [Q9BW92]3EBI-714543,EBI-1045099
TFAM [Q00059]3EBI-714543,EBI-1049924
TMED8 [Q6PL24]3EBI-714543,EBI-11603430
TMEM14B [Q9NUH8]3EBI-714543,EBI-8638294
TMEM248 [Q9NWD8]3EBI-714543,EBI-10314986
TMEM258 [P61165]3EBI-714543,EBI-12019210
TUFM [A0A384ME17]6EBI-714543,EBI-12261790
TUFM [P49411]3EBI-714543,EBI-359097
UBE2I [Q7KZS0]3EBI-714543,EBI-10180829
VMA21 [Q3ZAQ7]3EBI-714543,EBI-1055364
WDFY2 [Q96P53]3EBI-714543,EBI-9478589
WDYHV1 [Q96HA8]3EBI-714543,EBI-741158
WIPI2 [Q9Y4P8]3EBI-714543,EBI-719396
YIPF4 [Q9BSR8]3EBI-714543,EBI-751253
ZFYVE21 [Q9BQ24]6EBI-714543,EBI-2849569

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116812, 62 interactors

Protein interaction database and analysis system

More...IntActi		Q15041, 82 interactors

Molecular INTeraction database

More...MINTi		Q15041

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306788

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q15041 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane domains are required for its ability to shape the endoplasmic reticulum membrane into tubules.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARL6ip family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHBG Eukaryota
ENOG410Z6SH LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154937

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_100749_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q15041

Identification of Orthologs from Complete Genome Data

More...OMAi		NWDGDQE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q15041

TreeFam database of animal gene trees

More...TreeFami		TF105477

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033301 ARL6IP

The PANTHER Classification System

More...PANTHERi		PTHR20952:SF3 PTHR20952:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15041-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG 
        60         70         80         90        100
VVSLVFLIIY YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE 
       110        120        130        140        150
QQQRFHEICS NLVKTRRRAV GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW 
       160        170        180        190        200
VGQQVHNLLL TYLIVTSLLL LPGLNQHGII LKYIGMAKRE INKLLKQKEK 

KNE
Length:203
Mass (Da):23,363
Last modified:June 20, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE914D8FC9609FC6
GO
Isoform 2 (identifier: Q15041-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:174
Mass (Da):20,260
Checksum:iBB0332B543DA6899
GO
Isoform 3 (identifier: Q15041-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-156: Missing.

Show »
Length:151
Mass (Da):17,158
Checksum:i3E11F9A93A58A76F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTX6H3BTX6_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS91H3BS91_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPJ2H3BPJ2_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA06683 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110S → I in BAH13527 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08213938 – 203Missing in SPG61; unknown pathological significance. 1 PublicationAdd BLAST166

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0572971 – 29Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_057298105 – 156Missing in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D31885 mRNA Translation: BAA06683.1 Different initiation.
AK300869 mRNA Translation: BAH13361.1
AK301636 mRNA Translation: BAH13527.1
AC138811 Genomic DNA No translation available.
BC010281 mRNA Translation: AAH10281.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10572.1 [Q15041-1]
CCDS81951.1 [Q15041-2]

NCBI Reference Sequences

More...RefSeqi		NP_001300787.1, NM_001313858.1 [Q15041-2]
NP_055976.1, NM_015161.2 [Q15041-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304414; ENSP00000306788; ENSG00000170540 [Q15041-1]
ENST00000546206; ENSP00000440048; ENSG00000170540 [Q15041-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23204

UCSC genome browser

More...UCSCi		uc002dfl.2 human [Q15041-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31885 mRNA Translation: BAA06683.1 Different initiation.
AK300869 mRNA Translation: BAH13361.1
AK301636 mRNA Translation: BAH13527.1
AC138811 Genomic DNA No translation available.
BC010281 mRNA Translation: AAH10281.1
CCDSiCCDS10572.1 [Q15041-1]
CCDS81951.1 [Q15041-2]
RefSeqiNP_001300787.1, NM_001313858.1 [Q15041-2]
NP_055976.1, NM_015161.2 [Q15041-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116812, 62 interactors
IntActiQ15041, 82 interactors
MINTiQ15041
STRINGi9606.ENSP00000306788

PTM databases

iPTMnetiQ15041
PhosphoSitePlusiQ15041
SwissPalmiQ15041

Polymorphism and mutation databases

BioMutaiARL6IP1
DMDMi14424435

Proteomic databases

EPDiQ15041
jPOSTiQ15041
MassIVEiQ15041
MaxQBiQ15041
PaxDbiQ15041
PeptideAtlasiQ15041
PRIDEiQ15041
ProteomicsDBi24482
60389 [Q15041-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11964 268 antibodies

The DNASU plasmid repository

More...DNASUi		23204

Genome annotation databases

EnsembliENST00000304414; ENSP00000306788; ENSG00000170540 [Q15041-1]
ENST00000546206; ENSP00000440048; ENSG00000170540 [Q15041-2]
GeneIDi23204
KEGGihsa:23204
UCSCiuc002dfl.2 human [Q15041-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23204
DisGeNETi23204
EuPathDBiHostDB:ENSG00000170540.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARL6IP1
HGNCiHGNC:697 ARL6IP1
HPAiENSG00000170540 Low tissue specificity
MalaCardsiARL6IP1
MIMi607669 gene
615685 phenotype
neXtProtiNX_Q15041
OpenTargetsiENSG00000170540
Orphaneti401780 Autosomal recessive spastic paraplegia type 61
PharmGKBiPA162376894

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IHBG Eukaryota
ENOG410Z6SH LUCA
GeneTreeiENSGT00940000154937
HOGENOMiCLU_100749_0_0_1
InParanoidiQ15041
OMAiNWDGDQE
PhylomeDBiQ15041
TreeFamiTF105477

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23204 6 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARL6IP1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ARL6IP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23204
PharosiQ15041 Tbio

Protein Ontology

More...PROi		PR:Q15041
RNActiQ15041 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170540 Expressed in pigmented layer of retina and 235 other tissues
ExpressionAtlasiQ15041 baseline and differential
GenevisibleiQ15041 HS

Family and domain databases

InterProiView protein in InterPro
IPR033301 ARL6IP
PANTHERiPTHR20952:SF3 PTHR20952:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAR6P1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15041
Secondary accession number(s): B7Z6S5, B7Z791, F5GXP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2001
Last modified: June 17, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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