UniProtKB - Q15027 (ACAP1_HUMAN)

BLAST

>sp|Q15027|ACAP1_HUMAN Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1
MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFV
VGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGF
REARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVI
EDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQ
RHVLLKQKELGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKK
YKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIA
SAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQC
CDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVI
INQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQP
PVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPTMADALAHGADVNW
VNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFL
KRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFS
LMASDDPEKLSRRSHDLHTL

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History
Entry version 175 (12 Sep 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Gene

ACAP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.5 Publications

Miscellaneous

Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.

Activity regulationⁱ

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	420 – 443	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Biological process	Protein transport, Transport
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q15027
SIGNORⁱ	Q15027

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Alternative name(s): Centaurin-beta-1 Short name: Cnt-b1
Gene namesⁱ	Name:ACAP1 Synonyms:CENTB1, KIAA0050
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072818.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16467 ACAP1
MIMⁱ	607763 gene
neXtProtⁱ	NX_Q15027

Keywords - Cellular componentⁱ

Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	S → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	29	S → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	274	K → N: Loss of binding to PIP2 and PIP3. Loss of association with endosomal tubules when coexpressed with PIP5K1C. 1 Publication	1
Mutagenesisⁱ	277	S → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	280	F → A: Reduced membrane binding and ability to induce liposome tubulation. 1 Publication	1
Mutagenesisⁱ	280	F → E: Almost abolishes membrane binding. 1 Publication	1
Mutagenesisⁱ	280	F → W: Preserves membrane binding and ability to tubulate liposomes. 1 Publication	1
Mutagenesisⁱ	289	T → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	358	S → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	389	T → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	448	R → Q: Loss of GAP activity. No effect on GULP1 binding or association with endosomal tubules when coexpressed with PIP5K1C. 2 Publications	1
Mutagenesisⁱ	461	T → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	554	S → A: Loss of phosphorylation by PKB, interaction with ITGB1 and ITGB1-dependent cell migration. 2 Publications	1
Mutagenesisⁱ	554	S → D: Enhances interaction with ITGB1. 2 Publications	1
Mutagenesisⁱ	568	S → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	711	T → A: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	712	Y → F: No effect on interaction with ITGB1. 1 Publication	1
Mutagenesisⁱ	724	S → A: Loss of phosphorylation at S-554, interaction with ITGB1 and ITGB1-dependent cell migration. 1 Publication	1
Mutagenesisⁱ	724	S → D: Enhances interaction with ITGB1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9744
Open Targets More...OpenTargetsⁱ	ENSG00000072818
PharmGKBⁱ	PA26406

Polymorphism and mutation databases

BioMutaⁱ	ACAP1
DMDMⁱ	3183210

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074209	1 – 740	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1Add BLAST		740

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	485	Nitrated tyrosineCombined sources		1
Modified residueⁱ	554	Phosphoserine; by PKB1 Publication		1

Post-translational modificationⁱ

Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.1 Publication

Keywords - PTMⁱ

Nitration, Phosphoprotein

Proteomic databases

EPDⁱ	Q15027
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15027
PaxDbⁱ	Q15027
PeptideAtlas More...PeptideAtlasⁱ	Q15027
PRIDEⁱ	Q15027
ProteomicsDBⁱ	60378

PTM databases

iPTMnetⁱ	Q15027
PhosphoSitePlusⁱ	Q15027

Expressionⁱ

Tissue specificityⁱ

Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000072818 Expressed in 208 organ(s), highest expression level in testis
CleanExⁱ	HS_ACAP1
ExpressionAtlasⁱ	Q15027 baseline and differential
Genevisibleⁱ	Q15027 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA075570

HPAⁱ

HPA075570

Interactionⁱ

Subunit structureⁱ

Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	3	EBI-751746,EBI-401755

With

Entry

#Exp.

IntAct

Notes

GRB2

P62993

EBI-751746,EBI-401755

Protein-protein interaction databases

BioGridⁱ	115092, 8 interactors
CORUMⁱ	Q15027
IntActⁱ	Q15027, 10 interactors
STRINGⁱ	9606.ENSP00000158762

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1 – 4	Combined sources	4
Helixⁱ	7 – 12	Combined sources	6
Helixⁱ	15 – 68	Combined sources	54
Beta strandⁱ	69 – 71	Combined sources	3
Helixⁱ	74 – 113	Combined sources	40
Helixⁱ	115 – 117	Combined sources	3
Helixⁱ	118 – 143	Combined sources	26
Helixⁱ	149 – 212	Combined sources	64
Helixⁱ	214 – 248	Combined sources	35
Beta strandⁱ	258 – 260	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Beta strandⁱ	267 – 275	Combined sources	9
Turnⁱ	277 – 279	Combined sources	3
Beta strandⁱ	283 – 291	Combined sources	9
Beta strandⁱ	294 – 303	Combined sources	10
Beta strandⁱ	306 – 310	Combined sources	5
Helixⁱ	312 – 314	Combined sources	3
Beta strandⁱ	315 – 319	Combined sources	5
Beta strandⁱ	323 – 325	Combined sources	3
Beta strandⁱ	328 – 335	Combined sources	8
Beta strandⁱ	337 – 341	Combined sources	5
Helixⁱ	345 – 361	Combined sources	17
Helixⁱ	407 – 412	Combined sources	6
Turnⁱ	415 – 418	Combined sources	4
Turnⁱ	421 – 423	Combined sources	3
Beta strandⁱ	430 – 432	Combined sources	3
Turnⁱ	433 – 436	Combined sources	4
Beta strandⁱ	437 – 439	Combined sources	3
Helixⁱ	441 – 450	Combined sources	10
Turnⁱ	452 – 454	Combined sources	3
Beta strandⁱ	457 – 459	Combined sources	3
Turnⁱ	460 – 462	Combined sources	3
Helixⁱ	467 – 475	Combined sources	9
Helixⁱ	478 – 485	Combined sources	8
Turnⁱ	486 – 493	Combined sources	8
Helixⁱ	503 – 514	Combined sources	12
Helixⁱ	571 – 578	Combined sources	8
Beta strandⁱ	580 – 582	Combined sources	3
Helixⁱ	585 – 593	Combined sources	9
Turnⁱ	603 – 606	Combined sources	4
Helixⁱ	610 – 616	Combined sources	7
Helixⁱ	620 – 628	Combined sources	9
Helixⁱ	643 – 650	Combined sources	8
Helixⁱ	653 – 661	Combined sources	9
Helixⁱ	676 – 682	Combined sources	7
Helixⁱ	686 – 696	Combined sources	11
Helixⁱ	713 – 720	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q15027
SMRⁱ	Q15027
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q15027

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 226	BARAdd BLAST	226
Domainⁱ	265 – 360	PHPROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	405 – 527	Arf-GAPPROSITE-ProRule annotationAdd BLAST	123
Repeatⁱ	606 – 635	ANK 1Add BLAST	30
Repeatⁱ	639 – 668	ANK 2Add BLAST	30
Repeatⁱ	672 – 702	ANK 3Add BLAST	31

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 382	Required for formation of endosomal tubules when overexpressed with PIP5K1CAdd BLAST	382
Regionⁱ	405 – 740	Required for interaction with GULP1Add BLAST	336
Regionⁱ	525 – 566	Prevents interaction with ITGB1 when S-554 is not phosphorylatedAdd BLAST	42

Domainⁱ

PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes. Only one PH domain of one ACAP1 dimer inserts into the membrane, while the other PH domain acts primaryly to interact with adjacent ACAP1 dimers.1 Publication

The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	420 – 443	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0521 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000220815
HOVERGENⁱ	HBG050889
InParanoidⁱ	Q15027
KEGG Orthology (KO) More...KOⁱ	K12489
OMAⁱ	GPPEPMM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029F
PhylomeDBⁱ	Q15027
TreeFamⁱ	TF318315

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 1.25.40.20, 1 hit 2.30.29.30, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR000909 PLipase_C_PInositol-sp_X_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit PF00169 PH, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 3 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

Q15027-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTVKLDFEEC LKDSPRFRAS IELVEAEVSE LETRLEKLLK LGTGLLESGR 
        60         70         80         90        100
HYLAASRAFV VGICDLARLG PPEPMMAECL EKFTVSLNHK LDSHAELLDA 
       110        120        130        140        150
TQHTLQQQIQ TLVKEGLRGF REARRDFWRG AESLEAALTH NAEVPRRRAQ 
       160        170        180        190        200
EAEEAGAALR TARAGYRGRA LDYALQINVI EDKRKFDIME FVLRLVEAQA 
       210        220        230        240        250
THFQQGHEEL SRLSQYRKEL GAQLHQLVLN SAREKRDMEQ RHVLLKQKEL 
       260        270        280        290        300
GGEEPEPSLR EGPGGLVMEG HLFKRASNAF KTWSRRWFTI QSNQLVYQKK 
       310        320        330        340        350
YKDPVTVVVD DLRLCTVKLC PDSERRFCFE VVSTSKSCLL QADSERLLQL 
       360        370        380        390        400
WVSAVQSSIA SAFSQARLDD SPRGPGQGSG HLAIGSAATL GSGGMARGRE 
       410        420        430        440        450
PGGVGHVVAQ VQSVDGNAQC CDCREPAPEW ASINLGVTLC IQCSGIHRSL 
       460        470        480        490        500
GVHFSKVRSL TLDSWEPELV KLMCELGNVI INQIYEARVE AMAVKKPGPS 
       510        520        530        540        550
CSRQEKEAWI HAKYVEKKFL TKLPEIRGRR GGRGRPRGQP PVPPKPSIRP 
       560        570        580        590        600
RPGSLRSKPE PPSEDLGSLH PGALLFRASG HPPSLPTMAD ALAHGADVNW 
       610        620        630        640        650
VNGGQDNATP LIQATAANSL LACEFLLQNG ANVNQADSAG RGPLHHATIL 
       660        670        680        690        700
GHTGLACLFL KRGADLGARD SEGRDPLTIA METANADIVT LLRLAKMREA 
       710        720        730        740
EAAQGQAGDE TYLDIFRDFS LMASDDPEKL SRRSHDLHTL

Length:740

Mass (Da):81,536

Last modified:November 1, 1996 - v1

Checksum:ⁱ64891DA3CE00189C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	I3L268	I3L268_HUMAN		Arf-GAP with coiled-coil, ANK repea... Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	ACAP1	101	Annotation score:
	I3L0K9	I3L0K9_HUMAN		Arf-GAP with coiled-coil, ANK repea... Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	ACAP1	148	Annotation score:

Sequence cautionⁱ

The sequence BAA06418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048328	68	R → C. Corresponds to variant dbSNP:rs35933585Ensembl.	1
Natural variantⁱVAR_036178	114	K → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs759855054Ensembl.	1
Natural variantⁱVAR_036179	129	R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754740225Ensembl.	1
Natural variantⁱVAR_048329	533	R → W. Corresponds to variant dbSNP:rs35019942Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30758 mRNA Translation: BAA06418.2 Different initiation. BT009788 mRNA Translation: AAP88790.1 BC018543 mRNA Translation: AAH18543.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11101.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055531.1, NM_014716.3
UniGeneⁱ	Hs.337242

Genome annotation databases

Ensemblⁱ	ENST00000158762; ENSP00000158762; ENSG00000072818
GeneIDⁱ	9744
KEGGⁱ	hsa:9744
UCSC genome browser More...UCSCⁱ	uc002ggd.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15027	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1		BOVIN		745	UniRef90_Q15027
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Fragment)		wild yak		728
Centaurin-beta-1		MACFA		745
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1		PAPAN		743
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X2		DELLE		741
+117

Protein	Similar proteins		Species	Score	Length	Source
Q15027	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1		BOVIN		745	UniRef50_Q15027
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Fragment)		wild yak		728
Centaurin-beta-1		MACFA		745
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1		PAPAN		743
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1		PIG		741
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30758 mRNA Translation: BAA06418.2 Different initiation. BT009788 mRNA Translation: AAP88790.1 BC018543 mRNA Translation: AAH18543.1
CCDSⁱ	CCDS11101.1
RefSeqⁱ	NP_055531.1, NM_014716.3
UniGeneⁱ	Hs.337242

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JUE	X-ray	2.30	A/B	378-740	[»]
	3T9K	X-ray	2.30	A/B	378-740	[»]
	4CKG	electron microscopy	12.00	A/B/C/D	1-377	[»]
	4CKH	electron microscopy	14.00	A/B/C/D	1-377	[»]
	4F1P	X-ray	2.30	A/B	378-740	[»]
	4NSW	X-ray	2.20	A/B	1-377	[»]
ProteinModelPortalⁱ	Q15027
SMRⁱ	Q15027
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115092, 8 interactors
CORUMⁱ	Q15027
IntActⁱ	Q15027, 10 interactors
STRINGⁱ	9606.ENSP00000158762

PTM databases

iPTMnetⁱ	Q15027
PhosphoSitePlusⁱ	Q15027

Polymorphism and mutation databases

BioMutaⁱ	ACAP1
DMDMⁱ	3183210

Proteomic databases

EPDⁱ	Q15027
MaxQBⁱ	Q15027
PaxDbⁱ	Q15027
PeptideAtlasⁱ	Q15027
PRIDEⁱ	Q15027
ProteomicsDBⁱ	60378

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9744
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000158762; ENSP00000158762; ENSG00000072818
GeneIDⁱ	9744
KEGGⁱ	hsa:9744
UCSCⁱ	uc002ggd.3 human

Organism-specific databases

CTDⁱ	9744
DisGeNETⁱ	9744
EuPathDBⁱ	HostDB:ENSG00000072818.11
GeneCardsⁱ	ACAP1
HGNCⁱ	HGNC:16467 ACAP1
HPAⁱ	HPA075570
MIMⁱ	607763 gene
neXtProtⁱ	NX_Q15027
OpenTargetsⁱ	ENSG00000072818
PharmGKBⁱ	PA26406
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0521 Eukaryota COG5347 LUCA
GeneTreeⁱ	ENSGT00760000118874
HOGENOMⁱ	HOG000220815
HOVERGENⁱ	HBG050889
InParanoidⁱ	Q15027
KOⁱ	K12489
OMAⁱ	GPPEPMM
OrthoDBⁱ	EOG091G029F
PhylomeDBⁱ	Q15027
TreeFamⁱ	TF318315

Enzyme and pathway databases

SignaLinkⁱ	Q15027
SIGNORⁱ	Q15027

Miscellaneous databases

EvolutionaryTraceⁱ	Q15027
GeneWikiⁱ	CENTB1
GenomeRNAiⁱ	9744
Protein Ontology More...PROⁱ	PR:Q15027
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072818 Expressed in 208 organ(s), highest expression level in testis
CleanExⁱ	HS_ACAP1
ExpressionAtlasⁱ	Q15027 baseline and differential
Genevisibleⁱ	Q15027 HS

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 1.25.40.20, 1 hit 2.30.29.30, 1 hit 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR000909 PLipase_C_PInositol-sp_X_dom
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF01412 ArfGap, 1 hit PF00169 PH, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00248 ANK, 3 hits SM00105 ArfGap, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF48403 SSF48403, 1 hit SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACAP1_HUMAN
Accessionⁱ	Q15027Primary (citable) accession number: Q15027 Secondary accession number(s): Q53XN9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15027 (ACAP1_HUMAN)

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Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

ACAP1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Endosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ