TNIP1

Functionⁱ

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.5 Publications

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21988832
- 25416956
mitogen-activated protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12220502
polyubiquitin modification-dependent protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to lipopolysaccharide Source: GO_Central
defense response
Source: ProtInc
Traceable author statementⁱ
- 9923610
glycoprotein biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 9923610
inflammatory response Source: UniProtKB-KW
leukocyte cell-cell adhesion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17632516
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 20010814
MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
negative regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 12220502
negative regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 16684768
negative regulation of viral genome replication
Source: UniProtKB
Traceable author statementⁱ
- 9923610
positive regulation of inflammatory response Source: UniProtKB
positive regulation of protein deubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 16684768
positive regulation of transcription by RNA polymerase II Source: UniProtKB
protein deubiquitination Source: Reactome
translation
Source: ProtInc
Traceable author statementⁱ
- 9923610

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Inflammatory response

Biological process

Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5689896 Ovarian tumor domain proteases

Reactomeⁱ

R-HSA-5689896 Ovarian tumor domain proteases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TNFAIP3-interacting protein 1 Alternative name(s): A20-binding inhibitor of NF-kappa-B activation 1 Short name: ABIN-1 HIV-1 Nef-interacting protein Nef-associated factor 1 Short name: Naf1 Nip40-1 Virion-associated nuclear shuttling protein Short name: VAN Short name: hVAN
Gene namesⁱ	Name:TNIP1 Synonyms:KIAA0113, NAF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145901.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16903 TNIP1
MIMⁱ	607714 gene
neXtProtⁱ	NX_Q15025

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	472	D → N: Abolishes binding to polyubiquitin ('K-63'-linked and linear). 1 Publication		1
Mutagenesisⁱ	552	Y → F: Abolishes interaction with PI3K p85 regulatory subunit and abolishes interaction between SELPLG and PI3K p85 regulatory subunit. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10318
Open Targets More...OpenTargetsⁱ	ENSG00000145901
Orphanetⁱ	536 Systemic lupus erythematosus
PharmGKBⁱ	PA128394573

Polymorphism and mutation databases

BioMutaⁱ	TNIP1
DMDMⁱ	20138952

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096691	1 – 636	TNFAIP3-interacting protein 1Add BLAST		636

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	77	PhosphoserineCombined sources	1
Modified residueⁱ	284	PhosphoserineCombined sources	1
Modified residueⁱ	403	PhosphoserineCombined sources	1
Modified residueⁱ	438	PhosphothreonineCombined sources	1
Modified residueⁱ	442	PhosphoserineCombined sources	1
Modified residueⁱ	552	Phosphotyrosine1 Publication	1
Modified residueⁱ	571	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	599	Asymmetric dimethylarginine; alternateCombined sources	1
Modified residueⁱ	599	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	627	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.1 Publication

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q15025
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15025
PaxDbⁱ	Q15025
PeptideAtlas More...PeptideAtlasⁱ	Q15025
PRIDEⁱ	Q15025
ProteomicsDBⁱ	60376 60377 [Q15025-2]

PTM databases

iPTMnetⁱ	Q15025
PhosphoSitePlusⁱ	Q15025

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000145901 Expressed in 236 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_NAF1 HS_TNIP1
ExpressionAtlasⁱ	Q15025 baseline and differential
Genevisibleⁱ	Q15025 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037893 HPA037894 HPA071950

HPAⁱ

HPA037893
HPA037894
HPA071950

Interactionⁱ

Subunit structureⁱ

Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-357849,EBI-357849
AP1M1	Q9BXS5	3	EBI-357849,EBI-541426
BYSL	Q13895	7	EBI-357849,EBI-358049
CCDC112	Q8NEF3	3	EBI-357849,EBI-745040
CCNG1	P51959	7	EBI-357849,EBI-3905829
CDIP1	Q9H305	4	EBI-357849,EBI-2876678
CFAP53	Q96M91	3	EBI-357849,EBI-742422
CYSRT1	A8MQ03	4	EBI-357849,EBI-3867333
EHHADH	Q08426	3	EBI-357849,EBI-2339219
FAM161A	Q3B820	5	EBI-357849,EBI-719941
FAM168A	Q92567	3	EBI-357849,EBI-7957930
GABARAPL1	Q9H0R8	5	EBI-357849,EBI-746969
GABARAPL2	P60520	5	EBI-357849,EBI-720116
GIT2	Q14161	3	EBI-357849,EBI-1046878
GTF2B	Q00403	5	EBI-357849,EBI-389564
HDDC3	Q8N4P3	3	EBI-357849,EBI-750003
IKBKG	Q9Y6K9	4	EBI-357849,EBI-81279
ipaH9.8	Q8VSC3	4	EBI-357849,EBI-6125799	From Shigella flexneri.
KIFC3	Q9BVG8	3	EBI-357849,EBI-2125614
MAGEB18	Q96M61	5	EBI-357849,EBI-741835
MAGEH1	Q9H213	3	EBI-357849,EBI-473834
MAP1LC3A	Q9H492	5	EBI-357849,EBI-720768
MAP1LC3B	Q9GZQ8	3	EBI-357849,EBI-373144
MOB1B	Q7L9L4	3	EBI-357849,EBI-2558745
MOB3C	Q70IA8	3	EBI-357849,EBI-9679267
MORF4L1	Q9UBU8	3	EBI-357849,EBI-399246
MORF4L2	Q15014	3	EBI-357849,EBI-399257
NDC80	O14777	5	EBI-357849,EBI-715849
NFKB1	P19838	4	EBI-357849,EBI-300010
NIFK	Q9BYG3	3	EBI-357849,EBI-2561019
NME7	Q9Y5B8	7	EBI-357849,EBI-744782
OPTN	Q96CV9	15	EBI-357849,EBI-748974
PIN1	Q13526	6	EBI-357849,EBI-714158
PNKP	Q96T60	5	EBI-357849,EBI-1045072
RALBP1	Q15311	3	EBI-357849,EBI-749285
SNIP1	Q8TAD8	3	EBI-357849,EBI-749336
SYT6	Q5T7P8-2	3	EBI-357849,EBI-10246152
TAX1BP1	Q86VP1	5	EBI-357849,EBI-529518
TCEA2	Q15560	6	EBI-357849,EBI-710310
TCEANC2	Q96MN5	3	EBI-357849,EBI-5462748
TNFAIP3	P21580	6	EBI-357849,EBI-527670
TNIP3	Q96KP6	5	EBI-357849,EBI-2509913
TXLNA	P40222	5	EBI-357849,EBI-359793
VPS33B	Q9H267	8	EBI-357849,EBI-749072
ZBTB25	P24278	5	EBI-357849,EBI-739899
ZNHIT1	O43257	3	EBI-357849,EBI-347522

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21988832
- 25416956
mitogen-activated protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12220502
polyubiquitin modification-dependent protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115602, 110 interactors
CORUMⁱ	Q15025
Database of interacting proteins More...DIPⁱ	DIP-27577N
IntActⁱ	Q15025, 104 interactors
Molecular INTeraction database More...MINTⁱ	Q15025
STRINGⁱ	9606.ENSP00000317891

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15025
SMRⁱ	Q15025
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	94 – 412	Interaction with NefAdd BLAST	319
Regionⁱ	351 – 367	Interaction with Shigella flexneri ipah9.8Add BLAST	17
Regionⁱ	431 – 588	Required for inhibitory activity of TNF-induced NF-kappa-B activationBy similarityAdd BLAST	158
Regionⁱ	452 – 510	Ubiquitin-binding domain (UBD)Add BLAST	59

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	20 – 73	Sequence analysisAdd BLAST	54
Coiled coilⁱ	196 – 258	Sequence analysisAdd BLAST	63
Coiled coilⁱ	294 – 535	Sequence analysisAdd BLAST	242

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	524 – 530	Nuclear localization signalSequence analysis		7

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	539 – 636	Pro-richAdd BLAST		98

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEGE Eukaryota ENOG411180D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046908
HOGENOMⁱ	HOG000253048
HOVERGENⁱ	HBG019072
InParanoidⁱ	Q15025
OMAⁱ	MQGIKML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04AX
PhylomeDBⁱ	Q15025
TreeFamⁱ	TF351138

Family and domain databases

InterProⁱ	View protein in InterPro IPR033372 TNIP1
PANTHERⁱ	PTHR31882:SF3 PTHR31882:SF3, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q15025-1) [UniParc]FASTA Add to basket

Also known as: Alpha, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKA SGERYHVEPH PEHLCGAYPY 
       560        570        580        590        600
AYPPMPAMVP HHGFEDWSQI RYPPPPMAME HPPPLPNSRL FHLPEYTWRL 
       610        620        630 
PCGGVRNPNQ SSQVMDPPTA RPTEPESPKN DREGPQ

Length:636

Mass (Da):71,864

Last modified:August 1, 1999 - v2

Checksum:ⁱD81B96BEAD50D871

GO

Isoform 2 (identifier: Q15025-2) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
627-636: SPKNDREGPQ → PADLRLPRN

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKA SGERYHVEPH PEHLCGAYPY 
       560        570        580        590        600
AYPPMPAMVP HHGFEDWSQI RYPPPPMAME HPPPLPNSRL FHLPEYTWRL 
       610        620        630 
PCGGVRNPNQ SSQVMDPPTA RPTEPEPADL RLPRN

Show »

Length:635

Mass (Da):71,788

Checksum:ⁱFE65D2CE6E7B185B

GO

Isoform 3 (identifier: Q15025-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-53: Missing.

« Hide

        10         20         30         40         50
MEATRLRQKA EELVKDNELL PPPSPSLGSF DPLAELTGKD SNVTASPTAP 
        60         70         80         90        100
ACPSDKPAPV QKPPSSGTSS EFEVVTPEEQ NSPESSSHAN AMALGPLPRE 
       110        120        130        140        150
DGNLMLHLQR LETTLSVCAE EPDHGQLFTH LGRMALEFNR LASKVHKNEQ 
       160        170        180        190        200
RTSILQTLCE QLRKENEALK AKLDKGLEQR DQAAERLREE NLELKKLLMS 
       210        220        230        240        250
NGNKEGASGR PGSPKMEGTG KKAVAGQQQA SVTAGKVPEV VALGAAEKKV 
       260        270        280        290        300
KMLEQQRSEL LEVNKQWDQH FRSMKQQYEQ KITELRQKLA DLQKQVTDLE 
       310        320        330        340        350
AEREQKQRDF DRKLLLAKSK IEMEETDKEQ LTAEAKELRQ KVKYLQDQLS 
       360        370        380        390        400
PLTRQREYQE KEIQRLNKAL EEALSIQTPP SSPPTAFGSP EGAGALLRKQ 
       410        420        430        440        450
ELVTQNELLK QQVKIFEEDF QRERSDRERM NEEKEELKKQ VEKLQAQVTL 
       460        470        480        490        500
SNAQLKAFKD EEKAREALRQ QKRKAKASGE RYHVEPHPEH LCGAYPYAYP 
       510        520        530        540        550
PMPAMVPHHG FEDWSQIRYP PPPMAMEHPP PLPNSRLFHL PEYTWRLPCG 
       560        570        580 
GVRNPNQSSQ VMDPPTARPT EPESPKNDRE GPQ

Show »

Length:583

Mass (Da):66,012

Checksum:ⁱA97F0EB85F9F39DE

GO

Isoform 4 (identifier: Q15025-4) [UniParc]FASTA Add to basket

Also known as: Alpha2

The sequence of this isoform differs from the canonical sequence as follows:
530-593: Missing.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKP EYTWRLPCGG VRNPNQSSQV 
       560        570 
MDPPTARPTE PESPKNDREG PQ

Show »

Length:572

Mass (Da):64,500

Checksum:ⁱD1E76C1FBBA59E63

GO

Isoform 5 (identifier: Q15025-5) [UniParc]FASTA Add to basket

Also known as: Alpha4

The sequence of this isoform differs from the canonical sequence as follows:
530-556: ASGERYHVEPHPEHLCGAYPYAYPPMP → SLQKMTVRGLSETRLCHLAPPSSCRAS
557-636: Missing.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKS LQKMTVRGLS ETRLCHLAPP 

SSCRAS

Note: Less effective in the NF-kappa-B inhibitory effect.

Show »

Length:556

Mass (Da):62,609

Checksum:ⁱ757B3E9B83C35F42

GO

Isoform 6 (identifier: Q15025-6) [UniParc]FASTA Add to basket

Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
530-593: Missing.
627-636: SPKNDREGPQ → PADLRLPRN

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKP EYTWRLPCGG VRNPNQSSQV 
       560        570 
MDPPTARPTE PEPADLRLPR N

Show »

Length:571

Mass (Da):64,424

Checksum:ⁱ929F73D89B3D0A54

GO

Isoform 7 (identifier: Q15025-7) [UniParc]FASTA Add to basket

Also known as: Alpha3, Beta3

The sequence of this isoform differs from the canonical sequence as follows:
530-545: ASGERYHVEPHPEHLC → GTHRGCPRRLPERKVK
546-636: Missing.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540 
VTLSNAQLKA FKDEEKAREA LRQQKRKAKG THRGCPRRLP ERKVK

Show »

Length:545

Mass (Da):61,570

Checksum:ⁱ7F4AD5363F28608B

GO

Isoform 8 (identifier: Q15025-8) [UniParc]FASTA Add to basket

Also known as: Beta4

The sequence of this isoform differs from the canonical sequence as follows:
530-552: ASGERYHVEPHPEHLCGAYPYAY → SQLISDCQETRSHLHGVARASAG
553-636: Missing.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE 
        60         70         80         90        100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP 
       110        120        130        140        150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL 
       160        170        180        190        200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK 
       210        220        230        240        250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL 
       260        270        280        290        300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE 
       310        320        330        340        350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT 
       360        370        380        390        400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD 
       410        420        430        440        450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL 
       460        470        480        490        500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ 
       510        520        530        540        550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKS QLISDCQETR SHLHGVARAS 

AG

Show »

Length:552

Mass (Da):62,103

Checksum:ⁱ699AD04365381366

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MRZ4	A0A0A0MRZ4_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	619	Annotation score:
E7EW15	E7EW15_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	257	Annotation score:
H0YC17	H0YC17_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	146	Annotation score:
E7EMV7	E7EMV7_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	492	Annotation score:
E7EWG2	E7EWG2_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	133	Annotation score:
E7EW68	E7EW68_HUMAN	TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 1	TNIP1	143	Annotation score:

Sequence cautionⁱ

The sequence AAB41438 differs from that shown. Reason: Frameshift at positions 152 and 154.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	148	G → D in AAH12133 (PubMed:15489334).Curated	1
Sequence conflictⁱ	178	G → S in BAH13185 (PubMed:14702039).Curated	1
Sequence conflictⁱ	299	A → P in AAG42154 (PubMed:11090181).Curated	1
Sequence conflictⁱ	299	A → P in BAF34946 (PubMed:17016622).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_051453	103	P → S. Corresponds to variant dbSNP:rs2303018Ensembl.	1
Natural variantⁱVAR_051454	146	A → V. Corresponds to variant dbSNP:rs2233289Ensembl.	1
Natural variantⁱVAR_051455	151	P → A. Corresponds to variant dbSNP:rs2233290Ensembl.	1
Natural variantⁱVAR_051456	233	R → Q. Corresponds to variant dbSNP:rs2233292Ensembl.	1
Natural variantⁱVAR_051457	260	A → V. Corresponds to variant dbSNP:rs2233295Ensembl.	1
Natural variantⁱVAR_067965	263	R → W in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant dbSNP:rs117663772Ensembl.	1
Natural variantⁱVAR_067966	286	T → M in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs185683917Ensembl.	1
Natural variantⁱVAR_067967	374	I → T in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant dbSNP:rs748495842Ensembl.	1
Natural variantⁱVAR_067968	476	E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; loss of inhibitory activity on CARD11- and TNF-induced NF-kappa-B activation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045296	1 – 53	Missing in isoform 3. 3 PublicationsAdd BLAST	53
Alternative sequenceⁱVSP_055208	530 – 593	Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST	64
Alternative sequenceⁱVSP_055209	530 – 556	ASGER…YPPMP → SLQKMTVRGLSETRLCHLAP PSSCRAS in isoform 5. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_055210	530 – 552	ASGER…YPYAY → SQLISDCQETRSHLHGVARA SAG in isoform 8. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_055211	530 – 545	ASGER…PEHLC → GTHRGCPRRLPERKVK in isoform 7. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_055212	546 – 636	Missing in isoform 7. 1 PublicationAdd BLAST	91
Alternative sequenceⁱVSP_055213	553 – 636	Missing in isoform 8. 1 PublicationAdd BLAST	84
Alternative sequenceⁱVSP_055214	557 – 636	Missing in isoform 5. 1 PublicationAdd BLAST	80
Alternative sequenceⁱVSP_003913	627 – 636	SPKNDREGPQ → PADLRLPRN in isoform 2 and isoform 6. 3 Publications	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011895 mRNA Translation: CAA09855.1 AJ011896 mRNA Translation: CAA09856.1 AY012155 mRNA Translation: AAG42154.1 AB177543 mRNA Translation: BAF34946.1 AB177544 mRNA Translation: BAF34947.1 AB252970 mRNA Translation: BAF48787.1 AB252971 mRNA Translation: BAF48788.1 AB252972 mRNA Translation: BAF48789.1 AB252973 mRNA Translation: BAF48790.1 AB252974 mRNA Translation: BAF48791.1 AB252975 mRNA Translation: BAF48792.1 AB252976 mRNA Translation: BAF48793.1 AB252977 mRNA Translation: BAF48794.1 AB252978 mRNA Translation: BAF48795.1 AB252979 mRNA Translation: BAF48796.1 AB252980 mRNA Translation: BAF48797.1 AB252981 mRNA Translation: BAF48798.1 D30755 mRNA Translation: BAA06416.2 AK299975 mRNA Translation: BAH13185.1 BX640647 mRNA Translation: CAE45793.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61688.1 CH471062 Genomic DNA Translation: EAW61689.1 CH471062 Genomic DNA Translation: EAW61690.1 CH471062 Genomic DNA Translation: EAW61691.1 BC012133 mRNA Translation: AAH12133.1 BC014008 mRNA Translation: AAH14008.1 U39403 mRNA Translation: AAC99999.1 U83844 mRNA Translation: AAB41438.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34280.1 [Q15025-1] CCDS58982.1 [Q15025-3] CCDS58983.1 [Q15025-5] CCDS58984.1 [Q15025-4] CCDS58985.1 [Q15025-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001239314.1, NM_001252385.1 NP_001239315.1, NM_001252386.1 [Q15025-3] NP_001239319.1, NM_001252390.1 [Q15025-1] NP_001239320.1, NM_001252391.1 [Q15025-1] NP_001239321.1, NM_001252392.1 [Q15025-2] NP_001239322.1, NM_001252393.1 [Q15025-2] NP_001245383.1, NM_001258454.1 [Q15025-1] NP_001245384.1, NM_001258455.1 [Q15025-4] NP_001245385.1, NM_001258456.1 [Q15025-5] NP_006049.3, NM_006058.4 [Q15025-1] XP_006714814.1, XM_006714751.1 [Q15025-4] XP_006714815.1, XM_006714752.2 [Q15025-6]
UniGeneⁱ	Hs.355141 Hs.731557

Genome annotation databases

Ensemblⁱ	ENST00000315050; ENSP00000317891; ENSG00000145901 [Q15025-1] ENST00000518977; ENSP00000430971; ENSG00000145901 [Q15025-2] ENST00000520931; ENSP00000429891; ENSG00000145901 [Q15025-3] ENST00000521591; ENSP00000430760; ENSG00000145901 [Q15025-1] ENST00000522226; ENSP00000428187; ENSG00000145901 [Q15025-1] ENST00000523200; ENSP00000431105; ENSG00000145901 [Q15025-4] ENST00000523338; ENSP00000428243; ENSG00000145901 [Q15025-2] ENST00000524280; ENSP00000429912; ENSG00000145901 [Q15025-5] ENST00000610535; ENSP00000483944; ENSG00000145901 [Q15025-4] ENST00000610874; ENSP00000484665; ENSG00000145901 [Q15025-5]
GeneIDⁱ	10318
KEGGⁱ	hsa:10318
UCSC genome browser More...UCSCⁱ	uc003ltg.5 human [Q15025-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q15025	cDNA FLJ51936, highly similar to Nef-associated factor 1		HUMAN		598	UniRef100_Q15025
Isoform 3 of TNFAIP3-interacting protein 1		HUMAN		583

Protein	Similar proteins		Species	Score	Length	Source
Q15025	cDNA FLJ51936, highly similar to Nef-associated factor 1		HUMAN		598	UniRef90_Q15025
Uncharacterized protein		PAPAN		684
Uncharacterized protein		Cebus capucinus imitator		660
TNFAIP3 interacting protein 1		PANTR		645
Uncharacterized protein		PANPA		645
+154
Q15025-5	Uncharacterized protein		MANLE		557	UniRef90_Q15025-5
Uncharacterized protein		COLAP		557
Uncharacterized protein		CERAT		557
Uncharacterized protein		MACNE		557
TNFAIP3 interacting protein 1		SAIBB		557
+16
Q15025-7	Isoform 5 of TNFAIP3-interacting protein 1		HUMAN		556	UniRef90_Q15025-5
Uncharacterized protein		MANLE		557
Uncharacterized protein		COLAP		557
Uncharacterized protein		CERAT		557
Uncharacterized protein		MACNE		557
+16
Q15025-8	Isoform 5 of TNFAIP3-interacting protein 1		HUMAN		556	UniRef90_Q15025-5
Uncharacterized protein		MANLE		557
Uncharacterized protein		COLAP		557
Uncharacterized protein		CERAT		557
Uncharacterized protein		MACNE		557
+16

Protein	Similar proteins		Species	Score	Length	Source
Q15025	cDNA FLJ51936, highly similar to Nef-associated factor 1		HUMAN		598	UniRef50_Q15025
Uncharacterized protein		PAPAN		684
Uncharacterized protein		Cebus capucinus imitator		660
Uncharacterized protein		PANPA		645
TNFAIP3 interacting protein 1		PANTR		645
+263

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011895 mRNA Translation: CAA09855.1 AJ011896 mRNA Translation: CAA09856.1 AY012155 mRNA Translation: AAG42154.1 AB177543 mRNA Translation: BAF34946.1 AB177544 mRNA Translation: BAF34947.1 AB252970 mRNA Translation: BAF48787.1 AB252971 mRNA Translation: BAF48788.1 AB252972 mRNA Translation: BAF48789.1 AB252973 mRNA Translation: BAF48790.1 AB252974 mRNA Translation: BAF48791.1 AB252975 mRNA Translation: BAF48792.1 AB252976 mRNA Translation: BAF48793.1 AB252977 mRNA Translation: BAF48794.1 AB252978 mRNA Translation: BAF48795.1 AB252979 mRNA Translation: BAF48796.1 AB252980 mRNA Translation: BAF48797.1 AB252981 mRNA Translation: BAF48798.1 D30755 mRNA Translation: BAA06416.2 AK299975 mRNA Translation: BAH13185.1 BX640647 mRNA Translation: CAE45793.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61688.1 CH471062 Genomic DNA Translation: EAW61689.1 CH471062 Genomic DNA Translation: EAW61690.1 CH471062 Genomic DNA Translation: EAW61691.1 BC012133 mRNA Translation: AAH12133.1 BC014008 mRNA Translation: AAH14008.1 U39403 mRNA Translation: AAC99999.1 U83844 mRNA Translation: AAB41438.1 Frameshift.
CCDSⁱ	CCDS34280.1 [Q15025-1] CCDS58982.1 [Q15025-3] CCDS58983.1 [Q15025-5] CCDS58984.1 [Q15025-4] CCDS58985.1 [Q15025-2]
RefSeqⁱ	NP_001239314.1, NM_001252385.1 NP_001239315.1, NM_001252386.1 [Q15025-3] NP_001239319.1, NM_001252390.1 [Q15025-1] NP_001239320.1, NM_001252391.1 [Q15025-1] NP_001239321.1, NM_001252392.1 [Q15025-2] NP_001239322.1, NM_001252393.1 [Q15025-2] NP_001245383.1, NM_001258454.1 [Q15025-1] NP_001245384.1, NM_001258455.1 [Q15025-4] NP_001245385.1, NM_001258456.1 [Q15025-5] NP_006049.3, NM_006058.4 [Q15025-1] XP_006714814.1, XM_006714751.1 [Q15025-4] XP_006714815.1, XM_006714752.2 [Q15025-6]
UniGeneⁱ	Hs.355141 Hs.731557

3D structure databases

ProteinModelPortalⁱ	Q15025
SMRⁱ	Q15025
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115602, 110 interactors
CORUMⁱ	Q15025
DIPⁱ	DIP-27577N
IntActⁱ	Q15025, 104 interactors
MINTⁱ	Q15025
STRINGⁱ	9606.ENSP00000317891

PTM databases

iPTMnetⁱ	Q15025
PhosphoSitePlusⁱ	Q15025

Polymorphism and mutation databases

BioMutaⁱ	TNIP1
DMDMⁱ	20138952

Proteomic databases

EPDⁱ	Q15025
MaxQBⁱ	Q15025
PaxDbⁱ	Q15025
PeptideAtlasⁱ	Q15025
PRIDEⁱ	Q15025
ProteomicsDBⁱ	60376 60377 [Q15025-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10318
Structural Biology Knowledgebase	Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	10318
DisGeNETⁱ	10318
EuPathDBⁱ	HostDB:ENSG00000145901.14
GeneCardsⁱ	TNIP1
HGNCⁱ	HGNC:16903 TNIP1
HPAⁱ	HPA037893 HPA037894 HPA071950
MIMⁱ	607714 gene
neXtProtⁱ	NX_Q15025
OpenTargetsⁱ	ENSG00000145901
Orphanetⁱ	536 Systemic lupus erythematosus
PharmGKBⁱ	PA128394573
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEGE Eukaryota ENOG411180D LUCA
GeneTreeⁱ	ENSGT00510000046908
HOGENOMⁱ	HOG000253048
HOVERGENⁱ	HBG019072
InParanoidⁱ	Q15025
OMAⁱ	MQGIKML
OrthoDBⁱ	EOG091G04AX
PhylomeDBⁱ	Q15025
TreeFamⁱ	TF351138

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5689896 Ovarian tumor domain proteases

Reactomeⁱ

R-HSA-5689896 Ovarian tumor domain proteases

Miscellaneous databases

ChiTaRSⁱ	TNIP1 human
GeneWikiⁱ	TNIP1
GenomeRNAiⁱ	10318
Protein Ontology More...PROⁱ	PR:Q15025
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145901 Expressed in 236 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_NAF1 HS_TNIP1
ExpressionAtlasⁱ	Q15025 baseline and differential
Genevisibleⁱ	Q15025 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033372 TNIP1
PANTHERⁱ	PTHR31882:SF3 PTHR31882:SF3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNIP1_HUMAN
Accessionⁱ	Q15025Primary (citable) accession number: Q15025 Secondary accession number(s): A4F1W8 Q9H1J3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	August 1, 1999
	Last modified:	September 12, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q15025 (TNIP1_HUMAN)

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TNFAIP3-interacting protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

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Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ