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Entry version 177 (13 Feb 2019)
Sequence version 2 (01 Aug 1999)
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Protein

TNFAIP3-interacting protein 1

Gene

TNIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689896 Ovarian tumor domain proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TNFAIP3-interacting protein 1
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 1
Short name:
ABIN-1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Short name:
Naf1
Nip40-1
Virion-associated nuclear shuttling protein
Short name:
VAN
Short name:
hVAN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNIP1
Synonyms:KIAA0113, NAF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145901.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16903 TNIP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607714 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15025

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi472D → N: Abolishes binding to polyubiquitin ('K-63'-linked and linear). 1 Publication1
Mutagenesisi552Y → F: Abolishes interaction with PI3K p85 regulatory subunit and abolishes interaction between SELPLG and PI3K p85 regulatory subunit. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10318

Open Targets

More...
OpenTargetsi
ENSG00000145901

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394573

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138952

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966911 – 636TNFAIP3-interacting protein 1Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei438PhosphothreonineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei552Phosphotyrosine1 Publication1
Modified residuei571Asymmetric dimethylarginineBy similarity1
Modified residuei599Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei599Omega-N-methylarginine; alternateCombined sources1
Modified residuei627PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15025

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15025

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15025

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15025

PeptideAtlas

More...
PeptideAtlasi
Q15025

PRoteomics IDEntifications database

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PRIDEi
Q15025

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60376
60377 [Q15025-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15025

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15025

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145901 Expressed in 236 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15025 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15025 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037893
HPA037894
HPA071950

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115602, 112 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15025

Database of interacting proteins

More...
DIPi
DIP-27577N

Protein interaction database and analysis system

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IntActi
Q15025, 147 interactors

Molecular INTeraction database

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MINTi
Q15025

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317891

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15025

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15025

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 412Interaction with NefAdd BLAST319
Regioni351 – 367Interaction with Shigella flexneri ipah9.8Add BLAST17
Regioni431 – 588Required for inhibitory activity of TNF-induced NF-kappa-B activationBy similarityAdd BLAST158
Regioni452 – 510Ubiquitin-binding domain (UBD)Add BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili20 – 73Sequence analysisAdd BLAST54
Coiled coili196 – 258Sequence analysisAdd BLAST63
Coiled coili294 – 535Sequence analysisAdd BLAST242

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi524 – 530Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi539 – 636Pro-richAdd BLAST98

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEGE Eukaryota
ENOG411180D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000046908

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253048

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG019072

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15025

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKNDREG

Database of Orthologous Groups

More...
OrthoDBi
701614at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15025

TreeFam database of animal gene trees

More...
TreeFami
TF351138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033372 TNIP1

The PANTHER Classification System

More...
PANTHERi
PTHR31882:SF3 PTHR31882:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15025-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE
60 70 80 90 100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP
110 120 130 140 150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL
160 170 180 190 200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK
210 220 230 240 250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL
260 270 280 290 300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE
310 320 330 340 350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT
360 370 380 390 400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD
410 420 430 440 450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL
460 470 480 490 500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ
510 520 530 540 550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKA SGERYHVEPH PEHLCGAYPY
560 570 580 590 600
AYPPMPAMVP HHGFEDWSQI RYPPPPMAME HPPPLPNSRL FHLPEYTWRL
610 620 630
PCGGVRNPNQ SSQVMDPPTA RPTEPESPKN DREGPQ
Length:636
Mass (Da):71,864
Last modified:August 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD81B96BEAD50D871
GO
Isoform 2 (identifier: Q15025-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     627-636: SPKNDREGPQ → PADLRLPRN

Show »
Length:635
Mass (Da):71,788
Checksum:iFE65D2CE6E7B185B
GO
Isoform 3 (identifier: Q15025-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:583
Mass (Da):66,012
Checksum:iA97F0EB85F9F39DE
GO
Isoform 4 (identifier: Q15025-4) [UniParc]FASTAAdd to basket
Also known as: Alpha2

The sequence of this isoform differs from the canonical sequence as follows:
     530-593: Missing.

Show »
Length:572
Mass (Da):64,500
Checksum:iD1E76C1FBBA59E63
GO
Isoform 5 (identifier: Q15025-5) [UniParc]FASTAAdd to basket
Also known as: Alpha4

The sequence of this isoform differs from the canonical sequence as follows:
     530-556: ASGERYHVEPHPEHLCGAYPYAYPPMP → SLQKMTVRGLSETRLCHLAPPSSCRAS
     557-636: Missing.

Note: Less effective in the NF-kappa-B inhibitory effect.
Show »
Length:556
Mass (Da):62,609
Checksum:i757B3E9B83C35F42
GO
Isoform 6 (identifier: Q15025-6) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     530-593: Missing.
     627-636: SPKNDREGPQ → PADLRLPRN

Show »
Length:571
Mass (Da):64,424
Checksum:i929F73D89B3D0A54
GO
Isoform 7 (identifier: Q15025-7) [UniParc]FASTAAdd to basket
Also known as: Alpha3, Beta3

The sequence of this isoform differs from the canonical sequence as follows:
     530-545: ASGERYHVEPHPEHLC → GTHRGCPRRLPERKVK
     546-636: Missing.

Show »
Length:545
Mass (Da):61,570
Checksum:i7F4AD5363F28608B
GO
Isoform 8 (identifier: Q15025-8) [UniParc]FASTAAdd to basket
Also known as: Beta4

The sequence of this isoform differs from the canonical sequence as follows:
     530-552: ASGERYHVEPHPEHLCGAYPYAY → SQLISDCQETRSHLHGVARASAG
     553-636: Missing.

Show »
Length:552
Mass (Da):62,103
Checksum:i699AD04365381366
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRZ4A0A0A0MRZ4_HUMAN
TNFAIP3-interacting protein 1
TNIP1
619Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW15E7EW15_HUMAN
TNFAIP3-interacting protein 1
TNIP1
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMV7E7EMV7_HUMAN
TNFAIP3-interacting protein 1
TNIP1
492Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC17H0YC17_HUMAN
TNFAIP3-interacting protein 1
TNIP1
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWG2E7EWG2_HUMAN
TNFAIP3-interacting protein 1
TNIP1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW68E7EW68_HUMAN
TNFAIP3-interacting protein 1
TNIP1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB41438 differs from that shown. Reason: Frameshift at positions 152 and 154.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti148G → D in AAH12133 (PubMed:15489334).Curated1
Sequence conflicti178G → S in BAH13185 (PubMed:14702039).Curated1
Sequence conflicti299A → P in AAG42154 (PubMed:11090181).Curated1
Sequence conflicti299A → P in BAF34946 (PubMed:17016622).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051453103P → S. Corresponds to variant dbSNP:rs2303018Ensembl.1
Natural variantiVAR_051454146A → V. Corresponds to variant dbSNP:rs2233289Ensembl.1
Natural variantiVAR_051455151P → A. Corresponds to variant dbSNP:rs2233290Ensembl.1
Natural variantiVAR_051456233R → Q. Corresponds to variant dbSNP:rs2233292Ensembl.1
Natural variantiVAR_051457260A → V. Corresponds to variant dbSNP:rs2233295Ensembl.1
Natural variantiVAR_067965263R → W in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant dbSNP:rs117663772Ensembl.1
Natural variantiVAR_067966286T → M in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs185683917Ensembl.1
Natural variantiVAR_067967374I → T in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant dbSNP:rs748495842Ensembl.1
Natural variantiVAR_067968476E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; loss of inhibitory activity on CARD11- and TNF-induced NF-kappa-B activation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452961 – 53Missing in isoform 3. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_055208530 – 593Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_055209530 – 556ASGER…YPPMP → SLQKMTVRGLSETRLCHLAP PSSCRAS in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_055210530 – 552ASGER…YPYAY → SQLISDCQETRSHLHGVARA SAG in isoform 8. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_055211530 – 545ASGER…PEHLC → GTHRGCPRRLPERKVK in isoform 7. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055212546 – 636Missing in isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_055213553 – 636Missing in isoform 8. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_055214557 – 636Missing in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_003913627 – 636SPKNDREGPQ → PADLRLPRN in isoform 2 and isoform 6. 3 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ011895 mRNA Translation: CAA09855.1
AJ011896 mRNA Translation: CAA09856.1
AY012155 mRNA Translation: AAG42154.1
AB177543 mRNA Translation: BAF34946.1
AB177544 mRNA Translation: BAF34947.1
AB252970 mRNA Translation: BAF48787.1
AB252971 mRNA Translation: BAF48788.1
AB252972 mRNA Translation: BAF48789.1
AB252973 mRNA Translation: BAF48790.1
AB252974 mRNA Translation: BAF48791.1
AB252975 mRNA Translation: BAF48792.1
AB252976 mRNA Translation: BAF48793.1
AB252977 mRNA Translation: BAF48794.1
AB252978 mRNA Translation: BAF48795.1
AB252979 mRNA Translation: BAF48796.1
AB252980 mRNA Translation: BAF48797.1
AB252981 mRNA Translation: BAF48798.1
D30755 mRNA Translation: BAA06416.2
AK299975 mRNA Translation: BAH13185.1
BX640647 mRNA Translation: CAE45793.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61688.1
CH471062 Genomic DNA Translation: EAW61689.1
CH471062 Genomic DNA Translation: EAW61690.1
CH471062 Genomic DNA Translation: EAW61691.1
BC012133 mRNA Translation: AAH12133.1
BC014008 mRNA Translation: AAH14008.1
U39403 mRNA Translation: AAC99999.1
U83844 mRNA Translation: AAB41438.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34280.1 [Q15025-1]
CCDS58982.1 [Q15025-3]
CCDS58983.1 [Q15025-5]
CCDS58984.1 [Q15025-4]
CCDS58985.1 [Q15025-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001239314.1, NM_001252385.1
NP_001239315.1, NM_001252386.1 [Q15025-3]
NP_001239319.1, NM_001252390.1 [Q15025-1]
NP_001239320.1, NM_001252391.1 [Q15025-1]
NP_001239321.1, NM_001252392.1 [Q15025-2]
NP_001239322.1, NM_001252393.1 [Q15025-2]
NP_001245383.1, NM_001258454.1 [Q15025-1]
NP_001245384.1, NM_001258455.1 [Q15025-4]
NP_001245385.1, NM_001258456.1 [Q15025-5]
NP_006049.3, NM_006058.4 [Q15025-1]
XP_006714814.1, XM_006714751.1
XP_006714815.1, XM_006714752.2 [Q15025-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.355141
Hs.731557

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315050; ENSP00000317891; ENSG00000145901 [Q15025-1]
ENST00000518977; ENSP00000430971; ENSG00000145901 [Q15025-2]
ENST00000520931; ENSP00000429891; ENSG00000145901 [Q15025-3]
ENST00000521591; ENSP00000430760; ENSG00000145901 [Q15025-1]
ENST00000522226; ENSP00000428187; ENSG00000145901 [Q15025-1]
ENST00000523200; ENSP00000431105; ENSG00000145901 [Q15025-4]
ENST00000523338; ENSP00000428243; ENSG00000145901 [Q15025-2]
ENST00000524280; ENSP00000429912; ENSG00000145901 [Q15025-5]
ENST00000610535; ENSP00000483944; ENSG00000145901 [Q15025-4]
ENST00000610874; ENSP00000484665; ENSG00000145901 [Q15025-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10318

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10318

UCSC genome browser

More...
UCSCi
uc003ltg.5 human [Q15025-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011895 mRNA Translation: CAA09855.1
AJ011896 mRNA Translation: CAA09856.1
AY012155 mRNA Translation: AAG42154.1
AB177543 mRNA Translation: BAF34946.1
AB177544 mRNA Translation: BAF34947.1
AB252970 mRNA Translation: BAF48787.1
AB252971 mRNA Translation: BAF48788.1
AB252972 mRNA Translation: BAF48789.1
AB252973 mRNA Translation: BAF48790.1
AB252974 mRNA Translation: BAF48791.1
AB252975 mRNA Translation: BAF48792.1
AB252976 mRNA Translation: BAF48793.1
AB252977 mRNA Translation: BAF48794.1
AB252978 mRNA Translation: BAF48795.1
AB252979 mRNA Translation: BAF48796.1
AB252980 mRNA Translation: BAF48797.1
AB252981 mRNA Translation: BAF48798.1
D30755 mRNA Translation: BAA06416.2
AK299975 mRNA Translation: BAH13185.1
BX640647 mRNA Translation: CAE45793.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61688.1
CH471062 Genomic DNA Translation: EAW61689.1
CH471062 Genomic DNA Translation: EAW61690.1
CH471062 Genomic DNA Translation: EAW61691.1
BC012133 mRNA Translation: AAH12133.1
BC014008 mRNA Translation: AAH14008.1
U39403 mRNA Translation: AAC99999.1
U83844 mRNA Translation: AAB41438.1 Frameshift.
CCDSiCCDS34280.1 [Q15025-1]
CCDS58982.1 [Q15025-3]
CCDS58983.1 [Q15025-5]
CCDS58984.1 [Q15025-4]
CCDS58985.1 [Q15025-2]
RefSeqiNP_001239314.1, NM_001252385.1
NP_001239315.1, NM_001252386.1 [Q15025-3]
NP_001239319.1, NM_001252390.1 [Q15025-1]
NP_001239320.1, NM_001252391.1 [Q15025-1]
NP_001239321.1, NM_001252392.1 [Q15025-2]
NP_001239322.1, NM_001252393.1 [Q15025-2]
NP_001245383.1, NM_001258454.1 [Q15025-1]
NP_001245384.1, NM_001258455.1 [Q15025-4]
NP_001245385.1, NM_001258456.1 [Q15025-5]
NP_006049.3, NM_006058.4 [Q15025-1]
XP_006714814.1, XM_006714751.1
XP_006714815.1, XM_006714752.2 [Q15025-6]
UniGeneiHs.355141
Hs.731557

3D structure databases

ProteinModelPortaliQ15025
SMRiQ15025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115602, 112 interactors
CORUMiQ15025
DIPiDIP-27577N
IntActiQ15025, 147 interactors
MINTiQ15025
STRINGi9606.ENSP00000317891

PTM databases

iPTMnetiQ15025
PhosphoSitePlusiQ15025

Polymorphism and mutation databases

BioMutaiTNIP1
DMDMi20138952

Proteomic databases

EPDiQ15025
jPOSTiQ15025
MaxQBiQ15025
PaxDbiQ15025
PeptideAtlasiQ15025
PRIDEiQ15025
ProteomicsDBi60376
60377 [Q15025-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10318
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315050; ENSP00000317891; ENSG00000145901 [Q15025-1]
ENST00000518977; ENSP00000430971; ENSG00000145901 [Q15025-2]
ENST00000520931; ENSP00000429891; ENSG00000145901 [Q15025-3]
ENST00000521591; ENSP00000430760; ENSG00000145901 [Q15025-1]
ENST00000522226; ENSP00000428187; ENSG00000145901 [Q15025-1]
ENST00000523200; ENSP00000431105; ENSG00000145901 [Q15025-4]
ENST00000523338; ENSP00000428243; ENSG00000145901 [Q15025-2]
ENST00000524280; ENSP00000429912; ENSG00000145901 [Q15025-5]
ENST00000610535; ENSP00000483944; ENSG00000145901 [Q15025-4]
ENST00000610874; ENSP00000484665; ENSG00000145901 [Q15025-5]
GeneIDi10318
KEGGihsa:10318
UCSCiuc003ltg.5 human [Q15025-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10318
DisGeNETi10318
EuPathDBiHostDB:ENSG00000145901.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNIP1
HGNCiHGNC:16903 TNIP1
HPAiHPA037893
HPA037894
HPA071950
MIMi607714 gene
neXtProtiNX_Q15025
OpenTargetsiENSG00000145901
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA128394573

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEGE Eukaryota
ENOG411180D LUCA
GeneTreeiENSGT00510000046908
HOGENOMiHOG000253048
HOVERGENiHBG019072
InParanoidiQ15025
OMAiTKNDREG
OrthoDBi701614at2759
PhylomeDBiQ15025
TreeFamiTF351138

Enzyme and pathway databases

ReactomeiR-HSA-5689896 Ovarian tumor domain proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNIP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10318

Protein Ontology

More...
PROi
PR:Q15025

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145901 Expressed in 236 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ15025 baseline and differential
GenevisibleiQ15025 HS

Family and domain databases

InterProiView protein in InterPro
IPR033372 TNIP1
PANTHERiPTHR31882:SF3 PTHR31882:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15025
Secondary accession number(s): A4F1W8
, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q6N077, Q96EL9, Q99833, Q9H1J3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1999
Last modified: February 13, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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