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Protein

Condensin complex subunit 1

Gene

NCAPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).2 Publications

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 1
Alternative name(s):
Chromosome condensation-related SMC-associated protein 1
Chromosome-associated protein D2
Short name:
hCAP-D2
Non-SMC condensin I complex subunit D2
XCAP-D2 homolog
Gene namesi
Name:NCAPD21 PublicationImported
Synonyms:CAPD2, CNAP1, KIAA0159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000010292.12
HGNCiHGNC:24305 NCAPD2
MIMi615638 gene
neXtProtiNX_Q15021

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Microcephaly 21, primary, autosomal recessive (MCPH21)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH21 features include mild intellectual disability, intrauterine growth retardation, short stature, and microcephaly.
See also OMIM:617983
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0809538F → S in MCPH21; found in two patients from a consanguineous family; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1343 – 1348RRTTRR → AATTAA: Abolishes localization to the nucleus, while it only reduces chromosome binding. 1 Publication6
Mutagenesisi1358 – 1360KKK → AAA: Abolishes localization to the nucleus, while it only reduces chromosome binding. 1 Publication3

Keywords - Diseasei

Disease mutation, Primary microcephaly

Organism-specific databases

DisGeNETi9918
MalaCardsiNCAPD2
MIMi617983 phenotype
OpenTargetsiENSG00000010292
PharmGKBiPA162397021

Polymorphism and mutation databases

BioMutaiNCAPD2
DMDMi259016362

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950351 – 1401Condensin complex subunit 1Add BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1315PhosphoserineCombined sources1
Modified residuei1330PhosphoserineCombined sources1
Modified residuei1331PhosphothreonineCombined sources1
Modified residuei1333PhosphoserineCombined sources1
Modified residuei1339PhosphothreonineCombined sources1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1370PhosphoserineCombined sources1
Modified residuei1371PhosphoserineCombined sources1
Modified residuei1376PhosphoserineCombined sources1
Modified residuei1384Phosphothreonine; by CDK1By similarity1
Modified residuei1389Phosphothreonine; by CDK1By similarity1
Modified residuei1395PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15021
MaxQBiQ15021
PaxDbiQ15021
PeptideAtlasiQ15021
PRIDEiQ15021
ProteomicsDBi60373

PTM databases

iPTMnetiQ15021
PhosphoSitePlusiQ15021

Expressioni

Gene expression databases

BgeeiENSG00000010292 Expressed in 167 organ(s), highest expression level in lung
CleanExiHS_NCAPD2
ExpressionAtlasiQ15021 baseline and differential
GenevisibleiQ15021 HS

Organism-specific databases

HPAiCAB012423
HPA036947
HPA037363

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCAPHQ150034EBI-1044041,EBI-1046410

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115246, 69 interactors
ComplexPortaliCPX-979 Condensin I complex
CORUMiQ15021
IntActiQ15021, 17 interactors
MINTiQ15021
STRINGi9606.ENSP00000325017

Structurei

3D structure databases

ProteinModelPortaliQ15021
SMRiQ15021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 603Interactions with SMC2 and SMC4Add BLAST603

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1342 – 1362Bipartite nuclear localization signalAdd BLAST21

Domaini

The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.

Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.Curated

Phylogenomic databases

eggNOGiKOG0414 Eukaryota
COG5098 LUCA
GeneTreeiENSGT00390000017108
HOGENOMiHOG000068001
HOVERGENiHBG038048
InParanoidiQ15021
KOiK06677
OMAiVCHAIAN
OrthoDBiEOG091G00PU
PhylomeDBiQ15021
TreeFamiTF105712

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q15021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA
60 70 80 90 100
QGPLAMLQHF DTIYSILHHF RSIDPGLKED TLQFLIKVVS RHSQELPAIL
110 120 130 140 150
DDTTLSGSDR NAHLNALKMN CYALIRLLES FETMASQTNL VDLDLGGKGK
160 170 180 190 200
KARTKAAHGF DWEEERQPIL QLLTQLLQLD IRHLWNHSII EEEFVSLVTG
210 220 230 240 250
CCYRLLENPT INHQKNRPTR EAITHLLGVA LTRYNHMLSA TVKIIQMLQH
260 270 280 290 300
FEHLAPVLVA AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDPSGTKGF
310 320 330 340 350
AAFLTELAER VPAILMSSMC ILLDHLDGEN YMMRNAVLAA MAEMVLQVLS
360 370 380 390 400
GDQLEAAARD TRDQFLDTLQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT
410 420 430 440 450
RFQAVVALAV GRLADKSVLV CKNAIQLLAS FLANNPFSCK LSDADLAGPL
460 470 480 490 500
QKETQKLQEM RAQRRTAAAS AVLDPEEEWE AMLPELKSTL QQLLQLPQGE
510 520 530 540 550
EEIPEQIANT ETTEDVKGRI YQLLAKASYK KAIILTREAT GHFQESEPFS
560 570 580 590 600
HIDPEESEET RLLNILGLIF KGPAASTQEK NPRESTGNMV TGQTVCKNKP
610 620 630 640 650
NMSDPEESRG NDELVKQEML VQYLQDAYSF SRKITEAIGI ISKMMYENTT
660 670 680 690 700
TVVQEVIEFF VMVFQFGVPQ ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL
710 720 730 740 750
YLNPKGDSAR AKAQALIQNL SLLLVDASVG TIQCLEEILC EFVQKDELKP
760 770 780 790 800
AVTQLLWERA TEKVACCPLE RCSSVMLLGM MARGKPEIVG SNLDTLVSIG
810 820 830 840 850
LDEKFPQDYR LAQQVCHAIA NISDRRKPSL GKRHPPFRLP QEHRLFERLR
860 870 880 890 900
ETVTKGFVHP DPLWIPFKEV AVTLIYQLAE GPEVICAQIL QGCAKQALEK
910 920 930 940 950
LEEKRTSQED PKESPAMLPT FLLMNLLSLA GDVALQQLVH LEQAVSGELC
960 970 980 990 1000
RRRVLREEQE HKTKDPKEKN TSSETTMEEE LGLVGATADD TEAELIRGIC
1010 1020 1030 1040 1050
EMELLDGKQT LAAFVPLLLK VCNNPGLYSN PDLSAAASLA LGKFCMISAT
1060 1070 1080 1090 1100
FCDSQLRLLF TMLEKSPLPI VRSNLMVATG DLAIRFPNLV DPWTPHLYAR
1110 1120 1130 1140 1150
LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PEPQIAALAK
1160 1170 1180 1190 1200
NFFNELSHKG NAIYNLLPDI ISRLSDPELG VEEEPFHTIM KQLLSYITKD
1210 1220 1230 1240 1250
KQTESLVEKL CQRFRTSRTE RQQRDLAYCV SQLPLTERGL RKMLDNFDCF
1260 1270 1280 1290 1300
GDKLSDESIF SAFLSVVGKL RRGAKPEGKA IIDEFEQKLR ACHTRGLDGI
1310 1320 1330 1340 1350
KELEIGQAGS QRAPSAKKPS TGSRYQPLAS TASDNDFVTP EPRRTTRRHP
1360 1370 1380 1390 1400
NTQQRASKKK PKVVFSSDES SEEDLSAEMT EDETPKKTTP ILRASARRHR

S
Length:1,401
Mass (Da):157,182
Last modified:September 22, 2009 - v3
Checksum:i35E31642B94B513D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EN77E7EN77_HUMAN
Condensin complex subunit 1
NCAPD2
919Annotation score:
F5GZK7F5GZK7_HUMAN
Condensin complex subunit 1
NCAPD2
118Annotation score:
F5H431F5H431_HUMAN
Condensin complex subunit 1
NCAPD2
81Annotation score:

Sequence cautioni

The sequence BAA09930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1062M → I in BAA09930 (PubMed:8590280).Curated1
Sequence conflicti1218R → L in BAA09930 (PubMed:8590280).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0809538F → S in MCPH21; found in two patients from a consanguineous family; unknown pathological significance. 1 Publication1
Natural variantiVAR_02442183Q → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs714774Ensembl.1
Natural variantiVAR_057511580K → R. Corresponds to variant dbSNP:rs17725914Ensembl.1
Natural variantiVAR_024422797V → M. Corresponds to variant dbSNP:rs10849482Ensembl.1
Natural variantiVAR_0587131321T → S1 PublicationCorresponds to variant dbSNP:rs2240871Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63880 mRNA Translation: BAA09930.2 Different initiation.
AC006064 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88788.1
CH471116 Genomic DNA Translation: EAW88789.1
BC028182 mRNA Translation: AAH28182.1
CCDSiCCDS8548.1
RefSeqiNP_055680.3, NM_014865.3
UniGeneiHs.5719

Genome annotation databases

EnsembliENST00000315579; ENSP00000325017; ENSG00000010292
GeneIDi9918
KEGGihsa:9918
UCSCiuc001qoo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63880 mRNA Translation: BAA09930.2 Different initiation.
AC006064 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88788.1
CH471116 Genomic DNA Translation: EAW88789.1
BC028182 mRNA Translation: AAH28182.1
CCDSiCCDS8548.1
RefSeqiNP_055680.3, NM_014865.3
UniGeneiHs.5719

3D structure databases

ProteinModelPortaliQ15021
SMRiQ15021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115246, 69 interactors
ComplexPortaliCPX-979 Condensin I complex
CORUMiQ15021
IntActiQ15021, 17 interactors
MINTiQ15021
STRINGi9606.ENSP00000325017

PTM databases

iPTMnetiQ15021
PhosphoSitePlusiQ15021

Polymorphism and mutation databases

BioMutaiNCAPD2
DMDMi259016362

Proteomic databases

EPDiQ15021
MaxQBiQ15021
PaxDbiQ15021
PeptideAtlasiQ15021
PRIDEiQ15021
ProteomicsDBi60373

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315579; ENSP00000325017; ENSG00000010292
GeneIDi9918
KEGGihsa:9918
UCSCiuc001qoo.3 human

Organism-specific databases

CTDi9918
DisGeNETi9918
EuPathDBiHostDB:ENSG00000010292.12
GeneCardsiNCAPD2
H-InvDBiHIX0201829
HGNCiHGNC:24305 NCAPD2
HPAiCAB012423
HPA036947
HPA037363
MalaCardsiNCAPD2
MIMi615638 gene
617983 phenotype
neXtProtiNX_Q15021
OpenTargetsiENSG00000010292
PharmGKBiPA162397021
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0414 Eukaryota
COG5098 LUCA
GeneTreeiENSGT00390000017108
HOGENOMiHOG000068001
HOVERGENiHBG038048
InParanoidiQ15021
KOiK06677
OMAiVCHAIAN
OrthoDBiEOG091G00PU
PhylomeDBiQ15021
TreeFamiTF105712

Enzyme and pathway databases

ReactomeiR-HSA-2514853 Condensation of Prometaphase Chromosomes

Miscellaneous databases

ChiTaRSiNCAPD2 human
GeneWikiiNCAPD2
GenomeRNAii9918
PROiPR:Q15021
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010292 Expressed in 167 organ(s), highest expression level in lung
CleanExiHS_NCAPD2
ExpressionAtlasiQ15021 baseline and differential
GenevisibleiQ15021 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCND1_HUMAN
AccessioniPrimary (citable) accession number: Q15021
Secondary accession number(s): D3DUR4, Q8N6U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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