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Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

SART3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).By similarity4 Publications
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • U4 snRNA binding Source: UniProtKB
  • U6atac snRNA binding Source: UniProtKB
  • U6 snRNA binding Source: UniProtKB
  • ubiquitin-specific protease binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3Curated
Short name:
SART-3Imported
Alternative name(s):
Tat-interacting protein of 110 kDa1 Publication
Short name:
Tip1101 Publication
p110 nuclear RNA-binding protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SART3Imported
Synonyms:KIAA0156Imported, TIP1101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000075856.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16860 SART3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611684 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9733

Open Targets

More...
OpenTargetsi
ENSG00000075856

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34948

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SART3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002233132 – 963Squamous cell carcinoma antigen recognized by T-cells 3Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei10PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei657PhosphothreonineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei906Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15020

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15020

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15020

PeptideAtlas

More...
PeptideAtlasi
Q15020

PRoteomics IDEntifications database

More...
PRIDEi
Q15020

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60370
60371 [Q15020-2]
60372 [Q15020-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15020

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15020

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075856 Expressed in 232 organ(s), highest expression level in endothelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_SART3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15020 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15020 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044322

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3 (PubMed:15314151, PubMed:20595234). Interacts with USP15; the interaction is direct (PubMed:24526689). Interacts with HIV-1 Tat (PubMed:11959860).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115082, 194 interactors

Protein interaction database and analysis system

More...
IntActi
Q15020, 48 interactors

Molecular INTeraction database

More...
MINTi
Q15020

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228284

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15020

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q15020

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15020

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 158HAT 1Add BLAST33
Repeati164 – 195HAT 2Add BLAST32
Repeati201 – 237HAT 3Add BLAST37
Repeati242 – 275HAT 4Add BLAST34
Repeati324 – 356HAT 5Add BLAST33
Repeati359 – 391HAT 6Add BLAST33
Repeati394 – 430HAT 7Add BLAST37
Repeati487 – 520HAT 8Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini704 – 782RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini801 – 878RRM 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 351Mediates interaction with PRPF31 PublicationAdd BLAST350
Regioni487 – 520Required for interaction with USP41 PublicationAdd BLAST34
Regioni537 – 953Necessary and sufficient for U6 snRNA binding1 PublicationAdd BLAST417
Regioni600 – 670Required for nuclear localization1 PublicationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili21 – 46Sequence analysisAdd BLAST26
Coiled coili82 – 110Sequence analysisAdd BLAST29
Coiled coili559 – 619Sequence analysisAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi601 – 617Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi89 – 92Poly-Glu4
Compositional biasi612 – 616Poly-Lys5

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0128 Eukaryota
ENOG410XP88 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063708

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053888

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15020

KEGG Orthology (KO)

More...
KOi
K22611

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEDWDVA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G041L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15020

TreeFam database of animal gene trees

More...
TreeFami
TF317554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12391 RRM1_SART3, 1 hit
cd12392 RRM2_SART3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR008669 LSM_interact
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034217 SART3_RRM1
IPR034218 SART3_RRM2
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05391 Lsm_interact, 1 hit
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 7 hits
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT
60 70 80 90 100
MGPAWDQQEE GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER
110 120 130 140 150
LEEQLSINVY DYNCHVDLIR LLRLEGELTK VRMARQKMSE IFPLTEELWL
160 170 180 190 200
EWLHDEISMA QDGLDREHVY DLFEKAVKDY ICPNIWLEYG QYSVGGIGQK
210 220 230 240 250
GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE AARLEKVHSL
260 270 280 290 300
FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE
310 320 330 340 350
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY
360 370 380 390 400
SQYLDRQLKV KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS
410 420 430 440 450
VTFEKALNAG FIQATDYVEI WQAYLDYLRR RVDFKQDSSK ELEELRAAFT
460 470 480 490 500
RALEYLKQEV EERFNESGDP SCVIMQNWAR IEARLCNNMQ KARELWDSIM
510 520 530 540 550
TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD YPEHVCEVLL
560 570 580 590 600
TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ
610 620 630 640 650
RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS
660 670 680 690 700
IPAAGETQNV EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS
710 720 730 740 750
KDSITVFVSN LPYSMQEPDT KLRPLFEACG EVVQIRPIFS NRGDFRGYCY
760 770 780 790 800
VEFKEEKSAL QALEMDRKSV EGRPMFVSPC VDKSKNPDFK VFRYSTSLEK
810 820 830 840 850
HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN
860 870 880 890 900
ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP
910 920 930 940 950
QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK
960
MSNADFAKLF LRK
Length:963
Mass (Da):109,935
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06B26CEB8B19102A
GO
Isoform 2 (identifier: Q15020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-364: SQYLDRQLKVKDLV → RSTTESKGFGFICT
     365-963: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Inactive in U4/U6 snRNP recycling.1 Publication
Show »
Length:364
Mass (Da):41,829
Checksum:iD86B2562A7FA2E4E
GO
Isoform 3 (identifier: Q15020-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-129: LSINVYDYNCHVDLIRLLRLEGELT → VGPGVGSGHLPVFQVLGSPCPGPPP
     130-963: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):13,773
Checksum:iB41FC49C1C5E4C33
GO
Isoform 4 (identifier: Q15020-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-436: Missing.

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):105,584
Checksum:iA4D08EF2F14CFC93
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV04F8VV04_HUMAN
Squamous cell carcinoma antigen rec...
SART3
771Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHU8H0YHU8_HUMAN
Squamous cell carcinoma antigen rec...
SART3
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W667F8W667_HUMAN
Squamous cell carcinoma antigen rec...
SART3
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZM2F8VZM2_HUMAN
Squamous cell carcinoma antigen rec...
SART3
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVK9F8VVK9_HUMAN
Squamous cell carcinoma antigen rec...
SART3
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03880223D → E1 PublicationCorresponds to variant dbSNP:rs2072579Ensembl.1
Natural variantiVAR_038683591V → M Found in a patient with disseminated superficial actinic porokeratosis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs118203954EnsemblClinVar.1
Natural variantiVAR_038684621E → D. Corresponds to variant dbSNP:rs2287546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017248105 – 129LSINV…EGELT → VGPGVGSGHLPVFQVLGSPC PGPPP in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_017249130 – 963Missing in isoform 3. 1 PublicationAdd BLAST834
Alternative sequenceiVSP_017250351 – 364SQYLD…VKDLV → RSTTESKGFGFICT in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_017251365 – 963Missing in isoform 2. 1 PublicationAdd BLAST599
Alternative sequenceiVSP_057284401 – 436Missing in isoform 4. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020880 mRNA Translation: BAA78384.1
AF387506 mRNA Translation: AAK69347.1
D63879 mRNA Translation: BAA09929.1
AK290209 mRNA Translation: BAF82898.1
AC008119 Genomic DNA No translation available.
AC010206 Genomic DNA No translation available.
KF455716 Genomic DNA No translation available.
KF511170 Genomic DNA No translation available.
BC032601 mRNA Translation: AAH32601.1
BC041638 mRNA Translation: AAH41638.1
BC093784 mRNA Translation: AAH93784.1
BC103706 mRNA Translation: AAI03707.1
BC111983 mRNA Translation: AAI11984.1
BC143253 mRNA Translation: AAI43254.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9117.1 [Q15020-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055521.1, NM_014706.3 [Q15020-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.584842

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228284; ENSP00000228284; ENSG00000075856 [Q15020-1]
ENST00000431469; ENSP00000414453; ENSG00000075856 [Q15020-4]
ENST00000546611; ENSP00000448554; ENSG00000075856 [Q15020-3]
ENST00000546728; ENSP00000449743; ENSG00000075856 [Q15020-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9733

UCSC genome browser

More...
UCSCi
uc001tmz.2 human [Q15020-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020880 mRNA Translation: BAA78384.1
AF387506 mRNA Translation: AAK69347.1
D63879 mRNA Translation: BAA09929.1
AK290209 mRNA Translation: BAF82898.1
AC008119 Genomic DNA No translation available.
AC010206 Genomic DNA No translation available.
KF455716 Genomic DNA No translation available.
KF511170 Genomic DNA No translation available.
BC032601 mRNA Translation: AAH32601.1
BC041638 mRNA Translation: AAH41638.1
BC093784 mRNA Translation: AAH93784.1
BC103706 mRNA Translation: AAI03707.1
BC111983 mRNA Translation: AAI11984.1
BC143253 mRNA Translation: AAI43254.1
CCDSiCCDS9117.1 [Q15020-1]
RefSeqiNP_055521.1, NM_014706.3 [Q15020-1]
UniGeneiHs.584842

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DO4NMR-A791-877[»]
5CTQX-ray2.60A/B/C/D94-611[»]
5CTRX-ray3.01A/B278-611[»]
5CTTX-ray1.70B601-649[»]
5JJWX-ray3.01A280-578[»]
5JJXX-ray2.00A81-393[»]
5JPZX-ray3.04A/B96-574[»]
ProteinModelPortaliQ15020
SMRiQ15020
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115082, 194 interactors
IntActiQ15020, 48 interactors
MINTiQ15020
STRINGi9606.ENSP00000228284

PTM databases

iPTMnetiQ15020
PhosphoSitePlusiQ15020

Polymorphism and mutation databases

BioMutaiSART3
DMDMi74762140

Proteomic databases

EPDiQ15020
MaxQBiQ15020
PaxDbiQ15020
PeptideAtlasiQ15020
PRIDEiQ15020
ProteomicsDBi60370
60371 [Q15020-2]
60372 [Q15020-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228284; ENSP00000228284; ENSG00000075856 [Q15020-1]
ENST00000431469; ENSP00000414453; ENSG00000075856 [Q15020-4]
ENST00000546611; ENSP00000448554; ENSG00000075856 [Q15020-3]
ENST00000546728; ENSP00000449743; ENSG00000075856 [Q15020-2]
GeneIDi9733
KEGGihsa:9733
UCSCiuc001tmz.2 human [Q15020-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9733
DisGeNETi9733
EuPathDBiHostDB:ENSG00000075856.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SART3
HGNCiHGNC:16860 SART3
HPAiHPA044322
MIMi611684 gene
neXtProtiNX_Q15020
OpenTargetsiENSG00000075856
PharmGKBiPA34948

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0128 Eukaryota
ENOG410XP88 LUCA
GeneTreeiENSGT00900000141107
HOGENOMiHOG000063708
HOVERGENiHBG053888
InParanoidiQ15020
KOiK22611
OMAiLEDWDVA
OrthoDBiEOG091G041L
PhylomeDBiQ15020
TreeFamiTF317554

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SART3 human
EvolutionaryTraceiQ15020

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SART3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9733

Protein Ontology

More...
PROi
PR:Q15020

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000075856 Expressed in 232 organ(s), highest expression level in endothelial cell
CleanExiHS_SART3
ExpressionAtlasiQ15020 baseline and differential
GenevisibleiQ15020 HS

Family and domain databases

CDDicd12391 RRM1_SART3, 1 hit
cd12392 RRM2_SART3, 1 hit
Gene3Di1.25.40.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR008669 LSM_interact
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034217 SART3_RRM1
IPR034218 SART3_RRM2
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05391 Lsm_interact, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SM00360 RRM, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSART3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15020
Secondary accession number(s): A8K2E4
, B7ZKM0, Q2M2H0, Q58F06, Q8IUS1, Q96J95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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