UniProtKB - Q15013 (MD2BP_HUMAN)
Protein
MAD2L1-binding protein
Gene
MAD2L1BP
Organism
Homo sapiens (Human)
Status
Functioni
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.1 Publication
GO - Biological processi
- deactivation of mitotic spindle assembly checkpoint Source: UniProtKB
- regulation of exit from mitosis Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q15013 |
Names & Taxonomyi
Protein namesi | Recommended name: MAD2L1-binding proteinAlternative name(s): Caught by MAD2 protein p31(comet)1 Publication |
Gene namesi | Name:MAD2L1BP Synonyms:CMT2, KIAA0110 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21059, MAD2L1BP |
MIMi | 618136, gene |
neXtProti | NX_Q15013 |
VEuPathDBi | HostDB:ENSG00000124688.13 |
Subcellular locationi
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 83 | Q → A: Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-191. 1 Publication | 1 | |
Mutagenesisi | 191 | F → A: Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-83. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9587 |
OpenTargetsi | ENSG00000124688 |
PharmGKBi | PA134911020 |
Miscellaneous databases
Pharosi | Q15013, Tbio |
Genetic variation databases
BioMutai | MAD2L1BP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096310 | 1 – 274 | MAD2L1-binding proteinAdd BLAST | 274 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 102 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q15013 |
jPOSTi | Q15013 |
MassIVEi | Q15013 |
MaxQBi | Q15013 |
PaxDbi | Q15013 |
PeptideAtlasi | Q15013 |
PRIDEi | Q15013 |
ProteomicsDBi | 19077 60365 [Q15013-1] |
PTM databases
iPTMneti | Q15013 |
PhosphoSitePlusi | Q15013 |
Expressioni
Developmental stagei
During the cell cycle, levels increase and then remain constant until late mitosis after which they drop.1 Publication
Gene expression databases
Bgeei | ENSG00000124688, Expressed in bone marrow and 218 other tissues |
Genevisiblei | Q15013, HS |
Organism-specific databases
HPAi | ENSG00000124688, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAD2L1.
2 PublicationsBinary interactionsi
Hide detailsQ15013
Protein-protein interaction databases
BioGRIDi | 114955, 51 interactors |
DIPi | DIP-34492N |
IntActi | Q15013, 30 interactors |
MINTi | Q15013 |
STRINGi | 9606.ENSP00000410818 |
Miscellaneous databases
RNActi | Q15013, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q15013 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q15013 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 78 | Interaction with MAD2L1Add BLAST | 34 |
Sequence similaritiesi
Belongs to the MAD2L1BP family.Curated
Phylogenomic databases
eggNOGi | ENOG502QTUF, Eukaryota |
GeneTreei | ENSGT00390000003812 |
HOGENOMi | CLU_079654_0_0_1 |
InParanoidi | Q15013 |
OMAi | PNPSEPF |
OrthoDBi | 1492026at2759 |
PhylomeDBi | Q15013 |
TreeFami | TF331730 |
Family and domain databases
InterProi | View protein in InterPro IPR009511, MAD1/Cdc20-bound-Mad2-bd |
PANTHERi | PTHR15681, PTHR15681, 1 hit |
Pfami | View protein in Pfam PF06581, p31comet, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q15013-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPEAEVLS SAAVPDLEWY EKSEETHASQ IELLETSSTQ EPLNASEAFC
60 70 80 90 100
PRDCMVPVVF PGPVSQEGCC QFTCELLKHI MYQRQQLPLP YEQLKHFYRK
110 120 130 140 150
PSPQAEEMLK KKPRATTEVS SRKCQQALAE LESVLSHLED FFARTLVPRV
160 170 180 190 200
LILLGGNALS PKEFYELDLS LLAPYSVDQS LSTAACLRRL FRAIFMADAF
210 220 230 240 250
SELQAPPLMG TVVMAQGHRN CGEDWFRPKL NYRVPSRGHK LTVTLSCGRP
260 270
SIRTTAWEDY IWFQAPVTFK GFRE
Sequence cautioni
The sequence BAG59665 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | S → G in BAG59665 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 274 | E → D in CAG33174 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046268 | 1 – 15 | MAAPE…SAAVP → MARVPLGRSLTLSPRLEHNG MTSAHHNFRLPGSRDSPASA SQVAEII in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14811 mRNA Translation: BAA03552.1 AK297172 mRNA Translation: BAG59665.1 Different initiation. CR456893 mRNA Translation: CAG33174.1 AL136131 Genomic DNA No translation available. AL353602 Genomic DNA No translation available. BC002904 mRNA Translation: AAH02904.1 AL537692 mRNA No translation available. |
CCDSi | CCDS47431.1 [Q15013-3] CCDS4904.1 [Q15013-1] |
RefSeqi | NP_001003690.1, NM_001003690.1 [Q15013-3] NP_055443.1, NM_014628.2 [Q15013-1] |
Genome annotation databases
Ensembli | ENST00000372171; ENSP00000361244; ENSG00000124688 [Q15013-1] ENST00000451025; ENSP00000410818; ENSG00000124688 [Q15013-3] |
GeneIDi | 9587 |
KEGGi | hsa:9587 |
UCSCi | uc003ovu.4, human [Q15013-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14811 mRNA Translation: BAA03552.1 AK297172 mRNA Translation: BAG59665.1 Different initiation. CR456893 mRNA Translation: CAG33174.1 AL136131 Genomic DNA No translation available. AL353602 Genomic DNA No translation available. BC002904 mRNA Translation: AAH02904.1 AL537692 mRNA No translation available. |
CCDSi | CCDS47431.1 [Q15013-3] CCDS4904.1 [Q15013-1] |
RefSeqi | NP_001003690.1, NM_001003690.1 [Q15013-3] NP_055443.1, NM_014628.2 [Q15013-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QYF | X-ray | 2.30 | B/D | 36-274 | [»] | |
6F0X | electron microscopy | 4.60 | P | 1-274 | [»] | |
SMRi | Q15013 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114955, 51 interactors |
DIPi | DIP-34492N |
IntActi | Q15013, 30 interactors |
MINTi | Q15013 |
STRINGi | 9606.ENSP00000410818 |
PTM databases
iPTMneti | Q15013 |
PhosphoSitePlusi | Q15013 |
Genetic variation databases
BioMutai | MAD2L1BP |
Proteomic databases
EPDi | Q15013 |
jPOSTi | Q15013 |
MassIVEi | Q15013 |
MaxQBi | Q15013 |
PaxDbi | Q15013 |
PeptideAtlasi | Q15013 |
PRIDEi | Q15013 |
ProteomicsDBi | 19077 60365 [Q15013-1] |
Protocols and materials databases
Antibodypediai | 30554, 296 antibodies |
DNASUi | 9587 |
Genome annotation databases
Ensembli | ENST00000372171; ENSP00000361244; ENSG00000124688 [Q15013-1] ENST00000451025; ENSP00000410818; ENSG00000124688 [Q15013-3] |
GeneIDi | 9587 |
KEGGi | hsa:9587 |
UCSCi | uc003ovu.4, human [Q15013-1] |
Organism-specific databases
CTDi | 9587 |
DisGeNETi | 9587 |
GeneCardsi | MAD2L1BP |
HGNCi | HGNC:21059, MAD2L1BP |
HPAi | ENSG00000124688, Low tissue specificity |
MIMi | 618136, gene |
neXtProti | NX_Q15013 |
OpenTargetsi | ENSG00000124688 |
PharmGKBi | PA134911020 |
VEuPathDBi | HostDB:ENSG00000124688.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTUF, Eukaryota |
GeneTreei | ENSGT00390000003812 |
HOGENOMi | CLU_079654_0_0_1 |
InParanoidi | Q15013 |
OMAi | PNPSEPF |
OrthoDBi | 1492026at2759 |
PhylomeDBi | Q15013 |
TreeFami | TF331730 |
Enzyme and pathway databases
PathwayCommonsi | Q15013 |
Miscellaneous databases
BioGRID-ORCSi | 9587, 224 hits in 1007 CRISPR screens |
ChiTaRSi | MAD2L1BP, human |
EvolutionaryTracei | Q15013 |
GeneWikii | MAD2L1BP |
GenomeRNAii | 9587 |
Pharosi | Q15013, Tbio |
PROi | PR:Q15013 |
RNActi | Q15013, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124688, Expressed in bone marrow and 218 other tissues |
Genevisiblei | Q15013, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009511, MAD1/Cdc20-bound-Mad2-bd |
PANTHERi | PTHR15681, PTHR15681, 1 hit |
Pfami | View protein in Pfam PF06581, p31comet, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MD2BP_HUMAN | |
Accessioni | Q15013Primary (citable) accession number: Q15013 Secondary accession number(s): B4DLV3, E9PAT7, Q6IBB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families